An anonymous reader quotes an opinion piece from The Guardian, written by Prof Mark Pallen and Dr Aimee Parker (Quadram Institute, Norwich), Prof Nick Loman (University of Birmingham), Prof Alan Walker (University of Aberdeen): Contrary to what is implied in [this article], the weight of expert opinion in medical microbiology rejects the existence of a "brain microbiome" in the sense of a resident microbial community in healthy human brains. While pathogenic microbes -- such as Borrelia burgdorferi, which causes Lyme disease, or fungal pathogens like Cryptococcus neoformans -- can invade the brain and cause neurological symptoms, these are examples of infections, not evidence of a native microbial community.

Similarly, cognitive benefits of vaccines can be explained by their role in preventing infections or modulating immune responses and inflammation, rather than any impact on a "brain microbiome." Furthermore, the studies cited in the article have not undergone independent validation, nor do they provide any kind of consistent picture. This mirrors controversies around other supposed microbiomes -- such as that of the placenta -- which have failed to withstand independent scrutiny. Over a decade of research indicates that contamination, typically from laboratory reagents, is the most plausible explanation for such findings, particularly when even supposedly ultrapure water has been shown to harbor DNA signatures and culturable microbes.

If diverse microbes are truly abundant in the brain, why have they not been repeatedly and consistently cultured in over a century and a half of medical microbiology? Why have they not been observed in numerous microscopy studies of human brain tissue? Efforts to explore overlooked roles of microbes in neurological conditions are welcome, but they must be grounded in robust and reproducible science -- not speculative discussion of a "brain microbiome." In the article mentioned above, author Amy Fleming discusses the emerging research connecting infections such as Borrelia, Cryptococcus, and herpes viruses to reversible dementia, challenging the long-held belief that the brain is sterile.

She highlights the Alzheimer's Pathobiome Initiative, which investigates how brain infections may contribute to diseases like Alzheimer's, with the goal of developing new diagnostic tools and treatments. Vaccines like BCG and zoster have shown protective effects, while good hygiene, oral health, and a healthy lifestyle can help reduce risks.

The publisher of a high-profile, now-corrected study on black plastics has been removed from a critical index of academic journals amid questions about quality criteria, according to a report by Retraction Watch. From a report: On December 16, Clarivate -- a scholarly publication analytics company -- removed the journal Chemosphere from its platform, the Web of Science, which is a key index for academic journals. The indexing platform tracks citations and calculates journal "impact factors," a proxy for relevance in its field. It's a critical metric not only for the journals but for the academic authors of the journal's articles, who use the score in their pursuit of promotions and research funding.

To be included in the Web of Science, Clarivate requires journals to follow editorial quality criteria. According to Retraction Watch, Chemosphere has retracted eight articles this month and published 60 expressions of concern since April. In a December 12 news release, Chemosphere acknowledged the quality concerns and laid out steps it will take to improve its editorial process. Those include improvements to article vetting and peer review, along with assurances that articles will be retracted if there's evidence of policy breaches. "We believe that these measures will help us regain the standard of research integrity that has always been so important to us," the news release stated.

NASA has delayed the launch of SpaceX Crew-10 to late March 2025 to allow time for processing a new Dragon spacecraft, extending the stay of astronauts Butch Wilmore and Suni Williams on the ISS to about nine months. CNN reports: Williams and Wilmore launched to space in June, piloting the first crewed test flight of Boeing's Starliner spacecraft. Their trip, expected to last about a week, ballooned into a monthslong assignment after their vehicle experienced technical issues en route to the space station and NASA determined it would be too risky to bring them home aboard the Starliner.

The astronauts have since joined Crew-9, a routine space station mission originally slated to return to Earth no earlier than February after a handoff period with Crew-10. Now, Crew-10 will get off the ground at least a month later than expected because NASA and SpaceX teams need "time to complete processing on a new Dragon spacecraft for the mission," according to the space agency. "NASA and SpaceX assessed various options for managing the next crewed handover, including using another Dragon spacecraft," NASA noted in a blog post on Tuesday. "After careful consideration, the team determined that launching Crew-10 in late March, following completion of the new Dragon spacecraft, was the best option for meeting NASA's requirements and achieving space station objectives for 2025."

The CDC has confirmed the first case of severe bird flu in the United States. NPR reports: Louisiana health officials initially reported the infection last week, saying a person was hospitalized after being exposed to sick and dead birds in backyard flocks. On Wednesday, the Centers for Disease Control and Prevention shared their findings that indicate the H5N1 virus responsible for the illness belongs to a genetic lineage that's circulating in wild birds and poultry -- different from what's spreading in dairy cattle and driving the majority of infections in agricultural workers.

In the U.S., more than 60 people have been infected so far, although some research suggests the official tally may be an undercount. The illnesses linked to dairy cattle have largely led to mild illnesses in humans.

The version of the virus in the Louisiana case is the so-called "D1.1 genotype." It has previously popped up in poultry workers in Washington state, who developed mild symptoms after testing positive in October. More recently, however, a teenager in British Columbia was hospitalized after contracting this D1.1 strain of the virus. Canadian health officials were unable to figure out how that person was infected. Dr. Demetre Daskalakis with the CDC, told reporters on Wednesday that bird blu has a well-established history of leading to severe illness and death. He added: "Infections without a clear source of exposure do occur, neither these cases nor the cases with known animal or animal products exposure have resulted in human to human transmission." California Gov. Gavin Newsom declared a state of emergency as the H5N1 bird flu virus moves from the Central valley to Southern California herds. The declaration will allow for a more streamlined approach among state and local agencies to tackle the virus, providing "flexibility around staffing, contracting, and other rules to support California's evolving response,'" reports the Los Angeles Times, citing a statement from Newsom's office.

"Building on California's testing and monitoring system -- the largest in the nation -- we are committed to further protecting public health, supporting our agriculture industry, and ensuring that Californians have access to accurate, up-to-date information," said Newsom in a statement. "While the risk to the public remains low, we will continue to take all necessary steps to prevent the spread of this virus."

Further reading:
US Government Orders Nationwide Testing of Milk for Bird Flu to Stop the Virus's Spread
Bird Flu Fears Stoke the Race for an mRNA Flu Vaccine

Scripps Research scientists sent stem-cell-derived brain organoids to the ISS to study the effects of microgravity on brain cells, finding that the organoids matured faster and showed signs of specialization compared to Earth-grown controls. The findings have been published in the journal Stem Cells Translational Medicine. Phys.Org reports: To examine how the space environment impacts cellular functions, the team compared the cells' RNA expression patterns -- a measure of gene activity -- to identical "ground control" organoids that had remained on Earth. Surprisingly, they found that the organoids grown in microgravity had higher levels of genes associated with maturity and lower levels of genes associated with proliferation compared to the ground controls, meaning that the cells exposed to microgravity developed faster and replicated less than those on Earth. "We discovered that in both types of organoids, the gene expression profile was characteristic of an older stage of development than the ones that were on the ground," [says co-senior author Jeanne Loring, Ph.D., professor emeritus in the Department of Molecular Medicine and founding director of the Center for Regenerative Medicine at Scripps Research]. "In microgravity, they developed faster, but it's really important to know these were not adult neurons, so this doesn't tell us anything about aging."

The team also noted that contrary to their hypothesis, there was less inflammation and lower expression of stress-related genes in organoids grown in microgravity, but more research is needed to determine why. Loring speculates that microgravity conditions may more closely mirror the conditions experienced by cells within the brain compared to organoids grown under conventional lab conditions and in the presence of gravity. "The characteristics of microgravity are probably also at work in people's brains, because there's no convection in microgravity -- in other words, things don't move," says Loring. "I think that in space, these organoids are more like the brain because they're not getting flushed with a whole bunch of culture medium or oxygen. They're very independent; they form something like a brainlet, a microcosm of the brain." "The next thing we plan to do is to study the part of the brain that's most affected by Alzheimer's disease," says Loring. "We also want to know whether there are differences in the way neurons connect with each other in space. With these kinds of studies, you can't rely on earlier work to predict what the result would be because there is no earlier work. We're on the ground floor, so to speak; in the sky, but on the ground floor."

SpaceX has filed a petition to incorporate its Starbase facility in South Texas as a new city, aiming to streamline infrastructure development and support the growing workforce needed for Starship production and testing. Space.com reports: "To continue growing the workforce necessary to rapidly develop and manufacture Starship, we need the ability to grow Starbase as a community," SpaceX said in the petition, which was shared in a post on X (formally Twitter). "That is why we are requesting that Cameron County call an election to enable the incorporation of Starbase as the newest city in the Rio Grande Valley."

The petition was addressed to Cameron County Judge Eddie Trevino Jr., the county's top elected official. The next step will be for officials to review the petition to determine if it complies with statutory requirements. Then, an election would be held to incorporate Starbase. [...] With Starship expected to "fundamentally alter humanity's access to space," SpaceX aims to make the area of the Starbase launch site the "Gateway to Mars," the company wrote in the petition. [...] "Incorporating Starbase will streamline the processes required to build the amenities necessary to make the area a world class place to live -- for hundreds already calling it home, as well as for prospective workers eager to help build humanity's future in space," SpaceX officials said in the petition.

An Alabama woman became the third person to receive a pig kidney transplant, doctors at NYU Langone Health announced Tuesday. Towana Looney, 53, underwent the procedure on November 25 and was discharged December 6.

Her kidney came from a pig with 10 genetic modifications designed to prevent organ rejection. The surgery follows two previous pig kidney transplants this year -- Richard Slayman at Massachusetts General Hospital, who died two months post-surgery from cardiac complications, and Lisa Pisano at NYU Langone, whose transplanted kidney was removed after 47 days due to blood flow issues.

Ars Technica's Beth Mole reports: Editors of the environmental chemistry journal Chemosphere have posted an eye-catching correction to a study reporting toxic flame retardants from electronics wind up in some household products made of black plastic, including kitchen utensils. The study sparked a flurry of media reports a few weeks ago that urgently implored people to ditch their kitchen spatulas and spoons. Wirecutter even offered a buying guide for what to replace them with. The correction, posted Sunday, will likely take some heat off the beleaguered utensils. The authors made a math error that put the estimated risk from kitchen utensils off by an order of magnitude.

Specifically, the authors estimated that if a kitchen utensil contained middling levels of a key toxic flame retardant (BDE-209), the utensil would transfer 34,700 nanograms of the contaminant a day based on regular use while cooking and serving hot food. The authors then compared that estimate to a reference level of BDE-209 considered safe by the Environmental Protection Agency. The EPA's safe level is 7,000 ng -- per kilogram of body weight -- per day, and the authors used 60 kg as the adult weight (about 132 pounds) for their estimate. So, the safe EPA limit would be 7,000 multiplied by 60, yielding 420,000 ng per day. That's 12 times more than the estimated exposure of 34,700 ng per day. However, the authors missed a zero and reported the EPA's safe limit as 42,000 ng per day for a 60 kg adult. The error made it seem like the estimated exposure was nearly at the safe limit, even though it was actually less than a tenth of the limit. "We regret this error and have updated it in our manuscript," the authors said in a correction.

"This calculation error does not affect the overall conclusion of the paper," the correction reads. The study maintains that flame retardants "significantly contaminate" the plastic products, which have "high exposure potential."

Does space need environmentalists, asks the headline from a new article in Noema magazine. "As astrophysicist Neil deGrasse Tyson notes, the first trillionaire will be made in space.

"But amid such promising developments are worries among some scientists and environmentalists who fear humans will repeat the errors that resource extraction has wrought on Earth..." If we have mining in space, do we need a preemptive anti-mining campaign to protect our solar system from rampant exploitation before it is too late? Earth-bound environmental advocates and astrobiologists alike have concluded that, indeed, we need an environmental movement in space... [Daniel Capper, an adjunct professor of philosophy at the Metropolitan State University of Denver] is part of a small but growing chorus of intellectuals who argue that we must carve out protections sooner rather than later — backed by a concrete theoretical and legal framework — for certain areas of the solar system. The United Nations has convened a working group on the use of space resources, and the International Astronomical Union has set up a different working group to delineate places of special scientific value on the moon.

Some researchers have proposed creating a planetary park system in space, while others advocate for a circular space economy that minimizes the need for additional resources. The nonprofit For All Moonkind is advocating for the protection of space sites of cultural importance, like the Apollo 11 landing site. And the Astra Carta, backed by Britain's King Charles, advocates for making sustainability a key component of space activities... [Martin Elvis, an astronomer with the Center for Astrophysics at Harvard University and the Smithsonian Institution] proposed setting aside 7/8ths of the solar system as wilderness, in a paper published in 2019 in Acta Astronautica that he coauthored with King's College London philosopher Tony Milligan...

[T]he lack of norms — clear rules and regulations around space — is one of the most pressing threats to the space environment, advocates say. What might happen, for example, if the United States simply began scooping up asteroids for platinum, or if Blue Origin established a mine at the lunar South Pole without securing consensus from others? "We do not have good answers to those questions right now," Hanlon said. "This is something that I'm really concerned about." Much of the legal basis for the space environmentalism movement is currently contained in just one article of the Outer Space Treaty (OST), said Christopher Johnson, the director of legal affairs and space law at the Secure World Foundation. Article 9 of the OST contains the harmful contamination language and says actors must pay "due regard" to the interests of others. It also stipulates that "harmful interference" with the activities of others must be avoided. Those phrases could be interpreted in multiple ways and have yet to be meaningfully tested.
The article cites two concrete proposals moving forward:

• "The Artemis Accords, a set of principles for exploring and using resources in outer space established by the U.S. in 2020, argues that resource extraction does not constitute national appropriation, and is therefore allowed by the OST. It's an initial step toward securing a consensus on space regulations, and one that's to date received the signatures of 47 nations including Japan, the United Kingdom, France and Germany (though China and Russia are notably absent). Signing the Artemis Accords allows nations to participate in the Artemis program, and also play a role in shaping future norms in space, Johnson said, a potentially lucrative incentive... "

• "The UN's COPUOS, the same one responsible for the OST and the Moon Agreement, published a working paper in 2019 that laid out voluntary guidelines for the long-term sustainability of outer space activities. Recommendations from the committee's working group on principles for the use of space resources are due in 2027, and Johnson said draft guidelines are likely to emerge in early 2025."

"One day, our descendants might live among the stars," the article concludes. "But we must ask ourselves, what kind of place will they inherit?"

Researchers used Canada's national synchrotron light source facility "to analyze a new type of lithium-ion battery material — called a single-crystal electrode — that's been charging and discharging non-stop in a Halifax lab for more than six years," reports Tech Xplore.

The results? The battery material "lasted more than 20,000 cycles before it hit the 80% capacity cutoff," which they say is equivalent to driving 8 million kms (nearly 5 million miles). That's more than eight times the life of a regular lithium-ion battery that lasted 2,400 cycles before reaching the 80% cutoff — and "When the researchers looked at the single crystal electrode battery, they saw next to no evidence of this mechanical stress." (One says the material "looked very much like a brand-new cell." Toby Bond [a senior scientist at the CLS, who conducted the research for his Ph.D.] attributes the near absence of degradation in the new style battery to the difference in the shape and behavior of the particles that make up the battery electrodes... The single crystal is, as its name implies, one big crystal: it's more like an ice cube. "If you have a snowball in one hand, and an ice cube in the other, it's a lot easier to crush the snowball," says Bond. "The ice cube is much more resistant to mechanical stress and strain." While researchers have for some time known that this new battery type resists the micro cracking that lithium-ion batteries are so susceptible to, this is the first time anyone has studied a cell that's been cycled for so long...

Bond says what's most exciting about the research is that it suggests we may be near the point where the battery is no longer the limiting component in an EV — as it may outlast the other parts of the car. The new batteries are already being produced commercially, says Bond, and their use should ramp up significantly within the next couple of years. "I think work like this just helps underscore how reliable they are, and it should help companies that are manufacturing and using these batteries to plan for the long term."
Thanks to long-time Slashdot reader schwit1 for sharing the news.

Long-time Slashdot reader smooth wombat writes: Scientist have unlocked the secret to a bacteria dubbed 'Conan the Bacterium' which is listed in the Guinness Book of World Records as the most radiant-resistant life-form. Deinococcus radiodurans can withstand radiation doses 28,000 times greater than that which would kill a human [and every other organism]. In addition, this bacteria can survive on the outside of the International Space Station for three years. It can also withstand acid, cold, and dehydration (a D&D player's worst nightmare). All of this protection comes down to a unique antioxidant.

The antioxidant is formed by a simple group of small molecules called metabolites, including manganese, phosphate and a small peptide, or molecule, of amino acids.
CNN reports: The antioxidant is formed by a simple group of small molecules called metabolites, including manganese, phosphate and a small peptide, or molecule, of amino acids. Together, this powerful trilogy is more effective in protecting against radiation than manganese combined with just one of the other components, according to a new study published Monday in the Proceedings of the National Academy of Sciences.

The findings could be used to protect astronauts from high doses of cosmic radiation on future deep-space missions across our solar system, according to the study authors.

"We've long known that manganese ions and phosphate together make a strong antioxidant, but discovering and understanding the 'magic' potency provided by the addition of the third component is a breakthrough," said study coauthor Brian Hoffman, the Charles E. and Emma H. Morrison Professor of Chemistry and professor of molecular biosciences at Northwestern University's Weinberg College of Arts and Sciences, in a statement...

On Earth, the antioxidant could be used for protection against accidents that release radiation.

NASA believes Ingenuity's navigation system was responsible for its crash on the surface of Mars. Engineers determined that the helicopter's navigation system struggled to track features over smooth terrain, leading to a hard landing and structural failure. Universe Today reports: Now, almost a year after the incident, a team of engineers from NASA's Jet Propulsion Laboratory have been analyzing the data. Their findings will be published in the next few weeks however the team of engineers assert it was harder than expected to complete an accident investigation from 160 million kilometers. The faults lie in the navigation system that was designed to visually track surface features using a camera pointed at the round. The system worked during early flights over more textured terrain but as Ingenuity moved over the Jezero Crater, it began operating over featureless sand ripples.

The navigation system was designed to provide estimates of the helicopter's velocity, chiefly to enable it to land. The data revealed from Flight 72 revealed that the navigation system couldn't find features to track. Images showed that the lack of features led to a harder than usual touchdown leading to a pitch and roll of the craft. The sudden change of attitude led to increase load on the rotors, beyond their designed limits leading to the structural damage. "Even though Ingenuity will not be able to fly anymore it can still provide weather and avionics data to the Perseverance rover," notes Universe Today. "It will help us to understand more about the weather in its vicinity but perhaps its greatest legacy are its hours of flight on an alien world."

An anonymous reader quotes a report from Science Magazine: It would be a nightmare lab leak: Synthetic bacteria escape the petri dish and unleash a global plague that life on Earth is incapable of defending itself against. That's the concern raised by a group of eminent researchers in a Policy Forum published online today in Science. The commentary's 38 authors, from a broad range of disciplines, argue that governments worldwide should prohibit research and funding aimed at creating so-called mirror-image bacteria whose chemical makeup differs in a fundamental way from that of naturally existing organisms.

All of life's primary biomolecules can exist in two mirror-image forms, like a left and right hand. But only one form is found in nature. Proteins are left-handed, for example, and DNA and RNA are right-handed. Synthetic biologists have previously synthesized mirror-image proteins and genetic molecules. And mirror-image amino acids and peptides -- the building blocks of proteins -- have been incorporated into several approved drugs. Because natural enzymes struggle to break down mirror-image biomolecules, these components help the drugs survive longer in the body. [...]

The concern, he and others say, is that taking this line of work many steps further could result in fully mirror-image bacteria that could reproduce. Such organisms would likely be able to infect and potentially harm a wide range of microbes, plants, and animals while resisting the molecules that enable predators to kill and digest existing microbes. "They are essentially unassailable to those enzymes," says John Glass, a co-author and synthetic biologist at the J. Craig Venter Institute. Animals' immune systems would also struggle to cope with mirror bacteria. They "would be invisible to the immune system until it was too late," says Timothy Hand, a co-author and immunologist at the University of Pittsburgh. The Policy Forum authors acknowledge it will be at least a decade before synthetic biologists will be capable of creating these life forms. Nevertheless, they recommend halting all research aimed at that goal and urge funding agencies not to support it. "It's hard to overstate how severe these risks could be," says Ruslan Medzhitov, an immunologist at Yale University and one of the authors. "If mirror bacteria were to spread through infected animals and plants, much of the planet's many environments could be contaminated. ... Any exposure to contaminated dust or soil could be fatal."

Jack Szostak, a co-author and a 2019 Nobel Prize-winning chemist at the University of Chicago, adds: "The result could be catastrophic irreversible damage, perhaps far worse than any challenge we've previously encountered."

In an announcement that stunned New Zealand's research community, the country's center-right coalition government said it would divert half of the NZ$75 million Marsden Fund, the nation's sole funding source for fundamental science, to "research with economic benefits." From a report: Moreover, the fund would no longer support any social sciences and humanities research, and the expert panels considering these proposals would be disbanded.

Universities New Zealand, which represents the nation's eight universities, called the planned disinvestment in social science and humanities "astonishing." It was among several academic groups and many scientists calling for the government to reverse the unexpected decision.

In announcing the change, Minister of Science, Innovation and Technology Judith Collins said the fund should focus on "core science" that supports economic growth and "a science sector that drives high-tech, high-productivity, high-value businesses and jobs."

An international research team has for the first time imaged and controlled a type of magnetic flow called altermagnetism, which physicists say could be used to develop faster and more reliable electronic devices. Financial Times: A groundbreaking experiment at a powerful X-ray microscope in Sweden provides direct proof of the existence of altermagnetism, according to a paper published in Nature on Wednesday. Altermagnetic materials can sustain magnetic activity without themselves being magnetic.

The team from the UK's Nottingham university that led the research said the discovery has revolutionary potential for the electronics industry. "Altermagnets have the potential to lead to a thousand-fold increase in the speed of microelectronic components and digital memory, while being more robust and energy-efficient," said senior author Peter Wadley, Royal Society research fellow at Nottingham.

Hard disks and other components underpinning the modern computers industry process data in ferromagnetic materials, whose intrinsic magnetism limits their speed and packing density. Using altermagnetic materials will allow current to flow in non-magnetic products.

Global antibiotic use in livestock varies dramatically across regions, with some Asian countries using up to 80 times more antibiotics per kilogram of meat than European nations, according to new research published by Our World in Data. Thailand leads global antibiotic consumption in livestock, while Norway reports the lowest usage rates.

The study found that around 70% of global antibiotics are administered to farm animals rather than humans, raising concerns about antimicrobial resistance. Several European countries have successfully reduced veterinary antibiotic sales by more than half between 2011 and 2022 through stricter regulations, including requiring prescriptions and imposing taxes on sales.

The Netherlands saw a 54% decrease in pig farm antibiotic use between 2004 and 2016 without negative impacts on animal welfare or farm economics. Researchers suggest global livestock antibiotic use could fall by two-thirds if consumption were reduced to 50 milligrams per kilogram of meat produced.

Not every tech "advent calendar" involves programming puzzles. Instead the geek tradition of programming-language advent calendars "seems to have started way back in 2000," according to one history, "when London-based programmer Mark Fowler launched a calendar highlighting a different Perl module each day."

So the tradition continues...

• Nearly a quarter of a century later, there's still a Perl Advent Calendar, celebrating tips and tricks like "a few special packages waiting under the tree that can give your web applications a little extra pep in their step."

• And of course there's a separate advent calendar for Raku programmers.

• Since 2009 web performance consultant (and former Yahoo and Facebook engineer) Stoyan Stefanov has been pulling together an annual Web Performance calendar with helpful blog posts.

• There's also a JVM Advent calendar with daily helpful hints for Java programmers.

• Another advent calendar promises daily posts about C#.

• The HTMHell site — which bills itself as "a collection of bad practices in HTML, copied from real websites" — is celebrating the season with the "HTMHell Advent Calendar," promising daily articles on security, accessibility, UX, and performance.

• There's even an advent calendar with tips for the reverse-engineering framework Radar.

• There's still a lovely web-design themed calendar at Designcember.com.

And meanwhile developers at the Svelte frontend framework are actually promising to release something new each day, "whether it's a new feature in Svelte or SvelteKit or an improvement to the website!"

But not every tech advent calendar is about programming...

• Adafruit's managing director is publishing a Retrocomputing Advent Calendar — daily looks at the ghosts of computers past.

• The Atlantic continues its 17-year tradition of a Space Telescope advent calendar, featuring daily images from both NASA's Hubble telescope and James Webb Space Telescope

• The gaming blog Rock Paper Shotgun has been counting down their favorite games of 2024...

"In September 2024, U.S. scientists made key advances towards building a nuclear clock — a step beyond an atomic clock," according to ScienceAlert: In contrast to the atomic clock, the transition measured by this new device happens in the nucleus, or core, of the atom (hence the name), which gives it an even higher frequency. Thorium-229, the atom used for this study, offers a nuclear transition that can be excited by ultraviolet light. The team working on the nuclear clock overcame the technological challenge of building a frequency comb that works at the relatively high frequency range of ultraviolet light. This was a big step forward because nuclear transitions usually only become visible at much higher frequencies — like those of gamma radiation. But we are not able to accurately measure transitions in the gamma range yet.

The thorium atom transition has a frequency roughly one million times higher than the caesium atom's. This means that, although it has been measured with a lower accuracy than the current state-of-the-art strontium clock, it promises a new generation of clocks with much more precise definitions of the second. Measuring time to the nineteenth decimal place, as nuclear clocks could do, would allow scientists to study very fast processes... [G]eneral relativity is used to study high speed processes that could lead to overlaps with quantum mechanics. A nuclear clock will give us the technology necessary for proving these theories. [The clocks "will enable the study of the union of general relativity and quantum mechanics once they become sensitive to the finite wavefunction of quantum objects oscillating in curved space-time," according to the abstract of the researchers' paper.]

On a technological level, precise positioning systems such as GPS are based on complex calculations that require fine measurements of the time required by a signal to jump from one device to a satellite and onto another device. A better definition of the second will translate to much more accurate GPS. Time might be up for the caesium second, but a whole new world awaits beyond it.
As the researchers explain their paper's abstract,

60-year-old Chinese virologist Shi Zhengli led the Wuhan Institute of Virology's group studying bat coronaviruses (prompting Science magazine to call her "Bat Woman"). In June of 2020 Scientific American described Zhengli as "distressed because stories from the Internet and major media have repeated a tenuous suggestion that SARS-CoV-2 accidentally leaked from her lab — despite the fact that its genetic sequence does not match any her lab had previously studied."

More than four years later, Nature writes Friday that Zhengli "reported that none of the viruses stored in her freezers are the most recent ancestors of the virus SARS-CoV-2," presenting data at a conference in Japan "on dozens of new coronaviruses collected from bats in southern China." Shi has consistently said that SARS-CoV-2 was never seen or studied in her lab. But some commentators have continued to ask whether one of the many bat coronaviruses her team collected in southern China over decades was closely related to it. Shi promised to sequence the genomes of the coronaviruses and release the data. The latest analysis, which has not been peer reviewed, includes data from the whole genomes of 56 new betacoronaviruses, the broad group to which SARS-CoV-2 belongs, as well as some partial sequences. All the viruses were collected between 2004 and 2021.

"We didn't find any new sequences which are more closely related to SARS-CoV-1 and SARS-CoV-2," said Shi, in a pre-recorded presentation at the conference... The results support her assertion that the WIV lab did not have any bat-derived sequences from viruses that were more closely related to SARS-CoV-2 than were any already described in scientific papers, says Jonathan Pekar, an evolutionary biologist at the University of Edinburgh, UK. "This just validates what she was saying: that she did not have anything extremely closely related, as we've seen in the years since," he says.
"Earlier this year, Shi moved from the WIV to the Guangzhou Laboratory, a newly established national research institute for infectious diseases."

Space.com calls it "the once-in-a-lifetime reignition of a long-dead star in an explosion powerful enough to briefly match the brilliance of Polaris, the North Star." In March CNN promised this once-every-79-years event would happen "anytime between now and September."

But it didn't...

Space.com has a spectacular animation showing what this "recurring nova" was supposed to look like (described by CNN as a "sudden, brief explosion" from a collapsed/"white dwarf" star). "The highly-anticipated 'guest star' of the night sky has yet to deliver its grand performance," adds Space.com, "but we have an update." For a quick recap... T Coronae Borealis — often called T Cor Bor or T CrB — is home to a white dwarf, a dense, burnt-out star siphoning material from its companion star, which is a massive red giant close to the end of its life. This material spirals into an accretion disk around the white dwarf, where it slowly coats the star's surface. Every 80 years or so, the white dwarf manages to accumulate enough mass to trigger a nuclear explosion, sparking an outburst that boosts its typically dim magnitude of 10 to a bright 2.0 — that should look like a "new star" in the night sky to us...

[T]he elusive system continues to show signs that an outburst is still imminent. So, what gives? "We know it has to happen," astrophysicist Elizabeth Hays, who is watching T CrB every day using NASA's Fermi gamma-ray space telescope, told Space.com in a recent interview. "We just can't pin it down to the month."

The unpredictability stems partly from limited historical records of T CrB's outbursts. Only two such eruptions have been definitively observed in recent history: on May 12, 1866, when a star's outburst briefly outshined all the stars in its constellation, reaching magnitude 2.0, and again on February 9, 1946, when it peaked at magnitude 3.0. These events appear to follow the star's roughly 80-year cycle, suggesting that the next outburst may not occur until 2026. However, in February 2015, the system brightened in a manner reminiscent of its behavior in 1938, eight years before its 1946 eruption. This rise in brightness suggested T CrB's outburst was accelerated to 2023. The system also endured a "unique and mysterious" dimming about a year before its 1946 outburst, and a similar dip started in March last year, prompting astronomers to adjust their predictions to 2024.

Yet, the cause of this pre-eruption dip in brightness remains unclear, making it only a coincidental predictor. "We got really excited when it looked like it was doing similar things," said Hays. "Now we're learning, 'Oh, there's another piece we can't see.'" Moreover, the rate at which the red giant's material is being drawn toward the white dwarf may fluctuate over the years, making it trickier to put a date on the calendar for the outburst, Edward Sion, a professor of astronomy and astrophysics at Villanova University in Pennsylvania, told Space.com... "There's a lot of uncertainty about the actual average accretion rate," said Sion.
The article points out that last time there was an eruption, "there were no X-ray or gamma-ray telescopes in space, so there is no data from wavelengths other than optical to shed light on what happened before the outburst." But this time astrophysicist Hays says "We're getting the best dataset we've ever had on what does nova look like before it goes off".

Space.com says "this wealth of data will allow them to better predict future outbursts, and will eventually benefit models of how stars work."

Thanks to long-time Slashdot reader Okian Warrior for sharing the article.