An anonymous reader quotes a report from the Guardian: Millions of lives could be saved by a groundbreaking set of new vaccines for a range of conditions including cancer, experts have said. A leading pharmaceutical firm said it is confident that jabs for cancer, cardiovascular and autoimmune diseases, and other conditions will be ready by 2030. Studies into these vaccinations are also showing "tremendous promise", with some researchers saying 15 years' worth of progress has been "unspooled" in 12 to 18 months thanks to the success of the Covid jab.

Dr Paul Burton, the chief medical officer of pharmaceutical company Moderna, said he believes the firm will be able to offer such treatments for "all sorts of disease areas" in as little as five years. The firm, which created a leading coronavirus vaccine, is developing cancer vaccines that target different tumor types. Burton said: "We will have that vaccine and it will be highly effective, and it will save many hundreds of thousands, if not millions of lives. I think we will be able to offer personalized cancer vaccines against multiple different tumor types to people around the world."

He also said that multiple respiratory infections could be covered by a single injection -- allowing vulnerable people to be protected against Covid, flu and respiratory syncytial virus (RSV) -- while mRNA therapies could be available for rare diseases for which there are currently no drugs. Therapies based on mRNA work by teaching cells how to make a protein that triggers the body's immune response against disease. Burton said :"I think we will have mRNA-based therapies for rare diseases that were previously undruggable, and I think that 10 years from now, we will be approaching a world where you truly can identify the genetic cause of a disease and, with relative simplicity, go and edit that out and repair it using mRNA-based technology." But scientists warn that the accelerated progress, which has surged "by an order of magnitude" in the past three years, will be wasted if a high level of investment is not maintained.

A NASA instrument to provide unprecedented resolution of monitoring major air pollutants -- down to four square miles -- lifted off on its way to geostationary orbit at 12:30 a.m. EDT Friday. The Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument will improve life on Earth by revolutionizing the way scientists observe air quality from space. From a report: "The TEMPO mission is about more than just studying pollution -- it's about improving life on Earth for all. By monitoring the effects of everything from rush-hour traffic to pollution from forest fires and volcanoes, NASA data will help improve air quality across North America and protect our planet," said NASA Administrator Bill Nelson. [...] From a fixed geostationary orbit above the equator, TEMPO will be the first space-based instrument to measure air quality over North America hourly during the daytime and at spatial regions of several square miles -- far better than existing limits of about 100 square miles in the U.S. TEMPO data will play an important role in the scientific analysis of pollution, including studies of rush hour pollution, the potential for improved air quality alerts, the effects of lightning on ozone, the movement of pollution from forest fires and volcanoes, and even the effects of fertilizer application.

TEMPO's observations will dramatically improve the scientific data record on air pollution -- including ozone, nitrogen oxide, sulfur dioxide and formaldehyde -- not only over the continental United States, but also Canada, Mexico, Cuba, the Bahamas, and part of the island of Hispaniola. "Our TEMPO slogan is 'It's about time,' which hints at TEMPO's ability to provide hourly air pollution data," said Xiong Liu, deputy principal investigator for TEMPO at the Center for Astrophysics, Harvard & Smithsonian in Cambridge, Massachusetts. "After working on the TEMPO for more than 10 years, it is about time to launch TEMPO to produce real TEMPO data and start the new era of air quality monitoring over North America."

China has invited Venezuela to join its lunar research station project as the country works to gain partners for the endeavor. SpaceNews reports: Venezuela would be the first country to join China and Russia in the International Lunar Research Station (ILRS), which is planned to be constructed in the early 2030s using super heavy-lift launch vehicles. The launches will follow smaller, precursor missions later this decade. Marglad Bencomo, executive director of the Bolivarian Agency for Space Activities (ABAE), visited China's new, national Deep Space Exploration Laboratory (DSEL) March 30 to discuss cooperation and exchanges. She was met by Wu Yanhua, former deputy director of the China National Space Administration (CNSA) and now executive vice chairman of DSEL. The two sides exchanged in-depth views on international cooperation in the field of deep space exploration, according to a DSEL statement.

Bencomo said that Venezuela was willing to sign a China-Venezuela Memorandum of Understanding as soon as possible to jointly promote the construction of international lunar research stations, according to the DSEL statement. ABAE has been invited to attend an international forum hosted by DSEL during China's national "space day," held annually on April 24 since 2016, potentially providing a platform for signing an MOU. China and Russia presented a roadmap for the joint ILRS in St. Petersburg, Russia, in 2021 and opened the project to interested parties.

An anonymous reader quotes a report from MIT Technology Review: Embryos made from stem cells -- instead of a sperm and egg -- have been created from monkey cells for the first time. When researchers put these "synthetic embryos" into the uteruses of adult monkeys, some showed the initial signs of pregnancy. It's the furthest scientists have ever been able to take lab-grown embryos in primates -- and the work hints that it may one day be possible to generate fetuses this way. The team behind the research, Zhen Liu at the Chinese Academy of Sciences in Shanghai and his colleagues, started with embryonic stem cells originally taken from macaque monkey embryos. These cells have been grown in labs for multiple generations and, given the right conditions, have the potential to develop into pretty much any type of body cell, including those that make up organs, blood, and nervous system.

The team used a set of lab conditions, which they tweaked and improved, to encourage embryonic stem cells to develop further. Over several days, the cells began developing in a very similar way to embryos. The resulting blobs of cells are called blastoids, because they look like early embryos, which are called blastocysts. After the blastoids had been growing in a dish for seven days, the researchers put them through a series of tests to figure out how similar they were to typical embryos. In one test, the team separated the individual cells in the blastoids and checked to see which genes were expressed in each one. The team analyzed over 6,000 individual cells this way.

These tests revealed close similarities between the stem-cell-derived embryos and conventional monkey embryos. Some of the blastoids were grown for longer -- up to 17 days. These structures looked very much like typical embryos, the researchers say, although other scientists not involved in the study say more evidence is needed to prove just how similar they are. The only way to find out how embryo-like these blastoids really are is to test whether they can develop in a monkey's uterus. So the team put between eight and 10 seven-day-old blastoids into the uteruses of each of eight adult monkeys. The researchers then monitored the transferred blastoids for three weeks. The researchers believe that in three of these monkeys, the blastoids successfully implanted in the uterus and appeared to generate a yolk sac -- one of the very first signs of pregnancy. These monkeys also had elevated levels of pregnancy hormones. In other words, they would have had a positive pregnancy test. But within 20 days of transfer, the monkey blastoids stopped developing and seemed to come apart, say Liu and colleagues, who published their results in the journal Cell Stem Cell. The results suggest that blastoids still aren't perfect replicas of normal embryos. "That might be because a typical embryo is generated from an egg, which is then fertilized by sperm," reports MIT Technology Review. "A blastoid made from stem cells might express genes in the same way as a normal embryo, but it may be missing something crucial that normally comes from an egg."

"There's also a chance that the team might have seen more progress if the experiment had been done in more monkeys. After all, of the 484 blastoids that were developing at day seven, only five survived to day 17."

In a new study, scientists found that it's possible for people to form false memories of an event within seconds of it occurring. This almost-immediate misremembering seems to be shaped by our expectations of what should happen, the team says. Gizmodo reports: "This study is unique in two ways, in our opinion. First, it explores memory for events that basically just happened, between 0.3 and 3 seconds ago. Intuitively, we would think that these memories are pretty reliable," lead author Marte Otten, a neuroscientist at the University of Amsterdam, told Gizmodo in an email. "As a second unique feature, we explicitly asked people whether they thought their memories are reliable -- so how confident are they about their response?" To do this, they recruited hundreds of volunteers over a series of four experiments to complete a task: They would look at certain letters and then be asked to recall one highlighted letter right after. However, the scientists used letters that were sometimes reversed in orientation, so the volunteers had to remember whether their selection was mirrored or not. They also focused on the volunteers who were highly confident about their choices during the task.

Overall, the participants regularly misremembered the letters, but in a specific way. People were generally good at remembering when a typical letter was shown, with their inaccuracy rates hovering around 10%. But they were substantially worse at remembering a mirrored letter, with inaccuracy rates up to 40% in some experiments. And, interestingly enough, their memory got worse the longer they had to wait before recalling it. When they were asked to recall what they saw a half second later, for instance, they were wrong less than 20% of the time, but when they were asked three seconds later, the rate rose as high as 30%.

According to Otten, the findings -- published Wednesday in PLOS One -- indicate that our memory starts being shaped almost immediately by our preconceptions. People expect to see a regular letter, and don't get easily fooled into misremembering a mirrored letter. But when the unexpected happens, we might often still default to our missed prediction. This bias doesn't seem to kick in instantaneously, though, since people's short-term memory was better when they had to be especially quick on their feet. "It is only when memory becomes less reliable through the passage of a tiny bit of time, or the addition of extra visual information, that internal expectations about the world start playing a role," Otten said.

Virgin Orbit, founded by Richard Branson, filed for Chapter 11 bankruptcy on Tuesday after the satellite launching business struggled to secure long-term funding following a failed launch in January. From a report: The filing comes less than two years after Virgin Orbit first went public at a valuation of roughly $3 billion. But the January mishap left the company scrambling for new funding and forced it to halt operations. "We believe that the Chapter 11 process represents the best path forward to identify and finalize an efficient and value-maximizing sale," Virgin Orbit Chief Executive Dan Hart said in a statement. The company, which was spun off from space tourism firm Virgin Galactic in 2017, sends satellites into orbit using rockets launched from a modified Boeing 747 plane. The Long Beach, California-based company lodged the filing seeking a sale of its assets in a Delaware court days after announcing the layoff of roughly 85% of its 750 employees. Virgin Orbit listed assets of about $243 million and total debt at $153.5 million as of Sept. 30. The company went public in December 2021 through a blank-check merger, raising $255 million less than expected.

One of mathematics' most intriguing visual mysteries has finally been solved -- thanks to a hobbyist in England. From a report: The conundrum: is there a shape that can be arranged in a tile formation, interlocking with itself ad infinitum, without the resulting pattern repeating over and over again? In nature and on our bathroom walls, we typically see tile patterns that repeat in "a very predictable, regular way," says Dr Craig Kaplan, an associate professor of computer science at the University of Waterloo in Ontario. What mathematicians were interested in were shapes that "guaranteed non-periodicity" -- in other words, there was no way to tile them so that the overall pattern created a repeating grid. Such a shape would be known as an aperiodic monotile, or "einstein" shape, meaning, in roughly translated German, "one shape" (and conveniently echoing the name of a certain theoretical physicist).

"There's been a thread of beautiful mathematics over the last 60 years or so searching for ever smaller sets of shapes that do this," Kaplan says. "The first example of an aperiodic set of shapes had over 20,000 shapes in it. And of course, mathematicians worked to get that number down over time. And the furthest we got was in the 1970s," when the Nobel-prize winning physicist Roger Penrose found pairs of shapes that fit the bill. Now, mathematicians appear to have found what they were looking for: a 13-sided shape they call "the hat." The discovery was largely the work of David Smith of the East Riding of Yorkshire, who had a longstanding interest in the question and investigated the problem using an online geometry platform. Once he'd found an intriguing shape, he told the New York Times, he would cut it out of cardstock and see how he could fit the first 32 pieces together. "I am quite persistent but I suppose I did have a bit of luck," Smith told the Guardian in an email.

Patients diagnosed with conditions like anxiety and sleep disorders have become caught in the crosshairs of America's opioid crisis, as secret policies mandated by a national opioid settlement have turned filling legitimate prescriptions into a major headache. Bloomberg reports: In July, limits went into effect that flag and sometimes block pharmacies' orders of controlled substances such as Adderall and Xanax when they exceed a certain threshold. The requirement stems from a 2021 settlement with the US's three largest drug distributors -- AmerisourceBergen Corp., Cardinal Health Inc. and McKesson Corp. But pharmacists said it curtails their ability to fill prescriptions for many different types of controlled substances -- not just opioids. Independent pharmacists said the rules force them come up with creative workarounds. Sometimes, they must send patients on frustrating journeys to find pharmacies that haven't yet exceeded their caps in order to buy prescribed medicines. It's unclear how the thresholds are impacting major chain pharmacies.

The Drug Enforcement Administration regulates the manufacturing, distribution and sale of controlled substances, which can be dangerous when used improperly. Drugmakers and wholesalers were always supposed to keep an eye out for suspicious purchases and have long had systems to catch, report and halt these orders. The prescription opioid crisis, enabled by irresponsible drug company marketing and prescribing, led to a slew of lawsuits and tighter regulations on many parts of the health system, including monitoring of suspicious orders. One major settlement required the three largest distributors to set thresholds on orders of controlled substances starting last July.

The "suspicious order" terminology is a bit of a misnomer, pharmacists said. The orders themselves aren't suspicious, it's just that the pharmacy has exceeded its limit for a specific drug over a certain time period. Any order that puts the pharmacy over its limit can be stopped. As a result, patients with legitimate prescriptions get caught up in the dragnet. Adding to the confusion, the limits themselves are secret. Drug wholesalers are barred by the settlement agreement from telling pharmacists what the thresholds are, how they're determined or when the pharmacy is getting close to hitting them. The exact limit for each pharmacy is kept secret in order to prevent pharmacists from gaming the system, according to Krista Tongring, leader of the DEA compliance practice at Guidepost Solutions and a former agency attorney. The purpose, she said, is to keep pharmacies from manipulating "their ordering patterns so as to get around the thresholds." According to a Cardinal Health document, limits are "calculated on a daily, monthly, and quarterly basis," reports Bloomberg. "But without more detailed information, it's impossible for pharmacists to predict when they are going to have to turn patients away."

"Pharmacies can request increases to their thresholds, but those take time to adjudicate, leaving patients scrambling to find their daily medicines elsewhere in the meantime."

An anonymous reader quotes a report from Motherboard: Scientists have discovered "unexpected physics" by opening up "slits" in time, a new study reports, achieving a longstanding dream that can help to probe the behavior of light and pioneer advanced optical technologies. The mind-boggling approach is a time-based variation on the famous double-slit experiment, first performed by Thomas Young in 1801, which opened a window into the weird probabilistic world of quantum mechanics by revealing the dual nature of light as both a particle and a wave. The new temporal version of this test offered a glimpse of the mysterious physics that occur at ultrafast timescales, which may inform the development of quantum computing systems, among other next-generation applications.

In the original version of the double-slit experiment, light passes through two slits that are spatially separated on an opaque screen. A detector on the other side of the screen records the pattern of the light waves that emerges from the slits. These experiments show that the light waves change direction and interfere with each other after going through the slits, demonstrating that light behaves as both a wave and particle. This insight is one of the most important milestones in our ongoing journey into the quantum world, and it has since been repeated with other entities, such as electrons, exposing the trippy phenomena that occurs at the small scales of atoms.

Now, scientists led by Romain Tirole, a PhD student studying nanophotonics at Imperial College London, have created a "temporal analogue of Young's slit experiment" by firing a beam of light at a special metamaterial called Indium Tin Oxide, according to a study published on Monday in Nature Physics. Metamaterials are artificial creations endowed with superpowers that are not found in nature. For instance, the Indium Tin Oxide used in the new study can change its properties in mere femtoseconds, a unit equal to a millionth of a billionth of a second. This incredible variability allows light waves to interact with the metamaterial at key moments in ultrafast succession, called "time slits," which produces a time-based diffraction pattern that is analogous to the results returned in the spatial version of the experiment. [...] In other words, the super-speedy changeability of Indium Tin Oxide finally made a time slit experiment possible, after many years of eluding scientists. To bring this vision to reality, Tirole and his colleagues used lasers to switch the reflectance of the material on and off at high speeds.

Chemicals that were banned after they punched a hole in Earth's ozone layer are still building up at an alarming rate in our atmosphere, according to research published today in the journal Nature Geoscience. The chemicals were once widely used in air conditioning and refrigeration but were supposed to be phased out globally by 2010. From a report: Scientists were surprised to find that concentrations of several types of those chemicals have climbed since then, reaching a record high in 2020. The culprit could be alternative refrigerants that were meant to replace the ozone-depleting substances, the new research suggests. An even bigger problem? Researchers can't find where all the chemicals are leaking from. The ozone layer has managed to make a remarkable recovery over the past few decades. If emissions continue to climb, however, it could counteract some of that progress and exacerbate climate change.

Cruising at a depth of 8,336 meters (over 27,000 feet) just above the seabed, a young snailfish has become the deepest fish ever filmed by scientists during a probe into the abyss of the northern Pacific Ocean. From a report: Scientists from University of Western Australia and Tokyo University of Marine Science and Technology released footage of the snailfish on Sunday filmed last September by sea robots in deep trenches off Japan. Along with the filming the deepest snailfish, the scientists physically caught two other specimens at 8,022 meters and set another record for the deepest catch. Previously, the deepest snailfish ever spotted was at 7,703 meters in 2008, while scientists had never been able to collect fish from anywhere below 8,000 meters. "What is significant is that it shows how far a particular type of fish will descend in the ocean," said marine biologist Alan Jamieson, founder of the Minderoo-UWA Deep Sea Research Centre, who led the expedition. Scientists are filming in the trenches off Japan as part of a 10-year study into the deepest fish populations in the world. Snailfish are members of Liparidae family, and while most snailfish live in shallow water, others survive at some of the greatest depths ever recorded, Jamieson said.

A Canadian astronaut and three NASA veterans, including one of the world's most experienced female spacewalkers, will fly around the moon next year in the first piloted voyage beyond Earth orbit since the Apollo program ended 50 years ago, the space agency announced Monday. From a report: NASA's Reid Wiseman, Christina Koch and Victor Glover will join Canadian rookie Jeremy Hansen aboard an Orion crew capsule for the Artemis program's second fight, the first carrying a crew bound for the moon. The Artemis 2 mission is intended to pave the way toward the first moon landing -- Artemis 3 -- in the 2025-26 timeframe. Wiseman, Koch and Glover are all veterans of long-duration stays aboard the International Space Station while Hansen will be making his first space flight. Navy Capt. Wiseman, 47, a widowed father of two, is a veteran F/A-18F Super Hornet pilot who holds a master's in systems engineering. He launched aboard a Russian Soyuz spacecraft in 2014 and spent 165 days aboard the space station, then served as chief astronaut after his return to Earth.

Koch, 44, holds a master's in electrical engineering who has experience in Antarctic research. She also launched aboard a Soyuz and spent nearly a full year aboard the lab in 2019-20, venturing outside for six spacewalks, including three all-female excursions. With 42 hours and 15 minutes of EVA time, she ranks third on the list of most experienced female spacewalkers. Glover, 46, is a Navy captain, a father of four and one of only a half dozen African Americans in NASA's astronaut corps. He launched to the station aboard the first operational SpaceX Crew Dragon mission in 2021-22, logging 168 days in orbit. Glover is a veteran test pilot with more than 3,000 hours of flight time and more than 400 carrier landings. Hansen, a 47-year-old colonel in the Canadian armed forces and father of three, is a veteran F-18 fighter pilot. He will be the ninth Canadian to fly in space and the first to venture beyond Earth orbit.

America's Department of Defense "is gearing up for a future conflict in space," reports the Wall Street Journal, "as China and Russia deploy missiles and lasers that can take out satellites and disrupt military and civilian communications." The White House this month proposed a $30 billion annual budget for the U.S. Space Force, almost $4 billion more than last year and a bigger jump than for other services including the Air Force and the Navy.... A key aim of a stand-alone force was to plan, equip and defend U.S. interests in space for all of the services and focus attention on the emerging threats. For the first time, the spending request also includes plans for simulators and other equipment to train Guardians, as Space Force members are known, for potential battle....

Just as it is on Earth, China is the Pentagon's big worry in space. In unveiling a defense strategy late last year, the Biden administration cast China as the greatest danger to U.S. security. In space, the threats from China range from ground-launched missiles or lasers that could destroy or disable U.S. satellites, to jamming and other cyber interference and attacks in space, said Pentagon officials. China has invested heavily in its space program, with a crewed orbiting station, developing ground-based missiles and lasers as well as more surveillance capabilities. This is part of its broader military aims of denying adversaries access to space-based assets.

China is "testing on-orbit satellite systems which could be weaponized as they have already shown the capability to physically control and move other satellites," Gen. Chance Saltzman, chief of space operations for the U.S. Space Force, told a congressional hearing this month. "There's nothing we can do in space that's of any value if the networks that process the information and data are vulnerable to attack," Gen. Saltzman said. A central part of the Space Force's next tranche of military contracts for rocket launches is protecting them from attacks by China and other adversaries. The hope is to make satellites tougher to approach by adversaries' equipment as well as less susceptible to lasers and jamming from space or the ground, said Space Force leaders.
The article also notes the US Defense Department "is moving away from a small number of school bus-size satellites to a planned constellation of hundreds of smaller ones.

"The larger number of targets makes any one satellite less crucial to the network but also requires changes in the capabilities of the satellites themselves, the rockets that put them into orbit and the communications systems they host."

"Researchers have 'hacked' the earliest stages of photosynthesis," according to a new announcement from the University of Cambridge.

CNET reports: Scientists have studied photosynthesis in plants for centuries, but an international team believes they've unlocked new secrets in nature's great machine that could revolutionize sustainable fuels and fight climate change. The team says they've determined it's possible to extract an electrical charge at the best possible point in photosynthesis. This means harvesting the maximum amount of electrons from the process for potential use in power grids and some types of batteries. It could also improve the development of biofuels. While it's still early days, the findings, reported in the journal Nature, could reduce greenhouse gasses in the atmosphere and provide insights to improve photovoltaic solar panels.

The key breakthrough came when researchers observed the process of photosynthesis at ultrafast timescales. "We can take photos at different times which allow us to watch changes in the sample really, really quickly — a million billion times faster than your iPhone," Dr. Tomi Baikie, from the University of Cambridge's Cavendish Laboratory, told CNET....

Previous demonstrations connected cyanobacteria, algae and other plants to electrodes to create so-called bio-photoelectrochemical cells that tap into the photosynthetic process to generate electricity. Baikie said they were surprised to discover a previously unknown pathway of energy flow at the beginning of the process that could enable extracting the charge in a more efficient way.

It was 10 times brighter than any previously detected, reports the BBC, noting it illuminated much of the galaxy.

RockDoctor (Slashdot reader #15,477) writes: A recent paper on ArXiv describes a Gamma Ray Burst (GRB) whose light arrived late last year as one of the strongest ever observed. GRB 221009A was detected on October 9 last year (yes, that number is a date), so 5 and a bit months from event to papers published is remarkably quick, and I anticipate that there will be a lot more papers on it in the future. Stand-out points are :


- it lasted for more than ten hours after detection (a space x-ray telescope had time to orbit out of the Earth's shadow and observe it)
- it could (briefly) be observed by amateur astronomers.
- it is also one of the closest gamma-ray bursts seen and is among the most energetic and luminous bursts.


It's redshift is given as z= 0.151, which Wikipedia translates as occurring 1.9 billion years ago, at a distance of 2.4 billion light-years from Earth.

Observations have been made of the burst in radio telescopes (many sites, continuing), optical (1 site ; analysis of HST imaging is still in work), ultraviolet (1 space telescope), x-ray (2 space telescopes) and gamma ray (1 sapce telescope) — over a range of 1,000,000,000,000,000-fold (10^15) in wavelength. It's brightness is such that radio observatories are expected to continue to detect it for "years to come".

The model of the source is of several (3~10) Earth-masses of material ejected from (whatever, probably a compact body (neutron star or black dwarf) merger) and impacting the interstellar medium at relativistic speeds (Lorentz factor 9, velocity >99.2% of c). The absolute brightness of the burst is high (about 10^43 J) and it is made to seem brighter by being close, and also by the energy being emitted in a narrow jet ("beamed"), which we happen to be near the axis of.

General news sites are starting to notice the reports, including the hilarious acronym of "BOAT — Brightest Of All Time". Obviously, with observations having only occurred for about 50 years. we're likely to see something else as bright within the next 50 years.

The brightness of the x-rays from this GRB is such that the x-rays scattered from dust in our galaxy creates halos around the source — which are bright enough to see, and to tell us things about the dust in our galaxy (which is generally very hard to see). Those images are more photogenic than the normal imagery for GRBs — which is nothing — so you'll see them a lot.

"SpaceX has its first commercial cargo contract to the lunar surface," says Jaret Matthews, the founder of the tiny startup Astrolab which makes a moon rover the size of a Jeep Wrangler. The New York Times reports: On Friday, Astrolab announced that it had signed an agreement with SpaceX for its Flexible Logistics and Exploration Rover, or FLEX, to be a payload on an uncrewed Starship cargo mission that is to take off as early as mid-2026...." SpaceX, which did not respond to requests for comment, has yet to announce that it is planning this commercial Starship mission to the moon's surface, headed to the south polar region. Astrolab would be just one of the customers sharing the voluminous cargo compartment of the Starship flight, Mr. Matthews said.

Mr. Matthews, an engineer who previously worked at SpaceX and NASA's Jet Propulsion Laboratory, founded Astrolab less than four years ago. Located a stone's throw from SpaceX's headquarters in Hawthorne, Calif., it has about 20 full-time employees, he said.... Mr. Matthews declined to say how much it would cost to get FLEX to the moon or how much money Astrolab has raised. He said Astrolab would make money by lifting and deploying cargo for customers on the lunar surface. That could include scientific instruments. In the future, the rover could help build lunar infrastructure. "Essentially providing what I like to call last-mile mobility on the moon," Mr. Matthews said. "You can kind of think of it like being U.P.S. for the moon. And in this analogy, Starship is the container ship crossing the ocean, and we're the local distribution solution...."

Mr. Matthews said Astrolab already had several signed agreements for payloads. That appears to be part of the expanding potential market for [SpaceX's] Starship.... For NASA, Starship is how its astronauts will land on the moon during the Artemis III mission, currently scheduled for 2025. Before that, SpaceX is to conduct an uncrewed flight to demonstrate the capability of spacecraft to get to the moon and set down there in one piece. If those schedules hold, the commercial cargo mission with the Astrolab rover could take place the next year....

Farther into the future, the company has even grander visions. "Ultimately our goal is to have a fleet of rovers both on the moon and Mars," Mr. Matthews said. "And I really think I see these vehicles as the catalysts ultimately for the off-Earth economy."

"Chinese officials have released an updated analysis of more than 1,300 samples taken from the Wuhan wet market at the beginning of the Covid-19 pandemic," reports the Telegraph: In a preprint published on Wednesday, researchers from the Chinese Center for Disease Control and Prevention said there was "convincing evidence" that Sars-Cov-2 was spreading widely at Wuhan's Huanan seafood market in January 2020.
Dr Tedros Adhanom Ghebreyesus, head of the WHO, tells them "This data could and should have been shared three years ago." China's paper then called for "more work involving international coordination" to investigate the potential origins of SARS-CoV-2. "Surveillance of wild animals using a viromic approach should be enhanced to explore the potential natural and intermediate hosts for SARS-CoV-2, if any, which would help to prevent future pandemics caused by animal-origin coronaviruses or alike, with a spillover event."

But the Telegraph notes that China also "claimed it's not clear how Covid got there, as no virus was found in the 457 animal swabs taken from 18 species at the market. The data behind the latest Chinese research has proved controversial, after a team of international experts downloaded the genetic sequences that had been discreetly shared on a database called GISAID. Their analysis was the first conducted on the data outside China, which has been accused by the World Health Organization of withholding critical clues. In samples taken from the Wuhan market that tested positive for Covid, the international team found genetic material from wildlife known to be susceptible to Sars-Cov-2 — including racoon dogs, palm civets and Himalayan marmots. This does not prove these animals were infected, but does confirm they were being illegally sold at Huanan market in early 2020.

"What we are seeing is the genomic ghost of that animal in the stalls," said Dr Florence Débarre, an evolutionary biologist at the French National Centre for Scientific Research, who first spotted the data when trawling GISAID. "It's close to the best [evidence] we can get, because the animals were gone when they came to sample the markets," she told the Telegraph earlier this month....

The latest paper from China CDC — published on ChinaXiv on Wednesday — reveals that although researchers sampled 18 species including bamboo rats, wild boars and hedgehogs, they did not take specimens from animals including raccoon dogs now known to be susceptible to the virus. It is likely that this is because they had already been removed. Some researchers said this undermines the China CDC's suggestion that animals did not bring the virus into the market — a route that China has consistently discredited, much like the potential for a laboratory leak, as it does not want the origin to be within its own borders. "This claim that no live animals with the virus were found at the market is one of the most pernicious and misleading talking points proffered," said Dr Michael Worobey, an evolutionary biologist at the University of Arizona who led the international analysis.

"If no live raccoon dogs... or other plausible intermediate hosts species were tested (because they had all disappeared by the time this testing took place), then saying that the lack of Sars-CoV-2 live animals at the market is evidence against a zoonotic origin is at best misinformed. At worst, it is deliberate disinformation," he told the Telegraph.

The scientific community is reeling after NASA gutted funding for a key Venus mission that was "poised to answer some of the biggest questions about the planet and its volcanic activity," reports The Verge. From the report: This month saw the announcement of one of the most exciting findings about Venus in decades: the first direct evidence of an active volcano there. [...] This finding is "mind-blowing," Venus scientist Darby Dyar told The Verge, opening up possibilities to learn about Venus' geology and atmosphere as well as whether the planet was once habitable. But in the space science community, the excitement about this finding is being overshadowed by the "soft cancellation" of a key NASA Venus mission, which Dyar is also deputy principal investigator for and which had been set to launch in 2028.

The Venus Emissivity, Radio Science, InSAR, Topography, and Spectroscopy (VERITAS) mission was one of three missions set to explore Venus in the next few years, kicking off NASA's "decade of Venus" and seeing a return to the study of our planetary neighbor, which scientists have been calling for for years. But at the Lunar and Planetary Science Conference held recently in Houston, Texas, VERITAS principal investigator Sue Smrekar announced that the mission's funding had been completely gutted, leaving the mission in a state of precarious limbo.

This came as a surprise to many of the conference attendees, who were soon tweeting their support for the mission using the hashtag #SaveVERITAS. The Planetary Society also put out a statement describing the delay of the mission's launch by at least three years as "uncalled-for" and calling on NASA to commit to launching by 2029. NASA has cited problems with another mission, Psyche, as the reason for delaying VERITAS by at least three years. Both Psyche and VERITAS are managed by the Jet Propulsion Laboratory (JPL), the NASA / Caltech research center that is responsible for building robotic spacecraft such as the Mars rovers. JPL had problems meeting its requirements for the Psyche mission, which aims to visit a metal asteroid, and missed its launch date last year. An independent review into the missed launch found it was due to, among other problems, workforce issues at JPL. Budget cuts and cancellations aren't uncommon, but the situation with VERITAS is different because it "had already been selected by NASA to be part of its Discovery Program," adds the Verge. "Historically, once a mission has been selected by NASA, those working on it can be confident that funding will be available. If a delay happens -- as is not uncommon in large, complex missions -- then a lower level of funding is typically made available to keep the basic essentials in place, called bridge funding, until full funding can be restored."

Although the team asked NASA for bridge funding to maintain mission essentials, "virtually all of their funding has been cut, leaving them with a tiny $1.5 million per year," says the report. "This is a highly unusual situation for a selected mission because delaying and restarting missions is so expensive."

The UK government will defy scientific doubts to place a massive bet on technology to capture and store carbon dioxide in undersea caverns, to enable an expansion of oil and gas in the North Sea. From a report: Grant Shapps, the energy and net zero secretary, on Thursday unveiled the "powering up Britain" strategy, with carbon capture and storage (CCS) at its heart, during a visit to a nuclear fusion development facility in Oxford. Shapps said the continued production of oil and gas in the North Sea was still necessary, and that the UK had a geological advantage in being able to store most of the carbon likely to be produced in Europe for the next 250 years in the large caverns underneath the North Sea. "Unless you can explain how we can transition [to net zero] without oil and gas, we need oil and gas," he said. "I am very keen that we fill those cavities with storing carbon. I think there are huge opportunities for us to do that."

Shapps pointed to the $24.7bn the government is planning to spend over 20 years on developing CCS, which he said would generate new jobs and make the UK a world leader in the technology. Among the 1,000 pages of proposals to be published on Thursday will be boosts for offshore wind, hydrogen, heat pumps and electric vehicles. A green finance strategy, to be set out by the chancellor of the exchequer, Jeremy Hunt, will be aimed at mobilising private-sector money for investments in green industry, and there will be a consultation on carbon border taxes, aimed at penalising the import of high-carbon goods from overseas. But the plans contain no new government spending, and campaigners said they missed out key elements, such as a comprehensive programme of home insulation and a full lifting of the ban on new onshore wind turbines in England.

Researchers have discovered one of the most massive black holes ever discovered, clocking in at around 32.7 billion times the mass of the sun. It's located in a galaxy at the center of a massive cluster named Abell 1201, some 2.7 billion light-years away. ScienceAlert reports: The new figure exceeds previous estimates by at least 7 billion solar masses, demonstrating the power of curved light for measuring masses with precision. One way we can find these black holes is looking for an effect called gravitational lensing. This occurs when space-time itself is warped by mass; imagine space-time as a rubber sheet, and the mass as a heavy weight on it. Any light traveling through that region of space-time has to travel along a curved path, and that can look very interesting to an observer watching from afar. [...]

The central galaxy, or brightest cluster galaxy (BCG) of Abell 1201, is a large, diffuse elliptical galaxy well-known as a strong gravitational lens. A galaxy far beyond the BCG appears alongside it as an elongated smear, like an eyebrow closely wrapped around its outskirts. This smear was discovered in 2003; in 2017, astronomers found a second, fainter smear, even closer to the galactic center. This implies, astronomers proposed, the presence of a very large black hole at the center of the BCG, but the data available was not detailed enough to resolve the central mass, or reveal more about what was in there.

[Researchers] not only had access to more recent observations, but devised the tools to understand them. They conducted hundreds of thousands of simulations of light moving through the Universe, altering the mass of the black hole at the galaxy's center, looking for results that replicate the lensing we observe with Abell 1021 BCG. All but one of their models preferred a massive black hole at the center of the galaxy; and the best fit for the mass of that black hole was 32.7 billion times the mass of the Sun. That pushes it well into ultramassive territory, black holes more massive than 10 billion Suns, and close to the theoretical upper limit for black hole masses of 50 billion Suns. The research has been published in the Monthly Notices of the Royal Astronomical Society.