NASA's InSight lander has probably phoned home for the last time from the planet Mars. From a report: The space agency said the spacecraft did not respond to communications from Earth on Sunday, December 18. The lack of communications came as the lander's power-generating capacity has been declining in recent months due to the accumulation of Martian dust on its solar panels. NASA said that it is "assumed" that InSight has reached the end of its operations but that it will continue to try to contact the lander in the coming days. Also on Monday, the InSight Twitter account shared a photo with a message saying this was probably the last photo it was sending from Mars. UPDATE 12/21/22: NASA's InSight Mission Officially Over

A new study published in Nature Astronomy assessed the viability of turbines as an energy source for future Mars missions, and "the results hint that wind power could be an important pillar of energy generation on the red planet, assuming humans are able to successfully land there in the coming decades," reports Motherboard. From the report: Scientists have generally written off wind power as a key energy source for Mars missions, compared to solar and nuclear power, because Martian winds are extremely weak. Now, a team led by Victoria Hartwick, a postdoctoral fellow at NASA Ames Research Center, has used global climate models of Mars to show that, contrary to past assumptions, "wind power represents a stable, sustained energy resource across large portions of the Mars surface," according to the study. "Using a state-of-the-art Mars global climate model, we analyze the total planetary Martian wind potential and calculate its spatial and temporal variability," Hartwick and her colleagues said in the study. "We find that wind speeds at some proposed landing sites are sufficiently fast to provide a stand-alone or complementary energy source to solar or nuclear power." "Wind energy represents a valuable but previously dismissed energy resource for future human missions to Mars, which will be useful as a complementary energy source to solar power," the team added.

To assess whether wind power could fill that gap, Hartwick and her colleagues used the NASA Ames Mars global climate model to estimate wind speeds across the planet. Since Mars' atmosphere is very thin, with only 1 percent the density of Earth's atmosphere, Martian winds are pretty wimpy everywhere. Even so, the researchers found that several tantalizing locations could theoretically use wind as the only source of power, and that a combination of solar and wind power would unlock sites across a huge swath of the planet -- including icy locations at the poles.

To that point, the team identified several sites that would be particularly conducive to wind power, including locations within the icy northern regions of Deuteronilus Mensae and Protonilus Mensae. The researchers envision setting up medium-sized turbines, measuring 50 meters (160 feet) tall, to catch the stronger winds in these areas, allowing astronauts to subsist in the strange glacial terrain of an alien world. Turbines could also be effective if placed near topographical gradients, such as crater rims or the slopes of ancient volcanoes, to catch the gusts generated by these landscapes.

Scientists working on Australia's Great Barrier Reef have successfully trialled a new method for freezing and storing coral larvae they say could eventually help rewild reefs threatened by climate change. Reuters: Scientists are scrambling to protect coral reefs as rising ocean temperatures destabilise delicate ecosystems. The Great Barrier Reef has suffered four bleaching events in the last seven years including the first ever bleach during a La Nina phenomenon, which typically brings cooler temperatures. Cryogenically frozen coral can be stored and later reintroduced to the wild but the current process requires sophisticated equipment including lasers. Scientists say a new lightweight "cryomesh" can be manufactured cheaply and better preserves coral.

In a December lab trial, the world's first with Great Barrier Reef coral, scientists used the cryomesh to freeze coral larvae at the Australian Institute of Marine Sciences (AIMS). The coral had been collected from the reef for the trial, which coincided with the brief annual spawning window. "If we can secure the biodiversity of coral ... then we'll have tools for the future to really help restore the reefs and this technology for coral reefs in the future is a real game-changer," Mary Hagedorn, Senior Research Scientist at Smithsonian National Zoo and Conservation Biology Institute told Reuters from the AIMS lab.

Long-time Slashdot reader schwit1 shares a report from Science Alert: Could the sweetened drinks we're consuming be making us feel a little more anxious? A new study looking at the effects of the artificial sweetener aspartame on mice suggests that it's a possibility that's worth investigating further.

Approved by the US Food and Drug Administration (FDA) in 1981, aspartame is widely used in low-calorie foods and drinks. Today, it's found in nearly 5,000 different products, consumed by adults and children. When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

What's truly surprising is the effects could be seen in the animals' offspring, for up to two generations...

When the mice were given doses of diazepam — a drug once marketed as Valium, which is commonly used to treat anxiety in humans — anxiety-like behaviors stopped across all generations. The medication helps to regulate the same pathways in the brain that are altered by the effects of the aspartame.

An announcement from the University of Illinois Urbana-Champaign: An almost limitless supply of fresh water exists in the form of water vapor above Earth's oceans, yet remains untapped, researchers said. A new study from the University of Illinois Urbana-Champaign is the first to suggest an investment in new infrastructure capable of harvesting oceanic water vapor as a solution to limited supplies of fresh water in various locations around the world.

The study, led by civil and environmental engineering professor and Prairie Research Institute executive director Praveen Kumar, evaluated 14 water-stressed locations across the globe for the feasibility of a hypothetical structure capable of capturing water vapor from above the ocean and condensing it into fresh water — and do so in a manner that will remain feasible in the face of continued climate change. Kumar, graduate student Afeefa Rahman and atmospheric sciences professor Francina Dominguez published their findings in the journal Nature Scientific Reports....

"Eventually, we will need to find a way to increase the supply of fresh water as conservation and recycled water from existing sources, albeit essential, will not be sufficient to meet human needs. We think our newly proposed method can do that at large scales," Kumar said.

The researchers performed atmospheric and economic analyses of the placement of hypothetical offshore structures 210 meters in width and 100 meters in height. Through their analyses, the researchers concluded that capturing moisture over ocean surfaces is feasible for many water-stressed regions worldwide. The estimated water yield of the proposed structures could provide fresh water for large population centers in the subtropics....

"The climate projections show that the oceanic vapor flux will only increase over time, providing even more fresh water supply," graduate student Afeefa Rahman said. "So, the idea we are proposing will be feasible under climate change. This provides a much needed and effective approach for adaptation to climate change, particularly to vulnerable populations living in arid and semi-arid regions of the world." The researchers said one of the more elegant features of this proposed solution is that it works like the natural water cycle. "The difference is that we can guide where the evaporated water from the ocean goes," Dominguez said....

The researchers said this study opens the door for novel infrastructure investments that can effectively address the increasing global scarcity of fresh water.
Thanks to Slashdot reader L.Kynes for submitting the news.

The New York Times cites predictions from American's Defense Department that China could surpass U.S. space capabilities as soon as 2045. "I think it's entirely possible they could catch up and surpass us, absolutely," said the staff director of the United States Space Force. "The progress they've made has been stunning — stunningly fast."

But in a new article this week, the newspaper notes that China recenty sent space probes to the moon and to Mars — and invited foreign media to the launch of its space station in November — and looks back over decades of development: Thirty years ago, the Chinese government initiated a secret plan for its space program, including a key goal of building a space station by 2020. At the time, the country was 11 years from sending its first astronaut into space, and its space efforts were going through a rough patch: Chinese rockets failed in 1991, 1992, 1995 and twice in 1996. The worst failure, in 1996, was a rocket that tipped to the side, flew in the wrong direction and exploded 22 seconds after launch, showering a Chinese village with falling wreckage and flaming fuel that killed or injured at least 63 people.

While grand spaceflight plans of some nations have ended up many years behind schedule, China completed the assembly in orbit of its Tiangong space station in late October, only 22 months later than planned. And on Nov. 29, the Shenzhou 15 mission blasted off from China's Jiuquan Satellite Launch Center deep in the Gobi Desert and took three astronauts to the space station to begin permanent occupancy of the outpost.
The article notes that the U.S. Congress "ended up banning American space agencies in 2011 from spending any money to cooperate in space with China, except in limited circumstances."

But today Zhou Jianping, chief designer of China's crewed space program, asserts that "within a few years, we will be able to achieve the reuse of re-entry capsules for our new generation spaceships." Sending a person to Mars is an even bigger prize for China. It has placed an emphasis on shortening the duration of such a trip, perhaps with nuclear propulsion instead of conventional rocket engines. Officials are also determined that any journey will be a round-trip from which all astronauts return alive and in good health.... With nuclear propulsion, the trip could be trimmed to 500 days, Mr. Zhou said, without predicting whether China would adopt that approach.

A new study published in the journal PLoS ONE has reported on the first human tests of an experimental therapy using sound and light to treat Alzheimer's disease (AD). New Atlas reports: Over the last seven years, Li-Huei Tsai and colleagues at MIT's Picower Institute for Learning and Memory have been investigating an unusual hypothesis. The researchers found toxic proteins associated with Alzheimer's disease could be eliminated from mouse brains following exposure to flickering lights. Further research found the magic frequency was 40 Hz. When animals were exposed to both sound and light at that frequency, improvements in brain health were detected. Of course, these kinds of animal tests don't mean much if they can't be replicated in humans, so after further investigations revealed how this sensory therapy could be affecting a mouse brain, the researchers started preliminary human experiments. Working with colleagues at Massachusetts General Hospital, two clinical trials set out to test the therapy in humans.

The first Phase 1 study recruited 43 participants to test whether this kind of light and sound exposure was safe, and did anything to the human brain. Each subject was monitored using EEG measures while experiencing a short exposure to what has been dubbed by the researchers as GENUS (Gamma ENtrainment Using Sensory stimulation). This preliminary study comprised both healthy and cognitively impaired subjects, as well as participants with epilepsy in order to evaluate the seizure potential of the treatment. After a short exposure to the sensory stimulation, the researchers found a number of brain regions synchronize with the 40-Hz frequency.

The second trial recruited 15 participants with early-stage Alzheimer's disease. Each participant was given a device to take home and use for around an hour a day. The device was essentially a small LED white board with an iPad in the middle and a soundbar underneath. While watching videos on the iPad, the LED light panel on the white board would flicker at a rate of 40 Hz and the soundbar would play a 40-Hz tone. Half the cohort was randomized to a sham control condition, exposed to a constant white light and white noise. Compliance was relatively high between both the GENUS and the sham groups, with participants completing the daily requirement of exposure around 90 percent of the time. After around three months of use the researchers could detect statistically significant differences between the two groups, both on brain imaging and memory tests. The researchers are cautious not to overstate their initial findings, the report says. "It's early days for human studies [...], larger cohorts of patients are needed to better understand the impacts of this sensory stimulation and longer trials will hopefully establish more prominent beneficial effects."

Longtime Slashdot reader necro81 writes: A Soyuz spacecraft (MS-22) docked at the International Space Station appears to have developed a coolant leak, according to NASA and various news sources. YouTuber Scott Manley has further background and explanation.

The cause and severity are presently not known. There is no immediate danger to the crew. The leak was discovered during preparations for a planned spacewalk, which has since been cancelled. This Soyuz is the return spacecraft for three of the ISS' residents, but after this failure a replacement spacecraft may need to sent up.

A NASA-led international satellite mission was set for blastoff from Southern California early on Thursday on a major Earth science project to conduct a comprehensive survey of the world's oceans, lakes and rivers for the first time. Reuters reports: Dubbed SWOT, short for Surface Water and Ocean Topography, the advanced radar satellite is designed to give scientists an unprecedented view of the life-giving fluid covering 70% of the planet, shedding new light on the mechanics and consequences of climate change. A Falcon 9 rocket, owned and operated by billionaire Elon Musk's commercial launch company SpaceX, was set to liftoff before dawn on Thursday from the Vandenberg U.S. Space Force Base, about 170 miles (275 km) northwest of Los Angeles, to carry SWOT into orbit. If all goes as planned, the SUV-sized satellite will produce research data within several months.

Nearly 20 years in development, SWOT incorporates advanced microwave radar technology that scientists say will collect height-surface measurements of oceans, lakes, reservoirs and rivers in high-definition detail over 90% of the globe. The data, compiled from radar sweeps of the planet at least twice every 21 days, will enhance ocean-circulation models, bolster weather and climate forecasts and aid in managing scarce freshwater supplies in drought-stricken regions, according to researchers. One major thrust of the mission is to explore how oceans absorb atmospheric heat and carbon dioxide in a natural process that moderates global temperatures and climate change. [...] SWOT's ability to discern smaller surface features also be used to study the impact of rising ocean levels on coastlines.

An anonymous reader quotes a report from The Guardian: Genomics England is to test whether sequencing babies' genomes at birth could help speed up the diagnosis of about 200 rare genetic diseases, and ensure faster access to treatment. The study, which will sequence the genomes of 100,000 babies over the next two years, will explore the cost-effectiveness of the approach, as well as how willing new parents are to accept it. Although researchers will only search babies' genomes for genetic conditions that surface during early childhood, and for which an effective treatment already exists, their sequences will be held on file. This could open the door to further tests that could identify untreatable adult onset conditions, or other genetically determined traits, in the future.

The study aims to recruit 100,000 newborn children to undergo voluntary whole genome sequencing over the next two years, to assess the feasibility and effectiveness of the technology – including whether it could save the NHS money by preventing serious illness. It will also explore how researchers might access an anonymized version of this database to study people as they grow older, and whether a person's genome might be used throughout their lives to inform future healthcare decisions. For instance, if someone develops cancer when they are older, there may be an opportunity to use their stored genetic information to help diagnose and treat them. Dr Richard Scott, chief medical officer at Genomics England, said: "At the moment, the average time to diagnosis in a rare disease is about five years. This can be an extraordinary ordeal for families, and it also puts pressure on the health system. The question this program is responding to is: 'is there a way that we can get ahead of this?'"

"The bottom line here is about us taking a cautious approach, and developing a view jointly nationally about what the right approach is, and what the right safeguards are," he added.

An anonymous reader quotes a report from the Associated Press: The company said a possible melanoma vaccine it is studying with pharmaceutical giant Merck fared well in a small study of patients who had the cancer surgically removed. The drugmakers said a combination of the vaccine and Merck's immunotherapy Keytruda led to a statistically significant improvement in survival before the cancer returned in patients with advanced melanoma. [...] Like Spikevax (the vaccine used to help protect against COVID-19), the potential skin cancer vaccine uses mRNA technology. It trains a patient's immune system to recognize and respond specifically to mutations in the DNA of the patient's tumor.

In a mid-stage clinical trial involving 157 patients, researchers compared the vaccine-Keytruda combination with Keytruda alone. Keytruda, Merck's top seller, primes the body's immune system to detect and fight tumor cells. Regulators have approved it to treat several types of cancer. The patient group that took the potential vaccine and Keytruda saw a 44% reduction in the risk of death or the cancer returning, the companies said. The treatments continued for about a year in both groups unless the disease came back or side effects became too severe. Merck and Moderna expect to start a phase 3 study next year, and the companies say they intend to expand their approach to other tumor types.

Scientists studying fusion energy at Lawrence Livermore National Laboratory in California announced on Tuesday that they had crossed a major milestone in reproducing the power of the sun in a laboratory. From a report: Scientists for decades have said that fusion, the nuclear reaction that makes stars shine, could provide a future source of bountiful energy. The result announced on Tuesday is the first fusion reaction in a laboratory setting that actually produced more energy than it took to start the reaction.

"This is such a wonderful example of a possibility realized, a scientific milestone achieved, and a road ahead to the possibilities for clean energy," Arati Prabhakar, the White House science adviser, said during a news conference on Tuesday morning at the Department of Energy's headquarters in Washington, D.C. "And even deeper understanding of the scientific principles that are applied here." From an environmental perspective, fusion has always had a strong appeal. Within the sun and stars, fusion continually combines hydrogen atoms into helium, producing sunlight and warmth that bathes the planets.

In experimental reactors and laser labs on Earth, fusion lives up to its reputation as a very clean energy source, devoid of the pollution and greenhouse gases produced by the burning of fossil fuels and the dangerous long-lived radioactive waste created by current nuclear power plants, which use the splitting of uranium to produce energy. There was always a nagging caveat, however. In all of the efforts by scientists to control the unruly power of fusion, their experiments consumed more energy than the fusion reactions generated. That changed at 1:03 a.m. on Dec. 5 when 192 giant lasers at the laboratory's National Ignition Facility blasted a small cylinder about the size of a pencil eraser that contained a frozen nubbin of hydrogen encased in diamond.

An anonymous reader quotes a report from New Atlas: While anti-fog sprays work to a certain extent, warming a glass surface is a better way of keeping it fog-free. A new coating material is designed to do so, and it utilizes light-absorbing gold nanoparticles instead of electricity. Most of the anti-fog sprays used on things like eyeglasses incorporate hydrophilic (water-attracting) molecules. These draw in and evenly dispense condensation, making it easier to see through. By contrast, your car's rear window uses integrated elements to heat the glass, keeping condensation from forming in the first place.

Developed by a team at the ETH Zurich research institute, the new coating likewise uses heat -- but it doesn't require electricity. Instead, it uses a layer of clustered gold nanoparticles, sandwiched between two ultra-thin layers of titanium oxide -- the whole coating is just 10 nanometers thick, which is about one twelfth the thickness of a sheet of gold leaf. The gold nanoparticles absorb much of the infrared spectrum of incoming sunlight, causing the coating to become up to 8 degrees Celsius (14 degrees Fahrenheit) warmer than the ambient temperature. That said, the nanoparticles absorb very little visible light, allowing the coating to stay transparent. The refractive properties of the titanium oxide boost the efficiency of the heating effect. Additionally, the outer layer helps protect the gold from wear and tear. And as an added bonus, because the gold layer is electrically conductive, a power source such as a battery could be used to heat the coating when direct sunlight isn't an option. The study has been published in the journal Nature Nanotechnology.

"A teenage girl's incurable cancer has been cleared from her body," reports the BBC, "in the first use of a revolutionary new type of medicine...." Doctors at Great Ormond Street Hospital used "base editing" to perform a feat of biological engineering to build her a new living drug. Six months later the cancer is undetectable, but Alyssa is still being monitored in case it comes back.

Alyssa, who is 13 and from Leicester, was diagnosed with T-cell acute lymphoblastic leukaemia in May last year.... Her cancer was aggressive. Chemotherapy, and then a bone-marrow transplant, were unable to rid it from her body.... The team at Great Ormond Street used a technology called base editing, which was invented only six years ago [which] allows scientists to zoom to a precise part of the genetic code and then alter the molecular structure of just one base, converting it into another and changing the genetic instructions. The large team of doctors and scientists used this tool to engineer a new type of T-cell that was capable of hunting down and killing Alyssa's cancerous T-cells....

After a month, Alyssa was in remission and was given a second bone-marrow transplant to regrow her immune system.... Alyssa is just the first of 10 people to be given the drug as part of a clinical trial.
Her mother said that a year ago she'd been dreading Christmas, "thinking this is our last with her". But it wasn't.

And the BBC adds that applying the technology to cancer "only scratches the surface of what base editing could achieve.... There are already trials of base editing under way in sickle-cell disease, as well as high cholesterol that runs in families and the blood disorder beta-thalassemia."

Theoretical physicist Sankar Das Sarma wrote a thought-provoking essay for New Scientist magazine's Lost in Space-Time newsletter: I was recently reading an old article by string theorist Robbert Dijkgraaf in Quanta Magazine entitled "There are no laws of physics". You might think it a bit odd for a physicist to argue that there are no laws of physics but I agree with him. In fact, not only do I agree with him, I think that my field is all the better for it. And I hope to convince you of this too.

First things first. What we often call laws of physics are really just consistent mathematical theories that seem to match some parts of nature. This is as true for Newton's laws of motion as it is for Einstein's theories of relativity, Schrödinger's and Dirac's equations in quantum physics or even string theory. So these aren't really laws as such, but instead precise and consistent ways of describing the reality we see. This should be obvious from the fact that these laws are not static; they evolve as our empirical knowledge of the universe improves.

Here's the thing. Despite many scientists viewing their role as uncovering these ultimate laws, I just don't believe they exist.... I know from my 40 years of experience in working on real-life physical phenomena that the whole idea of an ultimate law based on an equation using just the building blocks and fundamental forces is unworkable and essentially a fantasy. We never know precisely which equation describes a particular laboratory situation. Instead, we always have to build models and approximations to describe each phenomenon even when we know that the equation controlling it is ultimately some form of the Schrödinger equation!
Even with quantum mechanics, space and time are variables that have to be "put in by hand," the article argues, "when space and time should come out naturally from any ultimate law of physics. This has remained perhaps the greatest mystery in fundamental physics with no solution in sight...."

"It is difficult to imagine that a thousand years from now physicists will still use quantum mechanics as the fundamental description of nature.... I see no particular reason that our description of how the physical universe seems to work should reach the pinnacle suddenly in the beginning of the 21st century and become stuck forever at quantum mechanics. That would be a truly depressing thought...!"

"Our understanding of the physical world must continue indefinitely, unimpeded by the search for ultimate laws. Laws of physics continuously evolve — they will never be ultimate."

Thanks to long-time Slashdot reader InfiniteZero for sharing the article!

Splashdown successful. The announcer on NASA's livestream called it a "text-book entry" for "America's new ticket to ride -- to the moon and beyond."

After flying over 239,000 miles — and 80 miles over the surface of the moon — NASA's uncrewed "Orion" capsule has returned from its 25-and-a-half day test flight in space.

NASA is still streaming its coverage. And CNN had emphasized that "This final step will be among the most important and dangerous legs of the mission." "We're not out of the woods yet. The next big test is the heat shield," NASA Administrator Bill Nelson told CNN in a phone interview Thursday, referring to the barrier designed to protect the Orion capsule from the excruciating physics of reentering the Earth's atmosphere. The spacecraft will be traveling about 32 times the speed of sound (24,850 miles per hour or nearly 40,000 kilometers per hour) as it hits the air — so fast that compression waves will cause the outside of the vehicle to heat to about 5,000 degrees Fahrenheit (2,760 degrees Celsius)....

As the capsule reaches around 200,000 feet (61,000 meters) above the Earth's surface, it will perform a roll maneuver that will briefly send the capsule back upward — sort of like skipping a rock across the surface of a lake.... "By dividing the heat and force of reentry into two events, skip entry also offers benefits like lessening the g-forces astronauts are subject to," said Joe Bomba, Lockheed Martin's Orion aerosciences aerothermal lead, in a statement....

As it embarks on its final descent, the capsule will slow down drastically, shedding thousands of miles per hour in speed until its parachutes deploy. By the time it splashes down, Orion will be traveling 20 miles per hour (32 kilometers per hour). While there are no astronauts on this test mission — just a few mannequins equipped to gather data and a Snoopy doll — Nelson, the NASA chief, has stressed the importance of demonstrating that the capsule can make a safe return.

This week the Atlantic published its list of "the 10 Most Promising Breakthrough Innovations of 2022."

"We didn't just get one 'unheard-of' cancer breakthrough; we got several in one year...." Is death reversible? It was this year for several pigs (or, at least, for their organs). By pumping an experimental substance into the veins and arteries of animals that had been lying deceased for an hour, Yale researchers got their hearts to start beating again. The technology is "very far away from use in humans," Stephen Latham, a bioethicist at Yale University, told The New York Times. In the short term, scientists said, they hope that their research could help doctors preserve the organs of the recently deceased for use in transplants. But the longer-term implications of the experiment can't be ignored: If we have the power to reanimate the heart or other organs of the recently deceased, at what point might we be able to reverse sudden deaths? Could we revive soldiers who bleed out on the battlefield? Could we stock hospitals and nursing homes with buckets of the stuff to resuscitate patients? Should every future American household keep some on hand in the event of a terrible accident?

These questions thrust us into the ethical realm and invoke spooky references to "The Monkey's Paw," Pet Sematary, and any number of stories about the dark side of trying to design an escape hatch from mortality. Perhaps, as this technology improves, that debate is on its way. But for millions of people who have lost loved ones to, say, a sudden heart attack or stroke, it's not remotely dystopian to imagine an injection that could reverse tragedies long considered irreversible....

The Power to Synthesize Life (Kind Of)
This summer, scientists grew an embryo in a lab without the use of sperm, or eggs, or a womb. It happened to be that of a mouse. But the species is of secondary importance.... Some scientists I consulted for this project said that the results, which were published this year in the science journal Cell, were the most important scientific breakthrough of 2022.

Scientists are not close to turning stem cells into human babies that make their first gasping cries in antiseptic laboratories. But this work does suggest a major leap forward in our ability to grow synthetic organs and more closely research the relationship between embryonic mutations and developmental diseases. As Paul Tesar, a developmental biologist at Case Western Reserve University School of Medicine, told Stat, "As soon as the science starts to move into a place where it's feasible to go from a stem cell population in a Petri dish all the way through to organ development, it's a pretty wild and remarkable time."
The article also notes that NuScale's small nuclear reactors received approval from the U.S. Nuclear Regulatory Commission, and "could be running by the end of the decade." Meanwhile, the start-up Quaise is working on drilling technology "that can vaporize granite with a highly concentrated beam of radio-frequency power. If such a technology became widely available, deep drilling would be commonplace and geothermal energy would be accessible on just about any patch of land. It would be as though humankind conceived of a magic wand that, waved across the Earth, makes any square mile as energy-rich as an oil-gushing stretch of Texas or Saudi Arabia."

The article also suggests one more possibility for the future. "Decades from now, millions of people may actually prefer the consistency and taste of meat that didn't come from an animal, because they'll know what they're buying when a cultivated rib eye is as consistent as an electrical gadget."

"After decades in the shadow of the reigning model for Alzheimer's disease, alternative explanations are finally getting the attention they deserve," writes Quanta magazine — in a 10,000-word update on where we are now: Three decades ago, scientists thought they had cracked the medical mystery of what causes Alzheimer's disease with an idea known as the amyloid cascade hypothesis. It accused a protein called amyloid-beta of forming sticky, toxic plaques between neurons, killing them and triggering a series of events that made the brain waste away.... Decades of work and billions of dollars went into funding clinical trials of dozens of drug compounds that targeted amyloid plaques. Yet almost none of the trials showed meaningful benefits to patients with the disease....

A stream of recent findings has made it clear that other mechanisms may be at least as important as the amyloid cascade as causes of Alzheimer's disease.... The emerging new models of the disease are more complex than the amyloid explanation, and because they are still taking shape, it's not clear yet how some of them may eventually translate into therapies. But because they focus on fundamental mechanisms affecting the health of cells, what's being learned about them might someday pay off in new treatments for a wide variety of medical problems, possibly including some key effects of aging.... While these alternate ideas were once hushed and thrown under the rug, now the field has broadened its attention.
The article explores the theory — derived from research on genetically-engineered mice — that neurons bulging with toxic accumulations of proteins and molecules could be mistaken for classic amyloid plaques outside cells. (But in fact "the extracellular amyloid plaques weren't killing the cells — because the cells were already dead.") Scientists are now also investigating lysosomes, cholesterol metabolism, and even the immune system.

To say that the amyloid hypothesis is dead would be overstating it, said Donald Weaver, a co-director of the Krembil Brain Institute in Toronto, but "I would say that the amyloid hypothesis is insufficient...."

By 2017, 146 drug candidates for treating Alzheimer's disease had been deemed unsuccessful. Only four drugs had been approved, and they treated the symptoms of the disease, not its underlying pathology. The results were so disappointing that in 2018, Pfizer pulled out of Alzheimer's research. A 2021 review that compared the results of 14 of the major trials confirmed that reducing extracellular amyloid did not greatly improve cognition....

The hypothesis took another hit last July when a bombshell article in Science revealed that data in the influential 2006 Nature paper linking amyloid plaques to cognitive symptoms of Alzheimer's disease may have been fabricated. The connection claimed by the paper had convinced many researchers to keep pursuing amyloid theories at the time.

Astronomers searched through 200,000 archival images from Hubble Space Telescope and made tens of thousands of measurements on these images to look for any residual background glow in the sky. Like turning out the lights in a room, they subtracted the light from stars, galaxies, planets and the zodiacal light. Surprisingly, a ghostly, feeble glow was left over. It's equivalent to the steady light of ten fireflies spread across the entire sky. Phys.Org reports: One possible explanation is that a shell of dust envelops our solar system all the way out to Pluto, and is reflecting sunlight. Seeing airborne dust caught in sunbeams is no surprise when cleaning the house. But this must have a more exotic origin. Because the glow is so smoothy distributed, the likely source is innumerable cometsâ"free-flying dusty snowballs of ice. They fall in toward the sun from all different directions, spewing out an exhaust of dust as the ices sublimate due to heat from the sun. If real, this would be a newly discovered architectural element of the solar system. It has remained invisible until very imaginative and curious astronomers, and the power of Hubble, came along. The research papers are published in The Astronomical Journal and The Astrophysical Journal Letters.

One of the great differences between Mars and Earth involves what's going on beneath the surface. Our planet remains a tectonically and volcanically active world -- witness the current eruptions in Hawaii -- while Mars has been a cold, geologically dead place for the past three billion years. That was the thinking at least. But a new paper in Nature Astronomy challenges that accepted wisdom. Mars, it suggests, may still be geologically active today. Time: The findings are the result of orbital photography, surface data, and computer modeling of a lowland region near the Martian equator known as Elysium Planitia -- where NASA's Mars InSight probe landed in 2018. Researchers from the University of Arizona Lunar and Planetary Laboratory analyzed recordings of Mars quakes taken by InSight and concluded that they all result from a series of subsurface fissures dubbed Cerberus Fossae, which stretch nearly 1,300 km (800 mi.) across the Martian surface. This gives rise to what are known as mantle plumes: blob-like masses of molten rock that rise to reach the base of the crust, causing quakes, faulting, and volcanic eruptions. Computer modeling of the region indicates that far from being geologically dead, Elysium Planitia experienced major volcanic eruptions as recently as 200 million years ago.