Medicine

New Form of Parkinson's Treatment Uses Real-Time Deep-Brain Stimulation 8

A newly FDA-approved form of adaptive deep-brain stimulation (DBS) for Parkinson's disease adjusts electrical stimulation in real time based on an individual's brain signals, improving symptom control and reducing medication dependence. Scientific American: For decades, Keith Krehbiel took high doses of medications with a debilitating side effect -- severe nausea -- following his diagnosis with early-onset Parkinson's disease at age 42 in 1997. When each dose wore off, he experienced dyskinesia -- involuntary, repetitive muscle movements. In his case, this consisted of head bobbing and weaving. Krehbiel is among one million Americans who live with this progressive neurological disorder, which causes slowed movements, tremors and balance problems. But soon after surgery to implant electrodes into specific areas of his brain in 2020, his life dramatically improved. "My tremor went away almost entirely," says Krehbiel, now age 70 and a professor emeritus of political science at the Stanford Graduate School of Business, whose Parkinson's symptoms began at age 40 and were initially misdiagnosed as repetitive stress injury from computer use. "I reduced my Parkinson's meds by more than two thirds," he adds. "And I no longer have a sensation of a foggy brain, nor nausea or dyskinesia."

Krehbiel was the first participant to enroll in a clinical trial testing a new form of deep-brain stimulation (DBS), a technology that gained approval from the U.S. Food and Drug Administration for Parkinson's tremor and essential tremor in 1997 (it was later approved for other symptoms and conditions). The new adaptive system adjusts stimulation levels automatically based on the person's individual brain signals. In late February it received FDA approval for Parkinson's disease "based on results of the international multicenter trial, which involved participants at 10 sites across a total of four countries -- the U.S., the Netherlands, Canada and France. This technology is suitable for anyone with Parkinson's, not just individuals in clinical trials, says Helen Bronte-Stewart, the recent trial's global lead investigator and a neurologist specializing in movement disorders at Stanford Medicine. "Like a cardiac pacemaker that responds to the rhythms of the heart, adaptive deep-brain stimulation uses a person's individual brain signals to control the electric pulses it delivers," Bronte-Stewart says. "This makes it more personalized, precise and efficient than older DBS methods."

"Traditional DBS delivers constant stimulation, which doesn't always match the fluctuating symptoms of Parkinson's disease," adds neurologist Todd Herrington, another of the trial's investigators and director of the deep-brain stimulation program at Massachusetts General Hospital. With adaptive DBS, "the goal is to adjust stimulation in real time to provide more effective symptom control, fewer side effects and improved patient quality of life." Current FDA approval of this adaptive system is for the treatment of Parkinson's only, not essential tremor, dystonia (a neurological disorder that causes excessive, repetitive and involuntary muscle contractions) or epilepsy, which still rely on traditional, continuous DBS, Herrington says.
Advertising

Roku Tests Autoplaying Ads Loading Before the Home Screen 59

Roku is testing autoplaying video ads that play before users can access the home screen. While Roku claims this is just an experiment, users are threatening to abandon the platform if the change becomes permanent. Ars Technica reports: Reports of Roku customers seeing video ads automatically play before they could view the OS' home screen started appearing online this week. A Reddit user, for example, posted yesterday: "I just turned on my Roku and got an unskippable ad for a movie, before I got to the regular Roku home screen." Multiple apparent users reported seeing an ad for the movie Moana 2. When reached for comment, a Roku spokesperson shared a company statement that confirms that the autoplaying ads are expected behavior but not a permanent part of Roku OS currently. Instead, Roku claimed, it was just trying the ad capability out.

Roku's representative said that Roku's business "has and will always require continuous testing and innovation across design, navigation, content, and our first-rate advertising products," adding: "Our recent test is just the latest example, as we explore new ways to showcase brands and programming while still providing a delightful and simple user experience."
Businesses

Alphabet Back In Talks To Buy Wiz For $30 Billion (yahoo.com) 14

Google's parent company Alphabet is reportedly in talks to acquire cybersecurity startup Wiz for approximately $30 billion. Last July, negotiations had advanced on a $23 billion deal, but the talks were put on hold to prioritize Wiz's IPO. Around the same time, Alphabet also walked away from a potential acquisition of online marketing software company HubSpot. Reuters reports: The startup provides cloud-based cybersecurity solutions powered by artificial intelligence that help companies identify and remove critical risks on cloud platforms. A buyout of this size will most likely face regulatory scrutiny as tech giants are kept under close watch for possible monopolistic practices.

If the deal goes through, it could help Alphabet tap into the cybersecurity industry and expand its booming cloud infrastructure segment, which generated more than $43 billion in revenue last year. Wiz was last valued at $12 billion in a private funding round in May 2024.

Windows

Huawei To Pivot To Linux, HarmonyOS as Microsoft Windows License Expires 37

Huawei will no longer be able to produce or sell Windows-based PCs as Microsoft's supply license to the Chinese tech company expires this month, according to Chinese tech site MyDrivers. The restriction comes as Huawei remains on the U.S. Department of Commerce's Entity List, requiring American companies to obtain special export licenses to conduct business with the firm.

Richard Yu, executive director of Huawei's consumer business unit, said the company is preparing to pivot to alternative operating systems. Huawei had previously announced plans to abandon Windows for future PC generations. The Chinese tech giant will introduce a new "AI PC" laptop in April running its own Kunpeng CPU and HarmonyOS, alongside a MateBook D16 Linux Edition, its first Linux-based laptop.
Education

Harvard Says Tuition Will Be Free For Families Making $200K or Less (go.com) 75

Harvard University on Monday announced that tuition will be free for students from families with annual incomes of $200,000 or less starting in the 2025-26 academic year. From a report: "Putting Harvard within financial reach for more individuals widens the array of backgrounds, experiences, and perspectives that all of our students encounter, fostering their intellectual and personal growth," Harvard University President Alan M. Garber said in a statement. "By bringing people of outstanding promise together to learn with and from one another, we truly realize the tremendous potential of the University."

The new plan will enable about 86% of U.S. families to qualify for Harvard financial aid and expand the Ivy League college's commitment to providing all undergrads the resources they need to enroll and graduate, according to Garber.

Businesses

Should Friday be the New Saturday? (nber.org) 47

Abstract of a paper published on National Bureau of Economic Research: This paper investigates self-reported wedges between how much people work and how much they want to work, at their current wage. More than two-thirds of full-time workers in German survey data are overworked -- actual hours exceed desired hours. We combine this evidence with a simple model of labor supply to assess the welfare consequences of tighter weekly hours limits via willingness-to-pay calculations. According to counterfactuals, the optimal length of the workweek in Germany is 37 hours. Introducing such a cap would raise welfare by .8-1.6% of GDP. The gains from a shortened workweek are largest for workers who are married, female, white collar, middle aged, and high income. An extended analysis integrates a non-constant wage-hours relationship, falling capital returns, and a shrinking tax base.
Government

Consumer Groups Push New Law Fighting 'Zombie' IoT Devices (consumerreports.org) 56

Long-time Slashdot reader chicksdaddy writes: A group of U.S. consumer advocacy groups on Wednesday proposed legislation to address the growing epidemic of "zombie" Internet of Things (IoT) devices that have had software support cut off by their manufacturer, Fight To Repair News reports.

The Connected Consumer Product End of Life Disclosure Act is a collaboration between Consumer Reports, US PIRG, the Secure Resilient Future Foundation (SRFF) and the Center for Democracy and Technology. It requires manufacturers of connected consumer products to disclose for how long they will provide technical support, security updates, or bug fixes for the software and hardware that are necessary for the product to operate securely.

The groups proposed legal requirements that manufacturers "must notify consumers when their devices are nearing the end of life and provide guidance on how to handle the device's end of life," while end-of-life notifications "must include details about features that will be lost, and potential vulnerabilities and security risks that may arise." And when an ISP-provided device (like a router) reaches its end of life, the ISP must remove them.

"The organizations are working with legislators at the state and federal level to get the model legislation introduced," according to Fight To Repair News.
Businesses

Remote Working Saved Zillow Money, Helped Recruiting, and Maintained Productivity (seattletimes.com) 40

Zillow CEO Jeremy Wacksman "recently told Entrepreneur magazine that almost five years of remote work has 'been fantastic for us,'" writes the Seattle Times. Zillow shifted to allowing people to work fully remote during the pandemic. It's been a recruiting and retention tool for Zillow as they "now see four times the number of job applicants for every job we have versus what we did before the pandemic," Wacksman said.

While Zillow still lists its corporate headquarters as Seattle, the company bills itself as "cloud-headquartered," with remote workers and satellite offices. Wacksman's comments are backed by serious real estate moves the company has made over the past five years. An annual report detailing Zillow's financial results for 2024 shows its Seattle headquarters and offices across the country are shrinking. In 2019, Zillow had 386,275 square feet of office space in Seattle after steadily gobbling up floors of the Russell Investments Center downtown over the prior five years. The company reported it had 113,470 square feet in Seattle at the end of 2024... The company has drastically cut costs by shedding offices. Zillow's total leasing costs reached $54 million in 2022 and dropped to $34 million last year... It expects those costs to decrease even further, to $18 million by 2029. Zillow is also taking advantage of subleasing some of its office space and expects $26 million in sublease income between 2025 and 2030...

Zillow's financial results from last year suggest the workforce has been productive while logging in from home. The company reported Tuesday that it beat Wall Street expectations for the last three months of 2024 with a quarterly revenue of $554 million. Wacksman said in a news release Tuesday that 2024 was a "remarkable year for Zillow," as it reached its goal of double-digit revenue growth.

Intel

Intel's Stock Jumps 18.8% - But What's In Its Future? (msn.com) 47

Intel's stock jumped nearly 19% this week. "However, in the past year through Wednesday's close, Intel stock had fallen 53%," notes Investor's Business Daily: The appointment of Lip-Bu Tan as CEO is a "good start" but Intel has significant challenges, Morgan Stanley analyst Joseph Moore said in a client note. Those challenges include delays in its server chip product line, a very competitive PC chip market, lack of a compelling AI chip offering, and over $10 billion in losses in its foundry business over the past 12 months. There is "no quick fix" for those issues, he said.
"There are things you can do," a Columbia business school associate professor tells the Wall Street Journal in a video interview, "but it's going to be incremental, and it's going to be extremely risky... They will try to be competitive in the foundry manufacturing space," but "It takes very aggressive investments."

Meanwhile, TSMC is exploring a joint venture where they'd operate Intel's factories, even pitching the idea to AMD, Nvidia, Broadcam, and Qualcomm, according to Reuters. (They add that Intel "reported a 2024 net loss of $18.8 billion, its first since 1986," and talked to multiple sources "familiar with" talks about Intel's future). Multiple companies have expressed interest in buying parts of Intel, but two of the four sources said the U.S. company has rejected discussions about selling its chip design house separately from the foundry division. Qualcomm has exited earlier discussions to buy all or part of Intel, according to those people and a separate source. Intel board members have backed a deal and held negotiations with TSMC, while some executives are firmly opposed, according to two sources.
"They say Lip-Bu Tan is the best hope to fix Intel — if Intel can be fixed at all," writes the Wall Street Journal: He brings two decades of semiconductor industry experience, relationships across the sector, a startup mindset and an obsession with AI...and basketball. He also comes with tricky China business relationships, underscoring Silicon Valley's inability to sever itself from one of America's top adversaries... [Intel's] stock has lost two-thirds of its value in four short years as Intel sat out the AI boom...

Manufacturing chips is an enormous expense that Intel can't currently sustain, say industry leaders and analysts. Former board members have called for a split-up. But a deal to sell all or part of Intel to competitors seems to be off the table for the immediate future, according to bankers. A variety of early-stage discussions with Broadcom, Qualcomm, GlobalFoundries and TSMC in recent months have failed to go anywhere, and so far seem unlikely to progress. The company has already hinted at a more likely outcome: bringing in outside financial backers, including customers who want a stake in the manufacturing business...

Tan has likely no more than a year to turn the company around, said people close to the company. His decades of investing in startups and running companies — he founded a multinational venture firm and was CEO of chip design company Cadence Design Systems for 13 years — provide indications of how Tan will tackle this task in the early days: by cutting expenses, moving quickly and trying to turn Intel back into an engineering-first company. "In areas where we are behind the competition, we need to take calculated risks to disrupt and leapfrog," Tan said in a note to Intel employees on Wednesday. "And in areas where our progress has been slower than expected, we need to find new ways to pick up the pace...."

Many take this culture reset to also mean significant cuts at Intel, which already shed about 15,000 jobs last year. "He is brave enough to adjust the workforce to the size needed for the business today," said Reed Hundt, a former Intel board member who has known Tan since the 1990s.

Government

US IRS To Re-Evaluate Modernization Investments In Light of AI Technology (msn.com) 35

The IRS is pausing its technology modernization efforts to reassess its strategy in light of AI advancements. Reuters reports: The agency will review a number of technology modernization initiatives that have been taken in recent years, including a new direct free filing system for tax returns that was launched last year under the Biden administration, the official told reporters. The official said the IRS did not have a specific number of staff cuts in mind as a result of the technology pause, but said there would be an opportunity to "realign the workforce to those new ways of doing business."
Businesses

Strava Bans User for Running in North Korea (dcrainmaker.com) 15

Fitness tracking platform Strava has terminated user accounts for uploading running activities recorded in North Korea, citing U.S. sanctions that prohibit offering online services to the country. A doctoral student researching North Korea had her account deleted after uploading a run recorded during a visit to the country. Another user was banned for a virtual treadmill workout set in North Korea, though their account was later reinstated.

"In accordance with mandatory U.S. sanctions and export controls, Strava does not allow users to post activities occurring there," the company told technology blogger Ray Maker in a statement. Unlike Strava, other major tech platforms including YouTube, Facebook and Apple do not appear to restrict content created in North Korea from being uploaded once users return home.
Businesses

T-Mobile Raising Rates for More Legacy Customers (cnet.com) 45

After raising rates last June for customers on some of its older plans, T-Mobile is pushing up costs again -- but it's not entirely clear how many people are affected. From a report: According to a memo obtained by CNET and sent to T-Mobile employees early this morning, some people will see a $5 per-line increase beginning with their April or May bills.

The memo by Jon Freier, president of T-Mobile's consumer group, states that customers affected by the price hike should be notified by the end of today, March 13. Only those who receive a notice will see the rate increase.

Freier cites the "rising costs over the past several years" as the impetus behind the price push. Other carriers are facing the same headwinds, such as Verizon last December and this January, and AT&T last January and June.

Earth

Bill Gates' Climate Group Lays Off US, Europe Policy Teams 110

Breakthrough Energy, the climate group founded by Bill Gates, has laid off dozens of employees in the U.S. and Europe, eliminating its public policy and partnerships teams as it shifts away from advocacy work. Its investment and grantmaking divisions will remain unaffected. The Detroit News reports: Breakthrough Energy is an umbrella organization founded by Gates that houses various initiatives aimed at accelerating the clean energy transition. It also encompasses Breakthrough Energy Ventures, one of the biggest investors in early-stage climate technologies with stakes in more than 120 companies, as well as a grantmaking program for early-seed stage company founders and Breakthrough Catalyst, a funding platform focused on emergent climate technologies. None of those divisions of the group were impacted by cuts, which were reported earlier by the New York Times.

[...] "In the United States especially, the conversation about climate has been sidetracked by politics," Gates wrote in the introduction to his 2021 book. "Some days, it can seem as if we have little hope of getting anything done." The climate pullback is happening at the same time as the US cuts foreign aid, a field where Gates is also a major donor. His nonprofit, the Gates Foundation, operates with a budget of billions and has a strong focus on overseas development.
"Bill Gates remains as committed as ever to advancing the clean energy innovations needed to address climate change," a Breakthrough Energy spokesperson said in an emailed statement. "His work in this area will continue and is focused on helping drive reliable affordable, clean energy solutions that will enable people everywhere to thrive."

On Wednesday, the EPA announced the agency will "undertake 31 historic actions in the greatest and most consequential day of deregulation in U.S. history..."
Businesses

Citigroup Plans To Slash IT Contractors, Hire Staff To Improve Controls (reuters.com) 23

An anonymous reader shares a report: Citigroup plans to dramatically reduce its reliance on IT contractors and hire thousands of employees for IT as the lender grapples with regulatory punishments over data governance and deficient controls. Citigroup's head of technology Tim Ryan told staff in recent weeks that the bank aims to cut back external contractors to 20% of those working in IT from the current 50%, according to an internal presentation to employees seen by Reuters.

The briefing did not give a precise time horizon for the changes. As part of the overhaul, Citi will replenish the ranks by hiring more staff, and aims to have 50,000 employees in technology, up from 48,000 in 2024, the presentation showed. "Citi is growing our internal technology capabilities to support our strategy to improve safety and soundness, enable revenue growth and drive efficiencies," Citi said in a statement to Reuters.

News

German Spy Agency Concluded COVID Virus Likely Leaked From Lab (reuters.com) 227

An anonymous reader shares a report: Germany's foreign intelligence service in 2020 put at 80%-90% the likelihood that the coronavirus behind the COVID-19 pandemic was accidentally released from China's Wuhan Institute of Virology, two German newspapers reported on Wednesday.

According to a joint report by publications Die Zeit and Sueddeutscher Zeitung, Germany's spying agency BND had indications that the institute had conducted gain-of-function experiments, whereby viruses are modified to become more transmissible to humans for research purposes.

It also had indications that numerous violations of safety regulations had occurred at the lab, the papers said. The spy agency assessment's was based on an unspecified intelligence operation code-named "Saaremaa" as well as on publicly-available data. It had been commissioned by the office of Germany's chancellor at the time, Angela Merkel, but never published, the report said.

Intel

Intel Appoints Lip-Bu Tan As CEO (cnbc.com) 21

Intel has appointed Lip-Bu Tan as its new CEO in an effort to turn around the struggling chipmaker, following the resignation of Pat Gelsinger. CNBC reports: Tan was previously CEO of Cadence Design Systems, which makes software used by all the major chip designers, including Intel. He was an Intel board member but departed last year, citing other commitments. Tan replaces interim co-CEOs David Zinsner and MJ Holthaus, who took over in December when former Intel CEO Patrick Gelsinger was ousted. Tan is also rejoining Intel's board. [...] Intel shares rose over 12% in extended trading on Wednesday.
Businesses

The Curious Surge of Productivity in US Restaurants (nber.org) 57

The abstract of a paper published on National Bureau of Economic Research: We document that, after remaining almost constant for almost 30 years, real labor productivity at U.S. restaurants surged over 15% during the COVID pandemic. This surge has persisted even as many conditions have returned to pre-pandemic levels. Using mobile phone data tracking visits and spending at more than 100,000 individual limited service restaurants across the country, we explore the potential sources of the surge.

It cannot be explained by economies of scale, expanding market power, or a direct result of COVID-sourced demand fluctuations. The restaurants' productivity growth rates are strongly correlated, however, with reductions in the amount of time their customers spend in the establishments, particularly with a rising share of customers spending 10 minutes or less. The frequency of such 'take-out' customers rose considerably during COVID, even at fast food restaurants, and never went back down. The magnitude of the restaurant-level relationship between productivity and customer dwell time, if applied to the aggregate decrease in dwell time, can explain almost all of the aggregate productivity increase in our sample.

Technology

D-Wave Claims 'Quantum Supremacy,' Beating Traditional Computers 19

D-Wave researchers have published findings in Science demonstrating what they call "quantum supremacy" by showing their quantum annealers can solve problems beyond the reach of classical computers. The team, led by Andrew D. King, demonstrated area-law scaling of entanglement in model quench dynamics of two-, three- and infinite-dimensional spin glasses.

The research shows quantum annealers rapidly generating samples that closely match solutions to the Schrodinger equation, supporting observed stretched-exponential scaling in matrix-product-state approaches. According to the paper, D-Wave's processors completed these magnetic materials simulations in under 20 minutes, while the same calculations would require nearly a million years on Oak Ridge National Laboratory's supercomputers.

The claim hasn't gone unchallenged. Miles Stoudenmire from the Flatiron Institute's Center for Computational Quantum Physics argues that classical computers can achieve comparable results using methods developed since D-Wave's initial findings. "We're just saying, 'Look, this one problem at this one time didn't beat classical computers. Try again,'" Stoudenmire noted. The quantum computing community has increasingly shifted terminology from "supremacy" to "advantage" or "utility," focusing on solving practical business or scientific problems faster, more accurately, or more economically than classical alternatives.
Businesses

Roomba-maker iRobot Warns of Possible Shutdown Within 12 Months (irobot.com) 77

Roomba maker iRobot has warned it may cease operations within 12 months unless it can refinance debt or find a buyer, just one day after launching a new vacuum cleaner line. In its March 12 quarterly report, the company disclosed it had spent $3.6 million to amend terms on a $200 million Carlyle Group loan from 2023, as U.S. revenue plunged 47% in the fourth quarter.

"Given these uncertainties and the implication they may have on the Company's financials, there is substantial doubt about the Company's ability to continue as a going concern for a period of at least 12 months from the date of the issuance of its consolidated 2024 financial statements," the company wrote.

The robot vacuum pioneer has initiated a formal strategic review after a failed Amazon acquisition, the departure of founder Colin Angle, and layoffs affecting over half its workforce. iRobot cited mounting competition from Chinese manufacturers and expects continued losses for "the foreseeable future."
Privacy

Allstate Insurance Sued For Delivering Personal Info In Plaintext (theregister.com) 23

An anonymous reader quotes a report from The Register: New York State has sued Allstate Insurance for operating websites so badly designed they would deliver personal information in plain-text to anyone that went looking for it. The data was lifted from Allstate's National General business unit, which ran a website for consumers who wanted to get a quote for a policy. That task required users to input a name and address, and once that info was entered, the site searched a LexisNexis Risk Solutions database for data on anyone who lived at the address provided. The results of that search would then appear on a screen that included the driver's license number (DLN) for the given name and address, plus "names of any other drivers identified as potentially living at that consumer's address, and the entire DLNs of those other drivers."

Naturally, miscreants used the system to mine for people's personal information for fraud. "National General intentionally built these tools to automatically populate consumers' entire DLNs in plain text -- in other words, fully exposed on the face of the quoting websites -- during the quoting process," the court documents [PDF] state. "Not surprisingly, attackers identified this vulnerability and targeted these quoting tools as an easy way to access the DLNs of many New Yorkers," according to the lawsuit. The digital thieves then used this information to "submit fraudulent claims for pandemic and unemployment benefits," we're told. ... [B]y the time the insurer resolved the mess, crooks had built bots that harvested at least 12,000 individuals' driver's license numbers from the quote-generating site.

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