Space

UK-backed OneWeb To Use Rival SpaceX Rockets After Russian Ban (theguardian.com) 40

OneWeb, the satellite company part-owned by the British state, is turning to Elon Musk's SpaceX for help after it was barred from using Russian rockets to launch its latest orbiters. From a report: Under the arrangement, the communications firm will partner with SpaceX for its first launches later this year, adding to the 428 micro-satellites it already has in low-earth orbit. OneWeb and SpaceX did not disclose the terms of the launch arrangement. The company quotes a standard price of $67m to launch a Falcon 9 rocket â" up from $62m earlier this year, "to account for excessive levels of inflation." The 12% increase is the first in nearly six years. OneWeb was forced to abandon its plans to launch on one of Russia's Soyuz rockets earlier this month, after Dmitry Rogozin, the head of the Russian space agency, demanded the satellites not be used for military purposes and the British government halt its financial backing.
Science

Gravity Could Solve Renewable Energy's Biggest Problem (cnn.com) 249

In the Swiss municipality of Arbedo-Castione, a 70-meter crane stands tall. Six arms protrude from the top, hoisting giant blocks into the sky. But these aren't building blocks, and the crane isn't being used for construction. From a report: The steel tower is a giant mechanical energy storage system, designed by American-Swiss startup Energy Vault, that relies on gravity and 35-ton bricks to store and release energy. When power demand is low, the crane uses surplus electricity from the Swiss grid to raise the bricks and stack them at the top. When power demand rises, the bricks are lowered, releasing kinetic energy back to the grid. It might sound like a school science project, but this form of energy storage could be vital as the world transitions to clean energy.

"There's a big push to get renewables deployed," Robert Piconi, founder of Energy Vault, tells CNN Business, adding that companies are under increasing pressure from governments, investors and employees to decarbonize. But relying on renewables for consistent power is impossible without energy storage, he says. Unlike a fossil fuel power station, which can operate night and day, wind and solar power are intermittent, meaning that if a cloud blocks the sun or there's a lull in the wind, electricity generation drops. To compete with fossil fuels, you need to "make renewables predictable," says Piconi, which means storing excess energy and being able to dispatch it when required.

[...] Instead, Energy Vault decided to base its technology on a method developed over 100 years ago, which is widely used to store renewable energy: pumped storage hydropower. During off-peak periods, a turbine pumps water from a reservoir on low ground to one on higher ground, and during periods of peak demand, the water is allowed to flow down through the turbine, generating electrical energy. Piconi says Energy Vault relies on gravity in the same way, but "instead of using water, we're using these composite blocks." By doing it this way, he says the company is not dependent on topography and doesn't have to dig out reservoirs or create dams, which can have negative effects on the environment.

Science

Researchers Discover a New (intermediate and Tetragonal) Form of Ice (phys.org) 6

Researchers at the University of Nevada, Las Vegas were trying to understand how water might behave under the high pressures inside distant planets.

But along the way the team discovered a new form of ice, reports Phys.org, "redefining the properties of water at high pressures." Solid water, or ice, is like many other materials in that it can form different solid materials based on variable temperature and pressure conditions, like carbon forming diamond or graphite. However, water is exceptional in this aspect as there are at least 20 solid forms of ice known to us.

A team of scientists working in UNLV's Nevada Extreme Conditions Lab pioneered a new method for measuring the properties of water under high pressure. The water sample was first squeezed between the tips of two opposite-facing diamonds — freezing into several jumbled ice crystals. The ice was then subjected to a laser-heating technique that temporarily melted it before it quickly re-formed into a powder-like collection of tiny crystals. By incrementally raising the pressure, and periodically blasting it with the laser beam, the team observed the water ice make the transition from a known cubic phase, Ice-VII, to the newly discovered intermediate, and tetragonal, phase, Ice-VIIt, before settling into another known phase, Ice-X....

While it's unlikely we'll find this new phase of ice anywhere on the surface of Earth, it is likely a common ingredient within the mantle of Earth as well as in large moons and water-rich planets outside of our solar system. The team's findings were reported in the March 17 issue of the journal Physical Review B.... The work also recalibrates our understanding of the composition of exoplanets, UNLV physicist Ashkan Salamat added. Researchers hypothesize that the Ice-VIIt phase of ice could exist in abundance in the crust and upper mantle of expected water-rich planets outside of our solar system, meaning they could have conditions habitable for life.

Thanks to long-time Slashdot reader fahrbot-bot for sharing the story...
Science

Sleeping With the Light On May Be Harmful To You (northwestern.edu) 36

"Exposure to even moderate ambient lighting during nighttime sleep, compared to sleeping in a dimly lit room, harms your cardiovascular function during sleep and increases your insulin resistance the following morning," announced Northwestern Medicine, citing a new study recently published in the Proceedings of the National Academy of Sciences.

The Washington Post reports: Researchers at Northwestern University had two groups of 10 young adults sleep in differently lit rooms. One group slept in rooms with dim light for two nights; the other slept one night in a room with dim night and the next in a room with moderate overhead light — about the equivalent of an overcast day. Participants wore heart monitors at night. In the morning, they did a variety of glucose tests.

Both groups got the same amount of sleep but their bodies experienced very different nights. Both groups responded well to insulin the first night, when they both slept in dim lighting. On the second night, however, the group sleeping in brighter lighting didn't respond as well to insulin. The dim light sleepers' insulin resistance scores fell about 4 percent on the second night, while the bright sleepers' rose about 15 percent. Their heart rates were faster on the bright night, too.

"[J]ust a single night of exposure to moderate room lighting during sleep can impair glucose and cardiovascular regulation, which are risk factors for heart disease, diabetes and metabolic syndrome," concludes senior study author Dr. Phyllis Zee. "It's important for people to avoid or minimize the amount of light exposure during sleep."

From Northwestern's announcement: There is already evidence that light exposure during daytime increases heart rate via activation of the sympathetic nervous system, which kicks your heart into high gear and heightens alertness to meet the challenges of the day. "Our results indicate that a similar effect is also present when exposure to light occurs during nighttime sleep," Zee said....

An earlier study published in JAMA Internal Medicine looked at a large population of healthy people who had exposure to light during sleep. They were more overweight and obese, Zee said. "Now we are showing a mechanism that might be fundamental to explain why this happens. We show it's affecting your ability to regulate glucose," Zee said.

Math

Linux Random Number Generator Sees Major Improvements (phoronix.com) 80

An anonymous Slashdot reader summarizes some important news from the web page of Jason Donenfeld (creator of the open-source VPN protocol WireGuard): The Linux kernel's random number generator has seen its first set of major improvements in over a decade, improving everything from the cryptography to the interface used. Not only does it finally retire SHA-1 in favor of BLAKE2s [in Linux kernel 5.17], but it also at long last unites '/dev/random' and '/dev/urandom' [in the upcoming Linux kernel 5.18], finally ending years of Slashdot banter and debate:

The most significant outward-facing change is that /dev/random and /dev/urandom are now exactly the same thing, with no differences between them at all, thanks to their unification in random: block in /dev/urandom. This removes a significant age-old crypto footgun, already accomplished by other operating systems eons ago. [...] The upshot is that every Internet message board disagreement on /dev/random versus /dev/urandom has now been resolved by making everybody simultaneously right! Now, for the first time, these are both the right choice to make, in addition to getrandom(0); they all return the same bytes with the same semantics. There are only right choices.

Phoronix adds: One exciting change to also note is the getrandom() system call may be a hell of a lot faster with the new kernel. The getrandom() call for obtaining random bytes is yielding much faster performance with the latest code in development. Intel's kernel test robot is seeing an 8450% improvement with the stress-ng getrandom() benchmark. Yes, an 8450% improvement.
Space

Could Dark Matter Be Explained by an Anti-Universe Running Backwards in Time? (livescience.com) 104

"A wild new theory suggests there may be another 'anti-universe,' running backward in time prior to the Big Bang," writes Live Science, citing a new paper recently accepted for publication in the journal Annals of Physics. The idea assumes that the early universe was small, hot and dense — and so uniform that time looks symmetric going backward and forward. If true, the new theory means that dark matter isn't so mysterious; it's just a new flavor of a ghostly particle called a neutrino that can only exist in this kind of universe.

And the theory implies there would be no need for a period of "inflation" that rapidly expanded the size of the young cosmos soon after the Big Bang. If true, then future experiments to hunt for gravitational waves, or to pin down the mass of neutrinos, could answer once and for all whether this mirror anti-universe exists....

Physicists have identified a set of fundamental symmetries in nature.... We live in an expanding universe. This universe is filled with lots of particles doing lots of interesting things, and the evolution of the universe moves forward in time. If we extend the concept of CPT [charge/parity/time] symmetry to our entire cosmos, then our view of the universe can't be the entire picture. Instead, there must be more. To preserve the CPT symmetry throughout the cosmos, there must be a mirror-image cosmos that balances out our own. This cosmos would have all opposite charges than we have, be flipped in the mirror, and run backward in time. Our universe is just one of a twin. Taken together, the two universes obey CPT symmetry.

The study researchers next asked what the consequences of such a universe would be. They found many wonderful things. For one, a CPT-respecting universe naturally expands and fills itself with particles, without the need for a long-theorized period of rapid expansion known as inflation. While there's a lot of evidence that an event like inflation occurred, the theoretical picture of that event is incredibly fuzzy. It's so fuzzy that there is plenty of room for proposals of viable alternatives....

We would never have access to our twin, the CPT-mirror universe, because it exists "behind" our Big Bang, before the beginning of our cosmos.

The theory ultimately just extends the symmetry of CPT, argues the article, "from applying to just the 'actors' of the universe (forces and fields) to the 'stage' itself, the entire physical object of the universe."

Thanks to long-time Slashdot reader fahrbot-bot for sharing the story!
Medicine

Ivermectin Didn't Protect People from COVID-19, Finds Largest Trial Yet (marketwatch.com) 289

"Researchers testing repurposed drugs against Covid-19 found that ivermectin didn't reduce hospital admissions, in the largest trial yet of the effect of the antiparasitic on the disease driving the pandemic," reports the Wall Street Journal: Public-health authorities and researchers have for months said the drug hasn't shown any benefit in treating the disease.... The latest trial, of nearly 1,400 Covid-19 patients at risk of severe disease, is the largest to show that those who received ivermectin as a treatment didn't fare better than those who received a placebo. "There was no indication that ivermectin is clinically useful," said Edward Mills, one of the study's lead researchers and a professor of health sciences at Canada's McMaster University in Hamilton, Ontario.
"That finding is consistent with long-standing FDA claims that ivermectin showed no benefits in clinical testing and could be dangerous in large doses," reports the New York Daily News.

These new findings "have been accepted for publication in a major peer-reviewed medical journal," notes Seeking Alpha.
AI

Simple Electrical Circuit Learns On Its Own -- With No Help From a Computer (science.org) 53

sciencehabit shares a report from Science.org: A simple electrical circuit has learned to recognize flowers based on their petal size. That may seem trivial compared with artificial intelligence (AI) systems that recognize faces in a crowd, transcribe spoken words into text, and perform other astounding feats. However, the tiny circuit outshines conventional machine learning systems in one key way: It teaches itself without any help from a computer -- akin to a living brain. The result demonstrates one way to avoid the massive amount of computation typically required to tune an AI system, an issue that could become more of a roadblock as such programs grow increasingly complex. [...] The network was tuned to perform a variety of simple AI tasks. For example, it could distinguish with greater than 95% accuracy between three species of iris depending on four physical measurements of a flower: the lengths and widths of its petals and sepals -- the leaves just below the blossom. That's a canonical AI test that uses a standard set of 150 images, 30 of which were used to train the network.
NASA

NASA's Megarocket, the Space Launch System, Rolls Out To Its Launchpad 83

On Thursday, NASA's new giant rocket, the Space Launch System, emerged out into the Florida air, embarking on a torturously slow 11-hour journey to its primary launchpad at Kennedy Space Center. The Verge reports: It was a big moment for NASA, having spent more than a decade on the development of this rocket, with the goal of using the vehicle to send cargo and people into deep space. The rollout of the SLS was just a taste of what's to come. The rocket will undergo what is known as a wet dress rehearsal in April, going through all the operations and procedures it will go through during a typical launch, including filling up its tanks with propellant. If that goes well, then the rocket will be rolled back to NASA's Vehicle Assembly Building, the giant cavernous building where the SLS was pieced together. Following a few more tests, the rocket will be rolled back out to the launchpad ahead of its first flight, scheduled for sometime this summer at the earliest. You can view photos from the SLS's big debut embedded in The Verge's article.
Science

Long Naps May Be Early Sign of Alzheimer's Disease, Study Shows (theguardian.com) 25

Taking long naps could be a precursor of Alzheimer's disease, according to a study that tracked the daytime sleeping habits of elderly people. From a report: The findings could help resolve the conflicting results of the effects of napping on cognition in older adults, with some previous studies highlighting the benefits of a siesta on mood, alertness and performance on mental tasks. The latest study suggests that an increase over time in naps was linked to a higher chance of developing mild cognitive impairment or Alzheimer's. The scientists think it is more likely that excessive napping could be an early warning sign, rather than it causing mental decline.

"It might be a signal of accelerated ageing," said Dr Yue Leng, an assistant professor of psychiatry at the University of California San Francisco. "The main takeaway is if you didn't used to take naps and you notice you're starting to get more sleepy in the day, it might be a signal of declining cognitive health." The scientists tracked more than 1,000 people, with an average age of 81, over several years. Each year, the participants wore a watch-like device to track mobility for up to 14 days. Each prolonged period of non-activity from 9am to 7pm was interpreted as a nap. The participants also underwent tests to evaluate cognition each year. At the start of the study 76% of participants had no cognitive impairment, 20% had mild cognitive impairment and 4% had Alzheimer's disease.

Moon

Ancient Magnetic Fields On the Moon Could Be Protecting Precious Ice (science.org) 32

sciencehabit shares a report from Science.org: For years, scientists have believed frigid craters at the Moon's poles hold water ice, which would be both a scientific boon and a potential resource for human missions. Now, researchers have discovered (PDF) a reason why the ice has persisted on an otherwise bone-dry world: Some polar craters may be protected by ancient magnetic fields. Researchers have known about the anomalies ever since the Apollo 15 and 16 missions in 1971 and 1972, when astronauts measured regions of unusual magnetic strength on the surface. Some anomalies are now known to be up to hundreds of kilometers across. Although their origin is debated, one possibility is they were created more than 4 billion years ago when the Moon had a magnetic field and iron-rich asteroids crashed into its surface. The resultant molten material may have been permanently magnetized.

Thousands of the anomalies are thought to exist across the lunar surface, but the team mapped ones at the south pole in detail using data from Japan's Kaguya spacecraft, which orbited the Moon from 2007 to 2009. They found at least two permanently shadowed craters that were overlapped by these anomalies, the Sverdrup and Shoemaker craters, and there are likely more. Although the remnant fields are thousands of times weaker than Earth's, they could be sufficient to deflect the solar wind. Craters with known anomalies could become prime targets for science and exploration. NASA is already planning to visit the south polar region with a rover due for launch next year, called VIPER, and the agency intends to send humans there later this decade as part of its Artemis program. Studying the ice could reveal how it was delivered, which may in turn shed light on how Earth got its water.

AI

AI Suggests 40,000 New Possible Chemical Weapons In Just Six Hours (theverge.com) 100

An anonymous reader quotes a report from The Verge: It took less than six hours for drug-developing AI to invent 40,000 potentially lethal molecules. Researchers put AI normally used to search for helpful drugs into a kind of "bad actor" mode to show how easily it could be abused at a biological arms control conference. All the researchers had to do was tweak their methodology to seek out, rather than weed out toxicity. The AI came up with tens of thousands of new substances, some of which are similar to VX, the most potent nerve agent ever developed. Shaken, they published their findings this month in the journal Nature Machine Intelligence. The Verge spoke with Fabio Urbina, lead author of the paper, to learn more about the AI. When asked how easy it is for someone to replicate, Urbina said it would be "fairly easy."

"If you were to Google generative models, you could find a number of put-together one-liner generative models that people have released for free," says Urbina. "And then, if you were to search for toxicity datasets, there's a large number of open-source tox datasets. So if you just combine those two things, and then you know how to code and build machine learning models -- all that requires really is an internet connection and a computer -- then, you could easily replicate what we did. And not just for VX, but for pretty much whatever other open-source toxicity datasets exist."

He added: "Of course, it does require some expertise. [...] Finding a potential drug or potential new toxic molecule is one thing; the next step of synthesis -- actually creating a new molecule in the real world -- would be another barrier."

As for what can be done to prevent this kind of misuse of AI, Urbina noted OpenAI's GPT-3 language model. People can use it for free but need a special access token to do so, which can be revoked at any time to cut off access to the model. "We were thinking something like that could be a useful starting point for potentially sensitive models, such as toxicity models," says Urbina.

"Science is all about open communication, open access, open data sharing. Restrictions are antithetical to that notion. But a step going forward could be to at least responsibly account for who's using your resources."
Medicine

Long Naps May Be Early Sign of Alzheimer's Disease, Study Shows (newatlas.com) 49

Taking long naps could be a precursor of Alzheimer's disease, according to a study that tracked the daytime sleeping habits of elderly people. The Guardian reports: The scientists think it is more likely that excessive napping could be an early warning sign, rather than it causing mental decline. The scientists tracked more than 1,000 people, with an average age of 81, over several years. Each year, the participants wore a watch-like device to track mobility for up to 14 days. Each prolonged period of non-activity from 9am to 7pm was interpreted as a nap. The participants also underwent tests to evaluate cognition each year. At the start of the study 76% of participants had no cognitive impairment, 20% had mild cognitive impairment and 4% had Alzheimer's disease.

For participants who did not develop cognitive impairment, daily daytime napping increased by an average 11 minutes a year. The rate of increase doubled after a diagnosis of mild cognitive impairment to a total of 24 minutes and nearly tripled to a total of 68 minutes after a diagnosis of Alzheimer's disease, according to the research published in the journal Alzheimer's and dementia. Overall, participants who napped more than an hour a day had a 40% higher risk of developing Alzheimer's than those who napped less than an hour a day; and participants who napped at least once a day had a 40% higher risk of developing Alzheimer's than those who napped less than once a day.

Medicine

Dentist Broke His Patients' Teeth To Make Millions Installing Crowns, Jury Finds (arstechnica.com) 103

A dentist in Wisconsin has been found guilty of deliberately breaking his patients' teeth with a drill so he could collect millions of dollars to repair the damage with dental crowns. ArsTechnica reports: The alleged scheme by licensed Grafton dentist Scott Charmoli, 61, appears to have begun in 2015, when the number of crowns he installed abruptly increased. In 2015, Charmoli installed 1,036 crowns, well over the 434 crowns he did in 2014. Amid the royal boom, his income increased by more than a million dollars, going from $1.4 million in 2014 to $2.5 million in 2015, according to court documents. From 2016 to 2019, Charmoli billed insurers and patients over $4.2 million for crown procedures, according to federal prosecutors. Charmoli ranked at or above the 95th percentile for the number of crowns installed by dentists in the state in each of those years, the report added.
Mars

ExoMars Rover Mission Officially Suspended As Europe Cuts Ties With Russia (gizmodo.com) 29

An anonymous reader quotes a report from Gizmodo: Today, the European Space Agency leadership took steps toward suspending the ExoMars mission, a joint project with Russian space agency Roscosmos. It's the latest scientific fallout from the Russian invasion of Ukraine, which has forced institutions collaborating with Russian entities to reevaluate their positions.

ExoMars a two-part mission: an orbiter, launched in 2016, that studies the chemistry of the Red Planet's atmosphere, and a Mars rover, named for scientist Rosalind Franklin and set to launch this year -- or at least, it was. The mission has been a long time coming; funding was granted 10 years ago this week, but technical delays and the covid-19 pandemic pushed the rover launch date back to fall 2022. That target was looking viable until the Russian invasion of Ukraine last month.

From the off, it was clear that ExoMars was in doubt. In a statement shortly after the invasion, the ESA said it was "fully implementing sanctions imposed on Russia by our Member States" and that "the sanctions and the wider context make a launch in 2022 very unlikely." The agency's most recent move codifies that unlikeliness. Meeting in Paris this week, the agency's ruling council unanimously mandated that the ESA Director General take steps to suspend cooperation with Roscosmos and authorized a study of how to get ExoMars off the ground without Roscosmos involvement. [...] In its newest statement, ESA announced that its director general would convene a meeting of the agency council in several weeks to submit proposals for how to proceed with ExoMars without Russian involvement.

Science

'Quantum Hair' Could Resolve Hawking's Black Hole Paradox, Say Scientists (theguardian.com) 96

Stephen Hawking's black hole information paradox has bedevilled scientists for half a century and led some to question the fundamental laws of physics. Now scientists say they may have resolved the infamous problem by showing that black holes have a property known as "quantum hair." From a report: If correct, this would mark a momentous advance in theoretical physics. Prof Xavier Calmet, of the University of Sussex, who led the work, said that after working on the mathematics behind the problem for a decade, his team made a rapid advance last year that gave them confidence that they had finally cracked it. "It was generally assumed within the scientific community that resolving this paradox would require a huge paradigm shift in physics, forcing the potential reformulation of either quantum mechanics or general relativity," said Calmet. "What we found -- and I think is particularly exciting -- is that this isn't necessary."

Hawking's paradox boils down to the following: the rules of quantum physics state that information is conserved. Black holes pose a challenge to this law because once an object enters a black hole, it is essentially gone for good -- along with any information encoded in it. Hawking identified this paradox and for decades it has continued to confound scientists. There have been innumerable proposed solutions, including a "firewall theory" in which information was assumed to burn up before entering the black hole, the "fuzzball theory" in which black holes were thought to have indistinct boundaries, and various exotic branches of string theory. But most of these proposals required rewriting of the laws of quantum mechanics or Einstein's theory of gravity, the two pillars of modern physics.

NASA

NASA's Webb Space Telescope Achieves Near-Perfect Focus (cbsnews.com) 46

BeerFartMoron shares a report from CBS News: After weeks of microscopic adjustments, NASA unveiled the first fully focused image from the James Webb Space Telescope Wednesday, a razor-sharp engineering photo of a nondescript star in a field of more distant galaxies that shows the observatory's optical system is working in near-flawless fashion. The goal was to demonstrate Webb can now bring starlight to a near-perfect focus, proving the $10 billion telescope doesn't suffer from any subtle optical defects like the aberration that initially hobbled the Hubble Space Telescope. The galaxies in the image were a bonus, whetting astronomers' appetites for discoveries to come. "This is one of the most magnificent days in my whole career at NASA, frankly, and for many of us astronomers, one of the most important days that we've had," said NASA science chief Thomas Zurbuchen. "Today we can announce that the optics will perform to specifications or even better. It's an amazing achievement."
Earth

Midwestern US Has Lost 57.6 Trillion Metric Tons of Soil Due To Agricultural Practices, Study Finds (phys.org) 153

An anonymous reader quotes a report from Phys.Org: A new study in the journal Earth's Future led by the University of Massachusetts Amherst shows that, since Euro-American settlement approximately 160 years ago, agricultural fields in the midwestern U.S. have lost, on average, two millimeters of soil per year. This is nearly double the rate of erosion that the USDA considers sustainable. Furthermore, USDA estimates of erosion are between three and eight times lower than the figures reported in the study. Finally, the study's authors conclude that plowing, rather than the work of wind and water, is the major culprit.

Using an extraordinarily sensitive GPS unit that looks more like a floor lamp than a hand-held device, the team walked dozens of transects, or perpendicular routes across the escarpment, from the untouched prairie to the eroded farm field, stopping every few inches to measure the change in altitude. They did this hundreds of times throughout the summers of 2017, 2018 and 2019. Once they had their raw data, the team used historical land-use records and cutting-edge computer models to reconstruct erosion rates throughout the Midwest. What they discovered is that Midwestern topsoil is eroding at an average rate of 1.9 millimeters per year. Put another way, the authors estimate that the Midwest has lost approximately 57.6 trillion metric tons of topsoil since farmers began tilling the soil, 160 years ago. And this is despite conservation practices put in place in the wake of the Dust Bowl in the 1930s.
As noted above, much of the erosion was due to tillage, or plowing. "The modeling that I do shows that tilling has a 'diffusive' effect," says Jeffrey Kwang, a postdoctoral researcher at UMass Amhers. "It melts the landscape away, flattening higher points in a field and filling in the hollows."

Furthermore, the USDA doesn't include "tillage erosion" in its own analysis, meaning it's drastically underestimated the rate of erosion that's occurred in the area. The team suggests that more sustainable practice, such as no-till farming and soil regeneration, "will likely be required to reduce soil erosion rates in the Midwest to levels that can sustain soil productivity, ecosystem services, and long-term prosperity."
Science

Brain-Imaging Studies Hampered by Small Data Sets, Study Finds (nytimes.com) 22

For two decades, researchers have used brain-imaging technology to try to identify how the structure and function of a person's brain connects to a range of mental-health ailments, from anxiety and depression to suicidal tendencies. But a new paper, published Wednesday in Nature, calls into question whether much of this research is actually yielding valid findings. The New York Times reports: Many such studies, the paper's authors found, tend to include fewer than two dozen participants, far shy of the number needed to generate reliable results. "You need thousands of individuals," said Scott Marek, a psychiatric researcher at the Washington University School of Medicine in St. Louis and an author of the paper. He described the finding as a "gut punch" for the typical studies that use imaging to try to better understand mental health.

Studies that use magnetic-resonance imaging technology commonly temper their conclusions with a cautionary statement noting the small sample size. But enlisting participants can be time-consuming and expensive, ranging from $600 to $2,000 an hour, said Dr. Nico Dosenbach, a neurologist at Washington University School of Medicine and another author on the paper. The median number of subjects in mental-health-related studies that use brain imaging is around 23, he added. But the Nature paper demonstrates that the data drawn from just two dozen subjects is generally insufficient to be reliable and can in fact yield 'massively inflated' findings," Dr. Dosenbach said.
The findings from the Nature paper can "absolutely" be applied to other fields beyond mental health, said Marek. "My hunch this is much more about population science than it is about any one of those fields," he said.
United States

Superbug-Infected Chicken Is Being Sold All Over the US (vice.com) 85

An anonymous reader quotes a report from Motherboard in collaboration with The Bureau of Investigative Journalism, an independent not-for-profit news organization based in London: Campylobacter is America's biggest cause of foodborne illness, just ahead of salmonella. Both are potentially fatal. Yet between 2015 and 2020, U.S. companies sold tens of thousands of meat products contaminated with campylobacter and salmonella, according to government sampling records obtained by the Bureau of Investigative Journalism. More than half of these were contaminated with antibiotic-resistant strains, a rapidly escalating issue that can be exacerbated by poor hygiene conditions. The poultry companies supply major grocery stores and fast-food chains. Tyson has supplied chicken to McDonald's, Perdue has sold to Whole Foods, and both have supplied Walmart.

Although the USDA deems a certain level of salmonella and campylobacter within poultry acceptable, 12 major U.S. poultry companies -- including poultry giants Perdue, Pilgrim's Pride, Tyson, Foster Farms, and Koch Foods -- have exceeded USDA standards for acceptable levels of salmonella multiple times since 2018, when the government began reporting contamination rates at individual plants, according to the department's records. The USDA still runs tests for campylobacter in processing plants but does not currently track whether plants exceed the contamination thresholds. Batches of poultry products with contamination rates above the limit don't have to be recalled, although plants that repeatedly exceed the thresholds can be temporarily shut down. Separate government records also show that between January 2015 and August 2019, the same 12 major U.S. poultry companies broke food safety rules on at least 145,000 occasions -- or on average more than 80 times a day. Poultry plant workers also claimed they have sometimes been asked to process rotten-smelling meat, have witnessed chicken tossed into grinders with dead insects, and found government safety inspectors apparently asleep on the job.

Campylobacter causes more than 100 deaths every year in America as well as 1.5 million infections. It also accounts for up to 40 percent of the country's cases of Guillain-Barré Syndrome [...]. Yet the sale of poultry products found to be contaminated with either that or salmonella bacteria remains perfectly legal. The level of salmonella and campylobacter that the USDA deems acceptable differs depending on the product. A maximum of 15.4 percent of chicken parts leaving a processing plant, for instance, can test positive for salmonella and the plant can still meet acceptable standards. The threshold for campylobacter is 7.7 percent. Many experts argue these levels are too lax.
The report also notes the concerning increase in antibiotic-resistant strains of bacteria. "The number of drug-resistant salmonella infections in the U.S. rose from around 159,000 in 2004 to around 222,000 in 2016," reports Motherboard, citing the CDC. "Campylobacter has become more resistant too: Ciprofloxacin, an antibiotic commonly used to treat it, is increasingly ineffective."

"The rise of superbugs is having increasingly serious human consequences. In order to treat these illnesses, doctors are turning more frequently to last-resort drugs, which often have more side effects. And if these fail, there's no choice but to let the disease take its course."

Slashdot Top Deals