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Science

Scientists Create World's Most Water-Resistant Surface (theguardian.com) 46

Sammy Gecsoyler reports via The Guardian: A research team in Finland, led by Robin Ras, from Aalto University, and aided by researchers from the University of Jyvaskyla, has developed a mechanism to make water droplets slip off surfaces with unprecedented efficacy. Cooking, transportation, optics and hundreds of other technologies are affected by how water sticks to surfaces or slides off them, and adoption of water-resistant surfaces in the future could improve many household and industrial technologies, such as plumbing, shipping and the auto industry. The research team created solid silicon surfaces with a "liquid-like" outer layer that repels water by making droplets slide off surfaces. The highly mobile topcoat acts as a lubricant between the product and the water droplets.

Sakari Lepikko, the lead author of the study, which was published in Nature Chemistry on Monday, said: "Our work is the first time that anyone has gone directly to the nanometer-level to create molecularly heterogeneous surfaces." By carefully adjusting conditions, such as temperature and water content, inside a reactor, the team could fine-tune how much of the silicon surface the monolayer covered. Using the new method, the team ended up creating the slipperiest liquid surface in the world. According to Lepikko, the discovery promises to have implications wherever droplet-repellent surfaces are needed. This covers hundreds of examples from daily life to industrial environments.

Science

One Month After Experimental Pig Heart Transplant, Doctors Say They See No Signs of Rejection or Infection 37

One month after an experimental procedure to transplant the heart of a genetically modified pig into a patient with end-stage heart disease, doctors say the heart is functioning on its own and shows no signs of rejection. From a reoport: In September, 58-year-old Lawrence Faucette underwent the surgery, only the second ever performed in a human. Faucette's heart disease and pre-existing conditions made him ineligible for a traditional human heart transplant. "The physicians taking care of him believe his heart function is excellent," said Dr. Bartley Griffith, director of the Cardiac and Lung Transplant Program at the University of Maryland School of Medicine who performed the surgery. "We've had no evidence of infections and no evidence of rejection right now."

Dr. Muhammad Mohiuddin, director of UMMC's Cardiac Xenotransplantation Program, said in an update shared on Friday, "we are withdrawing all the drugs that were initially supporting his heart. So now his heart is doing everything on its own." Mohiuddin said the focus now is making sure that Faucette has the strength to perform routine functions. "We are working very hard with our physical therapy team who are spending a lot of time helping him regain the strength that he's lost during last one month of hospital stay," Mohiuddin said.
Science

Masks Work. So What Went Wrong with a Highly Publicized COVID Mask Analysis? (scientificamerican.com) 501

A Harvard professor on the history of science looks at our response to the pandemic, criticizing "a report that gave the false impression that masking didn't help." From Scientific American: The group's report was published by Cochrane, an organization that collects databases and periodically issues "systematic" reviews of scientific evidence relevant to health care. This year it published a paper addressing the efficacy of physical interventions to slow the spread of respiratory illness such as COVID... The review of studies of masking concluded that the "results were inconclusive..." [and] it was "uncertain whether wearing [surgical] masks or N95/P2 respirators helps to slow the spread of respiratory viruses." Still, the authors were also uncertain about that uncertainty, stating that their confidence in their conclusion was "low to moderate." You can see why the average person could be confused... The Cochrane finding was not that masking didn't work but that scientists lacked sufficient evidence of sufficient quality to conclude that they worked...

Cochrane has made this mistake before. In 2016 a flurry of media reports declared that flossing your teeth was a waste of time... The answer demonstrates a third issue with the Cochrane approach: how it defines evidence. The organization states that its reviews "identify, appraise and synthesize all the empirical evidence that meets pre-specified eligibility criteria." The problem is what those eligibility criteria are. Cochrane Reviews base their findings on randomized controlled trials (RCTs), often called the "gold standard" of scientific evidence. But many questions can't be answered well with RCTs, and some can't be answered at all...

In fact, there is strong evidence that masks do work to prevent the spread of respiratory illness. It just doesn't come from RCTs. It comes from Kansas. In July 2020 the governor of Kansas issued an executive order requiring masks in public places. Just a few weeks earlier, however, the legislature had passed a bill authorizing counties to opt out of any statewide provision. In the months that followed, COVID rates decreased in all 24 counties with mask mandates and continued to increase in 81 other counties that opted out of them... Cochrane ignored this epidemiological evidence because it didn't meet its rigid standard.

I have called this approach "methodological fetishism," when scientists fixate on a preferred methodology and dismiss studies that don't follow it. Sadly, it's not unique to Cochrane. By dogmatically insisting on a particular definition of rigor, scientists in the past have landed on wrong answers more than once.

Vox also points out that while Cochrane's review included 78 studies, "only six were actually conducted during the Covid-19 pandemic... Instead, most of them looked at flu transmission in normal conditions, and many of them were about other interventions like hand-washing.

"Only two of the studies are about Covid and masking in particular. Furthermore, neither of those studies looked directly at whether people wear masks, but instead at whether people were encouraged or told to wear masks by researchers."
NASA

NASA Transmits Patches to the Two Voyager Probes Launched in 1977 (nasa.gov) 74

"It's not every day that you get to update the firmware on a device that was produced in the 1970s," writes Hackaday, "and rarely is said device well beyond the boundaries of our solar system.

"This is however exactly what the JPL team in charge of the Voyager 1 & 2 missions are facing, as they are in the process of sending fresh firmware patches over to these amazing feats of engineering."

From NASA's announcement: One effort addresses fuel residue that seems to be accumulating inside narrow tubes in some of the thrusters on the spacecraft. The thrusters are used to keep each spacecraft's antenna pointed at Earth. This type of buildup has been observed in a handful of other spacecraft... In some of the propellant inlet tubes, the buildup is becoming significant. To slow that buildup, the mission has begun letting the two spacecraft rotate slightly farther in each direction [almost 1 degree] before firing the thrusters. This will reduce the frequency of thruster firings... While more rotating by the spacecraft could mean bits of science data are occasionally lost — akin to being on a phone call where the person on the other end cuts out occasionally — the team concluded the plan will enable the Voyagers to return more data over time.

Engineers can't know for sure when the thruster propellant inlet tubes will become completely clogged, but they expect that with these precautions, that won't happen for at least five more years, possibly much longer. "This far into the mission, the engineering team is being faced with a lot of challenges for which we just don't have a playbook," said Linda Spilker, project scientist for the mission as NASA's Jet Propulsion Laboratory in Southern California. "But they continue to come up with creative solutions."

But that's not the only issue: The team is also uploading a software patch to prevent the recurrence of a glitch that arose on Voyager 1 last year. Engineers resolved the glitch, and the patch is intended to prevent the issue from occurring again in Voyager 1 or arising in its twin, Voyager 2...

In 2022, the onboard computer that orients the Voyager 1 spacecraft with Earth began to send back garbled status reports, despite otherwise continuing to operate normally... The attitude articulation and control system (AACS) was misdirecting commands, writing them into the computer memory instead of carrying them out. One of those missed commands wound up garbling the AACS status report before it could reach engineers on the ground.

The team determined the AACS had entered into an incorrect mode; however, they couldn't determine the cause and thus aren't sure if the issue could arise again. The software patch should prevent that.

"This patch is like an insurance policy that will protect us in the future and help us keep these probes going as long as possible," said JPL's Suzanne Dodd, Voyager project manager. "These are the only spacecraft to ever operate in interstellar space, so the data they're sending back is uniquely valuable to our understanding of our local universe."

Since their launch in 1977, NASA's two Voyager probes have travelled more than 12 billion miles (each!), and are still sending back data from beyond our solar system.
Mars

Could a Mud Lake on Mars Be Hiding Signs of Ancient Life? (space.com) 19

"Planetary scientists want to search for biosignatures in what they believe was once a Martian mud lake," reports Space.com: After scientists carefully studied what they believe are desiccated remnants of an equatorial mud lake on Mars, their study of Hydraotes Chaos suggests a buried trove of water surged onto the surface. If researchers are right, then this flat could become prime ground for future missions seeking traces of life on Mars... More generally, scientists suggest surface water on Mars froze over about 3.7 billion years ago as the atmosphere thinned and the surface cooled. But underground, groundwater might still have remained liquid in vast chambers. Moreover, life forms might have abided in those catacombs — leaving behind traces of their existence. Only around 3.4 billion years ago did that system of aquifers break down in Hydraotes Chaos, triggering floods of epic proportions that dumped mountains' worth of sediment onto the surface, the study suggests. Future close-up missions could someday examine that sediment for biosignatures...

Alexis Rodriguez, a senior scientist at the Planetary Science Institute in Arizona, and his colleagues pored over images of Hydraotes Chaos taken by NASA's Mars Reconnaissance Orbiter in search of more clues. In the midst of the chaos terrain's maelstrom lies a calm circle of relatively flat ground. This plain is pockmarked with cones and domes, with hints of mud bubbling from below — suggesting that sediment did not arrive via a rushing flash flood, but instead rose from underneath. Based on simulations, the authors suggest Hydraotes Chaos overlaid a reservoir of buried biosignature-rich water — potentially in the form of thick ice sheets.

Ultimately — potentially from the Red Planet's internal heat melting the ice — that water bubbled up to the surface and created a muddy lake. As the water dissipated, it would have left behind all those tantalizing biosignatures. Curiously, that water might have remained underground even after those megafloods. In fact, the authors' results suggest the sediment on the surface of this mud lake dates from only around 1.1 billion years ago: long after most of Mars's groundwater ought to have flooded out, and certainly long after Mars was habitable. With that timeline in mind, Rodriguez and colleagues plan to analyze what lies under the surface of the lake. That, Rodriguez tells Space.com, would allow scientists to establish when in Martian history the planet might have hosted life.

Rodriguez tells Space.com that this region is now "under consideration" for testing with an under-development NASA instrument called Extractor for Chemical Analysis of Lipid Biomarkers in Regolith (EXCALIBR) — that could test extraterrestrial rocks for biomarkers like lipids.
Science

California Supervolcano: Caltech's 'Chilling' Discovery In Long Valley Caldera (scitechdaily.com) 26

An anonymous reader shared this report from SciTechDaily: Since the 1980s, researchers have observed significant periods of unrest in a region of California's Eastern Sierra Nevada mountains characterized by swarms of earthquakes as well as the ground inflating and rising by almost half an inch per year during these periods. The activity is concerning because the area, called the Long Valley Caldera, sits atop a massive dormant supervolcano... What is behind the increased activity in the last few decades? Could it be that the area is preparing to erupt again? Or could the uptick in activity actually be a sign that the risk of a massive eruption is decreasing?

To answer these questions, Caltech researchers have created the most detailed underground images to date of the Long Valley Caldera, reaching depths up to 10 kilometers within the Earth's crust. These high-resolution images reveal the structure of the earth beneath the caldera and show that the recent seismic activity is a result of fluids and gases being released as the area cools off and settles down.

The work was conducted in the laboratory of Zhongwen Zhan (PhD '14), professor of geophysics. A paper describing the research was published on October 18 in the journal Science Advances. "We don't think the region is gearing up for another supervolcanic eruption, but the cooling process may release enough gas and liquid to cause earthquakes and small eruptions," says Zhan. "For example, in May 1980, there were four magnitude 6 earthquakes in the region alone."

Space

JWST's Disconnect With Cosmology Models Linked to 'Bursty Star Formations' (spokesman.com) 18

Images from the James Webb Space Telescope "don't match scientists' models of how the universe formed," reports the Washington Post.

"But it might not be time to dump the standard model of cosmology yet. " A recent analysis in the Astrophysical Journal Letters suggests an explanation for the surprisingly massive-seeming galaxies: brilliant, extremely bright bursts of newborn stars.

The galaxies photographed by the telescope looked far too mature and large to have formed so fully so soon after the universe began, raising questions about scientists' assumptions of galaxy formation. But when researchers ran a variety of computer simulations of the universe's earliest days, they discovered that the galaxies probably are not as large as they seem. Instead, they attribute their brightness to a phenomenon called "bursty star formation." As clouds of dust and debris collapse, they form dense, high-temperature cores and become stars. Bursty galaxies spit out new stars in intermittent, bright bursts instead of creating stars more consistently. Usually, these galaxies are low in mass and take long breaks between starbursts.

Because the galaxies in question look so bright in photos produced by the Webb telescope, scientists at first thought they were older and more massive. But bursty systems with the ability to produce extremely bright, abundant light may appear more massive than they really are.

"Not only does this finding explain why young galaxies appear deceptively massive, it also fits within the standard model of cosmology," explains the announcement: In the new study, Guochao Sun, who led the study, Northwestern's, Claude-André Faucher-Giguère, the study's senior author, and their team used advanced computer simulations to model how galaxies formed right after the Big Bang. The simulations produced cosmic dawn galaxies that were just as bright as those observed by the JWST...

Although other astrophysicists have hypothesized that bursty star formation could be responsible for the unusual brightness of galaxies at cosmic dawn, the Northwestern researchers are the first to use detailed computer simulations to prove it is possible. And they were able to do so without adding new factors that are unaligned with our standard model of the universe.

Space

Next Year, SpaceX Aims To Average One Launch Every 2.5 Days (arstechnica.com) 27

Stephen Clark reports via Ars Technica: Earlier this week, SpaceX launched for the 75th time this year, continuing a flight cadence that should see the company come close to 100 missions by the end of December. SpaceX plans to kick its launch rate into a higher gear in 2024. This will be largely driven by launches of upgraded Starlink satellites with the ability to connect directly with consumer cell phones, a service SpaceX calls "Starlink Direct to Cell," a company official told Ars this week. The goal next year is 12 launches per month, for a total of 144 Falcon rocket flights. Like this year, most of those missions will be primarily devoted to launching Starlink broadband satellites. So far in 2023, more than 60 percent of SpaceX's launches have delivered the company's own Starlink satellites into orbit.

Here are some numbers. Last year, SpaceX launched 61 missions. In 2021, the number was 31. In the last 12 months, SpaceX has launched 88 Falcon rockets, plus one test flight of the company's much larger Starship rocket. SpaceX's success in recovering and reusing Falcon 9 boosters and payload fairings has been vital to making this possible. SpaceX has gone past the original goal of launching each Falcon 9 booster 10 times before a major overhaul, first to 15 flights, and then recently certifying boosters for up to 20 missions. Technicians can swap out parts like engines, fins, landing legs, and valves that malfunction in flight or show signs of wear. With so many launches planned next year, 20 flights is probably not a stopping point. "We might go a little higher," the SpaceX official said.
SpaceX may also see an uptick in missions for external customers, like NASA, the U.S. Space Force, and commercial companies. "External demand for Falcon 9 and Falcon Heavy launches is 'steady,' the official said, but some customers that had launches scheduled for this year encountered delays with their satellites, moving them into 2024."
The Courts

Frying Pan Company Sued for Claiming Temperatures That Rival the Sun (theverge.com) 124

Can you heat up a pan to 30,000 degrees Fahrenheit? That's the burning question at the center of this proposed class action lawsuit, which claims the advertising for SharkNinja's nonstick cookware violates the laws of physics and thermodynamics. From a report: While SharkNinja is the company best known for its Shark robovacs and Ninja kitchen gadget, this lawsuit takes issue with the Ninja NeverStick Premium Cookware collection, a line of pots and pans it advertises as having superior nonsticking and nonflaking qualities thanks to its manufacturing process.

Instead of making its pans at a measly 900-degree temperature that other brands use, SharkNinja says it heats up the cookware to a maximum of 30,000 degrees Fahrenheit. That process, according to SharkNinja, fuses "plasma ceramic particles" to the surface of the pan, "creating a super-hard, textured surface that interlocks with our exclusive coating for a superior bond." But Patricia Brown, the person who filed this lawsuit, isn't buying it. As cited in Brown's lawsuit, NASA recently said the "surface of the Sun is a blisteringly hot 10,340 degrees Fahrenheit," meaning SharkNinja's manufacturing process reaches about three times that temperature.

Businesses

Pfizer Hikes Price of COVID Antiviral Paxlovid From $530 To Nearly $1,400 (arstechnica.com) 169

Pfizer this week revealed that it raised the list price of a course of Paxlovid -- its lifesaving antiviral drug used to reduce the risk of severe COVID-19 in those most vulnerable -- to nearly $1,400, more than double the roughly $530 the US government has paid for the treatment in the emergency phase of the pandemic. From a report: Pfizer CEO Albert Bourla had noted in an investor call at the beginning of the week that the company would increase the price of Paxlovid as it moves from government distribution to the commercial market at the end of this year. But, he did not announce the new list price then. Instead, the company revealed the more than twofold increase in a letter to pharmacies and clinics dated Wednesday. The Wall Street Journal was the first to report the list price of $1,390 after viewing the letter.

A Pfizer spokesperson told the Journal that "pricing for Paxlovid is based on the value it provides to patients, providers, and health care systems due to its important role in helping reduce COVID-19-related hospitalizations and deaths." A cost-effectiveness analysis last year determined the value of Paxlovid at between $563 and $906 per treatment course, according to nonprofit drug-pricing watchdog The Institute for Clinical and Economic Review.

Space

A Simple Streetlight Hack Could Protect Astronomy From Urban Light Pollution (space.com) 160

Tereza Pultarova reports via Space.com: Light pollution is a growing threat to astronomy, but a new streetlamp technology could restore clear views of the night sky. [...] A study published earlier this year found that stars are disappearing from the sky at an average rate of 10% per year. This trend affects even the world's most remote observatories. Germany-based startup StealthTransit recently tested a solution to this growing issue. "Unfortunately, this problem haunts almost all observatories today," Vlad Pashkovsky, StealthTransit's founder and CEO, told Space.com in an email. "Modern telescopes are highly sensitive and feel the impact of outdoor lighting of cities located at the distance of 50 or even 200 kilometers [30 to 120 miles]. This means that virtually every observatory on Earth either already needs, or will need in the future 10 years, protection from the light of large cities."

StealthTransit's solution relies on three components: A simple device that makes LED lights flicker at a very high frequency that is imperceptible to the human eye, a GPS receiver, and a specially designed shutter on the telescope's camera that can blink in sync with the LED lights. The GPS technology guides the telescope's shutter to open only during the fleeting moments when the LED lights are switched off. The experiments, conducted at an observatory in the Caucasus Mountains in Russia, showed that the technology, dubbed the DarkSkyProtector, could reduce unwanted sky glow in astronomical images by 94%. "We can say that the telescope was seeing almost a dark sky at this time," Pashkovsky said. "The important thing about our technology is that it makes all kinds of lights astronomy-friendly, including outdoor advertising and indoor lighting in apartments, offices and stores."

The technology could filter out lights from nearby towns and villages as well as those surrounding the observatory itself. It might sound impractical to refit an entire town with devices that allow lamps to blink, but Pashkovsky said that most existing LED lights can operate in the blinking mode and that new lamps designed specifically with sky protection in mind would be no costlier than existing LED technology. The most expensive element of the DarkSkyProtector system is the telescope shutter, which needs to be lightweight and agile enough to blink about 150 times per second. StealthTransit tested the prototype shutter on a 24-inch-wide (60 centimeters) telescope and hopes to make the technology available for larger telescopes. Although StealthTransit's technology is not yet ready for commercial use, Pashkovsky said, the firm hopes to have a product fit for the world's best telescopes in five to seven years.

Medicine

Canada Will Legalize Medically Assisted Dying For People Addicted To Drugs 265

An anonymous reader quotes a report from VICE News: Canada will legalize medically assisted dying for people who are addicted to drugs next spring, in a move some drug users and activists are calling "eugenics." The country's medical assistance in dying (MAID) law, which first came into effect in 2016, will be expanded next March to give access to people whose sole medical condition is mental illness, which can include substance use disorders. Before the changes take place, however, a special parliamentary committee on MAID will regroup to scrutinize the rollout of the new regulations, according to the Toronto Star.

Currently, people are eligible for MAID if they have a "grievous and irremediable medical condition", such as a serious illness or disability, that has put them in an advanced state of irreversible decline and caused enduring physical or psychological suffering -- excluding mental illness. Anyone who receives MAID must also go through two assessments from independent health care providers, among meeting other criteria. [...] As Canada prepares to legalize MAID for people with mental disorders, each province will have to develop its own protocol for how to assess people. Dr. Simon Colgan, lead physician for the Community Allied Mobile Palliative Partnership which provides palliative care to homeless people, said MAID requests "must be understood within the context of a person's lived experience and this takes time and relationship." He said any MAID protocols for people with substance use disorders should be made with the input of people with lived experiences.
"I don't think it's fair, and the government doesn't think it's fair, to exclude people from eligibility because their medical disorder or their suffering is related to a mental illness," said Dr. David Martell, physician lead for Addictions Medicine at Nova Scotia Health. "As a subset of that, it's not fair to exclude people from eligibility purely because their mental disorder might either partly or in full be a substance use disorder. It has to do with treating people equally."

On the flip side, some drug users and harm reduction advocates say they're upset drug users are being given access to MAID, as they feel other public health measures are lacking. "I just think that MAID when it has entered the area around mental health and substance use is really rooted in eugenics. And there are people who are really struggling around substance use and people do not actually get the kind of support and help they need," said Zoe Dodd, a Toronto-based harm reduction advocate.

Karen Ward, a drug user activist in Vancouver, said she considers the expansion of MAID to include people with substance use disorders a "statement in federal law that some people aren't really human." "The government has made death accessible while a better life remains impossible," she said. "Homes for all, guaranteed dignified incomes, access to healthcare, education and employment: these aren't radical demands."
Moon

India Plans To Land Astronauts On the Moon In 2040 (space.com) 86

The government of India said on Tuesday that it plans to put an astronaut on the moon by 2040 and build an Earth-orbiting space station by 2035. Space.com reports: On Aug. 23, India became just the fourth nation ever to soft-land a spacecraft -- its Chandrayaan-3 lander-rover duo -- on the surface of the moon. In a recent meeting with the Indian government department that manages the country's space program, Prime Minister Narendra Modi "directed that India should now aim for new and ambitious goals," according to an official statement. India's future moon exploration efforts will include a series of additional robotic Chandrayaan missions, a new launch pad and a heavy-lift launch vehicle, the statement added.

India's delayed Gaganyaan human spaceflight program, now aiming to fly three astronauts to low Earth orbit in 2025, will feature 20 major tests, including three uncrewed missions to test the launch vehicle over the course of the remainder of this year and all of next. [...] By the middle of the 2030s, India hopes to have a 20-ton space station in a fixed orbit 248 miles (400 kilometers) above Earth, with capabilities to host astronauts for 15 to 20 days at a time, K. Sivan, former chairman of the Indian Space Research Organization (ISRO), has previously said.

Further down the pipeline of missions, ISRO is planning a Venus orbiter called Shukrayaan-1 to study the surface of that hellishly hot planet. The payloads for that mission are currently being developed, current ISRO chairman S. Somanath had said last month. A second orbiter mission to Mars is also on the books, according to the latest statement. The nation's first, the Mars Orbiter Mission (MOM), was launched in 2013 and studied the Red Planet's atmosphere for eight years before it lost contact with Earth in April 2022. The follow-up mission, Mars Orbiter Mission 2 or MOM 2, will likely include cameras to study the planet's crust and may also include a lander, although many of the mission plans are yet to be finalized.

United Kingdom

Scientists Call on Ministers To Cut Limits For 'Forever Chemicals' in UK Tap Water (theguardian.com) 16

Acceptable levels of "forever chemicals" in drinking water should be reduced tenfold and a new national chemicals agency created to protect public health, the Royal Society of Chemistry (RSC) has told the UK government. From a report: The chartered body wants to see a reduction in the cap on levels of per- and polyfluoroalkyl substances (PFAS) in tap water. PFAS are a family of about 10,000 widely used chemicals that do not break down easily in the environment. Some have been linked to cancers, liver and thyroid disease, immune and fertility problems, and developmental defects in unborn children.

The current limit in UK drinking water, which is a guideline and not a statutory cap, is 100 nanograms a litre for individual PFAS. The RSC wants this reduced to 10ng/l and a new overall limit introduced of 100ng/l for a wider range of PFAS in drinking water. "In the Drinking Water Inspectorate's (DWI) own words, levels above 10ng/l pose a medium or high risk to public health," said Stephanie Metzger, a policy adviser at the RSC. "We're seeing more studies that link PFAS to a range of very serious medical conditions, and so we urgently need a new approach for the sake of public health."

Medicine

Amazon Starts Delivering Medications by Drone in Texas City (bloomberg.com) 29

Amazon has started delivering prescription medications by drone in a Texas city, broadening its still-experimental effort to deliver goods by air. From a report: The online retailer recently began listing drone delivery as an option for Amazon Pharmacy customers who are participating in a test program in College Station, one of two US cities where Amazon is delivering products using its unmanned, riding-lawnmower-sized vehicles. The company made the effort public on Wednesday ahead of a logistics press event held at a warehouse near Amazon's Seattle headquarters.

Quick delivery of medical supplies has emerged as one of the leading candidates for a viable delivery-by-drone business. Alphabet's Wing, United Parcel Service and drone startup Zipline have all set out to deliver medical goods, sometimes in trial programs centered around hospital campuses or planned communities. In most places, drone use remains limited to narrowly prescribed tests as regulators hash out regulations to limit risk to other aircraft and people on the ground.

Mars

Scientists Surprised By Source of Largest Quake Detected on Mars (reuters.com) 17

An anonymous reader shares a report: On May 4, 2022, NASA's InSight lander detected the largest quake yet recorded on Mars, one with a 4.7 magnitude -- fairly modest by Earth standards but strong for our planetary neighbor. Given Mars lacks the geological process called plate tectonics that generates earthquakes on our planet, scientists suspected a meteorite impact had caused this marsquake. But a search for an impact crater came up empty, leading scientists to conclude that this quake was caused by tectonic activity -- rumbling in the planet's interior -- and giving them a deeper understanding about what makes Mars shake, rattle and roll.

"We concluded that the largest marsquake seen by InSight was tectonic, not an impact. This is important as it shows the faults on Mars can host hefty marsquakes," said planetary scientist Ben Fernando of the University of Oxford in England, lead author of the research published this week in the journal Geophysical Research Letters. "We really thought that this event might be an impact." "This represents a significant step forward in our understanding of Martian seismic activity and takes us one step closer to better unraveling the planet's tectonic processes," added Imperial College London planetary scientist and study co-author Constantinos Charalambous, co-chair of InSight's Geology Working Group.

NASA retired InSight in 2022 after four years of operations. In all, InSight's seismometer instrument detected 1,319 marsquakes. Earth's crust - its outermost layer - is divided into immense plates that continually shift, triggering quakes. The Martian crust is a single solid plate. But that does not mean all is quiet on the Martian front. "There are still faults that are active on Mars. The planet is still slowly shrinking and cooling, and there is still motion within the crust even though there are no active plate tectonic processes going on anymore. These faults can trigger quakes," Fernando said.

Science

Scientists Propose Sweeping New Law of Nature, Expanding On Evolution (reuters.com) 112

An anonymous reader quotes a report from Ars Technica: When British naturalist Charles Darwin sketched out his theory of evolution in the 1859 book "On the Origin of Species" -- proposing that biological species change over time through the acquisition of traits that favor survival and reproduction -- it provoked a revolution in scientific thought. Now 164 years later, nine scientists and philosophers on Monday proposed a new law of nature that includes the biological evolution described by Darwin as a vibrant example of a much broader phenomenon, one that appears at the level of atoms, minerals, planetary atmospheres, planets, stars and more. It holds that complex natural systems evolve to states of greater patterning, diversity and complexity.

Titled the "law of increasing functional information," it holds that evolving systems, biological and non-biological, always form from numerous interacting building blocks like atoms or cells, and that processes exist -- such as cellular mutation -- that generate many different configurations. Evolution occurs, it holds, when these various configurations are subject to selection for useful functions. [...] The authors proposed three universal concepts of selection: the basic ability to endure; the enduring nature of active processes that may enable evolution; and the emergence of novel characteristics as an adaptation to an environment. Some biological examples of this "novelty generation" include organisms developing the ability to swim, walk, fly and think. Our species emerged after the human evolutionary lineage diverged from the chimpanzee lineage and acquired an array of traits including upright walking and increased brain size.
The research has been published in the journal Proceedings of the National Academy of Sciences.
Space

Blue Origin's New Spacecraft Can Build Projects In Space (pcmag.com) 38

Michael Kan reports via PCMag: Jeff Bezos' Blue Origin has announced a new spacecraft that promises to help humanity build and maintain projects in outer space. The company today debuted Blue Ring, a so-called "space platform" that can orbit Earth, but also travel around the Moon, with the goal of providing delivery and logistics support to other space projects. To do so, Blue Ring functions as a maneuverable platform that can host, transport, and refuel other spacecraft. In addition, it can relay data while also offering an "in-space" cloud computing capability, according to Blue Origin's announcement.

Other rockets, particularly those from rival SpaceX, can already send satellites up into predictable orbits around Earth. In contrast, Blue Ring is designed to serve customers for more "dynamic" space projects at varying orbits, Blue Origin Lars Hoffman VP tells Aviation Week. "It has a lot of capability and a lot of energy. It is a platform that has versatility across multiple missions and multiple customers on any given launch," Hoffman says.

The company adds that Blue Ring can travel with payloads of over 6,600 pounds. According to Aviation Week, Blue Origin is eyeing 2025 as a realistic launch date for the spacecraft, which has already received some interest from customers. Hoffman also says Blue Ring will be "launch-vehicle agnostic," allowing it to fly on a SpaceX Falcon 9 rocket or Blue Origin's own New Glenn, which is aiming to be used in its first mission next year.

Medicine

World Rugby To Introduce Smart Mouthguards To Detect Player Concussions 35

In an analysis piece for The Guardian, Sean Ingle discusses some of the smart technology and artificial intelligence being used in sports to fight against brain injuries. From the report: There was a hidden spectator of the NFL match between the Baltimore Ravens and Tennessee Titans in London on Sunday: artificial intelligence. As crazy as it may sound, computers have now been taught to identify on-field head impacts in the NFL automatically, using multiple video angles and machine learning. So a process that would take 12 hours -- for each game -- is now done in minutes. The result? After every weekend, teams are sent a breakdown of which players got hit, and how often.

This tech wizardry, naturally, has a deeper purpose. Over breakfast the NFL's chief medical officer, Allen Sills, explained how it was helping to reduce head impacts, and drive equipment innovation. Players who experience high numbers can, for instance, be taught better techniques. Meanwhile, nine NFL quarterbacks and 17 offensive linemen are wearing position-specific helmets, which have significantly more padding in the areas where they experience more impacts. What may be next? Getting accurate sensors in helmets, so the force of each tackle can also be estimated, is one area of interest. As is using biomarkers, such as saliva and blood, to better understand when to bring injured players back to action.

If that's not impressive enough, this weekend rugby union became the first sport to adopt smart mouthguard technology, which flags big "hits" in real time. From January, whenever an elite player experiences an impact in a tackle or ruck that exceeds a certain threshold, they will automatically be taken off for a head injury assessment by a doctor. No wonder Dr Eanna Falvey, World Rugby's chief medical officer, calls it a "gamechanger" in potentially identifying many of the 18% of concussions that now come to light only after a match.
Medicine

Roundup Herbicide Ingredient Connected To Epidemic Levels of Chronic Kidney Disease (phys.org) 106

A study conducted by Duke University researchers suggests that glyphosate, the active ingredient in Roundup, may be a potential cause of the mysterious kidney disease CKDu that has affected rural communities in Sri Lanka and similar regions around the world. The findings have been published in Environmental Science and Technology Letters. Phys.Org reports: Roundup is a glyphosate-based herbicide used to control weeds and other pests. Because it is supposed to break down in the environment within a few days to weeks, its use is relatively under-regulated by most public health agencies. But when glyphosate encounters certain trace metal ions that make water hard -- like magnesium and calcium -- glyphosate-metal ion complexes can form. Those complexes can persist up to seven years in water and 22 years in soil. In certain agricultural areas of Sri Lanka, the high, dry climate combined with its geological formations creates the perfect conditions for hard water. It is also in these regions that CKDu has reached epidemic levels, with as many as 10% of children aged 5-11 years exhibiting signs of early onset kidney damage.

[Nishad Jayasundara, the Juli Plant Grainger Assistant Professor of Global Environmental Health at Duke] believed that glyphosate may play a role in CKDu incidence because of the region's hard water, even though Sri Lanka has banned use of the herbicide. To test his hypothesis, Jayasundara teamed up with environmental chemist Lee Ferguson, an associate professor of civil and environmental engineering at Duke and his Ph.D. student Jake Ulrich. In collaboration with Mangala De Silva, a professor at the University of Ruhuna, Sri Lanka, the Duke team sampled more than 200 wells across four regions in Sri Lanka. Ferguson's lab at Duke employs high-resolution and tandem mass spectrometry to identify contaminants -- even the barest trace of them -- by their molecular weights. It's a highly sensitive method of identification and quantitation that allows a broad view into the pollutants present in a water system. Through this technique, the researchers found significantly higher levels of the herbicide in 44% of wells within the affected areas versus just 8% of those outside it.

"We really focused on drinking water here, but it's possible there are other important routes of exposure -- direct contact from agricultural workers spraying the pesticide, or perhaps food or dust," said Ferguson. "I'd like to see increased study with more emphasis looking at the links among these exposure routes. It still seems like there might be things we're missing." To this point, Ulrich also found elevated levels of fluoride and vanadium -- both of which are linked to kidney damage -- in the drinking water of most all of the communities with high incidence of CKDu. The researchers agree that more attention must be paid to the potential contributions each of these contaminants is playing, either individually or in concert with others. But given the reasoning for their glyphosate-based hypothesis going into the study and the herbicide's high levels of use worldwide, they also believe these results should serve as a serious warning when considering risk of exposure to glyphosate.

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