The Washington Post on scientists who "discovered that bacteria commonly found in wastewater can break down plastic to turn it into a food source, a finding that researchers hope could be a promising answer to combat one of Earth's major pollution problems." In a study published Thursday in Environmental Science and Technology, scientists laid out their examination of Comamonas testosteroni, a bacteria that grows on polyethylene terephthalate, or PET, a plastic commonly found in single-use food packaging and water bottles. PET makes up about 12 percent of global solid waste and 90 million tons of the plastic produced each year... Unlike most other bacteria, which thrive on sugar, C. testosteroni has a more refined palate, including chemically complex materials from plants and plastics that take longer to decompose.

The researchers are the first to demonstrate not only that this bacteria can break down plastic, but they also illuminate exactly how they do it. Through six meticulous steps, involving complex imaging and gene editing techniques, the authors found that the bacteria first physically break down plastic by chewing it into smaller pieces. Then, they release enzymes — components of a cell that speed up chemical reactions — to chemically break down the plastic into a carbon-rich food source known as terephthalate...

The bacteria take a few months to break down chunks of plastic, according to Rebecca Wilkes [a lead author on the study and postdoctoral researcher at the National Renewable Energy Laboratory]. As a result, if the bacteria are going to be efficient tools, a lot of optimization needs to take place to speed up the rate at which they decompose pollutants. One approach is to promote bacterial growth by providing them with an additional food source, such as a chemical known as acetate.
A senior author on the study (and associate professor of civil and environmental engineering at Northwestern University) tells the Washington Post that "The machinery in environmental microbes is still a largely untapped potential for uncovering sustainable solutions we can exploit."

The one-and-done nature of 23andMe is "indicative of a core business problem with the once high-flying biotech company that is now teetering on the brink of collapse," reports NPR. As 23andMe struggles for survival, many of its 15 million customers are left wondering what the company plans to do with all the data it has collected since it was founded in 2006. An anonymous reader shares an excerpt from the report: Andy Kill, a spokesperson for 23andMe, would not comment on what the company might do with its trove of genetic data beyond general pronouncements about its commitment to privacy. "For our customers, our focus continues to be on transparency and choice over how they want their data to be managed," he said. When signing up for the service, about 80% of 23andMe's customers have opted in to having their genetic data analyzed for medical research. "This rate has held steady for many years," Kill added. The company has an agreement with pharmaceutical giant GlaxoSmithKline, or GSK, that allows the drugmaker to tap the tech company's customer data to develop new treatments for disease. Anya Prince, a law professor at the University of Iowa's College of Law who focuses on genetic privacy, said those worried about their sensitive DNA information may not realize just how few federal protections exist. For instance, the Health Insurance Portability and Accountability Act, also known as HIPAA, does not apply to 23andMe since it is a company outside of the health care realm. "HIPAA does not protect data that's held by direct-to-consumer companies like 23andMe," she said.

Although DNA data has no federal safeguards, some states, like California and Florida, do give consumers rights over their genetic information. "If customers are really worried, they could ask for their samples to be withdrawn from these databases under those laws," said Prince. According to the company, all of its genetic data is anonymized, meaning there is no way for GSK, or any other third party, to connect the sample to a real person. That, however, could make it nearly impossible for a customer to renege on their decision to allow researchers to access their DNA data. "I couldn't go to GSK and say, 'Hey, my sample was given to you -- I want that taken out -- if it was anonymized, right? Because they're not going to re-identify it just to pull it out of the database," Prince said.

Vera Eidelman, a staff attorney with the American Civil Liberties Union who specializes in privacy and technology policy, said the patchwork of state laws governing DNA data makes the generic data of millions potentially vulnerable to being sold off, or even mined by law enforcement. "Having to rely on a private company's terms of service or bottom line to protect that kind of information is troubling -- particularly given the level of interest we've seen from government actors in accessing such information during criminal investigations," Eidelman said. She points to how investigators used a genealogy website to identify the man known as the Golden State Killer, and how police homed in on an Idaho murder suspect by turning to similar databases of genetic profiles. "This has happened without people's knowledge, much less their express consent," Eidelman said.

Neither case relied on 23andMe, and spokesperson Kill said the company does not allow law enforcement to search its database. The company has, however, received subpoenas to access its genetic information. According to 23andMe's transparency report, authorities have sought genetic data on 15 individuals since 2015, but the company has resisted the requests and never produced data for investigators. "We treat law enforcement inquiries, such as a valid subpoena or court order, with the utmost seriousness. We use all legal measures to resist any and all requests in order to protect our customers' privacy," Kill said. [...] In a September filing to financial regulators, [23andMe CEO Anne Wojcicki] wrote: "I remain committed to our customers' privacy and pledge," meaning the company's rules requiring consent for DNA to be used for research would remain in place, as well as allowing customers to delete their data. Wojcicki added that she is no longer considering offers to buy the company after previously saying she was.

"For the first time, scientists have created a flexible programmable chip that is not made of silicon..." reports IEEE Spectrum — opening new possibilities for implantable devices, on-skin computers, brain-machine interfaces, and soft robotics.

U.K.-based Pragmatic Semiconductor produced an "ultralow-power" 32-bit microprocessor, according to the article, and "The microchip's open-source RISC-V architecture suggests it might cost less than a dollar..." This shows potential for inexpensive applications like wearable healthcare electronics and smart package labels, according to the chip's inventors: For example, "we can develop an ECG patch that has flexible electrodes attached to the chest and a flexible microprocessor connected to flexible electrodes to classify arrhythmia conditions by processing the ECG data from a patient," says Emre Ozer, senior director of processor development at Pragmatic, a flexible chip manufacturer in Cambridge, England. Detecting normal heart rhythms versus an arrhythmia "is a machine learning task that can run in software in the flexible microprocessor," he says...

Pragmatic sought to create a flexible microchip that cost significantly less to make than a silicon processor. The new device, named Flex-RV, is a 32-bit microprocessor based on the metal-oxide semiconductor indium gallium zinc oxide (IGZO). Attempts to create flexible devices from silicon require special packaging for the brittle microchips to protect them from the mechanical stresses of bending and stretching. In contrast, pliable thin-film transistors made from IGZO can be made directly at low temperatures onto flexible plastics, leading to lower costs...

"Our end goal is to democratize computing by developing a license-free microprocessor," Ozer says... Other processors have been built using flexible semiconductors, such as Pragmatic's 32-bit PlasticARM and an ultracheap microcontroller designed by engineers in Illinois. Unlike these earlier devices, Flex-RV is programmable and can run compiled programs written in high-level languages such as C. In addition, the open-source nature of RISC-V also let the researchers equip Flex-RV with a programmable machine learning hardware accelerator, enabling artificial intelligence applications.

Each Flex-RV microprocessor has a 17.5 square millimeter core and roughly 12,600 logic gates. The research team found Flex-RV could run as fast as 60 kilohertz while consuming less than 6 milliwatts of power... The Pragmatic team found that Flex-RV could still execute programs correctly when bent to a curve with a radius of 3 millimeters. Performance varied between a 4.3 percent slowdown to a 2.3 percent speedup depending on the way it was bent.

An anonymous reader shared this story from SFGate: A boy who was kidnapped from an Oakland playground in 1951 has been found alive on the East Coast, a remarkable resolution to a mystery that has haunted his family for over half a century.

On February 21, 1951, 6-year-old Luis Armando Albino was playing with his older brother Roger at Jefferson Square Park. The boys had recently immigrated with their mother and four other siblings from Puerto Rico... That afternoon, Luis and 10-year-old Roger walked down the block from their home at 730 Brush Street to play in the park. They were approached by a woman in her 30s, wearing a green bandana over her hair, who began chatting with Luis in Spanish. She promised she would buy him candy if he came along with her, and little Luis agreed to join her. Wary, Roger trailed the pair for a while before returning home to alert an adult to the strange encounter. Oakland police were called by frantic family members and a search was immediately launched...

Antonia [the boy's mother] was convinced her son was alive. "She came once a week, then once a month, then at least once a year, to see the shake of the head, to have the answer 'no' translated for her although she could read it in the officers' faces," the Oakland Tribune wrote in 1966...

Decades passed.

In 2020, Luis' niece, Alida Alequin, took a DNA test on a whim, the Mercury News reported. The service returned several possible family members to the Oakland woman. One of them was a man who Alequin had never met. After some internet sleuthing, she began to suspect this man might be the missing uncle she'd heard so much about. She reached out to the man but didn't hear back.

Earlier this year, Alequin tried again. Armed with photos, she took her evidence to the Oakland Police Department's missing persons unit. In short order, the FBI and California Department of Justice were also investigating Alequin's lead. They discovered the man was living on the East Coast, had worked as a firefighter and served two tours in Vietnam with the Marine Corps. This week, the Mercury News first reported that a DNA test confirmed what Alequin suspected: This was Luis Albino.

In June, Luis flew to California to reunite with his family, among them his devoted brother Roger... For over 70 years, he lived on the East Coast believing he was the son of another couple....

When Luis met Alequin for the first time this summer, he held her in an embrace. "Thank you," he said, "for finding me."

China's once-booming venture capital industry is experiencing a severe downturn, with the number of new startups plummeting from 51,302 in 2018 to just 1,202 in 2023, according to data provider IT Juzi. This decline is starkly evident in science parks and innovation hubs across the country, where vacant offices and abandoned equipment have become commonplace, according to a stunning FT story.

Industry insiders attribute the crisis to a combination of factors, including China's economic slowdown, heightened US-China tensions, and President Xi Jinping's policies targeting the tech sector. The government's anti-corruption drive and increased scrutiny of successful entrepreneurs have further dampened the private sector's enthusiasm. The funding landscape has shifted dramatically, with state-backed funds now dominating the market. This has led to more conservative investment strategies, favoring lower-risk sectors like advanced manufacturing over traditionally popular areas such as biotech and consumer technology. Founders face increasingly stringent terms, including personal liability for investments and asset checks. Many established VC firms are downsizing operations and exploring overseas opportunities.

Wired interviews America's foreign policy chief, Secretary of State Antony Blinken, about U.S. digital polices, starting with a new "cybersecurity bureau" created in 2022 (which Wired previously reported includes "a crash course in cybersecurity, telecommunications, privacy, surveillance, and other digital issues.") Look, what I've seen since coming back to the State Department three and a half years ago is that everything happening in the technological world and in cyberspace is increasingly central to our foreign policy. There's almost a perfect storm that's come together over the last few years, several major developments that have really brought this to the forefront of what we're doing and what we need to do. First, we have a new generation of foundational technologies that are literally changing the world all at the same time — whether it's AI, quantum, microelectronics, biotech, telecommunications. They're having a profound impact, and increasingly they're converging and feeding off of each other.

Second, we're seeing that the line between the digital and physical worlds is evaporating, erasing. We have cars, ports, hospitals that are, in effect, huge data centers. They're big vulnerabilities. At the same time, we have increasingly rare materials that are critical to technology and fragile supply chains. In each of these areas, the State Department is taking action. We have to look at everything in terms of "stacks" — the hardware, the software, the talent, and the norms, the rules, the standards by which this technology is used.

Besides setting up an entire new Bureau of Cyberspace and Digital Policy — and the bureaus are really the building blocks in our department — we've now trained more than 200 cybersecurity and digital officers, people who are genuinely expert. Every one of our embassies around the world will have at least one person who is truly fluent in tech and digital policy. My goal is to make sure that across the entire department we have basic literacy — ideally fluency — and even, eventually, mastery. All of this to make sure that, as I said, this department is fit for purpose across the entire information and digital space.
Wired notes it was Blinken's Department that discovered China's 2023 breach of Microsoft systems. And on the emerging issue of AI, Blinken cites "incredible work done by the White House to develop basic principles with the foundational companies." The voluntary commitments that they made, the State Department has worked to internationalize those commitments. We have a G7 code of conduct — the leading democratic economies in the world — all agreeing to basic principles with a focus on safety. We managed to get the very first resolution ever on artificial intelligence through the United Nations General Assembly — 192 countries also signing up to basic principles on safety and a focus on using AI to advance sustainable development goals on things like health, education, climate. We also have more than 50 countries that have signed on to basic principles on the responsible military use of AI. The goal here is not to have a world that is bifurcated in any way. It's to try to bring everyone together.

An anonymous reader shared this report from USA Today: He's the founder of Telegram. He was arrested in France. He also claims to have fathered at least 100 children...

The 39-year-old Russian-born billionaire often keeps his personal life out of the spotlight. Something he has shared, however, is that, despite never marrying and preferring to live alone, he's fathered at least 100 children through anonymous sperm donation... Durov noted he plans to "open-source" his DNA so his biological children can find each other more easily. "I also want to help destigmatize the whole notion of sperm donation and incentivize more healthy men to do it, so that families struggling to have kids can enjoy more options," he wrote. "Defy convention — redefine the norm...!"
"Sperm donation has allowed many people to have families who otherwise wouldn't be able to," the article points out. But it also adds that the anonymous practice "has drawn several detractors, including from those who've been conceived through it." These people have shared with USA TODAY the mental turmoil of learning they have, in some cases, hundreds of half-siblings... One of the main criticisms of the practice is that the anonymity of the donor makes it difficult or impossible for donor-conceived people to learn about their health and treat genetically inherited medical issues. Even when donor-conceived people have their donor's identity and contact information, there's still no guarantee they'll respond or tell the truth. Also, most sperm banks in the United States aren't legally required to keep records of siblings or cap the number of families that can use a specific donor. As a result, donor-conceived people with many siblings often live in fear of accidentally having children with one of their half-siblings, or even having children with their own father if they were to pursue donor insemination.

An anonymous Slashdot reader shared this report from NBC News: A new approach to a routine blood test could predict a person's 30-year risk of heart disease, research published Saturday in the New England Journal of Medicine found.

Doctors have long assessed their patients' risk for cardiovascular disease by using a blood test to look at cholesterol levels, focusing particularly on LDL or "bad" cholesterol. But limiting blood testing to just cholesterol misses important — and usually silent — risk factors, experts say... Lead study author Dr. Paul Ridker, director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital in Boston and his team found that in addition to LDL cholesterol, two other markers — a type of fat in the blood called lipoprotein (a), or Lp(a), and an indicator of inflammation — are important predictors of a person's risk of heart attack, stroke and coronary heart disease...

In the study, the researchers analyzed data from nearly 30,000 U.S. women who were part of the Women's Health Study. On average, the women were 55 years old when they enrolled in the years 1992 through 1995. About 13% — roughly 3,600 participants — had either a heart attack or stroke, had surgery to fix a narrowed or blocked artery, or died from heart disease over the 30-year follow-up period... All of the women had blood tests done at the beginning of the study to measure their LDL cholesterol, Lp(a) and C-reactive protein levels, a marker of inflammation in the body. These measurements, individually as well as together, appeared to predict a woman's heart health over the next three decades, the study found.

Women with the highest levels of LDL cholesterol had a 36% higher risk for heart disease compared with those with the lowest levels. The highest levels of Lp(a) indicated a 33% elevated risk, and those with the highest levels of CRP were 70% more at risk for heart disease. When the three were looked at together, women who had the highest levels were 1.5 times more likely to have a stroke and over three times more likely to develop coronary heart disease over the next 30 years compared with women with the lowest levels.

All of the markers have been individually linked to higher risk of heart disease, but "all three represent different biological processes. They tell us why someone is actually at risk," Ridker said.

One of Slashdot's most-visited stories of all time was the 2016 story asking: Can Cow Backpacks Reduce Global Methane Emissions? "Enteric fermentation," or livestock's digestive process, accounts for 22 percent of all U.S. methane emissions, and the manure they produce makes up eight percent more, according to the U.S. Environmental Protection Agency... Methane, like carbon, is a greenhouse gas, but methane's global warming impact per molecule is 25 times greater than carbon's, according to the EPA.
Cow methane still "heats the Earth more than every flight across the world combined," the Washington Post added today, reporting on a new $30 million genetic engineering experiment undertaken by the Innovative Genomics Institute and the University of California at Davis.

Its mission: to transform a cow's gut so it no longer releases methane. Using tools that snip and transfer DNA, researchers plan to genetically engineer microbes in the cow stomach to eliminate those emissions. If they succeed, they could wipe out the world's largest human-made source of methane and help change the trajectory of planetary warming... The average cow produces around 220 pounds of methane per year, or around half the emissions of an average car; cows are currently responsible for around 4 percent of global warming, according to the Food and Agriculture Organization...

Scientists envision a kind of probiotic pill, given to the cow at birth, that can transform its microbiome permanently...

The current project doesn't target only a particular cow species — it takes aim at the microbiome itself, offering a solution that could apply to all of them. Brad Ringeisen, executive director at the genomics institute, cut his teeth running biotechnology at the U.S. defense research agency DARPA, which helped pioneer transformative innovations including the internet, miniaturized GPS, stealth aircraft and the computer mouse. "I'm taking the DARPA mentality here," he said. "Let's solve it for all cows, not just a fraction of the cows." ...]

"There's no reason a cow has to produce methane," Ringeisen said. So what if scientists could just ... turn it off?
"I personally think this is the one that can make the biggest impact in the world," Ringeisen said. "Say you could wave a magic wand and eliminate all those emissions."

The article says that currently the scientists are feeding red-seaweed oil to a cow to measure the changes, to prepare for their final goal: "replicate those changes with gene editing." (They're using machine learning to reassemble the hundreds of pieces of each miccroorganism's DNA, so they can understand which changes they need to make with their early-intervention probiotic.) Such a probiotic could also improve a farm's productivity. Cows can lose up to 12 percent of their energy through burping up methane; other ruminants, like sheep and goats, also lose energy in this way. "If there is a way to redirect that hydrogen and convert it into milk, meat, wool — it would be much more accepted by farmers," said Ermias Kebreab [a professor of animal science at UC-Davis].

Early treatments will be tested on the cows at Davis, with researchers tracking their burps to evaluate the drop-off in methane emissions. There is still a long way to go. While scientists have proved that they can gene-edit microbes, researchers have so far only shown that they can edit a small fraction of the microbes in the cow gut — or the human gut, for that matter. Institute researchers are developing microbial gene-editing tools, even as they are mapping the species of the microbiome. They are building the plane while flying it.

The teams have received enough funding for seven years of research. The project started last year, and they hope to have a trial treatment ready for testing in cows in the next two years.

In a blog post on Wednesday, Neuralink said its second human recipient is using the brain chip to play Counter-Strike 2 and develop 3D designs in CAD software. "Alex" was given the brain chip last month to help restore his autonomy after a spinal cord injury. PCMag reports: Like the first Neuralink patient, Noland Arbaugh, Alex has also been using the brain chip to play his favorite computer games, such as Counter-Strike 2. Before, Alex had to use a mouth-operated controller, called a QuadStick, to play the first-person shooter. But even then, the controller limited him to only moving or aiming his weapon at a single time, never simultaneously like a normal Counter-Strike player. In other words, Alex had to essentially switch back and forth between the mouse and keyboard functions while playing the game. But thanks to Neuralink, he can now aim with the implant, and simultaneously move while using the QuadStick. [...]

In the blog post, Neuralink also addressed a problem the company faced when placing the chip in Arbaugh, the first patient. Despite a successful surgery, about 85% of the thread-based electrodes attached to his brain later became displaced, undermining the full potential of the chip to read neural signals. Although Arbaugh can still use his implant effectively, Neuralink wanted to avoid a repeat with Alex. In response, the company developed several "mitigations," which include reducing the chance of an air pocket forming during surgery and placing the implant deeper into the brain tissue. "Promisingly, we have observed no thread retraction in our second participant," the company said of Alex.

Whether Alex's implant outperforms the brain chip in Arbaugh was left unclear. In the meantime, Neuralink says it's working on ways to enhance the controls on the technology "to deliver full mouse and video game controller functionality." "Additionally, we plan to enable the Link [brain chip] to interact with the physical world, allowing users to feed themselves and move more independently by controlling a robotic arm or their wheelchair," the company said. You can watch Alex playing Counter-Strike 2 on YouTube.

An anonymous reader quotes a report from Wired: Florida's ban on cultivated meat is being challenged in federal court in a lawsuit that was filed yesterday. The case is being brought by the cultivated meat firm Upside Foods and the Institute of Justice (IJ), a nonprofit public interest law firm. Florida governor Ron DeSantis signed the legislation making the sale of cultivated meat illegal in Florida on May 1, and the bill came into effect on July 1. Alabama passed a similar bill banning cultivated meat that will come into effect from October 1. The case brought by Upside Foods and the IJ argues that Florida's ban is unconstitutional in three different ways. First, they argue, the ban violates theSupremacy Clause that gives federal law priority over state law in certain instances. The court case argues that the Florida ban violates two different provisions in the Federal Meat Inspection Act and Poultry Products Inspection Act.

The legal complaint (PDF) also alleges that the ban violates theCommerce Clause, which gives the US Congress exclusive power to regulate interstate commerce. The IJ argues that the Commerce Clause restricts states from enacting laws that unduly restrict interstate commerce, and that Florida's ban in its current form has the effect of discriminating against it. "Florida's law has nothing to do with protecting health and safety," said IJ senior attorney Paul Sherman in a press conference today. "It is a transparent example of economic protectionism." Sherman said that Upside Foods and the IJ would also apply for a preliminary injunction that would allow the company to sell cultivated meat in Florida while the legal challenge is still ongoing. The complaint says that Upside had planned to distribute its cultivated chicken at Art Basel in Miami in early December 2024. The company protested the Florida ban by holding a tasting of its chicken on June 27 in Miami, shortly before the ban came into effect. Sherman said that the Alabama ban was also "in our sights" but that the IJ had targeted the Florida law as it came into effect before the Alabama ban. "We're hoping we'll be able to get a quick ruling [in Florida] on a preliminary injunction there," and use that as a precedent to challenge the Alabama ban, he said. "Consumers should decide what kind of meat they want to buy and feed their families -- not politicians," said the Good Food Institute (GFI), a nonprofit focused on advancing alternative proteins and which is serving as a consulting consul in this case. "This lawsuit seeks to protect these consumer rights, along with the rights of companies to compete in a fair and open marketplace."

The Wall Street Journal visits scientists at Harvard University's Wyss Institute for Biologically Inspired Engineering who are researching a "sugar-to-fiber" enzyme (normally used by plants to create stalks). They're testing a version they've "encased in spherical nanoparticles — tiny mesh-like cages made of pectin that allow the enzyme to be added to food without being activated until it reaches the intestine.

"Once there, a change in pH causes the cage to expand, freeing the enzyme to float through its holes and start converting sugar to fiber." The Wyss Institute's goal for its enzyme product was to reduce the sugar absorbed from food by 30%, though it has the potential to remove even more than that, says Sam Inverso, director of business development partnerships at the Wyss Institute. The enzyme's ability to turn sugar into fiber is also key, as most Americans don't get nearly enough fiber in their diet, says Adama Sesay, a senior engineer at the Wyss Institute who worked on the project...

The Wyss Institute is now licensing the technology to a company to help bring its enzyme product to market, a process that entails additional testing and work to secure regulatory approval. Inverso says that the aim is for the product to be available to U.S. food manufacturers within the next two years, and that other encapsulated enzymes could follow: products that reduce lactose absorption after drinking milk, or cut gluten after eating bread. For now the enzyme works better in solid food than in a liquid. Producing it in large quantities and at low cost is still a ways off — currently it's 100 times more expensive than raw sugar, Inverso says.
And the Journal notes they're not the only ones working on the problem: San Francisco-based startup Biolumen recently launched a product called Monch Monch, a drink mix made of fibrous, microscopic sponges designed to soak up sugar and prevent it from reaching the bloodstream. At mealtime consumers can blend a teaspoon of Monch Monch, which has no taste, smell or color, into drinks from water to wine. Once it has reached the stomach, the sponges start to swell and sequester sugar, reducing its burden on the body, says Dr. Robert Lustig, Biolumen's co-founder and chief medical officer... One gram of Monch Monch can sequester six grams of sugar, says Lustig... The product, introduced as a dietary supplement, can also be used as a food ingredient under a Food and Drug Administration principle known as "generally recognized as safe." Packets of Monch Monch are available for purchase online, and Biolumen says it is in talks with U.S. food manufacturers it declined to name about its use in other products...

Food companies are betting on other solutions for now. Cereal startup Magic Spoon uses allulose, a natural sugar found in figs and raisins that is growing in popularity, helped by FDA guidance that allows it to be excluded from sugar or added-sugar totals on nutrition labels. Ingredient company Tate & Lyle, which makes allulose from corn kernels, says the sweetener tastes like sugar and adds bulk and caramel color, but passes through the body without being metabolized... Chicago-based Blommer Chocolate recently launched a line of reduced-sugar chocolate and confectionery products made with Incredo, a sugar that has been physically altered to taste sweeter using a mineral carrier that dissolves faster in saliva and targets the sweet-taste receptors on the tongue. Incredo's use enables manufacturers to use up to 50% less sugar, the company says.
The article even notes that "researchers still working to reduce sugar are peddling new technologies, like individual sugar crystals modified to dissolve more quickly in the mouth, making food taste sweeter."

Late Friday Elon Musk appeared on Lex Fridman's podcast for a special eight-hour episode about Neuralink.

It's already been viewed 1,702,036 times on YouTube — and resulted in this report from Reuters: Neuralink has successfully implanted in a second patient its device designed to give paralyzed patients the ability to use digital devices by thinking alone, according to the startup's owner Elon Musk... [Musk] gave few details about the second participant beyond saying the person had a spinal cord injury similar to the first patient, who was paralyzed in a diving accident.

Musk said 400 of the implant's electrodes on the second patient's brain are working. Neuralink on its website states that its implant uses 1,024 electrodes... Musk said he expects Neuralink to provide the implants to eight more patients this year as part of its clinical trials.
Neuralink's device "has allowed the first patient to play video games, browse the internet, post on social media and move a cursor on his laptop," according to the article: The first patient, Noland Arbaugh, was also interviewed on the podcast, along with three Neuralink executives, who gave details about how the implant and the robot-led surgery work. Before Arbaugh received his implant in January, he used a computer by employing a stick in his mouth to tap the screen of a tablet device. Arbaugh said with the implant he now can merely think about what he wants to happen on the computer screen, and the device makes it happen... Arbaugh has improved on his previous world record for the speed at which he can control a cursor with thoughts alone "with only roughly 10, 15% of the electrodes working," Musk said on the podcast.
Fridman said his interview with Musk was "the longest podcast I've ever done," calling their conversation "fascinating, super technical, and wide-ranging... I loved every minute of it."

A new type of antibiotic "targets bacteria in two ways," writes SciTechDaily, which "could make it 100 million times harder for bacteria to develop resistance, according to recent research from the University of Illinois Chicago." Their experiments demonstrate that [a class of synthetic drugs called] macrolones can work two different ways — either by interfering with protein production or corrupting DNA structure. Because bacteria would need to implement defenses to both attacks simultaneously, the researchers calculated that drug resistance is nearly impossible. "The beauty of this antibiotic is that it kills through two different targets in bacteria," said Alexander Mankin, distinguished professor of pharmaceutical sciences at UIC. "If the antibiotic hits both targets at the same concentration, then the bacteria lose their ability to become resistant via the acquisition of random mutations in any of the two targets."

Macrolones are synthetic antibiotics that combine the structures of two widely used antibiotics with different mechanisms. Macrolides, such as erythromycin, block the ribosome, the protein manufacturing factories of the cell. Fluoroquinolones, such as ciprofloxacin, target a bacteria-specific enzyme called DNA gyrase.... "The main outcome from all of this work is the understanding of how we need to go forward," Mankin said. "And the understanding that we're giving to chemists is that you need to optimize these macrolones to hit both targets."
Thanks to long-time Slashdot reader schwit1 for sharing the news.

CNET visits a leading-edge company making an implantable brain-computer-interface that's "experimenting with ChatGPT integration..." We previously covered Synchron's unique approach to implanting its brain-computer-interface (BCI) without the need for open brain surgery. Now the company has integrated OpenAI's ChatGPT into its software, something it says is a world's first for a BCI company...

Typing out messages word by word with the help of a BCI is still time consuming. The addition of AI is seen as a way to make communication faster and easier by taking in the relevant context, like what was last said in a conversation, and anticipating answers a person might want to respond with, providing them with a menu of possible options. Now, instead of typing out each word, answers can be filled in with a single "click." There's a refresh button in case none of the AI answers are right... [ALS patient Mark, one of 10 people in the world testing Synchron's brain implant in a clinical trial] has noticed the AI getting better at providing answers that are more in line with things he might say. "Every once in a while it'll drop an f-bomb, which I tend to do occasionally," he says with a laugh.

Synchron CEO Tom Oxley tells me the company has been experimenting with different AI models for about a year, but the release of OpenAI's ChatGPT-4o in May raised some interesting new possibilities. The "o" in ChatGPT-4o stands for "omni," representative of the fact that this latest version is capable of taking in text, audio and visual inputs all at once to inform its outputs... Oxley envisions the future of BCIs as... having large language models like ChatGPT take in relevant context in the form of text, audio and visuals to provide relevant prompts that users can select with their BCI... Synchron's BCI is expected to cost between $50,000 and $100,000, comparable with the cost of other implanted medical devices like cardiac pacemakers or cochlear implants.
CNET has also released a video — titled "What It's Like Using a Brain Implant With ChatGPT."

Scientists at the University of Texas at Austin have developed a "smart soil" that can keep plants better hydrated and provide a controlled release of nutrients. As reported by New Atlas, tests found that it "drastically improved crop growth while using far less water." From the report: The soil gets its "smart" moniker thanks to the addition of a specially formulated hydrogel, which works to absorb more water vapor from the air overnight, then releasing it to the plants' roots during the day. Incorporating calcium chloride into the hydrogel also provides a slow release of this vital nutrient. The team tested the new smart soil in lab experiments, growing plants in 10 grams of soil, with some including 0.1 g of hydrogel. A day/night cycle was simulated, with 12 hours of darkness at 25 C (77 F) and either 60% or 90% relative humidity, followed by 12 hours of simulated sunlight at 35 C (95 F) and 30% humidity.

Sure enough, plants growing in the hydrogel soil showed a 138% boost to their stem length, compared to the control group. Importantly, the hydrogel-grown plants achieved this even while requiring 40% less direct watering. In future work, the team plans to try incorporating other types of fertilizers, and conducting longer field experiments. The research was published in the journal ACS Materials Letters.

A Californian startup funded by Bill Gates is making rich, fatty "butter" using just carbon dioxide and hydrogen, with other dairy-free alternatives in the works. New Atlas reports: The San Jose company, Savor, uses a thermochemical process to create its animal-like fat, which is free of the environmental footprint of both the dairy industry and plant-based alternatives. "They started with the fact that all fats are made of varying chains of carbon and hydrogen atoms," Gates wrote in a blog post. "Then they set out to make those same carbon and hydrogen chains -- without involving animals or plants. They ultimately developed a process that involves taking carbon dioxide from the air and hydrogen from water, heating them up, and oxidizing them to trigger the separation of fatty acids and then the formulation of fat."

"The idea of switching to lab-made fats and oils may seem strange at first," Gates wrote. "But their potential to significantly reduce our carbon footprint is immense. By harnessing proven technologies and processes, we get one step closer to achieving our climate goals." Savor's 'butter' is easily produced and scalable, but convincing people to swap out butter and other dairy products for 'experimental' foods will remain a challenge for the foreseeable future. Gates is hoping, however, that his support will do more than start a conversation. "The process doesn't release any greenhouse gases, and it uses no farmland and less than a thousandth of the water that traditional agriculture does," he added. "And most important, it tastes really good -- like the real thing, because chemically it is." The research has been published in the journal Nature Sustainability.

The Roddenberry Foundation — named for Star Trek creator Gene Roddenberry — "announced Tuesday that this year's biennial award would focus on artificial intelligence that benefits humanity," reports the Los Angeles Times: Lior Ipp, chief executive of the foundation, told The Times there's a growing recognition that AI is becoming more ubiquitous and will affect all aspects of our lives. "We are trying to ... catalyze folks to think about what AI looks like if it's used for good," Ipp said, "and what it means to use AI responsibly, ethically and toward solving some of the thorny global challenges that exist in the world...."

Ipp said the foundation shares the broad concern about AI and sees the award as a means to potentially contribute to creating those guardrails... Inspiration for the theme was also borne out of the applications the foundation received last time around. Ipp said the prize, which is "issue-agnostic" but focused on early-stage tech, produced compelling uses of AI and machine learning in agriculture, healthcare, biotech and education. "So," he said, "we sort of decided to double down this year on specifically AI and machine learning...."

Though the foundation isn't prioritizing a particular issue, the application states that it is looking for ideas that have the potential to push the needle on one or more of the United Nations' 17 sustainable development goals, which include eliminating poverty and hunger as well as boosting climate action and protecting life on land and underwater.
The Foundation's most recent winner was Sweden-based Elypta, according to the article, "which Ipp said is using liquid biopsies, such as a blood test, to detect cancer early."

"We believe that building a better future requires a spirit of curiosity, a willingness to push boundaries, and the courage to think big," said Rod Roddenberry, co-founder of the Roddenberry Foundation. "The Prize will provide a significant boost to AI pioneers leading these efforts." According to the Foundation's announcement, the Prize "embodies the Roddenberry philosophy's promise of a future in which technology and human ingenuity enable everyone — regardless of background — to thrive."

"By empowering entrepreneurs to dream bigger and innovate valiantly, the Roddenberry Prize seeks to catalyze the development of AI solutions that promote abundance and well-being for all."

Researchers have devised a way to extract energy from the photosynthesis process of algae, according to an announcement from Concordia University.

Suspended in a specialized solution, the algae forms part of a "micro photosynthetic power cell" that can actually generate enough energy to power low-power devices like Internet of Things (IoT) sensors. "Photosynthesis produces oxygen and electrons. Our model traps the electrons, which allows us to generate electricity," [says Kirankumar Kuruvinashetti, PhD 20, now a Mitacs postdoctoral associate at the University of Calgary.] "So more than being a zero-emission technology, it's a negative carbon emission technology: it absorbs carbon dioxide from the atmosphere and gives you a current. Its only byproduct is water."

[...] Muthukumaran Packirisamy, professor in the Department of Mechanical, Industrial and Aerospace Engineering and the paper's corresponding author, admits the system is not yet able to compete in power generation with others like photovoltaic cells. The maximum possible terminal voltage of a single micro photosynthetic power cell is only 1.0V. But he believes that, with enough research and development, including artificial intelligence-assisted integration technologies, this technology has the potential to be a viable, affordable and clean power source in the future.

It also offers significant manufacturing advantages over other systems, he says. "Our system does not use any of the hazardous gases or microfibres needed for the silicon fabrication technology that photovoltaic cells rely on. Furthermore, disposing of silicon computer chips is not easy. We use biocompatible polymers, so the whole system is easily decomposable and very cheap to manufacture."
In the paper the researchers also described it as a âoemicrobial fuel cellâ...

Avian influenza outbreaks on US dairy farms have raised concerns about milk safety, leading some to consider alternatives like engineered milk proteins. Startups like Remilk and Alpine Bio are using yeast and soybeans to produce key milk proteins, aiming to replace dairy cows and reduce environmental impact. However, competing with subsidized dairy industries and their efficient use of cow byproducts remains a challenge for these biotech ventures, MIT Technology Review reports. The story adds: Everyone agrees that cow's milk will be difficult to displace. It holds a special place in the human psyche, and we owe civilization itself, in part, to domesticated animals. In fact, they've left their mark in our genes, with many of us carrying DNA mutations that make cow's milk easier to digest. But that's why it might be time for the next technological step, says Alpine's CEO Magi Richani. "We raise 60 billion animals for food every year, and that is insane. We took it too far, and we need options," she says. "We need options that are better for the environment, that overcome the use of antibiotics, and that overcome the disease risk." It's not clear yet whether the bird flu outbreak on dairy farms is a big danger to humans. But making milk without cows would definitely cut the risk that an animal virus will cause a new pandemic. As Richani says: "Soybeans don't transmit diseases to humans."