The FDA on Thursday approved the first hearing aid software for Apple's latest AirPods Pro earbuds. According to Apple, the feature will be pushed to eligible devices through a software update in the coming weeks. The Washington Post reports: The move, which comes two years after the FDA first approved over-the-counter hearing aids, could help more Americans with hearing loss start getting help, the FDA said in a statement. The feature works by amplifying some sounds, such as voices, while minimizing others, such as ambient noise. Users can take a hearing test in the Apple Health app, and their AirPods will adjust sound level automatically based on the results. The feature is only available on the AirPods Pro 2, which cost $249.

The FDA says it tested Apple's hearing aid feature in a clinical study with 118 subjects who believed they had mild or moderate hearing loss. The study found that people who set up their AirPods using Apple's hearing test noticed similar benefits as people who had a professional set up the earbuds. Over-the-counter hearing aids are best for people with mild to moderate hearing loss, audiologists say, many of whom don't seek treatment. [...] However, consumer earbuds aren't a good solution for people with severe hearing loss, experts maintain, and most over-the-counter hearing devices will still require a trip to the audiologist for some fine tuning.

fjo3 shares a report from NASA: Engineers working on NASA's Voyager 1 probe have successfully mitigated an issue with the spacecraft's thrusters, which keep the distant explorer pointed at Earth so that it can receive commands, send engineering data, and provide the unique science data it is gathering. After 47 years, a fuel tube inside the thrusters has become clogged with silicon dioxide, a byproduct that appears with age from a rubber diaphragm in the spacecraft's fuel tank. The clogging reduces how efficiently the thrusters can generate force. After weeks of careful planning, the team switched the spacecraft to a different set of thrusters. [...]

Switching to different thrusters would have been a relatively simple operation for the mission in 1980 or even 2002. But the spacecraft's age has introduced new challenges, primarily related to power supply and temperature. The mission has turned off all non-essential onboard systems, including some heaters, on both spacecraft to conserve their gradually shrinking electrical power supply, which is generated by decaying plutonium. While those steps have worked to reduce power, they have also led to the spacecraft growing colder, an effect compounded by the loss of other non-essential systems that produced heat. Consequently, the attitude propulsion thruster branches have grown cold, and turning them on in that state could damage them, making the thrusters unusable.

The team determined that the best option would be to warm the thrusters before the switch by turning on what had been deemed non-essential heaters. However, as with so many challenges the Voyager team has faced, this presented a puzzle: The spacecraft's power supply is so low that turning on non-essential heaters would require the mission to turn off something else to provide the heaters adequate electricity, and everything that's currently operating is considered essential. Studying the issue, they ruled out turning off one of the still-operating science instruments for a limited time because there's a risk that the instrument would not come back online. After additional study and planning, the engineering team determined they could safely turn off one of the spacecraft's main heaters for up to an hour, freeing up enough power to turn on the thruster heaters. It worked. On Aug. 27, they confirmed that the needed thruster branch was back in action, helping point Voyager 1 toward Earth.

Scientists at Fermi National Accelerator Laboratory have observed the first neutrino interactions in the Short-Baseline Near Detector (SBND), marking a significant milestone in their efforts to explore neutrino oscillations and search for a potential fourth neutrino flavor that could challenge the Standard Model of particle physics. Phys.org reports: SBND is the final element that completes Fermilab's Short-Baseline Neutrino (SBN) Program and will play a critical role in solving a decades-old mystery in particle physics. Getting SBND to this point has been an international effort. The detector was built by an international collaboration of 250 physicists and engineers from Brazil, Spain, Switzerland, the United Kingdom and the United States. [...] The Short Baseline Neutrino Program at Fermilab will perform searches for neutrino oscillation and look for evidence that could point to this fourth neutrino. SBND is the near detector for the Short Baseline Neutrino Program while ICARUS, which started collecting data in 2021, is the far detector. A third detector called MicroBooNE finished recording particle collisions with the same neutrino beamline that same year.

The Short Baseline Neutrino Program at Fermilab differs from previous short-baseline measurements with accelerator-made neutrinos because it features both a near detector and far detector. SBND will measure the neutrinos as they were produced in the Fermilab beam and ICARUS will measure the neutrinos after they've potentially oscillated. So, where previous experiments had to make assumptions about the original composition of the neutrino beam, the SBN Program will definitively know. "Understanding the anomalies seen by previous experiments has been a major goal in the field for the last 25 years," said Schmitz. "Together SBND and ICARUS will have outstanding ability to test the existence of these new neutrinos."

An anonymous reader quotes a report from the Associated Press: A daredevil billionaire rocketed back into orbit Tuesday, aiming to perform the first private spacewalk and venture farther than anyone since NASA's Apollo moonshots. Unlike his previous chartered flight, tech entrepreneur Jared Isaacman shared the cost with SpaceX this time around, which included developing and testing brand new spacesuits to see how they'll hold up in the harsh vacuum. If all goes as planned, it will be the first time private citizens conduct a spacewalk, but they won't venture away from the capsule. Considered one of the riskiest parts of spaceflight, spacewalks have been the sole realm of professional astronauts since the former Soviet Union popped open the hatch in 1965, closely followed by the U.S. Today, they are routinely done at the International Space Station.

Isaacman, along with a pair of SpaceX engineers and a former Air Force Thunderbirds pilot, launched before dawn aboard a SpaceX Falcon 9 rocket from Florida. The spacewalk is scheduled for Thursday, midway through the five-day flight. But first the passengers are shooting for way beyond the International Space Station -- an altitude of 870 miles (1,400 kilometers), which would surpass the Earth-lapping record set during NASA's Project Gemini in 1966. Only the 24 Apollo astronauts who flew to the moon have ventured farther. The plan is to spend 10 hours at that height -- filled with extreme radiation and riddled with debris -- before reducing the oval-shaped orbit by half. Even at this lower 435 miles (700 kilometers), the orbit would eclipse the space station and even the Hubble Space Telescope, the highest shuttle astronauts flew.

All four wore SpaceX's spacewalking suits because the entire Dragon capsule will be depressurized for the two-hour spacewalk, exposing everyone to the dangerous environment. Isaacman and SpaceX's Sarah Gillis will take turns briefly popping out of the hatch. They'll test their white and black-trimmed custom suits by twisting their bodies. Both will always have a hand or foot touching the capsule or attached support structure that resembles the top of a pool ladder. There will be no dangling at the end of their 12-foot (3.6-meter) tethers and no jetpack showboating. Only NASA's suits at the space station come equipped with jetpacks, for emergency use only.

An anonymous reader quotes a report from Wired: A 41-year-old man in New Hampshire died last week after contracting a rare mosquito-borne illness called eastern equine encephalitis virus, also known as EEE or "triple E." It was New Hampshire's first human case of the disease in a decade. Four other human EEE infections have been reported this year, in Wisconsin, New Jersey, Massachusetts, and Vermont. Though this outbreak is small, and triple E does not pose a risk to most people living in the United States, public health officials and researchers are concerned about the threat the deadly virus poses to the public, both this year and in future summers. There is no known cure for the disease, which can cause severe flu-like symptoms and seizures in humans four to 10 days after exposure and kills between 30 and 40 percent of the people it infects (Warning: source paywalled; alternative source). Half of the people who survive a triple E infection are left with permanent neurological damage. Because of EEE's high mortality rate, state officials have begun spraying insecticide in Massachusetts, where 10 communities have been designated "critical" or "high risk" for triple E. Towns in the state shuttered their parks from dusk to dawn and warned people to stay inside after 6 pm, when mosquitoes are most active.

Like West Nile virus, another mosquito-borne illness that poses a risk to people in the US every summer, triple E is constrained by environmental factors that are changing rapidly as the planet warms. That's because mosquitoes thrive in the hotter, wetter conditions that climate change is producing. "We have seen a resurgence of activity with eastern equine encephalitis virus over the course of the past 10 or so years," said Theodore G. Andreadis, a researcher who studied mosquito-borne diseases at the Connecticut Agricultural Experiment Station, a state government research and public outreach outfit, for 35 years. "And we've seen an advancement into more northern regions where it had previously not been detected." Researchers don't know what causes the virus to surge and abate, but Andreadis said it's clear that climate change is one of the factors spurring its spread, particularly into new regions. [...]

Studies have shown that warmer air temperatures up to a certain threshold, around 90 degrees Fahrenheit, shorten the amount of time it takes for C. melanura eggs to hatch. Higher temperatures in the spring and fall extend the number of days mosquitoes have to breed and feed. And they'll feed more times in a summer season if it's warmer -- mosquitoes are ectothermic, meaning their metabolism speeds up in higher temperatures. Rainfall, too, plays a role in mosquito breeding and activity, since mosquito eggs need water to hatch. A warmer atmosphere holds more moisture, which means that even small rainfall events dump more water today than they would have last century. The more standing water there is in roadside ditches, abandoned car tires, ponds, bogs, and potholes, the more opportunities mosquitoes have to breed. And warmer water decreases the incubation period for C. melanura eggs, leading one study to conclude that warmer-than-average water temperatures "increase the probability for amplification of EEE." Climate change isn't the only factor encouraging the spread of disease vectors like mosquitoes. The slow reforestation of areas that were clear-cut for industry and agriculture many decades ago is creating new habitat for insects. At the same time, developers are building new homes in wooded or half-wooded zones in ever larger numbers, putting humans in closer proximity to the natural world and the bugs that live in it. The report notes that the best way to prevent mosquito bites is to "wear long sleeves and pants at dusk and dawn, when mosquitoes are most prone to biting, and regularly apply an effective mosquito spray." Local health departments can also help protect the public by "testing pools of water for mosquito larvae and conducting public awareness and insecticide spraying campaigns when triple E is detected," notes Wired.

A vaccine for the disease exists for horses, but because the illness is so rare "there is little incentive for vaccine manufacturers to develop a preventative for triple E in humans," adds the report.

Apple announced today that it's adding sleep apnea detection to the Apple Watch, including the Apple Watch Series 9, Series 10, and Apple Watch Ultra 2. The Verge reports: Sleep apnea is a disorder that causes you to stop breathing as you sleep. Sleep apnea is a feature that wearables makers have been working on for some time, with Samsung getting cleared by the FDA for sleep apnea tracking with the Galaxy Watch earlier this year. Apple says it's using the accelerometer on its watches to monitor a new metric that it calls "breathing disturbances." You'll be able to see your nightly breathing disturbance values in the Health app.

The company expects to get FDA clearance for its sleep apnea detection feature soon, and it plans to launch the feature in more than 150 countries and regions. The company says its sleep detection was validated in a study that was "unprecedented" in size for sleep apnea technology.

Apple says AirPods Pro 2 will receive a software feature "soon" that will turn the wireless earbuds into "clinical-grade" hearing aids. "This includes a hearing protection mode being enabled by default, offering passive noise cancellation in loud environments," adds 9to5Mac. From the report: Firstly, users can take a clinically-validated hearing test. The hearing test uses your AirPods and iPhone, and can be conducted by a user in under five times. The result of your hearing test can be viewed securely in the Health app. If hearing loss is detected, the hearing aid mode is then available to use. The AirPods will make it easier to hear sounds from the world around you. A custom hearing profile is automatically applied when listening to audio, like music or podcasts.

The hearing aid feature is currently making its way through the FDA and other regulatory bodies. Apple said the functionality will be available in more than 100 countries. The feature will be enabled through a free software update coming later this year to AirPods Pro 2.

Eastern equine encephalitis (EEE) cases have been reported in five U.S. states this year, including a fatal case in New Hampshire last month. The rare mosquito-borne illness, which has no known cure, kills 30-40% of those infected and often causes permanent neurological damage in survivors.

Public health officials are monitoring the situation closely. Massachusetts has implemented insecticide spraying in high-risk areas and issued advisories for residents to limit outdoor activities during peak mosquito hours.

Climate change may be contributing to EEE's spread, as warmer, wetter conditions favor mosquito breeding. Researchers note the virus has advanced into northern regions where it was previously undetected. From 2003 to 2019, the Northeast saw an increase to 4-5 cases per year on average, up from less than one annual case between 1964 and 2002.

"The first Starships to Mars will launch in 2 years," Elon Musk posted on X.com this weekend.

Musk said the launches will happen when the next Earth-Mars transfer window opens, which the science blog NextBigFuture identifies as "about November through December 2026." Musk noted that the 2026 missions "will be uncrewed to test the reliability of landing intact on Mars," but "If those landings go well, then the first crewed flights to Mars will be in 4 years."

"Flight rate will grow exponentially from there, with the goal of building a self-sustaining city in about 20 years. Being multiplanetary will vastly increase the probable lifespan of consciousness, as we will no longer have all our eggs, literally and metabolically, on one planet."

"China is on track to launch its Tianwen-3 mission to Mars in 2028, two years earlier than previously planned," writes the South China Morning Post, a change that one space policy research believes "suggests a rising confidence by China in its ability to get the technology right for the complex operation." On Thursday, Liu Jizhong, chief designer of China's Mars mission, told the Second International Conference on Deep Space Exploration in Huangshan, Anhui province, that the team aimed to bring back around 600 grams (21 oz) of Martian soil... A 2028 launch date should see Martian samples returned to Earth around July 2031, according to a previous presentation made by Tianwen-1 mission lead Sun Zezhou at Nanjing University in 2022.
The mission will actually consist of two launches from Earth, reports Space News: Two Long March 5 rocket launches will carry a lander and ascent vehicle and an orbiter and return module respectively. Entry, descent and landing will build on technology used for the Tianwen-1 rover landing. The mission may also include a helicopter and a six-legged crawling robot for collecting samples away from the landing site...

NASA is working on its own, more complex Mars sample return mission. However the program is being reassessed, following projected cost overruns. Studies are being conducted to identify concepts that can deliver samples faster and cheaper than current plans.

Liu stated that the search for evidence of life is the Tianwen-3's top scientific goal, according to state media China Central Television (CCTV). Earlier reporting notes that potential landing areas will be selected based partly on astrobiological relevance. This includes environments potentially suitable for the emergence of life and its preservation, such as sedimentary or hydrothermal systems, evidence of past aqueous activity and geological diversity.
"China states that it plans to work with scientists worldwide to cooperatively study and share Martian samples and data," according to the article: The China National Space Administration has made samples from its Chang'e-5 lunar nearside sample return mission available to research applications for international researchers. The same is expected for the recently-completed Chang'e-6 lunar farside mission."

Further ahead, Tianwen-3 will include partnering with countries and research institutions to define the objectives and tasks of a future Mars research station. This will include analyzing requirements, conducting conceptual studies, design implementation plans, and tackling key technological challenges.
Thanks to Slashdot reader Iamthecheese for sharing the news.

Harvard's school of public policy is publishing a Misinformation Review for peer-reviewed, scholarly articles promising "reliable, unbiased research on the prevalence, diffusion, and impact of misinformation worldwide."

This week it reported that "Academic journals, archives, and repositories are seeing an increasing number of questionable research papers clearly produced using generative AI." They are often created with widely available, general-purpose AI applications, most likely ChatGPT, and mimic scientific writing. Google Scholar easily locates and lists these questionable papers alongside reputable, quality-controlled research. Our analysis of a selection of questionable GPT-fabricated scientific papers found in Google Scholar shows that many are about applied, often controversial topics susceptible to disinformation: the environment, health, and computing.

The resulting enhanced potential for malicious manipulation of society's evidence base, particularly in politically divisive domains, is a growing concern... [T]he abundance of fabricated "studies" seeping into all areas of the research infrastructure threatens to overwhelm the scholarly communication system and jeopardize the integrity of the scientific record. A second risk lies in the increased possibility that convincingly scientific-looking content was in fact deceitfully created with AI tools and is also optimized to be retrieved by publicly available academic search engines, particularly Google Scholar. However small, this possibility and awareness of it risks undermining the basis for trust in scientific knowledge and poses serious societal risks.
"Our analysis shows that questionable and potentially manipulative GPT-fabricated papers permeate the research infrastructure and are likely to become a widespread phenomenon..." the article points out.

"Google Scholar's central position in the publicly accessible scholarly communication infrastructure, as well as its lack of standards, transparency, and accountability in terms of inclusion criteria, has potentially serious implications for public trust in science. This is likely to exacerbate the already-known potential to exploit Google Scholar for evidence hacking..."

An anonymous reader shared this report from USA Today: He's the founder of Telegram. He was arrested in France. He also claims to have fathered at least 100 children...

The 39-year-old Russian-born billionaire often keeps his personal life out of the spotlight. Something he has shared, however, is that, despite never marrying and preferring to live alone, he's fathered at least 100 children through anonymous sperm donation... Durov noted he plans to "open-source" his DNA so his biological children can find each other more easily. "I also want to help destigmatize the whole notion of sperm donation and incentivize more healthy men to do it, so that families struggling to have kids can enjoy more options," he wrote. "Defy convention — redefine the norm...!"
"Sperm donation has allowed many people to have families who otherwise wouldn't be able to," the article points out. But it also adds that the anonymous practice "has drawn several detractors, including from those who've been conceived through it." These people have shared with USA TODAY the mental turmoil of learning they have, in some cases, hundreds of half-siblings... One of the main criticisms of the practice is that the anonymity of the donor makes it difficult or impossible for donor-conceived people to learn about their health and treat genetically inherited medical issues. Even when donor-conceived people have their donor's identity and contact information, there's still no guarantee they'll respond or tell the truth. Also, most sperm banks in the United States aren't legally required to keep records of siblings or cap the number of families that can use a specific donor. As a result, donor-conceived people with many siblings often live in fear of accidentally having children with one of their half-siblings, or even having children with their own father if they were to pursue donor insemination.

The European Space Agency (ESA) has successfully 3D printed the first metal part aboard the International Space Station. This achievement marks a significant advancement in in-orbit manufacturing that could enable the production of essential spare parts and tools for future long-duration space missions. "The first metal shape was produced in August, and three more are planned as part of the experiment," notes The Register. "All four will eventually be returned to Earth for analysis -- two to ESA's technical center, ESTEC, in the Netherlands, one to the agency's astronaut training center in Cologne, and the last sample to the Technical University of Denmark." From the report: During a panel discussion following the UK premiere of Fortitude, a film about the emerging commercial space industry, Advenit Makaya, Advanced Manufacturing Engineer at ESA, remarked on the potential for recycling space debris in the process rather than having to rely on raw materials launched to the ISS. Rob Postema, ESA Project Manager for Metal 3D, told The Register that the agency was indeed looking at "circular" solutions in its drive for greater sustainability. However, don't hold your breath for putting bits of space garbage into one end and getting shiny metal parts out of the other: "A timeline is difficult to indicate, some early results are achieved with ground activities, ready to evaluate solutions in space."

The printer is overseen from the ground and operated for around four hours per day. The ground team has to check each layer via images and a scan of the surface area; printing a sample can take 10-25 days. However, Postema said: "Through automated control of the printing process as well as continuous operations, this can be substantially reduced." Knick-knacks from orbits are all well and good, but could something more substantial be produced? Yes, although not with this demonstrator, which can print to the outer dimensions of a soft drink can. Postema noted that while the demonstrator could manage smaller parts, either as a single unit or as part of larger structures, "there are definitely opportunities to create 3D shapes and parts with this technology larger than what we have done with this Technology Demonstrator."

Boeing's "beleaguered" Starliner spacecraft "successfully landed in New Mexico just after midnight Eastern time," reports NPR: After Starliner made a picture-perfect landing, Stich told reporters that the spacecraft did well during its return flight. "It was a bullseye landing," he said. "It's really great to get the spacecraft back...." He said while he and others on the team felt happy about the successful landing, "there's a piece of us, all of us, that we wish it would've been the way we had planned it" with astronauts on board when it landed...

Now that Starliner is back on the ground, Boeing and NASA will further analyze the thrusters to see if modifying the spacecraft or how it's flown could keep the thrusters from overheating in the future.
Futurism explains why NASA wanted an uncrewed Starliner flight: While attempting to duplicate the issue at NASA's White Sands Test Facility in New Mexico, engineers eventually found what appeared to be the smoking gun, as SpaceNews' Jeff Foust details in a detailed new breakdown of the timeline. A Teflon seal in a valve known as a "poppet" expanded as it was being heated by the nearby thrusters, significantly constraining the flow of the oxidizer — a disturbing finding, because it greatly degraded the thrusters' performance.

Worse, without being able to perfectly replicate and analyze the issue in the near vacuum of space, engineers weren't entirely sure how the issue was actually playing out in orbit... While engineers found that the thrusters had returned to a more regular shape after being fired in space, they were worried that similar deformations might take place during prolonged de-orbit firings.

A lot was on the line. Without perfect control over the thrusters, NASA became worried that the spacecraft could careen out of control. "For me, one of the really important factors is that we just don't know how much we can use the thrusters on the way back home before we encounter a problem," NASA associate administrator for space operations Ken Bowersox said, as quoted by SpaceNews.
Now CBS News reports that "the road ahead is far from clear" for Starliner: The service module was jettisoned as planned before re-entry, burning up in the atmosphere, and engineers will not be able to examine the hardware to pin down exactly what caused the helium leaks and degraded thruster performance during the ship's rendezvous with the station. Instead, they will face more data analysis, tests and potential redesigns expected to delay the next flight, with or without astronauts aboard, to late next year at the earliest.

"Even though it was necessary to return the spacecraft uncrewed, NASA and Boeing learned an incredible amount about Starliner in the most extreme environment possible," Ken Bowersox, space operations director at NASA Headquarters, said in a statement. "NASA looks forward to our continued work with the Boeing team to proceed toward certification of Starliner for crew rotation missions to the space station," Bowersox added. In any case, the successful landing was a shot in the arm for Boeing engineers and managers, who insisted the Starliner could have safely brought Wilmore and Williams back to Earth.

Steve Stich, manager of NASA's commercial crew program, agreed that if the crew had been on board "it would have been a safe, successful landing."
Two details about the astronauts now waiting for their February return flight from the International Space Station.

• NPR reports that "in case the space station suffers an emergency that forces an evacuation before that capsule arrives, the station's crew had to jerry-rig two extra seats in a different SpaceX spacecraft that's currently docked there."

• Space.com reports that when the uncrewed Starliner returned, "Among the gear that it carried home were the 'Boeing Blue' spacesuits that Williams and Wilmore wore aboard the capsule. The astronauts have no need for them now. "The suits are not compatible," Steve Stich, manager of NASA's Commercial Crew Program, said during a press conference on Wednesday (Sept. 4). "So the Starliner suits would not work in Dragon, and vice versa."

An intense heatwave across the US west has brought unusually warm temperatures to the region -- some of the highest of the season -- and broken heat records. From a report: Millions of Americans from Phoenix to Los Angeles to Seattle are under heat alerts. Even before this latest bout of extreme weather, which began on Wednesday and is expected to last through the weekend, summer 2024 was already considered the hottest summer on record.

In California, the desert city of Indio saw its hottest 5 September at 121F (49.4C), breaking a previous record of 120 from 2020, while Palm Springs tied its heat record for the day at 121F. The city recorded its all-time high of 124F in July. The Los Angeles region has not yet broken any records -- although Burbank tied for its all-time high of 114F -- the area is bracing for a days-long stretch of triple-digit temperatures. This week Phoenix marked 100 straight days at 100F or more and its hottest 5 September at 116F. In the Pacific north-west, schools around Portland closed early due to the heat and the typically cool Seattle broke its daily temperature record on Thursday at 89F.

This summer was the hottest on record across the world and the Earth saw its hottest day in recorded history on 22 July, which broke a record set the previous day. Heatwaves are growing more frequent, more extreme and longer-lasting in the US west and across the world as the climate crisis drives increasingly severe and dangerous weather conditions. Heatwaves are the weather event most directly affected by the climate crisis, an expert told the Guardian in July.

Researchers have discovered that people with depression have an expanded brain network, specifically the frontostriatal salience network, which is 73% larger compared to healthy individuals. "It's taking up more real estate on the brain surface than we see is typical in healthy controls," said Dr Charles Lynch, a co-author of the research, from Weill Cornell Medicine in New York. He added that expansion meant the size of other -- often neighboring -- brain networks were smaller. The Guardian reports: Writing in the journal Nature, Lynch and colleagues report how they used precision functional mapping, a new approach to brain imaging that analyses a host of fMRI (functional MRI) scans from each individual. The team applied this method to 141 people with depression and 37 people without it, enabling them to measure accurately the size of each participant's brain networks. They then took the average size for each group. They found that a part of the brain called the frontostriatal salience network was expanded by 73% on average in participants with depression compared with healthy controls.

These findings were supported by an analysis of single brain scans previously collected from 932 healthy people and 299 with depression. The team said the size of this brain network in people with depression did not change with time, mood or transcranial magnetic stimulation treatment. However, brain signals between different parts of the network became less synchronised when participants had certain symptoms of depression, with these changes also associated with the severity of future symptoms. The team added that an analysis of brain scans from 57 children who went on to develop depression as adolescents revealed this brain network was expanded years before their symptoms developed, while it was also expanded in adults with late onset depression.

The researchers said this suggested an expanded brain network could be a risk factor for developing depression, rather than a consequence of the condition. However, they said it was unclear to what extent this enlarged network was the result of genetics or experiences, and whether the association with depression arose from this expansion or from other brain networks consequently being smaller. The team added that their results could offer a way to explore whether certain people may be at increased risk of developing depression, and could help develop personalised treatments.

An anonymous reader quotes a report from ScienceAlert: Nobody knows what sleeping mushrooms dream of when their vast mycelial networks flicker and pulse with electrochemical responses akin to those of our own brain cells. But given a chance, what might this web of impulses do if granted a moment of freedom? An interdisciplinary team of researchers from Cornell University in the US and the University of Florence in Italy took steps to find out, putting a culture of the edible mushroom species Pleurotus eryngii (also known as the king oyster mushroom) in control of a pair of vehicles, which can twitch and roll across a flat surface. Through a series of experiments, the researchers showed it was possible to use the mushroom's electrophysiological activity as a means of translating environmental cues into directives, which could, in turn, be used to drive a mechanical device's movements. "By growing mycelium into the electronics of a robot, we were able to allow the biohybrid machine to sense and respond to the environment," says senior researcher Rob Shepherd, a materials scientist at Cornell.

By applying algorithms based on the extracellular electrophysiology of P. eryngii mycelia and feeding the output into a microcontroller unit, the researchers used spikes of activity triggered by a stimulus -- in this case, UV light -- to toggle mechanical responses in two different kinds of mobile device. In controlled experiments, the team used the signals from a fungal culture to govern the movements of a five-limbed soft robot and a four-wheeled untethered vehicle. They were able to influence and override the 'natural' impulses produced by the fungi, demonstrating an ability to harness the system's sensory abilities to meet an end goal. "This kind of project is not just about controlling a robot," says Cornell bioroboticist Anand Mishra. "It is also about creating a true connection with the living system. Because once you hear the signal, you also understand what's going on. Maybe that signal is coming from some kind of stresses. So you're seeing the physical response, because those signals we can't visualize, but the robot is making a visualization." The research has been published in the journal Science Robotics.

"Earth.com has an interesting article about the temporary "disappearance" of Saturn's rings in about six months," writes longtime Slashdot reader YVRGeek. From the report: Come March 2025, Saturn's majestic rings will become virtually invisible to earth-based observers. This phenomenon occurs due to the unique tilt of Saturn's axis, which will position the rings edge-on to our line of sight. [...] Saturn's axial tilt, which is the angle its axis leans compared to its orbit around the Sun, is about 27 degrees. As Saturn moves during its 29.5 year orbit around the Sun, this tilt means different parts of its rings and moons get sunlight at different angles, changing how they look. So, the rings are not really disappearing but rather playing a celestial game of hide and seek. At their reappearance, we can also enjoy an accentuated view of Saturn's moons.

An anonymous reader quotes a report from 404 Media, written by Jason Koebler: I've been videochatting with Mixael Swan Laufer for about 30 minutes about an exciting discovery when he points out that to date, the best way he's been able to bring attention to his organization is "the old school method of me performing a bunch of federal felonies on stage in front of a bunch of people." I stop him and ask: "In this case, what are the felonies?" "Well, the list is pretty long," he said. Laufer is the chief spokesperson of Four Thieves Vinegar Collective, an anarchist collective that has spent the last few years teaching people how to make DIY versions of expensive pharmaceuticals at a tiny fraction of the cost.

Four Thieves Vinegar Collective call what they do "right to repair for your body." Laufer has become well known for handing out DIY pills and medicines at hacking conferences, which include, for example, courses of the abortion drug misoprostol that can be manufactured for 89 cents (normal cost: $160) and which has become increasingly difficult to obtain in some states following the Supreme Court decision in Dobbs. In our call, Laufer had just explained that Four Thieves' had made some miscalculations as part of its latest project, to create instructions for replicating sofosbuvir (Sovaldi), a miracle drug that cures hepatitis C, which he planned to explain and reveal at the DEF CON hacking conference. Unlike many other drugs that treat viruses, Sovaldi does not suppress hepatitis C, a virus that kills roughly 250,000 people around the world each year. It cures it. [...]

Crucially, unlike other medical freedom organizations, Four Thieves isn't suggesting people treat COVID with Ivermectin, isn't shilling random supplements, and doesn't have any sort of commercial arm at all. Instead, they are helping people to make their own, identical pirated versions of proven and tested pharmaceuticals by taking the precursor ingredients and performing the chemical reactions to make the medication themselves. "We don't invent anything, really," Laufer said. "We take things that are on the shelf and hijack them. We like to take something established, and be like 'This works, but you can't get it.' Well, here's a way to get it." A slide at his talk reads "Isn't this illegal? Yeah. Grow up." Four Thieves has developed a suite of open-source tools to help achieve its goal. The core tool, Chemhacktica, is a software platform that uses machine learning to map chemical pathways for synthesizing desired molecules. It suggests potential chemical reactions, identifies precursor materials, and checks their availability for purchase.

The other is Microlab, an open-source controlled lab reactor built from affordable, off-the-shelf components costing between $300 and $500. It uses Chemhacktica's suggested pathways to create medications, and detailed instructions for building and operating the Microlab are provided. Additionally, the company developed a drag-and-drop recipe system called Apothecarium that generates executable files for the Microlab, offering step-by-step guidance on producing specific medications.

Laufer told 404 Media: "I am of the firm belief that we are hitting a watershed where economics and morality are coming to a head, like, 'Look: intellectual property law is based off some ideas that came out of 1400s Venice. They're not applicable and they're being abused and people are dying every day because of it, and it's not OK.'"

Further reading: Meet the Anarchists Making Their Own Medicine (Motherboard; 2018)

Research by the Federal Reserve Bank of New York, published on Tuesday, indicates that professional economic forecasters tend to overestimate their accuracy in long-term predictions while underestimating their short-term precision.

The study, which analyzed data from the Survey of Professional Forecasters from 1982 to 2022, revealed that for forecasts two to four quarters ahead, actual errors were two to four times greater than the forecasters' estimated uncertainty ranges for both GDP growth and inflation. In contrast, for predictions less than three months out, forecasters typically overestimated potential errors.

The study's author, Marco Del Negro, highlighted significant differences in uncertainty estimates among individual forecasters, suggesting that these findings challenge the rational expectations theory. Del Negro proposed that these discrepancies might stem from an over-reliance on varying models or priors in making longer-term forecasts.