Leveraging AI tools like RFDiffusion and PLACER, researchers were able to design a novel enzyme capable of breaking down plastic by targeting ester bonds, a key component in polyester. Ars Technica reports: The researchers started out by using the standard tools they developed to handle protein design, including an AI tool named RFDiffusion, which uses a random seed to generate a variety of protein backgrounds. In this case, the researchers asked RFDiffusion to match the average positions of the amino acids in a family of ester-breaking enzymes. The results were fed to another neural network, which chose the amino acids such that they'd form a pocket that would hold an ester that breaks down into a fluorescent molecule so they could follow the enzyme's activity using its glow.

Of the 129 proteins designed by this software, only two of them resulted in any fluorescence. So the team decided they needed yet another AI. Called PLACER, the software was trained by taking all the known structures of proteins latched on to small molecules and randomizing some of their structure, forcing the AI to learn how to shift things back into a functional state (making it a generative AI). The hope was that PLACER would be trained to capture some of the structural details that allow enzymes to adopt more than one specific configuration over the course of the reaction they were catalyzing. And it worked. Repeating the same process with an added PLACER screening step boosted the number of enzymes with catalytic activity by over three-fold.

Unfortunately, all of these enzymes stalled after a single reaction. It turns out they were much better at cleaving the ester, but they left one part of it chemically bonded to the enzyme. In other words, the enzymes acted like part of the reaction, not a catalyst. So the researchers started using PLACER to screen for structures that could adopt a key intermediate state of the reaction. This produced a much higher rate of reactive enzymes (18 percent of them cleaved the ester bond), and two -- named "super" and "win" -- could actually cycle through multiple rounds of reactions. The team had finally made an enzyme.

By adding additional rounds alternating between structure suggestions using RFDiffusion and screening using PLACER, the team saw the frequency of functional enzymes increase and eventually designed one that had an activity similar to some produced by actual living things. They also showed they could use the same process to design an esterase capable of digesting the bonds in PET, a common plastic. The research has been published in the journal Science.

Bruce66423 shares a report from The Guardian: Microscopic particles emitted from brake pads can be more toxic than those emitted in diesel vehicle exhaust, a study has found. This research shows that even with a move to electric vehicles, pollution from cars may not be able to be eradicated. The researchers found that a higher concentration of copper in some commonly used brake pads was associated with increased harmful effects on sensitive cells from people's lungs, as a result of particles being breathed in.

Exposure to pollution generated by cars, vans and lorries has been previously been linked to an increased risk of lung and heart disease. While past attention has mainly concentrated on exhaust emissions, particles are also released into the air from tyre, road and brake pad wear. These emissions are largely unregulated by legislation and the study found that these âoenon-exhaustâ pollution sources are now responsible for the majority of vehicle particulate matter emissions in the UK and parts of Europe, with brake dust the main contributor among them.

[...] The scientists examined the effects on lung health of particulate matter from four different types of brake pad with differing chemical compositions; low metallic, semi-metallic, non-asbestos organic and hybrid-ceramic. Results showed that of the four types of brake pads, non-asbestos organic pads were the most potent at inducing inflammation and other markers of toxicity, and were found to be more toxic to human lung cells than diesel exhaust particles. Ceramic pads were the second most toxic. Dr. Ian Mudway, senior lecturer at the school of public health at Imperial College London, cautioned that while the research on brake pad emissions appears sound, it is premature to conclude they are worse than diesel exhaust due to "uncontrolled variables" like brake disc types and particle composition.

Slashdot reader Bruce66423 also notes it "doesn't discuss the significance of regenerative breaking, which is a feature of at least some electric cars [that reduces brake pad wear by using the electric motor to slow down the vehicle and recover energy]."

The research has been published in the journal Particle and Fibre Technology.

China issued guidelines on Friday to promote biotech cultivation, focusing on gene-editing tools and developing new wheat, corn, and soybean varieties, as part of efforts to ensure food security and boost agriculture technology. From a report: The 2024-2028 plan aims to achieve "independent and controllable" seed sources for key crops, with a focus to cultivate high-yield, multi-resistant wheat, corn and high-oil, high-yield soybean and rapeseed varieties. The move comes as China intensifies efforts to boost domestic yields of key crops like soybeans to reduce reliance on imports from countries such as the United States amid a looming trade war.

An anonymous reader quotes a report from The Guardian: A groundbreaking NHS trial will attempt to boost patients' mood using a brain-computer-interface that directly alters brain activity using ultrasound. The device, which is designed to be implanted beneath the skull but outside the brain, maps activity and delivers targeted pulses of ultrasound to "switch on" clusters of neurons. Its safety and tolerability will be tested on about 30 patient in the 6.5 million-pound trial, funded by the UK's Advanced Research and Invention Agency (Aria).

[...] The latest trial will test a device developed by the US-based non-profit Forest Neurotech. In contrast to invasive implants, in which electrodes are inserted into a specific location in the brain, Forest 1 uses ultrasound to read-out and modify activity. Aria describes the device as "the most advanced BCI in the world" due to its ability to modify activity across multiple regions simultaneously. This widens potential future applications to a huge patient population affected by conditions such as depression, anxiety and epilepsy, which are all "circuit level" conditions rather than being localized in a specific brain region.

The NHS trial will recruit patients who, due to brain injury, have had part of their skull temporarily removed to relieve a critical buildup of pressure in the brain. This means the device can be tested without having to perform surgery. When placed beneath the skull, or in individuals with a skull defect, ultrasound can detect tiny changes in blood flow to produce 3D maps of brain activity with a spatial resolution of about 100 times that of a typical fMRI scan. The same implant can deliver focused ultrasound to mechanically nudge neurons towards firing, providing a way to remotely dial activity up at precise locations. Participants will wear the device on their scalp at the site of the skull defect for two hours. Their brain activity will be measured and researchers will test whether patients' mood and feelings of motivation can be reliably altered.

There are safety considerations, as ultrasound can cause tissue to heat up. Prof Elsa Fouragnan, a neuroscientist at the University of Plymouth, which is collaborating on the project, said: "What we're trying to minimize is heat. There's a safety and efficacy trade-off." She added that it would also be important to ensure that personality or decision-making were not altered in unintended ways -- for instance, making someone more impulsive. The study will run for three and a half years starting from March, with the first eight months focused on securing regulatory approval. If successful, Forest hopes to move into a full clinical trial for a condition such as depression. Aimun Jamjoom, a consultant neurosurgeon at the Barking, Havering and Redbridge university hospitals NHS trust, who is leading the project, said: "[T]he ability to offer a safer form of surgery is very exciting. If you look at conditions like depression or epilepsy, [up to] a third of these patients just don't get better. It's those groups where a technology like this could be a life-changing solution."

Jeff Bezos' space company Blue Origin is cutting about 10% of its workforce, a significant pullback aimed at slashing costs and refocusing resources after years of development work. From a report: The rocket and engine maker laid out the personnel shakeup during an all-hands employee meeting with Chief Executive Officer Dave Limp Thursday morning, confirming a workforce reduction first reported by Bloomberg. In a memo sent to employees, Limp said the company's growth led to "more bureaucracy and less focus" than needed after a hiring spree over the past few years.

After years of expansion bankrolled by Bezos, who started Amazon and is the world's third-richest person, Blue Origin is looking to trim manager ranks as it works to clear some $10 billion worth of launch contracts. With a staff of more than 10,000, the layoffs stand to impact over 1,000 roles.

Convicted Theranos founder, Elizabeth Holmes, had her first interview since being reported to prison in 2023, telling People magazine that she is still working on "research and inventions" in the healthcare space. Here's an excerpt from the article: Scheduled for release on April 3, 2032, Holmes says she hopes to travel with her family and to fight for reform of criminal justice system. She recently drafted an American Freedom Act bill -- a seven-page handwritten document -- to bolster the presumption of innocence and change criminal procedure. "This will be my life's work," says Holmes, adding that she is speaking out now as part of her mission to advocate on behalf of incarcerated persons and those ripped away from their children.

And, despite her global reputation as a biotech con artist who put lives at risk, she says she's continuing to write patents for new inventions and plans to resume her career in healthcare technology after her release. "There is not a day I have not continued to work on my research and inventions," she says. "I remain completely committed to my dream of making affordable healthcare solutions available to everyone."

For now, however, she is sustained by weekend visits from her family, when she can cuddle Invicta, watch William gather acorns in the prison yard and hold Evans's hand and briefly hug and kiss. (Conjugal visits are not allowed.) "It kills me to put my family through pain the way I do," she says. "But when I look back on my life, and these angels that have come into it, I can get through anything. It makes me want to fight for all of it."

Astronomers have discovered a perfect ring of light in a galaxy 590 million light-years away. "The phenomenon is known as an Einstein ring, and it was discovered circumscribing the galaxy NGC 6505 in data collected by the European Space Agency's Euclid space telescope," reports SpaceAlert. From the report: [...] In the case of the newly discovered Einstein ring, the light that encircles the near galaxy is from a more distant galaxy, sitting some 4.42 billion light-years away, whose light has been warped by the curvature of space-time around NGC 6505. It's a very lucky arrangement of objects: they are aligned in such a way that the distant galaxy's light is stretched into a perfect ring, with brighter blobs representing replicated images of the galaxy at four points around the ring.

And the closeness of NGC 6505 makes it even more astonishing. Only five other lenses have been discovered so close; simulations suggest this new lens only had a 0.05 percent chance of existing, never mind being discovered. The more distant galaxy had never been seen before; now, scientists have the perfect tool to study it in greater detail than would be possible without the lens. The research has been published in Astronomy & Astrophysics.

Longtime Slashdot reader JoeRobe writes: Scientists associated with the Kilometer Cube Neutrino Telescope, or KM3NeT, have reported detection of an ultra-high energy neutrino deep in the Mediterranean sea. The neutrino reportedly had an energy of 120 million billion electron volts (1.2x10^17 eV, or 120 PeV). This is similar to the energy of ping-pong ball traveling ~5 m/s, but all that energy was packed into a single subatomic particle. According to the New York Times, "Here, squeezed into one of the tiniest flecks of matter in our universe, that energy amounted to tens of thousands of times more than what can be achieved by the world's premier particle accelerator, the Large Hadron Collider at CERN."

According to the authors of the Nature paper, the direction of the neutrino "is compatible with the extension of the galactic interstellar medium," but they did not find any catalogued source that would produce such a high energy neutrino, within the Milky Way or from about 40 other galaxies that could be candidates.

Phys.org describes the impressive scale of the KM3NeT detector array: "It is located at 3,450 m depth, about 80 km from the coast of Portopalo di Capo Passero, Sicily. Its 700 m high detection units (DUs) are anchored to the seabed and positioned about 100 m apart. Every DU is equipped with 18 Digital Optical Modules (DOM) each containing 31 photomultipliers (PMTs). In its final configuration, ARCA will comprise 230 DUs. The data collected are transmitted via a submarine cable to the shore station at the INFN Laboratori Nazionali del Sud. The KM3NeT/ORCA (Oscillation Research with Cosmics in the Abyss) detector is optimized to study the fundamental properties of the neutrino itself. It is located at a depth of 2,450 m, about 40 km from the coast of Toulon, France. It will comprise 115 DUs, each 200 m high and spaced by 20 m. The data collected by ORCA are sent to the shore station at La Seyne Sur Mer." "This ultra-high energy neutrino may originate directly from a powerful cosmic accelerator," surmises Phys.org. "Alternatively, it could be the first detection of a cosmogenic neutrino. However, based on this single neutrino it is difficult to conclude its origin."

Children working in India's fruit and vegetable markets can perform complex mental calculations with ease, yet struggle with basic written math tests that determine their academic future, according to new research that raises troubling questions about mathematics education worldwide.

The study, published in Nature, reveals how traditional education systems are failing to tap into the mathematical talents of students who develop practical skills outside the classroom, particularly those from lower-income families. MIT economist Abhijit Banerjee, who grew up watching young market vendors deftly handle complicated transactions, led the research. His team found that while these children could rapidly perform mental arithmetic, they performed poorly on standard written assessments like long division problems.

The findings come at a critical moment when mathematics education must evolve to meet modern demands, incorporating data literacy and computational skills alongside traditional mathematics. The research points to systemic issues, including a global shortage of trained mathematics teachers and assessment systems that reward memorization over reasoning. Without addressing these challenges, researchers warn, naturally talented students from disadvantaged backgrounds may never reach their potential in fields like research, entrepreneurship, or teaching.

Microplastics can move through mice brains and block blood vessels, essentially mimicking blood clots that could potentially be fatal or otherwise disrupt brain function. From a report: The findings are detailed in a peer-reviewed paper for which researchers for the first time used real-time imaging to track bits of plastic as they moved through and accumulated in brain blood vessels. When one piece of plastic got stuck, others accumulated behind it, like a "car crash," the authors reported.

The authors then found decreased motor function in those mice exposed to microplastics, suggesting impacts on the brain. While mounting evidence has linked microplastics to neurotoxicity, the research is the first to suggest how -- it probably reduces blood flow. "This revelation offers a lens through which to comprehend the toxicological implications of microplastics that invade the bloodstream," the Peking University authors wrote.

Scientists have found evidence suggesting that Earth's inner core has changed shape over the past 20 years, possibly deforming at its edges due to interactions with the liquid outer core and gravitational forces. The BBC reports: The inner core is usually thought to be shaped like a ball, but its edges may actually have deformed by 100 million or more in height in places, according to Prof John Vidale who led the research. [...] The new analysis looked at seismic wave patterns from earthquakes that repeated in the same location between 1991 and 2023. That helped to show how the inner core is changing over time. Prof Vidale, an earth scientist at the University of Southern California, found more evidence to back up the theory that during those years the inner core slowed down around 2010. But his team also found the evidence of the inner core's changing shape. It appears to be happening at the boundary of the inner and outer core, where the inner core is close to melting point. The liquid flow of the outer core as well as pull from an uneven gravity field may cause deformation. Prof Hrvoje Tkalcic from Australian National University said the findings could allow scientists "to make more informed estimates of some important material properties, such as the viscosity of the inner core, which is one of the least known quantities in modern science."

The research is published in the scientific journal Nature Geoscience.

Europe's Euclid space telescope has captured a rare "Einstein ring," showing light from a distant galaxy bent into a perfect circle by the gravity of another galaxy sitting between Earth and the source, the European Space Agency said.

The phenomenon, spotted around galaxy NGC 6505 some 590 million light-years from Earth, reveals the warping of space predicted by Einstein's theory of relativity. The background galaxy, located 4.42 billion light-years away, appears as a complete ring of light around NGC 6505.

"An Einstein ring as perfect as this is extremely rare," said Open University astronomer Stephen Serjeant. Analysis shows NGC 6505 contains about 11% dark matter, a key focus of Euclid's mission to map the universe.

Today T-Mobile announced what they're calling "the next big thing in wireless" — T-Mobile Starlink. But the real surprise is "The beta is now open for absolutely everyone — yes, even Verizon and AT&T customers — to register for free access until July."

And, as they explained to Americans watching the Super Bowl, "If you can see the sky you're connected." Now in public beta, this breakthrough service, developed in partnership with Starlink, uses straight-out-of-a-sci-fi-movie satellite and mobile communications technology to help keep people connected — even you, Verizon and AT&T customers — in the more than 500,000 square miles of the country unreached by any carrier's earth-bound cell towers. That's nearly the size of two Texases...! The beauty of the service is its simplicity: users don't need to do anything out of the ordinary. When a user's cell phone gets out of range of a cell tower, the phone automatically connects to the T-Mobile Starlink network. No need to manually connect. Messages are sent and received just as they are today on a traditional network, even group texts and reactions. And it works on most smartphones from the last four years. It's not limited to a few smartphones or operating systems...

The beta is free until July at which point T-Mobile Starlink will be included at no extra cost on Go5G Next (including variations like Go5G Next 55+), T-Mobile's best plan. Business customers will also get T-Mobile Starlink at no extra cost on Go5G Business Next, first responder agencies on T-Priority plans and other select premium rate plans. T-Mobile customers on any other plan can add the service for $15/month per line. Through February, T-Mobile customers who have registered for the beta can secure a $10/month per line Early Adopter Discount, 33% off the full price.

AT&T and Verizon customers hate dead zones, too

When your service is amazing and different, you want as many people to try it as possible. T-Mobile is giving AT&T and Verizon customers the opportunity to try out T-Mobile Starlink satellite service on their existing phones... During the beta period, Verizon and AT&T customers can experience T-Mobile Starlink text messaging for free, and once the service launches in July, it will be available for $20/month per line... More details and consumer registration can be found here.

A Vision for Universal Coverage

As T-Mobile and Starlink continue to work towards eliminating mobile deadzones, the companies welcome wireless providers from around the world to join their growing alliance, which aims to provide reciprocal roaming for all participating carriers. So far, KDDI (Japan), Telstra (Australia), Optus (Australia), One NZ (New Zealand), Salt (Switzerland), Entel (Chile & Peru), Rogers (Canada) and Kyivstar (Ukraine) are among the providers that have signed on to join the cause and launch satellite-to-mobile technology. Learn more about the alliance and how providers can join at direct.starlink.com.

Friday the Orlando Sentinel covered NASA's 2024 mission-safety report from the Aerospace Safety Advisory Panel (formed in 1968). The report "commended the agency's handling of last year's beleaguered Boeing's Starliner mission [prioritizing astronaut safety], but revealed yet another issue found during the flight and questioned the agency's needs for the spacecraft in the future..." [The report] stated that it was unclear how a decision was made to waive a failure tolerance requirement on some of the thrusters without flight or qualification data to justify the decision. "These examples illustrate the panel's concern that, absent role clarity, risk management choices could unintentionally devolve to contractors, whose interests may not fully align with NASA's," the report warned...

It also revealed that in addition to the thruster and leak issues on the propulsion module driving the decision to fly home without astronauts, Starliner had a new issue as it made its way back to Earth. "Overall, Starliner performed well across all major systems in the undock, deorbit, and landing sequences; however, an additional mono propellant thruster failure was discovered in the crew module — distinct from the failures in the service module experienced during orbit," the report stated. "Had the crew been aboard, this would have significantly increased the risk during reentry, confirming the wisdom of the decision."

As far as Starliner's path to certification, the ASAP report said it would continue to monitor several unresolved issues with thrusters and seek information on how NASA and Boeing plan to get the spacecraft certified. "While the thruster issues have received considerable attention, the panel has previously noted other Starliner issues that require resolution prior to certification," it stated. That includes a battery redesign and work to strengthen the landing airbag apparatus. "Beyond these technical matters, schedule and budget pose substantial challenges to Starliner certification," the report added...

"Until the Starliner certification plan is well understood, it remains unclear as to whether a second provider will be available prior to the end of the ISS's operational life [in 2030]," the report stated.
The report "also suggested that NASA immediately adapt next-generation extravehicular mobility units, or EVUs," reports ExecutiveGov, "as current space suits astronauts use for operations outside the ISS are now beyond their design life."

Twisting two atomically thin sheets of graphene enables "a host of exceptional properties," writes MIT News, "including unconventional superconductivity." (Which makes this graphene "a promising building block for future quantum-computing devices.")

And now "We find the superfluid stiffness to be much larger than expected..." a team of researchers reported this week in Nature. Hackaday explains that "Part of the problem has been that it is hard to make large pieces of multi-layer graphene. By creating two-ply pieces and using special techniques, an international team is finding that quantum geometry explains how graphene superconductors resist changes in current flow more readily than conventional superconductors."

Or, as Science Alert puts it, "Forced to run a labyrinth of carbon atoms uniquely arranged in twisted stacks, electrons do some rather peculiar things." Researchers from the University of British Columbia in Canada, the University of Washington and Johns Hopkins University in the US, and the National Institute for Materials Science in Japan recently discovered a strange new state of matter in the dynamics of currents flowing through layers of graphene.

The findings confirm predictions on how electrons ought to behave when squeezed into crystalline arrangements, and may contribute fresh ideas on how to achieve reliable approaches to quantum computing or reveal ways to develop room-temperature superconduction... Graphene has been increasingly seen as something of a wonder material over recent decades, its lattice of carbon atoms connected in a way that leaves spare electrons to leap about like tokens in a game of quantum checkers. Physicists have consistently bent the rules of this game, finding new and unusual ways to alter properties of resistance or coordinate into exotic states. For these reasons, graphene has become a perfect playground to search for clues on low-resistance conductivity or test the boundaries of various quantum effects.
This week MIT research scientist Joel Wang (a co-lead on the study) said "There's a whole family of 2D superconductors that is waiting to be probed, and we are really just scratching the surface." New Scientist explores where their research could lead: Why do cold thin sheets of carbon offer no resistance to electric currents? Two experiments are bringing us closer to an answer — and maybe even to practical room-temperature superconductors... Past experiments have shown that very cold stacks of two or three layers of graphene can superconduct, or perfectly conduct electricity without resistance and energy loss, if some of the sheets are rotated by a special angle. But why this happens remained mysterious... [B]oth teams had to innovate a setup where the tiny graphene flakes were exposed to microwaves while the researchers slowly varied properties like temperature, which must be kept very low for superconductivity to occur at all...

"We are finding interesting laws which seem to emerge in both these material systems. Maybe what we are uncovering is something deeper," says [Harvard postdoctoral researcher Abhishek Banerjee]. Both teams are planning on performing similar experiments with other very thin superconductors.

After the powerful solar storm of May 2024, scientists detected two new temporary radiation belts around Earth -- one of which contained something we had never seen before: energetic protons. ScienceAlert reports: "These are really high-energy electrons and protons that have found their way into Earth's inner magnetic environment," says astronomer David Sibeck of NASA's Goddard Space Flight Center, who was not involved with the research. "Some might stay in this place for a very long time." In fact, the belts remained intact for much longer than previous temporary radiation belts generated by solar storms: three months, compared to the weeks we'd normally expect.

Subsequent solar storms in June and August of 2024 knocked most of the particles out of orbit, significantly diminishing the density of the belts. A small amount, however, still remains up there, hanging out with Earth. What's more, the proton belt may remain intact for over a year. Ongoing measurements will help scientists measure its longevity and decay rate.

This is important information to have: particles in Earth orbit can pose a hazard to satellites hanging out up there, so knowing the particle density and the effects solar storms can have thereon can help engineers design mitigation strategies to protect our technology. At the moment, though, the hazard posed by the new radiation belts is unquantified. Future studies will be needed to determine the risks these, and future belts, might pose. The findings have been published in the Journal of Geophysical Research: Space Physics.

An anonymous reader quotes a report from BleepingComputer: Hospital Sisters Health System notified over 882,000 patients that an August 2023 cyberattack led to a data breach that exposed their personal and health information. Established in 1875, HSHS works with over 2,200 physicians and has around 12,000 employees. It also operates a network of physician practices and 15 local hospitals across Illinois and Wisconsin, including two children's hospitals. The non-profit healthcare system said in data breach notifications sent to those impacted that the incident was discovered on August 27, 2023, after detecting that the attacker had gained access to HSHS' network.

After the security breach, its systems were also impacted by a widespread outage that took down "virtually all operating systems" and phone systems across Illinois and Wisconsin hospitals. HSHS also hired external security experts to investigate the attack, assess its impact, and help its IT team restore affected systems. [...] While the incident and the resulting outage have all the signs of a ransomware attack, no ransomware operation has claimed the breach. Following the forensic investigation, HSHS found that the attackers had accessed files on compromised systems between August 16 and August 27, 2023.

The information accessed by the threat actors while inside HSHS' systems varies for each impacted individual, and it includes a combination of name, address, date of birth, medical record number, limited treatment information, health insurance information, Social Security number, and/or driver's license number. While HSHS added that there is no evidence that the victims' information has been used in fraud or identity theft attempts, it warned affected individuals to monitor their account statements and credit reports for suspicious activity. The health system also offers those affected by the breach one year of free Equifax credit monitoring.

An anonymous reader quotes a report from The Guardian: In the most comprehensive study of its kind, scientists have found that generally, the world feels brighter when you wake up. People start the day in the best frame of mind in the morning, but end in the worst, at about midnight, the findings suggest, with the day of the week and the season also playing a part. Mental health also tends to be more varied at weekends but steadier during the week, according to the study led by University College London. "Generally, things do seem better in the morning," the researchers concluded. Their findings were published in the journal BMJ Mental Health. [...]

The results showed that happiness, life satisfaction, and worthwhile ratings were all higher on Mondays and Fridays than on Sundays, while happiness was also higher on Tuesdays. There was no evidence that loneliness differed across days of the week. There was clear evidence of a seasonal influence on mood. Compared with winter, people tended to have lower levels of depressive and anxiety symptoms and loneliness, and higher levels of happiness, life satisfaction and feeling that life was worthwhile in the three other seasons. Mental health was best in the summer across all outcomes. But the season didn't affect the associations observed across the day, however. Scientists suggest that the findings may be due to physiological changes linked to the body's circadian rhythm. Cortisol, a hormone that influences mood and motivation, peaks after waking and declines by bedtime, which may contribute to better mental health earlier in the day.

Factors like sleep cycles, weather, and when participants chose to respond to the survey could have influenced the findings. There's also the differences between weekdays and weekends, which have their own variations in daily routines.

After a $523 million charge on its CST-100 Starliner program in 2024, Boeing's total losses on the commercial crew vehicle now exceed $2 billion -- and there's still no clear timeline for its next flight. SpaceNews reports: In the company's 10-K annual filing with the U.S. Securities and Exchange Commission Feb. 3, Boeing said it took $523 million in charges on Starliner in 2024. The company blamed the losses on "schedule delays and higher testing and certification costs as well as higher costs for post certification missions."

The company had reported a $125 million charge in the second quarter and a $250 million charge in the third quarter. The company warned Jan. 23 it would take an additional loss in the fourth quarter but did not disclose a figure when it released its financial results five days later. The annual loss implies a $148 million loss in the fourth quarter.

The $523 million in charges is the most Boeing has recorded in a single year on Starliner, exceeding $489 million it reported in 2019. The company's cumulative charges on Starliner are now just over $2 billion. "Risk remains that we may record additional losses in future periods," the company stated in the 10-K filing.

NASA is planning to host a live Twitch stream next week from the International Space Station (ISS). "The stream, which takes place on February 12th at 11:45AM ET on NASA's Twitch channel, will feature Don Pettit, an astronaut currently on the ISS, and Matt Dominick, who returned to Earth from the ISS in October," reports The Verge. From the report: The astronauts will discuss "daily life aboard the space station and the research conducted in microgravity" and viewers will be able to ask them questions, according to a blog post.

"This Twitch event from space is the first of many," Brittany Brown, director of the Office of Communications Digital and Technology Division at NASA Headquarters in Washington, says in the post. "We spoke with digital creators at TwitchCon about their desire for streams designed with their communities in mind, and we listened. In addition to our spacewalks, launches, and landings, we'll host more Twitch-exclusive streams like this one."