Medicine

The Mosquito-Borne Disease 'Triple E' Is Spreading In the US As Temperatures Rise (grist.org) 54

An anonymous reader quotes a report from Wired: A 41-year-old man in New Hampshire died last week after contracting a rare mosquito-borne illness called eastern equine encephalitis virus, also known as EEE or "triple E." It was New Hampshire's first human case of the disease in a decade. Four other human EEE infections have been reported this year, in Wisconsin, New Jersey, Massachusetts, and Vermont. Though this outbreak is small, and triple E does not pose a risk to most people living in the United States, public health officials and researchers are concerned about the threat the deadly virus poses to the public, both this year and in future summers. There is no known cure for the disease, which can cause severe flu-like symptoms and seizures in humans four to 10 days after exposure and kills between 30 and 40 percent of the people it infects (Warning: source paywalled; alternative source). Half of the people who survive a triple E infection are left with permanent neurological damage. Because of EEE's high mortality rate, state officials have begun spraying insecticide in Massachusetts, where 10 communities have been designated "critical" or "high risk" for triple E. Towns in the state shuttered their parks from dusk to dawn and warned people to stay inside after 6 pm, when mosquitoes are most active.

Like West Nile virus, another mosquito-borne illness that poses a risk to people in the US every summer, triple E is constrained by environmental factors that are changing rapidly as the planet warms. That's because mosquitoes thrive in the hotter, wetter conditions that climate change is producing. "We have seen a resurgence of activity with eastern equine encephalitis virus over the course of the past 10 or so years," said Theodore G. Andreadis, a researcher who studied mosquito-borne diseases at the Connecticut Agricultural Experiment Station, a state government research and public outreach outfit, for 35 years. "And we've seen an advancement into more northern regions where it had previously not been detected." Researchers don't know what causes the virus to surge and abate, but Andreadis said it's clear that climate change is one of the factors spurring its spread, particularly into new regions. [...]

Studies have shown that warmer air temperatures up to a certain threshold, around 90 degrees Fahrenheit, shorten the amount of time it takes for C. melanura eggs to hatch. Higher temperatures in the spring and fall extend the number of days mosquitoes have to breed and feed. And they'll feed more times in a summer season if it's warmer -- mosquitoes are ectothermic, meaning their metabolism speeds up in higher temperatures. Rainfall, too, plays a role in mosquito breeding and activity, since mosquito eggs need water to hatch. A warmer atmosphere holds more moisture, which means that even small rainfall events dump more water today than they would have last century. The more standing water there is in roadside ditches, abandoned car tires, ponds, bogs, and potholes, the more opportunities mosquitoes have to breed. And warmer water decreases the incubation period for C. melanura eggs, leading one study to conclude that warmer-than-average water temperatures "increase the probability for amplification of EEE." Climate change isn't the only factor encouraging the spread of disease vectors like mosquitoes. The slow reforestation of areas that were clear-cut for industry and agriculture many decades ago is creating new habitat for insects. At the same time, developers are building new homes in wooded or half-wooded zones in ever larger numbers, putting humans in closer proximity to the natural world and the bugs that live in it.
The report notes that the best way to prevent mosquito bites is to "wear long sleeves and pants at dusk and dawn, when mosquitoes are most prone to biting, and regularly apply an effective mosquito spray." Local health departments can also help protect the public by "testing pools of water for mosquito larvae and conducting public awareness and insecticide spraying campaigns when triple E is detected," notes Wired.

A vaccine for the disease exists for horses, but because the illness is so rare "there is little incentive for vaccine manufacturers to develop a preventative for triple E in humans," adds the report.
Medicine

Sleep Apnea Detection Is Coming To the Apple Watch 40

Apple announced today that it's adding sleep apnea detection to the Apple Watch, including the Apple Watch Series 9, Series 10, and Apple Watch Ultra 2. The Verge reports: Sleep apnea is a disorder that causes you to stop breathing as you sleep. Sleep apnea is a feature that wearables makers have been working on for some time, with Samsung getting cleared by the FDA for sleep apnea tracking with the Galaxy Watch earlier this year. Apple says it's using the accelerometer on its watches to monitor a new metric that it calls "breathing disturbances." You'll be able to see your nightly breathing disturbance values in the Health app.

The company expects to get FDA clearance for its sleep apnea detection feature soon, and it plans to launch the feature in more than 150 countries and regions. The company says its sleep detection was validated in a study that was "unprecedented" in size for sleep apnea technology.
Medicine

AirPods Pro 2 Adds 'Clinical Grade' Hearing Aid Feature 47

Apple says AirPods Pro 2 will receive a software feature "soon" that will turn the wireless earbuds into "clinical-grade" hearing aids. "This includes a hearing protection mode being enabled by default, offering passive noise cancellation in loud environments," adds 9to5Mac. From the report: Firstly, users can take a clinically-validated hearing test. The hearing test uses your AirPods and iPhone, and can be conducted by a user in under five times. The result of your hearing test can be viewed securely in the Health app. If hearing loss is detected, the hearing aid mode is then available to use. The AirPods will make it easier to hear sounds from the world around you. A custom hearing profile is automatically applied when listening to audio, like music or podcasts.

The hearing aid feature is currently making its way through the FDA and other regulatory bodies. Apple said the functionality will be available in more than 100 countries. The feature will be enabled through a free software update coming later this year to AirPods Pro 2.
Medicine

The Mosquito-Borne Disease 'Triple E' Is Spreading in the US as Temperatures Rise (wired.com) 68

Eastern equine encephalitis (EEE) cases have been reported in five U.S. states this year, including a fatal case in New Hampshire last month. The rare mosquito-borne illness, which has no known cure, kills 30-40% of those infected and often causes permanent neurological damage in survivors.

Public health officials are monitoring the situation closely. Massachusetts has implemented insecticide spraying in high-risk areas and issued advisories for residents to limit outdoor activities during peak mosquito hours.

Climate change may be contributing to EEE's spread, as warmer, wetter conditions favor mosquito breeding. Researchers note the virus has advanced into northern regions where it was previously undetected. From 2003 to 2019, the Northeast saw an increase to 4-5 cases per year on average, up from less than one annual case between 1964 and 2002.
Mars

Elon Musk: Starships Launch for Mars in 2026. Crewed Flights Possible By 2028 (nextbigfuture.com) 210

"The first Starships to Mars will launch in 2 years," Elon Musk posted on X.com this weekend.

Musk said the launches will happen when the next Earth-Mars transfer window opens, which the science blog NextBigFuture identifies as "about November through December 2026." Musk noted that the 2026 missions "will be uncrewed to test the reliability of landing intact on Mars," but "If those landings go well, then the first crewed flights to Mars will be in 4 years."

"Flight rate will grow exponentially from there, with the goal of building a self-sustaining city in about 20 years. Being multiplanetary will vastly increase the probable lifespan of consciousness, as we will no longer have all our eggs, literally and metabolically, on one planet."
China

China To Launch Mars-Sampling Mission In 2028 (spacenews.com) 64

"China is on track to launch its Tianwen-3 mission to Mars in 2028, two years earlier than previously planned," writes the South China Morning Post, a change that one space policy research believes "suggests a rising confidence by China in its ability to get the technology right for the complex operation." On Thursday, Liu Jizhong, chief designer of China's Mars mission, told the Second International Conference on Deep Space Exploration in Huangshan, Anhui province, that the team aimed to bring back around 600 grams (21 oz) of Martian soil... A 2028 launch date should see Martian samples returned to Earth around July 2031, according to a previous presentation made by Tianwen-1 mission lead Sun Zezhou at Nanjing University in 2022.
The mission will actually consist of two launches from Earth, reports Space News: Two Long March 5 rocket launches will carry a lander and ascent vehicle and an orbiter and return module respectively. Entry, descent and landing will build on technology used for the Tianwen-1 rover landing. The mission may also include a helicopter and a six-legged crawling robot for collecting samples away from the landing site...

NASA is working on its own, more complex Mars sample return mission. However the program is being reassessed, following projected cost overruns. Studies are being conducted to identify concepts that can deliver samples faster and cheaper than current plans.

Liu stated that the search for evidence of life is the Tianwen-3's top scientific goal, according to state media China Central Television (CCTV). Earlier reporting notes that potential landing areas will be selected based partly on astrobiological relevance. This includes environments potentially suitable for the emergence of life and its preservation, such as sedimentary or hydrothermal systems, evidence of past aqueous activity and geological diversity.

"China states that it plans to work with scientists worldwide to cooperatively study and share Martian samples and data," according to the article: The China National Space Administration has made samples from its Chang'e-5 lunar nearside sample return mission available to research applications for international researchers. The same is expected for the recently-completed Chang'e-6 lunar farside mission."

Further ahead, Tianwen-3 will include partnering with countries and research institutions to define the objectives and tasks of a future Mars research station. This will include analyzing requirements, conducting conceptual studies, design implementation plans, and tackling key technological challenges.

Thanks to Slashdot reader Iamthecheese for sharing the news.
Social Networks

GPT-Fabricated Scientific Papers Found on Google Scholar by Misinformation Researchers (harvard.edu) 81

Harvard's school of public policy is publishing a Misinformation Review for peer-reviewed, scholarly articles promising "reliable, unbiased research on the prevalence, diffusion, and impact of misinformation worldwide."

This week it reported that "Academic journals, archives, and repositories are seeing an increasing number of questionable research papers clearly produced using generative AI." They are often created with widely available, general-purpose AI applications, most likely ChatGPT, and mimic scientific writing. Google Scholar easily locates and lists these questionable papers alongside reputable, quality-controlled research. Our analysis of a selection of questionable GPT-fabricated scientific papers found in Google Scholar shows that many are about applied, often controversial topics susceptible to disinformation: the environment, health, and computing.

The resulting enhanced potential for malicious manipulation of society's evidence base, particularly in politically divisive domains, is a growing concern... [T]he abundance of fabricated "studies" seeping into all areas of the research infrastructure threatens to overwhelm the scholarly communication system and jeopardize the integrity of the scientific record. A second risk lies in the increased possibility that convincingly scientific-looking content was in fact deceitfully created with AI tools and is also optimized to be retrieved by publicly available academic search engines, particularly Google Scholar. However small, this possibility and awareness of it risks undermining the basis for trust in scientific knowledge and poses serious societal risks.

"Our analysis shows that questionable and potentially manipulative GPT-fabricated papers permeate the research infrastructure and are likely to become a widespread phenomenon..." the article points out.

"Google Scholar's central position in the publicly accessible scholarly communication infrastructure, as well as its lack of standards, transparency, and accountability in terms of inclusion criteria, has potentially serious implications for public trust in science. This is likely to exacerbate the already-known potential to exploit Google Scholar for evidence hacking..."
Biotech

Telegram CEO Durov Fathered Over 100 Kids as an Anonymous Sperm Donor (msn.com) 88

An anonymous reader shared this report from USA Today: He's the founder of Telegram. He was arrested in France. He also claims to have fathered at least 100 children...

The 39-year-old Russian-born billionaire often keeps his personal life out of the spotlight. Something he has shared, however, is that, despite never marrying and preferring to live alone, he's fathered at least 100 children through anonymous sperm donation... Durov noted he plans to "open-source" his DNA so his biological children can find each other more easily. "I also want to help destigmatize the whole notion of sperm donation and incentivize more healthy men to do it, so that families struggling to have kids can enjoy more options," he wrote. "Defy convention — redefine the norm...!"

"Sperm donation has allowed many people to have families who otherwise wouldn't be able to," the article points out. But it also adds that the anonymous practice "has drawn several detractors, including from those who've been conceived through it." These people have shared with USA TODAY the mental turmoil of learning they have, in some cases, hundreds of half-siblings... One of the main criticisms of the practice is that the anonymity of the donor makes it difficult or impossible for donor-conceived people to learn about their health and treat genetically inherited medical issues. Even when donor-conceived people have their donor's identity and contact information, there's still no guarantee they'll respond or tell the truth. Also, most sperm banks in the United States aren't legally required to keep records of siblings or cap the number of families that can use a specific donor. As a result, donor-conceived people with many siblings often live in fear of accidentally having children with one of their half-siblings, or even having children with their own father if they were to pursue donor insemination.
ISS

ESA Prints 3D Metal Shape In Space For First Time (theregister.com) 8

The European Space Agency (ESA) has successfully 3D printed the first metal part aboard the International Space Station. This achievement marks a significant advancement in in-orbit manufacturing that could enable the production of essential spare parts and tools for future long-duration space missions. "The first metal shape was produced in August, and three more are planned as part of the experiment," notes The Register. "All four will eventually be returned to Earth for analysis -- two to ESA's technical center, ESTEC, in the Netherlands, one to the agency's astronaut training center in Cologne, and the last sample to the Technical University of Denmark." From the report: During a panel discussion following the UK premiere of Fortitude, a film about the emerging commercial space industry, Advenit Makaya, Advanced Manufacturing Engineer at ESA, remarked on the potential for recycling space debris in the process rather than having to rely on raw materials launched to the ISS. Rob Postema, ESA Project Manager for Metal 3D, told The Register that the agency was indeed looking at "circular" solutions in its drive for greater sustainability. However, don't hold your breath for putting bits of space garbage into one end and getting shiny metal parts out of the other: "A timeline is difficult to indicate, some early results are achieved with ground activities, ready to evaluate solutions in space."

The printer is overseen from the ground and operated for around four hours per day. The ground team has to check each layer via images and a scan of the surface area; printing a sample can take 10-25 days. However, Postema said: "Through automated control of the printing process as well as continuous operations, this can be substantially reduced." Knick-knacks from orbits are all well and good, but could something more substantial be produced? Yes, although not with this demonstrator, which can print to the outer dimensions of a soft drink can. Postema noted that while the demonstrator could manage smaller parts, either as a single unit or as part of larger structures, "there are definitely opportunities to create 3D shapes and parts with this technology larger than what we have done with this Technology Demonstrator."

ISS

Boeing's Starliner Makes 'Picture Perfect' Landing - Without Its Crew (npr.org) 103

Boeing's "beleaguered" Starliner spacecraft "successfully landed in New Mexico just after midnight Eastern time," reports NPR: After Starliner made a picture-perfect landing, Stich told reporters that the spacecraft did well during its return flight. "It was a bullseye landing," he said. "It's really great to get the spacecraft back...." He said while he and others on the team felt happy about the successful landing, "there's a piece of us, all of us, that we wish it would've been the way we had planned it" with astronauts on board when it landed...

Now that Starliner is back on the ground, Boeing and NASA will further analyze the thrusters to see if modifying the spacecraft or how it's flown could keep the thrusters from overheating in the future.

Futurism explains why NASA wanted an uncrewed Starliner flight: While attempting to duplicate the issue at NASA's White Sands Test Facility in New Mexico, engineers eventually found what appeared to be the smoking gun, as SpaceNews' Jeff Foust details in a detailed new breakdown of the timeline. A Teflon seal in a valve known as a "poppet" expanded as it was being heated by the nearby thrusters, significantly constraining the flow of the oxidizer — a disturbing finding, because it greatly degraded the thrusters' performance.

Worse, without being able to perfectly replicate and analyze the issue in the near vacuum of space, engineers weren't entirely sure how the issue was actually playing out in orbit... While engineers found that the thrusters had returned to a more regular shape after being fired in space, they were worried that similar deformations might take place during prolonged de-orbit firings.

A lot was on the line. Without perfect control over the thrusters, NASA became worried that the spacecraft could careen out of control. "For me, one of the really important factors is that we just don't know how much we can use the thrusters on the way back home before we encounter a problem," NASA associate administrator for space operations Ken Bowersox said, as quoted by SpaceNews.

Now CBS News reports that "the road ahead is far from clear" for Starliner: The service module was jettisoned as planned before re-entry, burning up in the atmosphere, and engineers will not be able to examine the hardware to pin down exactly what caused the helium leaks and degraded thruster performance during the ship's rendezvous with the station. Instead, they will face more data analysis, tests and potential redesigns expected to delay the next flight, with or without astronauts aboard, to late next year at the earliest.

"Even though it was necessary to return the spacecraft uncrewed, NASA and Boeing learned an incredible amount about Starliner in the most extreme environment possible," Ken Bowersox, space operations director at NASA Headquarters, said in a statement. "NASA looks forward to our continued work with the Boeing team to proceed toward certification of Starliner for crew rotation missions to the space station," Bowersox added. In any case, the successful landing was a shot in the arm for Boeing engineers and managers, who insisted the Starliner could have safely brought Wilmore and Williams back to Earth.

Steve Stich, manager of NASA's commercial crew program, agreed that if the crew had been on board "it would have been a safe, successful landing."

Two details about the astronauts now waiting for their February return flight from the International Space Station.
  • NPR reports that "in case the space station suffers an emergency that forces an evacuation before that capsule arrives, the station's crew had to jerry-rig two extra seats in a different SpaceX spacecraft that's currently docked there."
  • Space.com reports that when the uncrewed Starliner returned, "Among the gear that it carried home were the 'Boeing Blue' spacesuits that Williams and Wilmore wore aboard the capsule. The astronauts have no need for them now. "The suits are not compatible," Steve Stich, manager of NASA's Commercial Crew Program, said during a press conference on Wednesday (Sept. 4). "So the Starliner suits would not work in Dragon, and vice versa."

Earth

Heatwave Across US West Breaks Records For Highest Temperatures (theguardian.com) 73

An intense heatwave across the US west has brought unusually warm temperatures to the region -- some of the highest of the season -- and broken heat records. From a report: Millions of Americans from Phoenix to Los Angeles to Seattle are under heat alerts. Even before this latest bout of extreme weather, which began on Wednesday and is expected to last through the weekend, summer 2024 was already considered the hottest summer on record.

In California, the desert city of Indio saw its hottest 5 September at 121F (49.4C), breaking a previous record of 120 from 2020, while Palm Springs tied its heat record for the day at 121F. The city recorded its all-time high of 124F in July. The Los Angeles region has not yet broken any records -- although Burbank tied for its all-time high of 114F -- the area is bracing for a days-long stretch of triple-digit temperatures. This week Phoenix marked 100 straight days at 100F or more and its hottest 5 September at 116F. In the Pacific north-west, schools around Portland closed early due to the heat and the typically cool Seattle broke its daily temperature record on Thursday at 89F.

This summer was the hottest on record across the world and the Earth saw its hottest day in recorded history on 22 July, which broke a record set the previous day. Heatwaves are growing more frequent, more extreme and longer-lasting in the US west and across the world as the climate crisis drives increasingly severe and dangerous weather conditions. Heatwaves are the weather event most directly affected by the climate crisis, an expert told the Guardian in July.

Medicine

Part of Brain Network Much Bigger In People With Depression, Scientists Find 47

Researchers have discovered that people with depression have an expanded brain network, specifically the frontostriatal salience network, which is 73% larger compared to healthy individuals. "It's taking up more real estate on the brain surface than we see is typical in healthy controls," said Dr Charles Lynch, a co-author of the research, from Weill Cornell Medicine in New York. He added that expansion meant the size of other -- often neighboring -- brain networks were smaller. The Guardian reports: Writing in the journal Nature, Lynch and colleagues report how they used precision functional mapping, a new approach to brain imaging that analyses a host of fMRI (functional MRI) scans from each individual. The team applied this method to 141 people with depression and 37 people without it, enabling them to measure accurately the size of each participant's brain networks. They then took the average size for each group. They found that a part of the brain called the frontostriatal salience network was expanded by 73% on average in participants with depression compared with healthy controls.

These findings were supported by an analysis of single brain scans previously collected from 932 healthy people and 299 with depression. The team said the size of this brain network in people with depression did not change with time, mood or transcranial magnetic stimulation treatment. However, brain signals between different parts of the network became less synchronised when participants had certain symptoms of depression, with these changes also associated with the severity of future symptoms. The team added that an analysis of brain scans from 57 children who went on to develop depression as adolescents revealed this brain network was expanded years before their symptoms developed, while it was also expanded in adults with late onset depression.

The researchers said this suggested an expanded brain network could be a risk factor for developing depression, rather than a consequence of the condition. However, they said it was unclear to what extent this enlarged network was the result of genetics or experiences, and whether the association with depression arose from this expansion or from other brain networks consequently being smaller. The team added that their results could offer a way to explore whether certain people may be at increased risk of developing depression, and could help develop personalised treatments.
Robotics

Engineers Gave a Mushroom a Robot Body and Let It Run Wild (sciencealert.com) 64

An anonymous reader quotes a report from ScienceAlert: Nobody knows what sleeping mushrooms dream of when their vast mycelial networks flicker and pulse with electrochemical responses akin to those of our own brain cells. But given a chance, what might this web of impulses do if granted a moment of freedom? An interdisciplinary team of researchers from Cornell University in the US and the University of Florence in Italy took steps to find out, putting a culture of the edible mushroom species Pleurotus eryngii (also known as the king oyster mushroom) in control of a pair of vehicles, which can twitch and roll across a flat surface. Through a series of experiments, the researchers showed it was possible to use the mushroom's electrophysiological activity as a means of translating environmental cues into directives, which could, in turn, be used to drive a mechanical device's movements. "By growing mycelium into the electronics of a robot, we were able to allow the biohybrid machine to sense and respond to the environment," says senior researcher Rob Shepherd, a materials scientist at Cornell.

By applying algorithms based on the extracellular electrophysiology of P. eryngii mycelia and feeding the output into a microcontroller unit, the researchers used spikes of activity triggered by a stimulus -- in this case, UV light -- to toggle mechanical responses in two different kinds of mobile device. In controlled experiments, the team used the signals from a fungal culture to govern the movements of a five-limbed soft robot and a four-wheeled untethered vehicle. They were able to influence and override the 'natural' impulses produced by the fungi, demonstrating an ability to harness the system's sensory abilities to meet an end goal. "This kind of project is not just about controlling a robot," says Cornell bioroboticist Anand Mishra. "It is also about creating a true connection with the living system. Because once you hear the signal, you also understand what's going on. Maybe that signal is coming from some kind of stresses. So you're seeing the physical response, because those signals we can't visualize, but the robot is making a visualization."
The research has been published in the journal Science Robotics.
Space

Saturn's Rings Will Vanish Temporarily In Six Months (earth.com) 17

"Earth.com has an interesting article about the temporary "disappearance" of Saturn's rings in about six months," writes longtime Slashdot reader YVRGeek. From the report: Come March 2025, Saturn's majestic rings will become virtually invisible to earth-based observers. This phenomenon occurs due to the unique tilt of Saturn's axis, which will position the rings edge-on to our line of sight. [...] Saturn's axial tilt, which is the angle its axis leans compared to its orbit around the Sun, is about 27 degrees. As Saturn moves during its 29.5 year orbit around the Sun, this tilt means different parts of its rings and moons get sunlight at different angles, changing how they look. So, the rings are not really disappearing but rather playing a celestial game of hide and seek. At their reappearance, we can also enjoy an accentuated view of Saturn's moons.
Medicine

The Rise of DIY, Pirated Medicine (404media.co) 295

An anonymous reader quotes a report from 404 Media, written by Jason Koebler: I've been videochatting with Mixael Swan Laufer for about 30 minutes about an exciting discovery when he points out that to date, the best way he's been able to bring attention to his organization is "the old school method of me performing a bunch of federal felonies on stage in front of a bunch of people." I stop him and ask: "In this case, what are the felonies?" "Well, the list is pretty long," he said. Laufer is the chief spokesperson of Four Thieves Vinegar Collective, an anarchist collective that has spent the last few years teaching people how to make DIY versions of expensive pharmaceuticals at a tiny fraction of the cost.

Four Thieves Vinegar Collective call what they do "right to repair for your body." Laufer has become well known for handing out DIY pills and medicines at hacking conferences, which include, for example, courses of the abortion drug misoprostol that can be manufactured for 89 cents (normal cost: $160) and which has become increasingly difficult to obtain in some states following the Supreme Court decision in Dobbs. In our call, Laufer had just explained that Four Thieves' had made some miscalculations as part of its latest project, to create instructions for replicating sofosbuvir (Sovaldi), a miracle drug that cures hepatitis C, which he planned to explain and reveal at the DEF CON hacking conference. Unlike many other drugs that treat viruses, Sovaldi does not suppress hepatitis C, a virus that kills roughly 250,000 people around the world each year. It cures it. [...]

Crucially, unlike other medical freedom organizations, Four Thieves isn't suggesting people treat COVID with Ivermectin, isn't shilling random supplements, and doesn't have any sort of commercial arm at all. Instead, they are helping people to make their own, identical pirated versions of proven and tested pharmaceuticals by taking the precursor ingredients and performing the chemical reactions to make the medication themselves. "We don't invent anything, really," Laufer said. "We take things that are on the shelf and hijack them. We like to take something established, and be like 'This works, but you can't get it.' Well, here's a way to get it." A slide at his talk reads "Isn't this illegal? Yeah. Grow up."
Four Thieves has developed a suite of open-source tools to help achieve its goal. The core tool, Chemhacktica, is a software platform that uses machine learning to map chemical pathways for synthesizing desired molecules. It suggests potential chemical reactions, identifies precursor materials, and checks their availability for purchase.

The other is Microlab, an open-source controlled lab reactor built from affordable, off-the-shelf components costing between $300 and $500. It uses Chemhacktica's suggested pathways to create medications, and detailed instructions for building and operating the Microlab are provided. Additionally, the company developed a drag-and-drop recipe system called Apothecarium that generates executable files for the Microlab, offering step-by-step guidance on producing specific medications.

Laufer told 404 Media: "I am of the firm belief that we are hitting a watershed where economics and morality are coming to a head, like, 'Look: intellectual property law is based off some ideas that came out of 1400s Venice. They're not applicable and they're being abused and people are dying every day because of it, and it's not OK.'"

Further reading: Meet the Anarchists Making Their Own Medicine (Motherboard; 2018)
Math

Are Professional Forecasters Overconfident? (newyorkfed.org) 32

Research by the Federal Reserve Bank of New York, published on Tuesday, indicates that professional economic forecasters tend to overestimate their accuracy in long-term predictions while underestimating their short-term precision.

The study, which analyzed data from the Survey of Professional Forecasters from 1982 to 2022, revealed that for forecasts two to four quarters ahead, actual errors were two to four times greater than the forecasters' estimated uncertainty ranges for both GDP growth and inflation. In contrast, for predictions less than three months out, forecasters typically overestimated potential errors.

The study's author, Marco Del Negro, highlighted significant differences in uncertainty estimates among individual forecasters, suggesting that these findings challenge the rational expectations theory. Del Negro proposed that these discrepancies might stem from an over-reliance on varying models or priors in making longer-term forecasts.
Earth

Northern Lights Imperiled Infrastructure From Power Grids To Satellites (bloomberg.com) 51

An anonymous reader quotes a Bloomberg article, written by Jason Leopold: The aurora borealis, or northern lights, is a colorful display in the night sky that comes from geomagnetic storms in space. When charged particles from the sun smash into the Earth's upper atmosphere, they create bright, kaleidoscopic ribbons of light, typically in polar regions. Really big solar action can interfere with GPS systems and power grids. That's exactly what happened on May 10, when there were three "coronal mass ejections" (my future metal band name) that produced one of the most powerful solar storms in 500 years, hence the dazzling, polychromatic sky visible even from South America. Turns out, the extreme space weather also disrupted life on Earth.

Six days after the northern lights, I filed a Freedom of Information Act request with NOAA. I was curious how the agency reacted to the atmospheric event and whether the public deserved to be concerned. I asked NOAA's Space Weather Prediction Center and National Weather Service for a wide range of records, including emails, photographs, satellite images and threat assessments. A couple of weeks ago, NOAA turned over some interesting documents. The short version is, while we marveled at the light show, scientists were concerned. According to one internal memo, the geomagnetic storm was an "extreme," rare event and if NOAA scientists hadn't been on their game it could have been catastrophic.

A May 14, three-page after action memo disseminated by Clinton Wallace, the director of the Space Weather Prediction Center, described the storm's impact and explained the celestial phenomenon. He said "Solar Cycle 25," a phase of solar sunspot activity that began in December 2019 and continues through 2030, "has been more active than anticipated, with an intense surge in solar activity marking the beginning of May." "A large group of unstable sunspots on the Sun's surface unleashed several powerful solar flares, immediately affecting the Earth's outer atmosphere and causing disruptions in high-frequency (HF) radio communications," he wrote. "This had significant implications for trans-oceanic aviation, which relies heavily on HF radio for communication over long distances."

On May 9, a day before the northern lights extravaganza, staff at the Space Weather Prediction Center "activated" the North American Electric Reliability Corp. hotline to make sure the regulator was prepared. Wallace's memo said NERC gave about 3,000 electric utility companies a six-hour head start to get ready. The space weather officials also advised the Federal Emergency Management Agency and the Department of Homeland Security's Cybersecurity and Infrastructure Security Agency on preparedness. Wallace wrote in his memo that the storm caused "significant disruptions across multiple sectors, including navigation, power grids, aviation, and satellite operations." He also noted that the severity of the geomagnetic storm "underscored the interconnectedness and vulnerability of modern infrastructure to space weather." Although Wallace said the space weather scientists took steps to mitigate any potential disaster, their work "highlighted areas for improvement in preparedness and response." He didn't elaborate.

Science

Mobile Phones Not Linked To Brain Cancer, Biggest Study To Date Finds (theguardian.com) 83

Mobile phones are not linked to brain and head cancers, a comprehensive review of the highest quality evidence available commissioned by the World Health Organization has found. From a report: Led by the Australian Radiation Protection and Nuclear Safety Agency (Arpansa), the systematic review examined more than 5,000 studies from which the most scientifically rigorous were identified and weak studies were excluded. The final analysis included 63 observational studies in humans published between 1994 and 2022, making it "the most comprehensive review to date," the review lead author, associate prof Ken Karipidis, said. "We concluded the evidence does not show a link between mobile phones and brain cancer or other head and neck cancers."

Published on Wednesday, the review focused on cancers of the central nervous system (including brain, meninges, pituitary gland and ear), salivary gland tumours and brain tumours. The review found no overall association between mobile phone use and cancer, no association with prolonged use (if people use their mobile phones for 10 years or more), and no association with the amount of mobile phone use (the number of calls made or the time spent on the phone).

Science

How Do Gold Nuggets Form? Earthquakes May Be the Key (nationalgeographic.com) 44

Scientists have finally solved a long-standing mystery about the geologic process behind these large pieces of gold found in quartz rock. From a report: Gold has always been a hot commodity. But these days, finding a nugget isn't too tricky: Much of the world's gold is mined from natural veins of quartz, a glassy mineral that streaks through large chunks of Earth's squashed-up crust. But the geologic process that put gold nuggets there in the first place was a mystery. Now, a new study published today in Nature Geoscience has come up with a convincing, and surprising, answer: electricity, and earthquakes -- lots of them.

Those nuggets owe their existence to the strange electrical properties of common quartz. When squished or jiggled, the mineral generates electricity. That drags gold particles out of fluid in Earth's crust. The particles crystallize out as grains of gold -- and, over time, with enough electrical stimulation, those grains bloom into nuggets. "If you shake quartz, it makes electricity. If you make electricity, gold comes out," says Christopher Voisey, a geologist at Monash University in Australia and the lead author of the new paper. Earthquakes are the most likely natural source of that shaking, and the team's lab experiments show that earthquakes can make gold nuggets.

The idea that gold nuggets appear because of electricity instead of a more conventional geologic process is, at first, a peculiar thought. But "it makes complete sense," says Thomas Gernon, a geoscientist at the University of Southampton in England and who was not involved with the new work. Quartz veins host a disproportionate number of gold nuggets and their environments experience plenty of earthquakes.

ISS

The Speaker on Boeing's Starliner Spacecraft Has Started Making Strange Noises (arstechnica.com) 104

An anonymous reader shared this report from Ars Technica: On Saturday NASA astronaut Butch Wilmore noticed some strange noises emanating from a speaker inside the Starliner spacecraft.

"I've got a question about Starliner," Wilmore radioed down to Mission Control, at Johnson Space Center in Houston. "There's a strange noise coming through the speaker ... I don't know what's making it." [Ars Technica embeded a clip of the conversation including the rhythmic, sonar-like noise which was shared online by a Michigan-based meteorologist.] Wilmore said he was not sure if there was some oddity in the connection between the station and the spacecraft causing the noise, or something else. He asked the flight controllers in Houston to see if they could listen to the audio inside the spacecraft. A few minutes later, Mission Control radioed back that they were linked via "hardline" to listen to audio inside Starliner, which has now been docked to the International Space Station for nearly three months.

Wilmore, apparently floating in Starliner, then put his microphone up to the speaker inside Starliner. Shortly thereafter, there was an audible pinging that was quite distinctive. "Alright Butch, that one came through," Mission control radioed up to Wilmore. "It was kind of like a pulsing noise, almost like a sonar ping."

"I'll do it one more time, and I'll let y'all scratch your heads and see if you can figure out what's going on," Wilmore replied. The odd, sonar-like audio then repeated itself. "Alright, over to you. Call us if you figure it out."

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