An anonymous reader quotes a report from The Guardian: A team of Chinese scientists will be the first in the world to apply the revolutionary gene-editing technique known as CRISPR on human subjects. Led by Lu You, an oncologist at Sichuan University's West China hospital in Chengdu, China, the team plan to start testing cells modified with CRISPR on patients with lung cancer in August, according to the journal Nature. CRISPR is a game-changer in bioscience; a groundbreaking technique which can find, cut out and replace specific parts of DNA using a specially programmed enzyme named Cas9. Its ramifications are next to endless, from changing the color of mouse fur to designing malaria-free mosquitoes and pest-resistant crops to correcting a wide swath of genetic diseases like sickle-cell anaemia in humans. The Sichuan University trial, it is important to note, does not edit the germ-line; its effects will not be hereditary. What the researchers plan to do is enroll patients with metastatic non-small cell lung cancer, Nature reported, and for whom other treatment options -- including chemotherapy and radiotherapy -- have failed. They will then extract immune cells from the patients' blood and use CRISPR to add a new genetic sequence which will help the patient's immune system target and destroy the cancer. The cells will then be re-introduced into the patients' bloodstream. The Guardian does note that CRISPR was approved for human trials in the U.S., but if it begins on schedule in August the Sichuan University study will beat them to the punch of being the first of its kind.
An anonymous reader writes: Android Police is reporting that the Android software company Cyanogen Inc. will be laying off 20 percent of its workforce, and will transition from OS development to applications. The Android Police report says "roughly 30 out of the 136 people Cyanogen Inc. employs" are being cut, and that the layoffs "most heavily impact the open source arm" of the company. Android Police goes on to say that CyanogenMod development by Cyanogen Inc "may be eliminated entirely." Ars Technica notes the differences between each "Cyanogen" branding. Specifically, CyanogenMod is a "free, open source, OS heavily based on Android and compatible with hundreds of devices," while Cyanogen Inc. is "a for-profit company that aims to sell Cyanogen OS to OEMs." It appears that many of the core CyanogenMod developers will no longer be paid to work on CyanogenMod, though the community is still free to develop the software." Android Police details the firing process in their report: "Layoffs reportedly came after a long executive retreat for the company's leaders and were conducted with no advanced notice. Employees who were not let go were told not to show up to work today. Those who did show up were the unlucky ones: they had generic human resources meetings rather ominously added to their calendars last night. So, everyone who arrived at Cyanogen Inc. in Seattle this morning did so to lose their job (aside from those conducting the layoffs)." Early last year, Microsoft invested in a roughly $70 million round of equity financing for the then-startup Cyanogen Inc. Not too long before that, Google tried to acquire Cyanogen Inc., but the company turned down Google's offer to seek funding from investors and major tech companies at a valuation of around $1 billion. Cyanogen Inc. CEO Kirt McMaster once said the company was "attempting to take Android away from Google" and that it was "putting a bullet through Google's head."
chicksdaddy quotes a report from Security Ledger: The Automotive industry's main group for coordinating policy on information security and "cyber" threats has published a "Best Practices" document, giving individual automakers guidance on implementing cybersecurity in their vehicles for the first time. The Automotive Information Sharing and Analysis Center (ISAC) released the Automotive Cybersecurity Best Practices document on July 21st, saying the guidelines are for auto manufacturers as well as their suppliers. The Best Practices cover organizational and technical aspects of vehicle cybersecurity, including governance, risk management, security by design, threat detection, incident response, training, and collaboration with appropriate third parties. Taken together, they move the auto industry closer to standards pioneered decades ago and embraced by companies like Microsoft. They call on automakers to design software to be secure from the ground up and to take a sober look at risks to connected vehicles as part of the design process. Automakers are urged to test for and respond to software vulnerabilities, to develop methods for assessing and fixing security vulnerabilities, to create training programs, promote cybersecurity awareness for both information technology and vehicle specific risks, and educate employees about security awareness. The document comes after a Kelly Blue Book survey that found that 62% of drivers think "connected cars will be hacked," and that 42% say they "want cars to be more connected."
An anonymous reader quotes a report from ABC News: Virginia Sen. Tim Kaine has been chosen as Hillary Clinton's running mate -- a man she called a "relentless optimist" who "devoted his life to fighting for others." Kaine has long been considered to be at the top of Clinton's short list. He was previously vetted for the vice presidency by Barack Obama in 2008. Kaine was an early supporter of Clinton's, appearing at a "Ready for Hillary" breakfast in May 2014 where he urged her to enter the 2016 presidential race. Kaine told NBC in June that he "encouraged her to run in May of 2014, because I could telescope forward and see some of the challenges that this nation would be facing. And I decided that by reason of character, by reason of background, and experience, but also especially by reason of results, she would be the most qualified person to be president in January of 2017." Prior to being elected to the Senate, Kaine served as governor and lieutenant governor of Virginia. In 2009, President Obama picked Kaine to lead the Democratic National Committee. Last week, Republican presidential nominee Donald Trump announced Mike Pence as his VP running mate.
An anonymous reader writes from a report via Portland Press Herald: Volkswagen plans to fix the engines that were rigged to cheat on emissions tests by updating computer software and installing a larger catalytic converter to trap harmful nitrogen oxide, according to two dealers who were briefed by executives on the matter. The dealers said that limited details of the plan were made public last week at a regional dealer meeting in Newark, New Jersey, by Volkswagen of America Chief Operating Officer Mark McNabb. Portland Press Herald reports: "One dealer said the group was told that early testing of a small sample of repaired cars showed that the fix made 'no discernible difference' in the cars' mileage, horsepower or torque. Both dealers said they were told that more testing was needed and that the plans still had to be approved by the U.S. Environmental Protection Agency and the California Air Resources Board. One of the dealers said the so-called 'Generation 1' diesels -- about 325,000 VW Jettas, Golfs, Passats and Beetles from the 2009 to 2014 model years – would get new software and bigger catalytic converters in January or February of next year. About 90,000 'Generation 2' Passats already have sufficient emissions systems and would get only a software update early next year. Another 67,000 'Generation 3' 2015 models would get software in October and would get additional hardware a year later, the dealer said. Dealers also were told that they'd be reimbursed by VW for sales losses due to the scandal, and that new vehicles are coming." Last month, Volkswagen agreed to a record $14.7 billion settlement over the emissions cheating.
ErichTheRed writes: This isn't perfect, but it is the first attempt I've seen at removing the "body shop" loophole in the H-1B visa system. A bill has been introduced in Congress that would raise the minimum wage for an H-1B holder from $60K to $100K, and place limits on the body shop companies that employ mostly H-1B holders in a pass-through arrangement. Whether it's enough to stop the direct replacement of workers, or whether it will just accelerate offshoring, remains to be seen. But, I think removing the most blatant and most abused loopholes in the rules is a good start. "The high-skilled visa program is critical to ensuring American companies can attract and retain the world's best talent," said Issa in a statement. "Unfortunately, in recent years, this important program has become abused and exploited as a loophole for companies to replace American workers with cheaper labor from overseas."
An anonymous reader quotes a report from DSLReports: Comcast plans to roll-out prepaid cable TV and internet services later this year in portions of Illinois and four other states. According to a company announcement, Comcast's Xfinity Prepaid Services lets users sign up for TV or internet services and renew service for seven or 30 days at a time -- instead of paying by the month. A one-time setup fee of $80 includes equipment and 30 days of service, with users paying $15 for an additional seven days and $45 for an additional 30 days. "We want to create an easy, pay-as-you-go option for people who want more flexibility and predictability when buying our services," said Marcien Jenckes, Executive Vice President, Consumer Services, Comcast Cable. "And our partnership with Boost Mobile will give Xfinity Prepaid customers even more places where they can conveniently sign-up and pay-as-they-go."
An anonymous reader writes from a report via The Guardian: Director Oliver Stone talked to whistleblower Edward Snowden in front of an audience at a question and answer session on Thursday evening. He compared Snowden's anxiety over his own appearance in his Snowden biopic film "Snowden" to that of Donald Trump, who was cut from one of his films six years before. Snowden replied: "I'd like to avoid that association." At the event, Snowden did also shed some light on his personal life, years after his revelation of the NSA's secret surveillance of the American public's internet activity resulted in criminal charges under the Espionage Act that led to his exile in Russia. "I can confirm that I am not living in a box," Snowden said. "I actually live a surprisingly free life. This was not the most likely outcome. I didn't actually expect to make it out of Hawaii. I thought it was incredibly risky. I had a lot of advantages in doing what I did; I worked for the CIA on the human intelligence side, I worked for the NSA on the signals intelligence side, and I taught counterintelligence. This is not something that's covered that well in the media. I was about as well placed as anybody could be, and I still thought I was going to get rolled up at the airport and that there were going to be knocks on the doors of the journalists." When asked what he thought about Gordon-Levitt's performance in the film where he plays Edward Snowden, Snowden responded: "This is one of the things that's kind of crazy and surreal about this kind of experience: I don't think anybody looks forward to having a movie made about themselves, especially someone who is a privacy advocate. Some of my family members have said, 'He sounds just like you!' I can't hear it myself but if he can pass the family test he's doing all right." Snowden agreed to participate on the film because he thought it could raise awareness in ways his own advocacy could not. Snowden was also in the news recently for developing a way for potentially imperiled smartphone users to monitor whether their devices are making any potentially compromising radio transmissions.
Mastercard has agreed to purchase a controlling stake in VocalLink, the payments processor that handles most payroll and household bill processing in the UK. The American payment giant will be paying up to $1.14 billion. Fortune reports: According to MasterCard MA, the deal would create "the first true combination of the traditional person-to-merchant cards business with a clearing business." That is, of course, presuming it clears regulatory scrutiny. VocaLink runs Link, the network that provides interoperability between British ATMs, as well as BACS, the clearing house for payments between bank accounts, and Faster Payments, the inter-bank transfer system for Internet and telephone-based payments.FastCompany explains what this could mean for MasterCard users.
An anonymous reader writes: Apple has confirmed to TechCrunch that Pokemon Go has attracted more downloads in the App Store during its first week than any other app in App Store history. What's even more surprisingly is that the app was only available in a few countries at the time -- it initially launched in New Zealand, Australia and the U.S. Apple didn't provide the number of downloads, but one can assume it's well into the millions. Pokemon Go is expected to become even more popular as it becomes available in more countries -- the game just launched in Japan today. With millions of downloads in the first week alone, Pokemon Go is expected to generate large sums of money for Apple. The Guardian is reporting that Apple will "rake in $3 billion in revenue from Pokemon Go in the next one to two years as gamers buy 'PokeCoins' from its app store."
An anonymous reader shares a Reuters report: China is aiming for a top-10 ranking in automation for its industries by 2020 by putting more robots in its factories, the International Federation of Robotics (IFR) said. China's push to modernize its manufacturing with robotics is partly a response to labor shortages and fast-rising wages. But the world's second-largest economy still has far lower robot penetration than other big industrialized economies -- just 36 per 10,000 manufacturing workers in 2015, ranking it 28th among the world's most automated nations. By 2020, it aims to boost penetration to 150 per 10,000 workers, IFR said in a statement, citing Wang Ruixiang, President of the China Machinery Industry Federation. To help reach that goal, China aims for sales of 100,000 domestically produced industrial robots a year by 2020, up 49 percent compared with last year, the IFR said in a statement at an industry summit in Shanghai, where the Chinese federation's chief was speaking.
An anonymous reader writes from a report via Digital Trends: Researchers at Purdue University and the University of Tennessee have found a non-chemical way to extend regular milk's shelf life to around 2-3 weeks, and without affecting the nutrients or flavor. The technology they've developed involves increasing the temperature of milk by just 10 degrees for less than a second, which is well below the 70-degree Celsius threshold needed for pasteurization. That quick heat blast is still able to eliminate more than 99 percent of the bacteria left from pasteurization. "The developed technology uses low temperature, short time (LTST) in a process that disperses milk in the form of droplets with low heat/pressure variation over a short treatment time in conjunction with pasteurization," Bruce Applegate, Purdue's associate professor in the Department of Food Science, explained to Digital Trends. "The resultant product was subjected to a taste panel and participants had equal or greater preference for the LTST pasteurized milk compared to normally pasteurized milk. The shelf was determined to be a minimum of two weeks longer than the standard shelf life from pasteurization alone." As for whether or not this method will make its way to store shelves, it won't in the near future. "Currently an Ohio-based milk processor is using this technology and distributing the milk," Applegate says. "The unit is approved for processing milk in Ohio and distribution nationwide. The product is currently being distributed, however it has not been labeled as extended shelf life milk. Once the commercial application is validated the milk will be labelled with the extended shelf life." Scientists from Duke University believe there may be a large source of hydrogen gas under the ocean, caused by rocks forming from fast-spreading tectonic plates.
New submitter pyroclast writes: According to research from Duke University, rocks forming from fast-spreading tectonic plates create hydrogen gas in large quantities. The tectonic alternation of hydrolyzed ultramafic rock to serpentinized rock has the byproduct of hydrogen gas. Science Daily reports: "'A major benefit of this work is that it provides a testable, tectonic-based model for not only identifying where free hydrogen gas may be forming beneath the seafloor, but also at what rate, and what the total scale of this formation may be, which on a global basis is massive,' said [researcher] Lincoln F. Pratson[.] 'Most scientists previously thought all hydrogen production occurs only at slow-spreading lithosphere, because this is where most serpentinized rocks are found. Although faster-spreading lithosphere contains smaller quantities of this rock, our analysis suggests the amount of H2 produced there might still be large,' [researcher Stacy] Worman said. [S]cientists need to understand where the gas goes after it's produced. 'Maybe microbes are eating it, or maybe it's accumulating in reservoirs under the seafloor. We still don't know,' Worman said. 'Of course, such accumulations would have to be quite significant to make hydrogen gas produced by serpentinization a viable fuel source.'"
An anonymous reader writes from a report via Engadget: Spotify is now opening its data to targeted advertising. "Everything from your age and gender, to the music genres you like to listen to will be available to various third-party companies," reports Engadget. "Spotify is calling it programmatic ad buying (Warning: source may be paywalled) and has already enabled it." The nearly 70 million people that currently use Spotify's free, ad-supported streaming service across 59 countries will be affected. The ads will be audio-based and stretch between 15-30 seconds in length. The advertisers who buy ad spots will be able to look for specific users by viewing their song picks to find the best matches for the products they're selling. Two weeks ago, China has released its first ever set of digital ad regulations that seems to all but ban ad blocking.
An anonymous reader quotes a report from ABC News: A Texas man who acted as a secret agent for the Russian government and illegally exported cutting-edge military technology to Russia has been sentenced to 10 years in prison. Alexander Fishenko learned his punishment Thursday in federal court in New York. He pleaded guilty in September to crimes including acting as a Russian agent. The 50-year-old Fishenko is a U.S. and Russian citizen. He owned Houston-based Arc Electronics Inc. Prosecutors say he led a scheme that evaded strict export controls for micro-electronics commonly used in missile guidance systems, detonation triggers and radar systems. Prosecutors say his company shipped about $50 million worth of technologies to Russia between 2002 and 2012. In other Russian-related news, a Russian government-owned news site Sputnik has reported that the Kremlin is building a nuclear space bomber that should be flight-ready by 2020.