An anonymous reader quotes a report from New Atlas: Name a type of organic matter and chances are some type of organism has evolved to eat it. Plants, meat, algae, insects and bacteria are all consumed by different creatures, but now scientists have discovered something new on the menu -- viruses. Since viruses are found absolutely everywhere, it's inevitable that organisms will consume them incidentally. But researcher John DeLong at the University of Nebraska-Lincoln wanted to find out if any microbes actively ate viruses, and whether such a diet could support the physiological growth of individuals and the population growth of a community. "They're made up of really good stuff: nucleic acids, a lot of nitrogen and phosphorous," said DeLong. "Everything should want to eat them. So many things will eat anything they can get ahold of. Surely something would have learned how to eat these really good raw materials."

To test the hypothesis, DeLong and his team collected samples of pond water, isolated different microbes, and then added large amounts of chlorovirus, a freshwater inhabitant that infects green algae. Over the next few days the team tracked the population size of the viruses and the other microbes to see if the latter was eating the former. And sure enough, one particular microbe seemed to be snacking on the viruses -- a ciliate known as Halteria. In water samples with no other food source for the ciliates, Halteria populations grew by about 15 times within two days, while chlorovirus levels dropped 100-fold. In control samples without the virus, Halteria didn't grow at all.

These experiments show that the newly coined term "virovory" can now take its place among herbivory, carnivory et al, with Halteria crowned the first known virovore. But of course, it's unlikely to be the only one out there, and the researchers plan to continue investigating the phenomenon, including its effects on food webs and larger systems like the carbon cycle. The research was published in the journal Proceedings of the National Academy of Sciences.

NASA is exploring whether SpaceX's Crew Dragon spacecraft can potentially offer an alternative ride home for some crew members of the International Space Station after a Russian capsule sprang a coolant leak while docked to the orbital lab. Reuters reports: NASA and Russia's space agency, Roscosmos, are investigating the cause of a punctured coolant line on an external radiator of Russia's Soyuz MS-22 spacecraft, which is supposed to return its crew of two cosmonauts and one U.S. astronaut to Earth early next year. But the Dec. 14 leak, which emptied the Soyuz of a vital fluid used to regulate crew cabin temperatures, has derailed Russia's space station routines, with engineers in Moscow examining whether to launch another Soyuz to retrieve the three-man team that flew to ISS aboard the crippled MS-22 craft. If Russia cannot launch another Soyuz ship, or decides for some reason that doing so would be too risky, NASA is weighing another option.

"We have asked SpaceX a few questions on their capability to return additional crew members on Dragon if necessary, but that is not our prime focus at this time," NASA spokeswoman Sandra Jones said in a statement to Reuters. It was unclear what NASA specifically asked of SpaceX's Crew Dragon capabilities, such as whether the company can find a way to increase the crew capacity of the Dragon currently docked to the station, or launch an empty capsule for the crew's rescue. But the company's potential involvement in a mission led by Russia underscores the degree of precaution NASA is taking to ensure its astronauts can safely return to Earth, should one of the other contingency plans arranged by Russia fall through.

An anonymous reader quotes a report from Space.com: Take a grand tour of the solar system tonight (Dec. 28) as each of the planets in the solar system will be visible at the same time. As 2022 comes to an end, skywatchers can take in the rare sight of all of the planets in our solar system (aside from Earth) together in the sky. Mercury, Venus, Mars, Jupiter and Saturn are all currently visible simultaneously with the naked eye. The two outermost planets, Uranus and Neptune, can meanwhile be observed with binoculars or a telescope.

The five planets visible with the naked eye -- Venus, Mercury, Saturn, Jupiter and Mars, in that order -- will line up in the sky starting from the southwestern horizon. Mercury, the smallest planet in the solar system, will be difficult to see with the eye, but it's possible if dark sky conditions are right. Uranus, visible only through binoculars or a telescope, can be found between Mars and Jupiter, while Neptune will be visible through optics between Saturn and Jupiter. The Virtual Telescope Project is hosting a free "grand tour of the solar system" livestream starting at 12:30 p.m. EST (1730 GMT) on Wednesday (Dec. 28). The live webcast is also available on their YouTube channel.

The report notes that this "grand tour" happens roughly every one to two years, on average. "In June 2022, skywatchers were treated to five planets -- Mercury, Venus, Mars, Jupiter and Saturn -- arranged in a rare alignment the likes of which hadn't occurred since 1864," the report adds.

Over the last 20 years, there has been twice as much sea level rise on Italy's Amalfi coast as on Spain's Costa del Sol, a study shows. From a report: Researchers combined data from tide gauges and satellites with ice melt measurements to model sea level change across the Mediterranean basin since 1960. To their surprise, they found that sea level fell by about 9mm between 1960 and 1989, owing to increased atmospheric pressure over the basin. But since 1989, ocean warming and land ice melting have driven rapid sea level rise, reaching an average rate of 3.6mm a year in the Mediterranean basin over the last two decades. The rise has not been spread evenly, however. Their findings, which are published in JGR Oceans, show that the Adriatic, Aegean and Levantine seas have risen by 8cm over two decades, while the Cretan passage in the eastern Mediterranean has risen by half this amount.

SpaceX launched the first batch of a new generation of Starlink satellites into orbit early Wednesday (Dec. 28) and nailed a rocket landing at sea to mark a record 60th flight of the year. From a report: A Falcon 9 rocket topped with 54 upgraded Starlink internet satellites -- the first generation 2 (Gen2) versions of the SpaceX fleet -- lit up the predawn sky with a smooth launch at 4:34 a.m. EST (0934 GMT) from the Cape Canaveral Space Force Station in Florida. "Under our new license, we are now able to deploy satellites to new orbits that will add even more capacity to the network," Jesse Anderson, a SpaceX production and engineering manager, said during live launch commentary. "Ultimately, this enables us to add more customers and provide faster service, particularly in areas that are currently oversubscribed."

About eight minutes after liftoff, the Falcon 9 first stage returned to Earth with a landing on the SpaceX drone ship A Shortfall of Gravitas in the Atlantic Ocean, where rough recovery weather threatened to delay the launch. The touchdown marked a successful end to SpaceX's 60th launch of SpaceX in 2022, nearly doubling the 31 launches set as a SpaceX record in 2021. The Falcon 9 first stage on this mission made its 11th flight with Wednesday's launch. The booster previously flew five Starlink missions, launched two U.S. GPS satellites, the Nilesat 301 commercial satellite and carried two different private astronaut crews on the Inspiration4 and Ax-1 missions, SpaceX has said. The company will also attempt to recover the two payload fairing halves that made up the Falcon 9's nose cone, which had both flown before, for later reuse, Anderson said.

Scientists have developed a blood test to diagnose Alzheimer's disease without the need for expensive brain imaging or a painful lumbar puncture, where a sample of cerebrospinal fluid (CSF) is drawn from the lower back. If validated, the test could enable faster diagnosis of the disease, meaning therapies could be initiated earlier. The Guardian reports: Current guidelines recommend detection of three distinct markers: abnormal accumulations of amyloid and tau proteins, as well as neurodegeneration -- the slow and progressive loss of neuronal cells in specified regions of the brain. This can be done through a combination of brain imaging and CSF analysis. However, a lumbar puncture can be painful and people may experience headaches or back pain after the procedure, while brain imaging is expensive and takes a long time to schedule.

Although current blood tests can accurately detect abnormalities in amyloid and tau proteins, detecting markers of nerve cell damage that are specific to the brain has been harder. [Prof Thomas Karikari at the University of Pittsburgh, in Pennsylvania] and his colleagues around the world focused on developing an antibody-based blood test that would detect a particular form of tau protein called brain-derived tau, which is specific to Alzheimer's disease. They tested it in 600 patients at various stages of Alzheimer's and found that levels of the protein correlated well with levels of tau in the CSF, and could reliably distinguish Alzheimer's from other neurodegenerative diseases. Protein levels also closely corresponded with the severity of amyloid plaques and tau tangles in brain tissue from people who had died with Alzheimer's. The research was published in the journal Brain.

An anonymous reader shares a report: One of the hottest tickets at this year's Society for Neuroscience meeting in San Diego was a session on psychedelic drugs. About 1,000 brain scientists squeezed into an auditorium at the San Diego Convention Center for the symposium, called Psychedelics and Neural Plasticity. They'd come to hear talks on how drugs like psilocybin and MDMA can alter individual brain cells, can help rewire the brain, and may offer a new way to treat disorders ranging from depression to chronic pain.

[...] Brain plasticity may explain why a single dose of a psychedelic drug can have a long-lasting impact on disorders like anxiety, depression and PTSD. "It can be months or years," says Dr. Gitte Knudsen a neurologist from University of Copenhagen in Denmark who spoke at the psychedelics session. "It's a stunning effect." These long-term effects have been shown with drugs including psilocybin, LSD and DMT (ayahuasca), Knudsen says. In contrast, most existing psychiatric drugs need to be taken every day. But psychedelic drugs have some drawbacks. They can cause nausea or produce hallucinations that are frightening or unpleasant.

An anonymous reader shares a report: Deep brain stimulation is already used to treat severe cases of epilepsy and a few movement disorders such as Parkinson's. But depression is more complicated -- partly because we still don't fully understand what's going on in the brain when it occurs. "Depression is a complex illness," says Patricio Riva Posse, a neurologist at the Emory School of Medicine in Atlanta, Georgia, who was not involved in the trial. "It's not like trying to correct one tremor -- there's a whole universe of symptoms." These include low mood, suicidality, inability to experience pleasure, and changes in motivation, sleep, and appetite.

Doctors have been using electricity to treat brain disorders -- including depression -- for decades, and some studies have found that electrodes placed deep inside the brain can jolt some people out of their symptoms. But results vary. Neuroscientists hope that by getting a better idea of what's happening inside the brains of people with symptoms like John's, they can make the treatment more effective. John is one of five people who have volunteered to have their brains probed as part of a clinical trial. At the start of 2020, he had a total of 14 electrodes implanted across his brain. For nine days, he stayed in a hospital with protruding cables wrapped around his head, while neuroscientists monitored how his brain activity correlated with his mood.

The researchers behind the trial say they have developed a "mood decoder" -- a way of being able to work out how someone is feeling just by looking at brain activity. Using the decoder, the scientists hope to be able to measure how severe a person's depression is, and target more precisely where the electrodes are placed to optimize the effect on the patient's mood. So far, they have analyzed the results of three volunteers. What they have found is extremely promising, says Sameer Sheth, a neurosurgeon based at Baylor College of Medicine in Houston, Texas, who is leading the trial. Not only have he and his colleagues been able to link volunteers' specific brain activity with their mood, but they have also found a way to stimulate a positive mood. "This is the first demonstration of successful and consistent mood decoding of humans in these brain regions," says Sheth. His colleague Jiayang Xiao presented the findings at the Society for Neuroscience's annual meeting in San Diego in November.

Many of the nation's largest nonprofit hospital systems, which give aid to poorer communities to earn tax breaks, have been leaving those areas and moving into wealthier ones as they have added and shed hospitals in the last two decades. From a report: As nonprofits, these regional and national giants reap $8.8 billion from tax breaks annually, by one Johns Hopkins University researcher's estimate. Among their obligations, they are expected to provide free medical care to those least able to afford it. Many top nonprofits, however, avoid communities where more people are likely to need that aid, according to a Wall Street Journal analysis of nearly 470 transactions. As these systems grew, many were more likely to divest or close hospitals in low-income communities than to add them.

Since 2001, half the hospitals divested by CommonSpirit Health, a large Catholic system based in Chicago, were in communities where the poverty rate was above the medians for state hospital markets, compared with 30% of those it added. At Bon Secours Mercy Health, formed by the 2018 merger of two growing regional nonprofits, about 42% of hospitals it divested were in areas with higher poverty, compared with 27% of hospitals it added. Of hospitals divested or closed by St. Louis-based Ascension, about half were located in higher-poverty areas, compared with 40% of the Catholic system's acquisitions.

At the same time, many top nonprofits were moving more aggressively to add hospitals in more affluent areas. At Mercy, a St. Louis-based hospital nonprofit, 56% of new hospitals were in places with lower poverty rates, compared with 25% of those it shed. About two-thirds of the hospitals it added were in markets where the share of households with incomes of at least $200,000 was above the state median. That compared with 25% of those the system shed. Of hospitals acquired by Florida-based AdventHealth, nearly two-thirds were in low-poverty areas, compared with 40% of those they divested. And 59% had a larger share of higher-income households, compared with 40% of those they exited.

"Last week at the 2022 American Geophysical Union (AGU) Fall Meeting, planetary scientists and astronomers discussed how new machine-learning techniques are changing the way we learn about our solar system," reports Space.com, "from planning for future mission landings on Jupiter's icy moon Europa to identifying volcanoes on tiny Mercury...." For many tasks in astronomy, it can take humans months, years or even decades of effort to sift through all the necessary data... "You can find up to 10,000, hundreds of thousands of boulders, and it's very time consuming," Nils Prieur, a planetary scientist at Stanford University in California said during his talk at AGU. Prieur's new machine-learning algorithm can detect boulders across the whole moon in only 30 minutes. It's important to know where these large chunks of rock are to make sure new missions can land safely at their destinations. Boulders are also useful for geology, providing clues to how impacts break up the rocks around them to create craters.

Computers can identify a number of other planetary phenomena, too: explosive volcanoes on Mercury, vortexes in Jupiter's thick atmosphere and craters on the moon, to name a few. During the conference, planetary scientist Ethan Duncan, from NASA's Goddard Space Flight Center in Maryland, demonstrated how machine learning can identify not chunks of rock, but chunks of ice on Jupiter's icy moon Europa. The so-called chaos terrain is a messy-looking swath of Europa's surface, with bright ice chunks strewn about a darker background. With its underground ocean, Europa is a prime target for astronomers interested in alien life, and mapping these ice chunks will be key to planning future missions.

Upcoming missions could also incorporate artificial intelligence as part of the team, using this tech to empower probes to make real-time responses to hazards and even land autonomously. Landing is a notorious challenge for spacecraft, and always one of the most dangerous times of a mission.

Like a visit from an old friend, it's Donald Knuth's annual Christmas tree lecture for 2022. "Because of the pandemic, it's been three years since Knuth has been able to honor this tradition," notes The New Stack: 2022 marks the 60th anniversary of that fateful day in 1962 when a 24-year-old Donald Knuth started writing " The Art of Computer Programming." Now approaching his 85th birthday, Knuth has become almost a legend in the world of computer programming — and he's still writing additional volumes for his massive analysis of algorithms. But every year, right around Christmas time, there's another tradition. Knuth gives a special lecture "pitched at non-specialists" for a small audience at Stanford University (where Knuth is a professor emeritus) and a larger audience online...

Hunched over a notepad (which was projected onto a screen behind him), Knuth began the 26th annual Christmas lecture by pointing out that the evening's topic had been hiding in plain sight for two decades. For the first 20 years, they'd called them the "Christmas tree" lectures, since "trees are one of the most important things to a computer scientist. And every year I learned at least two new cool things about trees..."

About five years ago they'd changed the name to just "Christmas lectures" — but the problem wasn't that trees stopped being interesting. "I still learn cool things about trees every year. But they're getting harder and harder to explain to a general audience!"

So this year's triumphant "homecoming" lecture would indeed include trees — specifically a phenomenon Knuth describes as "twintrees," along with Baxter permutations, and Floorplans. Knuth noted they're all topics touched on in the latest volume of The Art of Computer Programming, before jokingly reminding the audience that his book makes an excellent Christmas present.
By the end of the lecture, Knuth had written algorithms for all three mathematical concepts — then connected all three algorithms with Linux pipes to show what happens when you convert one kind of sequence into the other and then into the other.

"I get back, of course, the one I started with!"

CNN shares the historic close-up snowflake photos of Wilson Bentley, the first person to capture the details of the individual "snow crystal" ice that makes up snowflakes.

It was 1885, just 69 years after the invention of the camera, and after years of trial and error, "He went on to photograph more than 5,000 of these "ice flowers" during his lifetime — never finding any duplicates — and the images still mesmerize to this day." Every snow crystal shares a common six-sided or six-pointed structure — it's how frozen water molecules arrange themselves — but they will always vary from one another because each falls from the sky in its own unique way and experiences slightly different atmospheric conditions on its travel down to earth. Some of their arms may look long and skinny. Others may appear short and flat or somewhere in between. The possibilities are endless and fascinating....

"He had the mind of a scientist and the soul of a poet, and you can see that in his writings," said Sue Richardson, Bentley's great-grandniece who is vice president of the board for the Jericho Historical Society. "He wrote many, many articles over the years for scientific publications and for other magazines like Harper's Bazaar and National Geographic. "He also kept very detailed weather records and very detailed journals of every photograph that he took of a snow crystal — the temperature, the humidity, what part of the storm it came from. He kept very detailed information, and then these weather records that he kept and the theories that he developed about how snow crystals formed in the atmosphere, those were proven true...."

It wasn't easy, however, to get those snow crystals on camera. It took almost three years, Richardson said, for Bentley to figure out how to successfully photograph one — which he did just a month shy of his 20th birthday. The first obstacle was figuring out how to attach the microscope to the camera. And then there was the challenge of getting each crystal photographed before it could melt away. "He worked in an unheated woodshed at the back of the house. He had to," Richardson said. "And the microscope slides, everything, had to be an ambient temperature or they'd melt" the crystal....

A children's book about him won the Caldecott Medal in 1999.
Bentley never had formal education, according to his grandniece (who grew up hearing stories about this famous ancestor). One says that when Wilson Bentley was given an old microscope at age 15, "The first time he looked at a snow crystal under it, he was hooked. Just the beauty, the intricate detail. He was totally hooked."

Reason.com notes NASA's successful completion of its Artemis I mission, calling it "part of NASA's ambitious program to bring American astronauts back to the moon for the first time in half a century. And then on to Mars."

But then they ask if the project is worth the money, with the transportation policy director at the libertarian "Reason Foundation" think tank, Robert W. Poole, arguing instead that NASA "isn't particularly interested in cost savings, and its decision making is overly driven by politics." NASA would have been better off replacing the costly and dated Space Launch System used in the Artemis program. But it didn't. This probably has a lot to do with the fact that it was largely constructed and engineered in Alabama, the home state of Senate Appropriations Committee Chair Richard Shelby, who has a history of strong-arming NASA to preserve jobs for his constituents.
Long-time Slashdot reader SonicSpike shared the article, which ultimately asks whether it'd be faster and cheaper to just rely on private companies: In 2009, the private sector saw one of its biggest champions ascend to become the number two person at NASA. Lori Garver pushed to scrap the Constellation program as a way to entice the private sector to fill in the gaps. She also spearheaded the Commercial Crew Program, which continues to employ commercial contractors to ferry astronauts to the International Space Station. Today, companies like Elon Musk's SpaceX are launching rockets at a faster pace and for a fraction of what NASA spends. In 2022, the company successfully launched 61 rockets, each with a price tag between $100 million and 150 million.

Private companies already design and lease NASA much of its hardware. Poole says there's no reason NASA can't take it a step further and just use the SpaceX starship to cover the entire journey from Earth to the moon and eventually to Mars. "If the current NASA plan goes ahead to have the SpaceX Starship actually deliver the astronauts from the lunar outpost orbit to the surface of the moon and bring them back, that would be an even more dramatic refutation of the idea that only NASA should be doing space transportation," he says.

Poole says that instead of flying its own missions, NASA should play a more limited and supportive role. "The future NASA role that makes the most sense is research and development to advance science," he says.
But for a contrary opinion, Slashdot reader youn counters that "You can bash NASA all you want but a big reason the private sector is where it is at is because it funded research 12 years ago." They share a CNET article noting the $6 billion NASA budgeted over five years "to kick-start development of a new commercial manned spaceflight capability."

And Slashdot reader sg_oneill argues that "Its gonna be a century before we're really colonizing the moon and/or Mars... because we have a lot of science to do first. How do you do a civilization with zero energy inputs from the rest of humanity? How do we deal with radiation? How do bodies work in low G? (Mars is about 1/3 the gravbity of earth). This needs science, and to get science we need NASA, even if private enterprise is building the rockets."

An anonymous reader shares a report: The Food and Drug Administration (FDA) considers aging to be a natural process. This makes it difficult to get FDA approval for drugs that seek to slow or reverse the biological process of aging. Instead, drugs intended to target aging must target a disease that often results from the aging process in order to demonstrate efficacy and gain approval. But there is growing consensus and effort among scientists to convince the FDA that aging itself should be classified as a disease and an appropriate target for drug development.

This could be a major milestone for not just industry, but society. If the FDA is swayed, the resulting regulatory shift could mean approval of drugs or treatments that slow or reverse the aging process generally, before a patient develops disease. Researchers who view aging as a medical condition aren't referring only to the inevitable passage of time. Instead, they view aging as a process of deterioration of our structure and function at the cellular level; the hallmark characteristics of which are genomic instability and damage to our DNA. And the World Health Organization (WHO) supports this view -- WHO describes the process of aging as "... the impact of the accumulation of a wide variety of molecular and cellular damage over time."

Israeli researchers say they have developed gene-edited hens that lay eggs from which only female chicks hatch. From a report: The breakthrough could prevent the slaughter of billions of male chickens each year, which are culled because they don't lay eggs. The female chicks, and the eggs they lay when they mature, have no trace of the original genetic alteration Animal welfare group, Compassion in World Farming, has backed the research. Dr Yuval Cinnamon from the Volcani institute near Tel Aviv, who is the project's chief scientist, told BBC News that the development of what he calls the ''Golda hen'' will have a huge impact on animal welfare in the poultry industry.

"I am very happy that we have developed a system that I think can truly revolutionise the industry, first of all for the benefit of the chickens but also for all of us, because this is an issue that affects every person on the planet," he said. The scientists have gene edited DNA into the Golda hens that can stop the development of any male embryos in eggs that they lay. The DNA is activated when the eggs are exposed to blue light for several hours. Female chick embryos are unaffected by the blue light and develop normally. The chicks have no additional genetic material inside them nor do the eggs they lay, according to Dr Cinnamon. "Farmers will get the same chicks they get today and consumers will get exactly the same eggs they get today," he said. "The only minor difference in the production process is that the eggs will be exposed to blue light."

The Biden administration has strengthened limits on smog-forming pollution from buses, delivery vans, tractor-trailers and other trucks, the first time in more than 20 years that tailpipe standards have been tightened for heavy-duty vehicles. From a report: The new rule from the Environmental Protection Agency is designed to cut nitrogen oxide from the vehicles by 48 percent by 2045. Nitrogen dioxide is a poisonous gas that has been linked to cardiovascular problems and respiratory ailments like asthma. The rule will require manufacturers to cut the pollutant from their vehicles starting with the model year 2027. But the new rule is not as stringent as one proposed by the E.P.A. in March, which would have cut the pollutant as much as 60 percent by 2045. And the agency stopped short of âârequiring that truck manufacturers also cut greenhouse gas emissions associated with burning diesel fuel or convert their fleets to electric models.

Walking like John Cleese's character, Mr. Teabag, in Monty Python's famous "Ministry of Silly Walks" skit requires considerably more energy expenditure than a normal walking gait because the movement is so inefficient, according to a new paper published in the annual Christmas issue of the British Medical Journal. From a report: In fact, just 11 minutes a day of walking like Mr. Teabag was equivalent to 75 minutes of vigorously intense physical activity per week, presenting a novel means of boosting cardiovascular fitness. "Half a century ago, the [Ministry of Silly Walks] skit might have unwittingly touched on a powerful way to enhance cardiovascular fitness in adults," the authors wrote. "Had an initiative to promote inefficient movement been adopted in the early 1970s, we might now be living among a healthier society."

The BMJ's Christmas issue is typically more lighthearted, though the journal maintains that the papers published therein still "adhere to the same high standards of novelty, methodological rigor, reporting transparency, and readability as apply in the regular issue." Past years have included papers on such topics as why 27 is not a dangerous age for musicians, the side effects of sword swallowing, and measuring the toxicity of the concoction brewed in Roald Dahl's 1981 book George's Marvelous Medicine. (It's very toxic indeed.) The most widely read was 1999's infamous "Magnetic resonance imaging of male and female genitals during coitus and female sexual arousal."

An anonymous reader quotes a report from Scientific American: Most people have two sex chromosomes, either two X's or an X and a Y, which give rise to female or male biological attributes on a spectrum. Studies suggest these chromosomes also have much broader effects, contributing to processes that include immune system function, neuronal development, disease susceptibility and reactions to drugs. But scrutinizing the specific role of X and Y chromosomes is challenging. With current tools, it is difficult to disentangle the effects of genes versus hormones, for example. Now scientists have devised a tool that could overcome this obstacle -- by generating XX and XY cells from a single person for the first time. This unique set of cells could help researchers tackle long-standing questions about how sex chromosomes affect disease and the role they play in early development.

Benjamin Reubinoff, a professor of obstetrics and gynecology at the Hadassah Medical Center in Israel, and his team began the project to overcome barriers facing investigations of sex differences in humans. Currently there are two major ones, according to Reubinoff: the difficulty of separating chromosomal and hormonal effects and the inability to pinpoint the effects of X and Y chromosomes while ruling out contributions from the rest of a person's genetic makeup. "The main reason for doing this study was the lack of a good model to study differences between males and females in humans," Reubinoff says. "There have been animal models, but a model in humans was not available." To create such a model, Reubinoff, his former M.D. and Ph.D. student Ithai Waldhorn and their colleagues first obtained white blood cells previously collected from a person with Klinefelter syndrome, a condition in which male individuals are born with an extra X chromosome. The cells came from the repositories of the Coriell Institute for Medical Research, where people donate samples for use in a wide range of biomedical research projects. The donor had a rare "mosaic" form of the condition, in which some of their cells had three sex chromosomes (XXY), some had two X chromosomes, and some had one X and one Y. The researchers reprogrammed all three cell types into induced pluripotent stem cells, which have the capacity to self-renew and to develop into neurons, muscle cells or other cell types.

Ultimately the team generated XX and XY cells that -- apart from their sex chromosomes -- were genetically identical. The researchers then conducted a series of experiments replicating findings from prior studies with other models. For example, they confirmed previously reported differences in genes that were turned on in XX or XY cells. They also coaxed their stem cells to develop into immature versions of neurons and found evidence of previously reported sex differences in early neural development. "It was reassuring to see that the model really shows differences between the sexes that were reported from other systems," Reubinoff says. The findings were published last month in Stem Cell Reports. "This is a very well-designed study that validates the notion that sex differences start early in development -- and that they depend on the sex chromosomes because that's the only thing that can account for those differences," says Nora Engel, a professor of cancer and cell biology at Temple University.

"As a quick follow-up to yesterday's post about InSight's final photo, the InSight Lander's mission is now officially over after 2 failed communications attempts," writes Slashdot reader davidwr. From a NASA press release: NASA's InSight mission has ended after more than four years of collecting unique science on Mars. Mission controllers at the agency's Jet Propulsion Laboratory (JPL) in Southern California were unable to contact the lander after two consecutive attempts, leading them to conclude the spacecraft's solar-powered batteries have run out of energy -- a state engineers refer to as "dead bus."

"I watched the launch and landing of this mission, and while saying goodbye to a spacecraft is always sad, the fascinating science InSight conducted is cause for celebration," said Thomas Zurbuchen, associate administrator of NASA's Science Mission Directorate in Washington. "The seismic data alone from this Discovery Program mission offers tremendous insights not just into Mars but other rocky bodies, including Earth." You can read more about the InSight Mars Lander at NASA's website.

Aria Alamalhodaei writes via TechCrunch: We're going to have to wait a little longer for Rocket Lab's American debut. The company, which is headquartered in Los Angeles, was due to launch a trio of satellites for radio-frequency analytics customer HawkEye 360 to orbit from the company's new site at Virginia Space's Mid-Atlantic Regional Spaceport. It would've marked the first time a Rocket Lab vehicle has taken off from U.S. soil. But the company said late yesterday that strong upper-levels winds made today -- the final day in the launch window -- a no-go, pushing the launch to January.

It's certainly a bummer. The mission was due to have a handful of firsts: Not only marking the first time Electron takes off from U.S. soil, but also the first time a rocket flies with novel flight safety software that Rocket Lab and NASA say is a gamechanger for American launch plans. That software, an autonomous flight termination system, will reduce range costs and prime Rocket Lab to serve the launch needs of the U.S. defense agencies.

"This flight just doesn't symbolize another launch pad for Rocket Lab," CEO Peter Beck told reporters in a media briefing last Wednesday. "It's a standing up of a new capability for the nation." That capability is called the NASA Autonomous Flight Termination Unit (NAFTU), a key component of the Pegasus software, which was jointly developed by Rocket Lab and the space agency. Autonomous flight termination capabilities will be required on all Department of Defense launches by 2025.