Alzheimer's Progresses Faster in Educated People 226
Nrbelex writes "Bloomberg news is reporting that 'High levels of education speeds up the progression of Alzheimer's disease, according to a study published in next month's issue of the Journal of Neurology, Neurosurgery and Psychiatry. Mental agility dropped every year among Alzheimer's disease patients with each additional year of education, leading to an additional 0.3 percent deterioration, the researchers from the Columbia University Medical Center in New York found. The speed of thought processes and memory were particularly affected.'"
Have the statistics been properly done here? (Score:3, Interesting)
Re:Have the statistics been properly done here? (Score:3, Insightful)
That's assuming they get to the end point at the same time, which may not be true.
Given statistics been properly done here ... (Score:2)
That's assuming they get to the end point at the same time, which may not be true.
The end point of Alzheimers is death. Yes, it's true.
But you raise a good followup research study question there.
Remember that the data is observed over many years, partially through other people's observations, and measurements
Re:Have the statistics been properly done here? (Score:2)
If I stole Bill Gates' lunch money, he'd still have plenty of dough left.
Re:Have the statistics been properly done here? (Score:5, Interesting)
I guess there was more truth there than the authors realized.
Education vs Intelligence (Score:4, Insightful)
This study is really saying that in cases where people have been socially conditioned for a longer period of time are better able to fend off Alzheimer's for longer periods.
Genius is usually associated with strange social behavior or thinking and just a step away from madness. Educated people are predictable and controllable and well...social.
They are just more structured, maybe that structure just helps them hang on a bit longer before they fall. I get the feeling that all the commentators are mistaking "knowing things" with being intelligent.
Re:Have the statistics been properly done here? (Score:5, Interesting)
The researchers said one possible explanation is what has been dubbed the "cognitive reserve" theory.
This holds that highly educated people either have a greater number of nerve connections in their brains, or the nerve connections that they have are more efficient.
Therefore, when the damaging changes associated with Alzheimer's - such as the deposition of toxic protein clumps - start to take place, educated people are better placed to resist their effect at first.
However, the subsequent impact is likely to be greater than it would be in less educated brains, because of the higher levels of accumulated damage.
In other words (I think), educated people simply don't show the effects of Alzheimers as fast. By the time anybody notices that anything is wrong, a great deal of damage already exists. So since it is already at a later stage when you first notice it, it looks from the outside as though the person has very quickly reached an advanced stage of Alzheimers. Instead, they have been resisting Alzheimers for ages.
There was a New Scientist article about this...
Re:Have the statistics been properly done here? (Score:2)
After I read this story, I couldn't get a line from Blade Runner out of my head: "A candle that burns twice as bright, burns half as long."
And some candles are bigger than others.
Re:Have the statistics been properly done here? (Score:2, Insightful)
If you have more to lose, and you are set to the same level as someone with less to lose, you have lost more.
The statistics are probably fine, but the analysis seems flawed.
Re:Have the statistics been properly done here? (Score:3, Informative)
Re:Have the statistics been properly done here? (Score:2)
Also note later in the study that this was the result of only 312 patients in NYC. I have to wonder how many significant digits the 0.3% per year degradation number has. For me, this is hardly conclusive.
Re:Have the statistics been properly done here? (Score:2)
Well, I have a degree in Psych. and am a security engineer (I know, I know... but it's the title on my business cards) for a large global company. I am also one of the few subject matter experts in crypto at our company. Except for some very specialized training (mostly crypto), most of my IT knowledge wa
Makes Sense (Score:2, Funny)
Re:Makes Sense (Score:5, Funny)
This administration is doing its best to make that a reality
Re:Makes Sense (Score:2)
Re:Makes Sense (Score:2)
An old joke (Score:2)
The more you know, the more you forget.
The more you forget, the less you know.
So why study?
Um, I either forgot or never knew who first wrote that.
Re:Makes Sense (Score:2)
Finally.. a reason to be proud of my horrible memory.
Maybe... (Score:5, Insightful)
So what (Score:3, Funny)
Curry ...Tumeric ...ALZ.... (Score:2)
with only 1% of people 65 and older having the condition.
The specific ingredient has been narrowed down to tumeric, the
spice often used in spicy mustard
A recent study suggests that the reason might be a diet high in curcumin,
a compound found in turmeric which is used in curry, which has long been
used as an herbal treatment in that country.
http://www.alz.org/News/04Q4/122304.asp [alz.org]
Once again nature provides, I wonder what other cures simple gro
Re:Maybe... (Score:2)
Re:Maybe... (Score:2)
A Disease for Stupid People...? (Score:3, Funny)
Re:A Disease for Stupid People...? (Score:5, Insightful)
From Bloomberg UK: Previous studies have shown that people with high levels of education are less likely to develop Alzheimer's disease. The new study shows that the brains of more educated people can tolerate changes for longer periods of time, meaning signs of decreased mental agility typical of Alzheimer's disease appear later. When those signs do appear, the disease progresses faster than it does in less educated patients.
So the results of this one study don't mean much. If all previous research shows the opposite, then either a) this study is flawed and the conclusions inaccurate or b) this study uses new methodology, breaks new ground, and has discovered a new series of conditions for Alzheimer's propogation. The results won't be conclusive until more studies of this same type are produced verifying these results.
Re:A Disease for Stupid People...? (Score:3, Insightful)
"Previous studies have shown that people with high levels of education are less likely to develop Alzheimer's disease."
In other words, there is a negative correlation between education level and developing Alzheimer's.
"The new study shows that the brains of more educated people can tolerate changes for longer periods of time, meaning signs of decreased mental agil
Upon further review... (Score:2)
Faux pas; I didn't parse out the meaning of the sentence properly. I retract my statement.
Re:A Disease for Stupid People...? (Score:2)
They are comparing the progression of the disease *after* the signs have been detected. People with higher levels of education manage to tolerate the effects of the disease longer before the signs appear. Thus Alzheimer is detected at later stages in those people.
If you are rolling down a hill and realize what's happening later than the others, you'll find yourself going faster.
Does it really mean (Score:5, Insightful)
Braking from 100 km/h to 0 in 5 seconds is a harder deceleration than from 30 km/h to 0 in 5 seconds, for sure.
causal versus symptomatic (Score:3, Insightful)
Besides, 0.3 percent difference sounds awfully low. I highly doubt that their margin of error could have even been close to this, given that these are human subjects, after all.
Could it possibly be... (Score:2)
Dementia (Score:2, Interesting)
Yeah, seriously, people, it's not just "knowledge going away" - though there is that. It's a grown man barricading a door at night, thinking his 6-year old niece might be a serious threat to him. It's these weird bipolar shifts in attitudes and perceptions. Somebody can be their best friend one day, and an unscrupulous traitor the next.
I think I could deal with my dad becoming forgetful, losing capability to work with computers and electronics, and so on - though that's sad, too,
A bit misleading title (Score:5, Informative)
Previous studies have shown that people with high levels of education are less likely to develop Alzheimer's disease. The new study shows that the brains of more educated people can tolerate changes for longer periods of time, meaning signs of decreased mental agility typical of Alzheimer's disease appear later. When those signs do appear, the disease progresses faster than it does in less educated patients.
So, the more educated are actually less likely to have symptoms at the same age. I'm curious how they measured the drop off in ability, and the article doesn't say.
Re:A bit misleading title (MOD PARENT UP) (Score:5, Insightful)
The most worthwhile comment so far on the whole thread.
The previous studies have shown that people with high levels of education are less likely to develop the disease, which was interesting and a bit mystifying.
This study shows that perhaps that's not really what's going on. Perhaps something about education that makes you more resistant to the disease and more able to compensate for the slow decline it induces, but once you do start declining, it happens faster. The two studies together make a lot of sense and point to a mechanism. Either taken alone seems a bit strange.
Re:A bit misleading title (MOD PARENT UP) (Score:3, Insightful)
Re:A bit misleading title (MOD PARENT UP) (Score:2)
Re:A bit misleading title (Score:2, Insightful)
http://www.neuroanatom [wisc.edu]
Happy Morons (Score:3, Funny)
No need to understand
I wish I was a moron
My God! perhaps I am!
Re:Happy Morons (Score:2)
Bogus (Score:5, Insightful)
Re:Bogus (Score:4, Informative)
Well, it is already established that more educated people have a lower risk [nih.gov] of Alzheimer's, and a later onset [nih.gov]. This study, however, follows a few hundred already diagnosed patients for five years, and notes that the rate of cognitive decline is faster in the more educated patients. Probably they just didn't have enough coffee [nih.gov] Be a little more interesting when the study itself is available instead of the press release.
Re:Bogus, or Why Coffee Is Critical (Score:2)
Personally, I think they should all just move to Seattle and drink more coffee.
Oh, wait, th
Physical activity differences (Score:2)
I'd be curious to see how this study lines up with those that suggest that regular physical activity helps to fend off such degenerative neural problems. That might tie in with the more sedentary existence that many white-collar types find themselves living as they become "knowledge" workers sitting at a desk. You know: the types that, instead of a brisk walk, take a break from working in front
Re:Bogus (Score:2)
Unless you're like the so many of us who are past our late twenties and still in grad school.
0.3%?? (Score:5, Insightful)
Re:0.3%?? (Score:5, Insightful)
Every time a study is linked here, somebody starts spouting off about a sample of N people can't be significant or how some small effect size can't be significant. That's not how statistical significance works.
For the youngsters here, I'd strongly recommend taking time out from your CS classes to take an introductory stat class....
Re:0.3%?? (Score:2)
How could you possibly know that? (Score:3, Informative)
Ok, Statty Mc Statenstein, do the math for us. I've included a handy link to test for significance, all you have to do is plug in the numbers and give us your answers.
http://www.coolth.com/siginsig.htm [coolth.com]
http://www.infoworks.ride.uri.edu/2000/techbrief/t echbrief5.htm [uri.edu]
http://www.visualstatistics.net/Visual%20Statistic s%20Multimedia/z_square_ratio.htm [visualstatistics.net]
Since we all like to have facts that support our arguments, all you have to d
Re:0.3%?? (Score:2)
That's just wrong. Unless you see the data and their analysis technique, you really don't know how the conclusions were reached. In their paper, you would expect to find a section on how data was collected, the assumptions being made, and the statistical methods used to draw their conclusions. Correlation isn't an on/off phenomenem, there can be weak correlation and strong correlation. Just because there is a weak cor
Re:0.3%?? (Score:2)
Deterioration not noticeable? (Score:2)
Like this
If the jar was full
Or, maybe the "undeducated" have more redundancy built in, which is probably why some of them hold on to what the educated consider "strange" beliefs.
I'm just speculating here. Also, as a tr
RIP: Claue Shannon (Score:2)
Re:RIP: Claue Shannon (Score:2)
I was hoping for the rantings of a half-crazed man who has just figured out that he's lost his mind.
Re:RIP: Claue Shannon (Score:3, Funny)
Wrong article - try this one: http://apple.slashdot.org/article.pl?sid=06/02/16
yeah ok (Score:3, Insightful)
I'm lost (Score:2, Funny)
Beginner! (Score:2)
Er... though I still don't have my MS. (Done in May. *crossfingers*)
Does this make me "more" educated, because of the total time involved, or "less" because I've spread it all out over such a long period of time? (low [credits/year] average.)
Perhaps it has already begun.
Anyone hiring ElecEngs? I'll only be there a bit before retirement!
Where's my teeth?!
Not so fast.... (Score:3, Informative)
The actual rate of decline, they claimed, is no different.
Additional 0.3% deterioration? (Score:5, Interesting)
"All the patients underwent around four neurological assessments, each of which comprised a dozen separate tests of brain function."
Given that Alzheimers affects everyone in different ways, I guess I'm just a little leery of a study that's claiming that it can quantitatively compare the mental facilities of one victim to another.
Re:Additional 0.3% deterioration? (Score:2)
Actually, "Alzheimer's disease" affects people in relatively similar ways, whereas "dementia" affects everyone in different ways. This is because "Alzheimer's disease" is one *very specific* type of "dementia." Simply because one is "demented" does not imply they have "Alzheimer's disease." Other forms of dementia include Vascular Dementia, Parkinson's Dementia, Diffuse Lewy Body Disease, Korsakoff's Dementia, etc... (to name just a few). Know
MOD PARENT UP:Additional 0.3% deterioration? (Score:2)
Re:Additional 0.3% deterioration? How tested (Score:2)
"All the patients underwent around four neurological assessments, each of which comprised a dozen separate tests of brain function."
Well, let's see, there's a Physical evaluation, Hachinski Ischemic Scale, UPDRS Motor Exam, Clinical Dementia Rating Scale (CDR), Neuropsychiatric Inventory (NPI), Behavioral Assesment - Geriatric Depression Scale (GDS), Functional Assessment (FAQ), Clinicial Judgement of Symptoms Onset, Neur
Re:Additional 0.3% deterioration? (Score:2)
Not really, AC. It's not the actual assessment that bothers me. It's the scoring of the assessment. Suppose we have categories A and B that we're testing against. Now suppose that one test subject scores higher on A and lower on B than another test subject. Which patient has really lost more brain function as a whole? Is A more important than B? Is the baseline for sccoring even comparable between A and B? I'd much rather see the results of these
matter of scale (Score:2)
also less to deteriorate. Its like saying, that people
doing professional sports have a faster decay of their
muscle power when aging and base this on the time to run
one mile. The study measures it in
percentages but I guess, it is very difficult to
deteriorate basic intellectual skills.
It all depends on the scale.
Stress (Score:2)
Wierd. (Score:2)
Yes! (Score:2)
Of course... what do they REALLY mean by educated? I mean, I would be doing myself a disfavor if I claimed someone with a college degree was better at my job than I just because of a piece of paper - so is it actually due to brain usage, or is it because I didn't soak my brain in drugs and alcohol for 4 years?
Hence the saying (Score:2)
This state is commonly known as the Ph.D.
Possibly (Score:2)
1) As has been pointed out in the comments, educated folks have more to lose, and (arguably) notice it sooner than less-endowed folks.
2) The thought processes of (most) educated folks are (arguably) more "conscious & deliberate" rather than "habitual", and therefore would be more succeptable to the Alz. degradation - and more noticeable to the victim. From personal experience (Mom-now) I can state that the thought and behavioral "ha
And in another study... (Score:2)
This sort of garbage is what makes researchers look bad.
0.3% (Score:2)
On a more positive note (Score:2)
Basically it's saying that the microglia in the brain try to destroy the plaques that cause the symptoms of the disease. For whatever reason, the microglia in the brain aren't very effective, but those
I may have Alzheimer's... (Score:2)
.3% (Score:2)
Reflection of Rote Memorization? (Score:5, Interesting)
For example, I can point to five people at my current job - each a very skilled software engineer, and each very skilled in debating other topics in current events; among those five people are 1 PhD, 2 Masters, 1 college drop-out, and 1 high school drop out. The one thing we all agree on? Much of traditional American education has become primarily a matter of rote memorization - there is very little teaching of theory and problem solving involved.
Further, I saw a different study some years ago that showed a strong correlation between studying the arts late in life and delaying the onset of Alzheimers. Proficiency in the arts tends to require lots of understanding of abstract concepts, akin to studying theory in more technical fields, and requires little rote memorization.
That is to say, is it possible that the study hit on people whose minds have become less plastic as a result of education? People whose brains have been conditioned to be crystalizable by massive repetition instead of adaptable to new situations? Or, to take the nature instead of nurture angle, was the study skewed heavy on people with more crystaline brains, because such people are more proficient in an educational environment heavy on rote memorization?
Re:Reflection of Rote Memorization? (Score:3, Insightful)
Has become? When did you go to school, 1875?
I've been out of grade school for nearly 20 years now, and back then it was mostly rote memorization. My parents went to school nearly 50 years ago and it was even MORESO rote learning.
How many kids today drill on multiplication tables? Learn physics primarily by memorizing 3,000 different formulae? Write book reports based soley on the ability to remember the events in the st
Re:Reflection of Rote Memorization? or Age (Score:3, Informative)
Many develop the disease between 55 and 95, so let's take the median, which is 75 (actually, more like 72, since fewer people are 95 than 55), so they went to school from ages 6 to 18 or 6 to 24, which means they went to college in the 1940s or thereabouts.
I have a lot to learn still... (Score:2)
Consider two fields. One is just an unmanaged bunch of grass, the other is cultivated and irrigated. Both field
Play more GO! (Score:3, Interesting)
Well, if you trust in anectodal evidence:
http://users.eniinternet.com/bradleym/Mind.html [eniinternet.com] (Playing Go seems to "innoculate" one from Alzheimer's.)
So... I'm looking for ways to not just delay, but AVOID such a debilitating disease.
My body can fail me, and I'll accept it.
If my mind goes, someone shoot me please.
But you're less likely be diagnosed with it (Score:2)
One I particularly liked was of a Convent where before admission the nuns had to submit an essay on why the wanted to join. The essays were all kept. By comparing the essays of those who later died of Alzheimers with those who didn't it was show there was a stong negative correlation with increasing complexit
Pop psychology (Score:2)
So Ignorance really is bliss (Score:2)
Maybe they should look into Black Currants (Score:2, Informative)
http://www.theartofdrink.com/blog/2006/01/creme_d
A glass of Cassis a day, keeps the doctor away?
I knew it!! (Score:2)
So, what was Reagan's excuse? (Score:2)
Re:So, what was Reagan's excuse? (Score:2)
This is explained in New Scientist (Score:2, Informative)
A cure may be around the corner (Score:2)
Misleading (Score:2, Interesting)
It's not that the disease progresses quicker, it is only after diagnosis it progresses quicker. This probably means that on average the disease starts at the same time but that it manifests itself earlier in 'uneducated' people.
A theory is that educated people can 'route' around the disease better, so don't display external symptoms. Their education leads, on average, to them having more connections in their brain. However, a critical point i
Angular speed vs. linear speed (Score:2)
I guess.
Preposterous (Score:2)
As an intelligent person I will only this (Score:2)
Nonsense. (Score:2)
Just because you went through school in your 20's doesn't mean you keep on using your mind. From knowing some of the kids I see going to university today, I'd say there is very little proof that it means people use their minds during school. Heck, George Bush is an ivy league graduate, and it is very likely that he suffered brain damaged from all his booz
No, its not faster (Score:2, Funny)
Re: (Score:2)
Read between the Lines (Score:3, Informative)
1. People with more education develop Alzheimers later; and
2. People with more education take longer to deteriorate due to Alzheimer's but progress thru the symptoms faster.
Based on the data (and there is no truth to me having a stack of Alzheimer's patient data and control data on my desk
A. If you are highly educated, you may (or may not) have a long way to fall before your symptoms become obvious to others - the tests we have measure your abilities to do various tests, remember things, all kinds of stuff that you may develop strategies to compensate for given higher education (or don't develop strategies).
B. If you start with a high level of ability, you have a longer way to fall before unable to complete tasks, but if the disease affects your neural pathways (and it does, and we do need more brains, so we can study that, got one to spare?) then going from 200 to 150 to 100 to 50 to dead is similar to going from 100 to 75 to 50 to 25 to dead. Same time, sharper fall. However, you may be more capable for a longer time. Note, I did not say IQ, but ability - not the same thing at all.
Again, to get the real answers, you should read the original paper as published in the original scientific journal.
But, in the end, seems the best thing you can do is:
a. get some exercise, even if just gardening or walking to the grocery store to buy milk;
b. increase your mental abilities, because then if you do start failing, you'll be capable much longer, which is better;
c. realize that you have less than a 5 percent risk around 60-70 and a 20 percent risk around 90+
d. you'll probably die from the massive storm caused from Global Warming kicking up the power on your Sunset cruise in the Caribbean when you retire anyway, so this is all moot.
I've got you beat... (Score:2)
Re:I've got you beat... (Score:2)
Re:Ronald Reagan (Score:2)
Re:College and Alzheimer's (Score:2)
Not really. He would have been recorded as having 16 years of education (12 for high school, 4 for college four-year degree), not 19 years (12 for high school, 7 for actual physical years).
At least for US data measurement standards.