An anonymous reader shares a report: With progress in the battle against cancer progressing slowly on Earth, California researchers have teamed up with astronauts to take the battle to the stars. In space, the weak pull of gravity, also known as microgravity, places cells under incredible stress, causing them to age more rapidly. This phenomenon allows scientists to witness the progression of cancer growth -- and the effect of cancer treatments -- much more rapidly than they could on Earth.

When the Axiom 3 spaceflight launched from Kennedy Space Center in Cape Canaveral, Fla., on Jan. 18, bound for the International Space Station, it took with it four crewmembers and some other unusual passengers -- miniature tumor organoids produced from the cells of cancer patients, grown in the lab by scientists at the University of California San Diego. Axiom 3 was slated for splashdown on Saturday but has been delayed until Tuesday, at the earliest, due to weather, according to SpaceX, which manufactured the Crew Dragon spacecraft used for the mission.

It wasn't the first time the team -- led by Dr. Catriona H.M. Jamieson, a hematologist and medical professor at the college -- sent such samples into space. It previously launched stem cells on multiple Space X flights and noticed that pre-leukemic changes occurred, unseen during the same timeframe in controls on the ground. "We said, 'Wait, what if you send cancer up?'" Jamieson tells Fortune. "'Will the cancer go from bad to worse?' And the answer is yes, under conditions of stress" caused by microgravity.

Researchers at Cern have submitted plans for a next-generation particle accelerator that's at least three times the size of the Large Hadron Collider. The Guardian reports: The Large Hadron Collider, built inside a 27km circular tunnel beneath the Swiss-French countryside, smashes together protons and other subatomic particles at close to the speed of light to recreate the conditions that existed fractions of a second after the big bang. The machine, the world's largest collider, was used in the discovery of the Higgs boson in 2012, nearly 50 years after the particle was proposed by Peter Higgs, the theoretical physicist at the University of Edinburgh, and several other researchers. The feat was honored with the Nobel prize in physics the following year.

But since the discovery of the Higgs boson, the collider has not revealed any significant new physics that might shed light on some of the deepest mysteries of the universe, such as the nature of dark matter or dark energy, why matter dominates over antimatter, and whether reality is permeated with hidden extra dimensions. Cern drew up plans for the next machine, the Future Circular Collider (FCC), in 2019. The $21.5 billion (20 billion euro) machine would have a 91km circumference and aim to smash subatomic particles together at a maximum energy of 100 teraelectronvolts (TeV). The Large Hadron Collider achieves maximum energies of 14TeV.

On Friday, the Cern council discussed a midterm review of a feasibility study for the FCC. If the plans go ahead, the organization would ask for approval in the next five years and hope to have the machine built and ready for operations in the 2040s when the LHC has completed its runs. Prof Fabiola Gianotti, the director general of Cern, said: "If approved, the FCC would be the most powerful microscope ever built to study the laws of nature at the smallest scales and highest energies, with the goal of addressing some of the outstanding questions in today's fundamental physics and our understanding of the universe."

An anonymous reader quotes a report from Popular Science: As detailed in the new issue of the journal Cell Stem Cell, University of Wisconsin-Madison researchers have developed a novel 3D-printing approach for creating cultures that grow and operate similar to brain tissue. While traditional 3D-printing involves layering "bio-ink" vertically like a cake, the team instead tasked their machine to print horizontally, as if playing dominoes. As New Atlas explains, researchers placed neurons grown from pluripotent stem cells (those capable of becoming multiple different cell types) within a new bio-ink gel made with fibrinogen and thrombin, biomaterials involved in blood clotting. Adding other hydrogels then helped loosen the bio-ink to solve for the 3 encountered during previous 3D-printed tissue experiments. According to Su-Chun Zhang, a research lead and UW-Madison professor of neuroscience and neurology, the resultant tissue is resilient enough to maintain its structure, but also sufficiently malleable to permit adequate levels of oxygen and nutrient intake for the neurons. "The tissue still has enough structure to hold together but it is soft enough to allow the neurons to grow into each other and start talking to each other," Zhang explains in a recent university profile.

Because of their horizontal construction, the new tissue cells formed connections not only within each layer, but across them, as well -- much like human neurons. The new structures could interact thanks to producing neurotransmitters, and even created support cell networks within the 3D-printed tissue. In these experiments, the team printed both cerebral cortex and striatum cultures. Although responsible for very different functions -- the former associated with thought, language, and voluntary movement; the latter tied to visual information -- the two 3D-printed tissues could still communicate, "in a very special and specific way," Zhang said. Researchers believe their technique isn't limited to creating just those two types of cultures, but hypothetically "pretty much any type of neurons [sic] at any time," according to Zhang. This means the 3D-printing method could eventually help study how healthy portions of the brain interact with parts affected by Alzheimers, examining cell signal pathways in Downs syndrome, as well as use tissue to test new drugs. "Our brain operates in networks," Zhang explained. "We want to print brain tissue this way because cells do not operate by themselves. They talk to each other. This is how our brain works and it has to be studied all together like this to truly understand it."

The "technology building blocks" for space solar are already available, reports Clean Technica. "It's just a matter of scaling, systems integration, and adjustments for space-hardiness."

And several groups are looking at it — including the U.S. Space Force To help push costs down, the California Institute of Technology has proposed a sandwich-type solar module that integrates solar harvesting along with conversion to a radio frequency into one compact package, accompanied by a built-in antenna. Last month researchers at the school wrapped up a months-long, in-space test of different types of solar cells. Another approach is illustrated by the Michigan startup Virtus Solis, an industry partner of the University of Bristol. Last June the company and the school received £3.3 million in funding from the UK Net Zero Innovation program, for developing an open-source model for testing the performance of large, centralized antennas in space. "The concept depends upon the use of gigascale antenna arrays capable of delivering over 2GW of power from space onto similar gigascale antenna arrays either at sea or on the ground," the school explained.

As for how such a thing would be launched into space, that's where the U.S. Space Force comes in. Last August, the Space Force awarded a small business contract to the U.S. startup Orbital Composites. The company is tasked with the mission of developing its patented "quantum antenna" and in-space fabrication tools for secure communications in space applications, including space-to-space as well as space-to-Earth and vice versa. The basic idea is to let 3D printing doing much of the work in space. According to Orbital, in-space fabrication would save more than 100 times the cost of applying conventional fabrication methods to large-scale orbiting antennas. "By harnessing the potential of In-Space Servicing, Assembly, and Manufacturing (ISAM), the company eyes the prospect of creating significantly larger space antennas," Orbital Composites explains. "By fabricating antennas in space, larger and more complex designs are possible that eliminate the constraints of launch and rocket fairings...."

If you're guessing that a hookup between Virtus and Orbital is in the works, that's a good guess. On February 1, at the SpaceCOM conference in Orlando, Florida, Virtus Solis let slip that it is working with Orbital Composites on a space solar pilot project. If all goes according to plan, the project will be up and running in 2027, deploying Virtus's robot-enabled fabrication system with Orbital's 3D printing. As of this writing the two companies have not posted details, but Space News picked up the thread. "The 2027 mission is designed to showcase critical power-generation technologies including in-space assembly of solar panels and transmission of more than one kilowatt to Earth," Space News explained. "The news release calls the 2027 mission "a precursor to large-scale commercial megawatt-class solar installations in space by 2030...."

To be clear, Orbital's press release about its new Space Force quantum antenna contract does not mention anything in particular about space solar. However, the pieces of the puzzle fit. Along with the Virtus and Grumman connections, in October of 2022 Orbital won a small business contract through SpaceWERX, the Space Force's innovative technologies funding arm, to explore the capabilities of ISAM systems.
"SpaceWERX comes under the umbrella of the U.S. Air Force's AFWERX innovation branch, which has developed a program called SSPIDR, short for Space Solar Power Incremental Demonstrations and Research Project," the article points out. (While Virtus believes most space-based solar power systems could deliver megawatt hours of electricity at prices comparable to today's market.)

An anonymous reader shared this report from Slate: Last November, the American Ornithological Society, or AOS, announced that it would change the common names of all American birds named after people. There are 152 such "eponymic" names (that is, birds that are named after a specific person, like Bicknell's Thrush) on the AOS' official checklist, and the group is planning to start with between 70 and 80 species predominantly found in the U.S. and Canada. In the coming years, birds like Cooper's Hawk, Wilson's Snipe, and Lincoln's Sparrow will be stripped of their eponyms and given new common English names.

The eponymic naming issue has been heating up in the bird world for a few years now. Birds got their English names when they were "discovered" by Western scientists, or otherwise identified as a new species. This meant ornithologists had the honor of coming up with whatever moniker they wanted, and frequently named birds in honor of a benefactor, a friend, or the person who shot the first known specimen. But a growing number of ornithologists and nonscientist birders are questioning why we're stuck with names decided on a whim hundreds of years ago, especially when the names aren't very good...

Rather than attempt the impossible task of reviewing the people with birds named after them one by one, the AOS said it would just scrap them all and start from scratch. But that's where the real challenge comes in — because lots of bird names are pretty bad. Not offensive bad, like named after a Confederate general, but just unsatisfactory bad. There was never any standardization for how common bird names were granted, which means those names are all over the place and provide little guidance for what renaming should look like.
Birds are named after their identifying features, size, habitat, the sound they make, or where they were first discovered. So the American Ornithological Society announced it will "conduct an open, inclusive, and scientifically rigorous pilot program in 2024 to develop its new approach to English bird names in the U.S. and Canada." [T]here are few specifics yet, and no easy way to organize the public and whittle down suggestions in the lawless and nonsensical world of bird names. But the AOS has committed to change: Unlike the closed-door decisions of the past, this will be a public process. The plan is to take suggestions — from field marks, Indigenous names, colloquialisms ... from anywhere — narrow it down, somehow, to a few options, and let people decide... Our new bird names won't be ideal — none of them are — but, for the first time, they will belong to us.

"Japan's first moon mission has likely come to an end after a surprising late-game comeback," reports Mashable, "with the spacecraft taking one last photo of its surroundings before the deep-freeze of night... showing ominous shadows cast upon a slope of the Shioli crater, its landing site on the near side of the moon." Since Monday, the spacecraft has analyzed rocks around the crater with a multi-band spectral camera. JAXA picked the landing spot because of what it could tell scientists about the moon's formation... The special camera completed its planned observation, able to study more targets than originally expected, according to an English translation of a news release from the space agency... "Based on the large amount of data we have obtained, we are proceeding with (analyses) to identify rocks and estimate the chemical composition of minerals, which will help solve the mystery of the origin of the moon," JAXA said in a statement translated by Google...

The spacecraft has now entered a dormant state, prompted by nightfall on the moon. Because one rotation of the moon is about 27 Earth days, the so-called "lunar night," when the moon is no longer receiving sunlight, lasts about two weeks. Not much can survive the -270 degrees Fahrenheit brought on by darkness — not even robots. In this freezing temperature, soldered joints on hardware and mechanical parts break, and batteries die. But rest assured, the JAXA team will try to communicate with its scrappy moon lander when the sun rises again.
In mid-week Japan's space agency posted that "Although SLIM was not designed for the harsh lunar nights, we plan to try to operate again from mid-February, when the Sun will shine again on SLIM's solar cells."

Later they posted that they'd sent a command to turn on SLIM's communicator again "just in case, but with no response, we confirmed SLIM had entered a dormant state. This is the last scene of the Moon taken by SLIM before dusk."

Nicholas Wise is a fluid dynamics researcher who moonlights as a scientific fraud buster, reports Science magazine. And last June he "was digging around on shady Facebook groups when he came across something he had never seen before." Wise was all too familiar with offers to sell or buy author slots and reviews on scientific papers — the signs of a busy paper mill. Exploiting the growing pressure on scientists worldwide to amass publications even if they lack resources to undertake quality research, these furtive intermediaries by some accounts pump out tens or even hundreds of thousands of articles every year. Many contain made-up data; others are plagiarized or of low quality. Regardless, authors pay to have their names on them, and the mills can make tidy profits.

But what Wise was seeing this time was new. Rather than targeting potential authors and reviewers, someone who called himself Jack Ben, of a firm whose Chinese name translates to Olive Academic, was going for journal editors — offering large sums of cash to these gatekeepers in return for accepting papers for publication. "Sure you will make money from us," Ben promised prospective collaborators in a document linked from the Facebook posts, along with screenshots showing transfers of up to $20,000 or more. In several cases, the recipient's name could be made out through sloppy blurring, as could the titles of two papers. More than 50 journal editors had already signed on, he wrote. There was even an online form for interested editors to fill out...

Publishers and journals, recognizing the threat, have beefed up their research integrity teams and retracted papers, sometimes by the hundreds. They are investing in ways to better spot third-party involvement, such as screening tools meant to flag bogus papers. So cash-rich paper mills have evidently adopted a new tactic: bribing editors and planting their own agents on editorial boards to ensure publication of their manuscripts. An investigation by Science and Retraction Watch, in partnership with Wise and other industry experts, identified several paper mills and more than 30 editors of reputable journals who appear to be involved in this type of activity. Many were guest editors of special issues, which have been flagged in the past as particularly vulnerable to abuse because they are edited separately from the regular journal. But several were regular editors or members of journal editorial boards. And this is likely just the tip of the iceberg.
The spokesperson for one journal publisher tells Science that its editors are receiving bribe offers every week..

Thanks to long-time Slashdot reader schwit1 for sharing the article..

The New York Times reports on a potential fix for global warming being proiposed by "a small but growing number of astronomers and physicists... the equivalent of a giant beach umbrella, floating in outer space. " The idea is to create a huge sunshade and send it to a far away point between the Earth and the sun to block a small but crucial amount of solar radiation, enough to counter global warming. Scientists have calculated that if just shy of 2% of the sun's radiation is blocked, that would be enough to cool the planet by 1.5 degrees Celsius, or 2.7 Fahrenheit, and keep Earth within manageable climate boundaries. The idea has been at the outer fringes of conversations about climate solutions for years. But as the climate crisis worsens, interest in sun shields has been gaining momentum, with more researchers offering up variations. There's even a foundation dedicated to promoting solar shields.

A recent study led by the University of Utah explored scattering dust deep into space, while a team at the Massachusetts Institute of Technology is looking into creating a shield made of "space bubbles." Last summer, Istvan Szapudi, an astronomer at the Institute for Astronomy at the University of Hawaii, published a paper that suggested tethering a big solar shield to a repurposed asteroid. Now scientists led by Yoram Rozen, a physics professor and the director of the Asher Space Research Institute at Technion-Israel Institute of Technology, say they are ready to build a prototype shade to show that the idea will work.

To block the necessary amount of solar radiation, the shade would have to be about 1 million square miles, roughly the size of Argentina, Rozen said. A shade that big would weigh at least 2.5 million tons — too heavy to launch into space, he said. So, the project would have to involve a series of smaller shades. They would not completely block the sun's light but rather cast slightly diffused shade onto Earth, he said. Rozen said his team was ready to design a prototype shade of 100 square feet and is seeking between $10 million and $20 million to fund the demonstration. "We can show the world, 'Look, there is a working solution, take it, increase it to the necessary size," he said...

Rozen said the team was still in the predesign phase but could launch a prototype within three years after securing funds. He estimated that a full-size version would cost trillions (a tab "for the world to pick up, not a single country," he said) but reduce the Earth's temperature by 1.5 Celsius within two years. "We at the Technion are not going to save the planet," Rozen said. "But we're going to show that it can be done."

Jennifer Ouellette reports via Ars Technica: A typical lawn sprinkler features various nozzles arranged at angles on a rotating wheel; when water is pumped in, they release jets that cause the wheel to rotate. But what would happen if the water were sucked into the sprinkler instead? In which direction would the wheel turn then, or would it even turn at all? That's the essence of the "reverse sprinkler" problem that physicists like Richard Feynman, among others, have grappled with since the 1940s. Now, applied mathematicians at New York University think they've cracked the conundrum, per a recent paper published in the journal Physical Review Letters -- and the answer challenges conventional wisdom on the matter. "Our study solves the problem by combining precision lab experiments with mathematical modeling that explains how a reverse sprinkler operates," said co-author Leif Ristroph of NYU's Courant Institute. "We found that the reverse sprinkler spins in the 'reverse' or opposite direction when taking in water as it does when ejecting it, and the cause is subtle and surprising." [...]

Enter Leif Ristroph and colleagues, who built their own custom sprinkler that incorporated ultra-low-friction rotary bearings so their device could spin freely. They immersed their sprinkler in water and used a special apparatus to either pump water in or pull it out at carefully controlled flow rates. Particularly key to the experiment was the fact that their custom sprinkler let the team observe and measure how water flowed inside, outside, and through the device. Adding dyes and microparticles to the water and illuminating them with lasers helped capture the flows on high-speed video. They ran their experiments for several hours at a time, the better to precisely map the fluid-flow patterns.

Ristroph et al. found that the reverse sprinkler rotates a good 50 times slower than a regular sprinkler, but it operates along similar mechanisms, which is surprising. "The regular or 'forward' sprinkler is similar to a rocket, since it propels itself by shooting out jets," said Ristroph. "But the reverse sprinkler is mysterious since the water being sucked in doesn't look at all like jets. We discovered that the secret is hidden inside the sprinkler, where there are indeed jets that explain the observed motions." A reverse sprinkler acts like an "inside-out rocket," per Ristroph, and although the internal jets collide, they don't do so head-on. "The jets aren't directed exactly at the center because of distortion of the flow as it passes through the curved arm," Ball wrote. "As the water flows around the bends in the arms, it is slung outward by centrifugal force, which gives rise to asymmetric flow profiles." It's admittedly a subtle effect, but their experimentally observed flow patterns are in excellent agreement with the group's mathematical models.

An anonymous reader quotes a report from NPR: The Environmental Protection Agency is proposing that nine PFAS, also known as "forever chemicals," be categorized as hazardous to human health. The EPA signed a proposal Wednesday that would deem the chemicals "hazardous constituents" under the Resource Conservation and Recovery Act. For the agency to consider a substance a hazardous constituent, it has to be toxic or cause cancer, genetic mutation or the malformations of an embryo. The full list of the nine substances can be found here.

The agency cited various studies in which forever chemicals were found to cause a litany of "toxic effects" in humans and animals, including, but not limited to cancer, a decreased response to vaccinations, high cholesterol, decrease in fertility in women, preeclampsia, thyroid disorders and asthma, the EPA said. Short for "per-and polyfluoroalkyl substances," PFAS cover thousands of man-made chemicals. PFAS are often used for manufacturing purposes, such as in nonstick cookware, adhesives, firefighting foam, turf and more. PFAS have been called "forever chemicals" because they break down very slowly and can accumulate in people, animals and the environment. Further reading: 'Forever Chemicals' Taint Nearly Half of US Tap Water, Study Estimates

NASA is starting to take its first steps toward opening a commercial pathway to Mars. From a report: This week, the space agency's Jet Propulsion Laboratory issued a new solicitation to the industry titled "Exploring Mars Together: Commercial Services Studies." This is a request for proposals from the US space industry to tell NASA how they would complete one of four private missions to Mars, including delivering small satellites into orbit or providing imaging services around the red planet.

"The Mars Exploration Program Draft Plan through the next two decades would utilize more frequent lower cost missions to achieve compelling science and exploration for a larger community," the document states. "To realize the goals of the plan, government and US industry would partner to leverage current and emerging Earth and lunar products and commercial services to substantially lower the overall cost and accelerate leadership in deep space exploration."

NASA will pay proposers $200,000 for a study of one of the reference missions or $300,000 for a maximum of two studies. The space agency said it intends to award "multiple" contract awards. In its 496-page solicitation, NASA outlines four "design reference missions" that companies can bid on. Basically, the space agency is asking companies how they would go about fulfilling these tasks.

doc1623 shares a report from Ars Technica: Scientists at the University of Arizona decided to investigate whether closing the toilet lid before flushing reduces cross-contamination of bathroom surfaces by airborne bacterial and viral particles via "toilet plumes." The bad news is that putting a lid on it doesn't result in any substantial reduction in contamination, according to their recent paper published in the American Journal of Infection Control. The good news: Adding a disinfectant to the toilet bowl before flushing and using disinfectant dispensers in the tank significantly reduce cross-contamination. [...]

The scientists conducted their experiment with E. coli (as a host bacteria) and coliphage MS2; the latter is not a human or animal pathogen but serves as a useful model. The public toilet used in the experiment was located in a stall in the restroom of an office building. That toilet was tankless, relying on water-line pressure for flushing, with no lid and a U-shaped seat with a gap in the front. The home toilet was a standard siphonic toilet with a tank and lid in a private residence; there was no gap on the center of the seat. Toilet bowls were seeded with MS2 and flushed. After one minute, samples were taken from various restroom surfaces: the top and bottom of toilet seats, the bowl rim, three locations on the floor, and the right and left walls. The team also conducted a similar experiment involving cleaning the bowls with toilet brushes, both with and without Lysol toilet bowl cleaner. All those samples were then tested for MS2 contamination.

The results: both the tops and bottoms of the lidless public toilet seats had more contamination compared to household seats, but otherwise, there was no statistical significance in the degree of contamination between lidless public toilets and household toilets with lids. And the surface contamination did indeed persist even after repeated flushes. The toilet seat was the worst offender with the greatest degree of contamination, which the authors suggest "reflects the airflow that occurs during toilet flushing, i.e., largely around the top and bottom of the toilet seat." That same airflow is likely a factor in spreading the contamination to restroom floors and walls. Perhaps the least surprising finding is that rigorous cleaning with a toilet bowl brush and Lysol reduced the contamination by 99.99 percent compared to cleaning with just a brush. Therefore, "The most effective strategy for reducing restroom cross-contamination associated with toilet flushing include the addition of a disinfectant to the toilet bowl before flushing and the use of disinfectant/detergent dispensers in the toilet tank," the authors concluded. They also recommend regularly disinfecting all restroom surfaces after flushing or cleaning with a toilet brush in health care facilities -- which often have a lot of immunocompromised people -- and if someone in your house has an active infection like norovirus. The findings have been published in the journal American Journal of Infection Control.

Slashdot reader doc1623 writes: "This headline brought me joy today, so I thought I would share (I could honestly care less about reading the article but joy is joy, I take it where I can find it.)"

New submitter Smonster shares a report from the New York Times: With restrictions on space and weight, what would you bring if you were going to Mars? An ideal option might be a single material that can shift shapes into any object you imagine. In the morning, you could mold that material into utensils for eating. When breakfast is done, you could transform your fork and knife into a spade to tend to your Martian garden. And then when it's happy hour on the red planet, that spade could become a cup for your Martian beer. What sounds like science fiction is, perhaps, one step closer to reality.

Researchers at the University of Chicago Pritzker School of Molecular Engineering have created a new type of plastic with properties that can be set with heat and then locked in with rapid cooling, a process known as tempering. Unlike classic plastics, the material retains this stiffness when returned to room temperature. The findings, published in the journal Science on Thursday, could someday change how astronauts pack for space.

"Rather than taking all the different plastics with you, you take this one plastic with you and then just give it the properties you need as you require," said Stuart Rowan, a chemist at the University of Chicago and an author of the new study. But space isn't the only place the material could be useful. Dr. Rowan's team also sees its potential in other environments where resources are scare -- like at sea or on the battlefield. It could also be used to make soft robots and to improve plastics recycling.

An anonymous reader quotes a report from Ars Technica: Biotechnology company Biogen is abandoning Aduhelm, its questionable Alzheimer's drug that has floundered on the market since its scandal-plagued regulatory approval in 2021 and brow-raising pricing. On Wednesday, the company announced it had terminated its license for Aduhelm (aducanumab) and will stop all development and commercialization activities. The rights to Aduhelm will revert back to the Neurimmune, the Swiss biopharmaceutical company that discovered it.

Biogen will also end the Phase 4 clinical trial, ENVISION, that was required by the Food and Drug Administration to prove Biogen's claims that Aduhelm is effective at slowing progression of Alzheimer's in its early stages -- something two Phase 3 trials failed to do with certainty. In the announcement, Biogen noted it took a financial hit of $60 million in the fourth quarter of 2023 to close out its work on Aduhelm, which the company at one point reportedly estimated would bring in as much as $18 billion in revenue per year.

An anonymous reader shares a report: In a somewhat groundbreaking yet bizarre scientific feat, MIT biotechnology PhD student researcher Lauren "Ren" Ramlan has coaxed a simulation of the humble E. coli bacteria into a rudimentary screen capable of displaying the iconic video game. However, before you get too excited about playing games in a petri dish, there's a catch. According to Ramlan's simulation, displaying a single frame of Doom on these bioluminescent bacteria -- should anyone attempt to do this with the real thing -- would take roughly 70 minutes, with a full reset to the bacteria's original state taking a whopping eight hours and 20 minutes.

Dubbed a step into the world of biological screens, Ramlan engineered a system where the bacteria would function as 1-bit pixels, toggling between light and dark states. This bio-display utilizes a well plate in a 32x48 array, each containing genetically modified E. coli that can be induced to fluoresce, creating a grid of pixel-like structures.

An anonymous reader quotes a report from The Guardian: The first lab-grown freshwater eel meat has been produced, potentially solving a diner's dilemma. Rampant overfishing has caused eel populations to plummet and prices to soar, but the cultivated eel could provide the delicacy guilt-free. The eel meat was produced by Forsea Foods in Israel from embryonic cells of a freshwater eel. The company collaborated with a Japanese chef to create unagi kabayaki, marinated grilled eel over rice, and unagi nigiri, a type of sushi.

The company aims to scale up its operation and have the cultivated eel on sale in about two years. Japan's prime minister, Fumio Kishida, last year backed the development of a cultivated meat industry. The restaurant price in Japan is about $250 a kilogram, and Forsea Foods expects the price of the cultivated eel to match that of the wild-caught eel. [...] Forsea Foods' strategy is to target species at risk of extinction in the wild that also command high prices in restaurants and shops, with eel meeting both criteria. The very complex life cycle of eels, involving long migrations from rivers to the ocean and several distinct life stages, means it is not possible to farm them like some fish.

The cultivated eel was produced using organoids, tiny bundles of tissue originally developed for use in medical research. The organoids are made of embryonic stem cells taken from fertilized eel eggs. These cells can develop into any kind of tissue and, as they grow, they self-organize into the structure of real meat. The final product also contains some plant-based ingredients. Other approaches to cultivated meat require greater use of expensive growth factor chemicals and scaffolds for cells to grow on [...]. The technique is particularly suited to fish and seafood, whose meat is fairly uniform unlike, for example, marbled beef, he said. Like other cultivated meat, the product is not produced using antibiotics or hormones. Forsea Foods is the only company known to be producing cultivated meat using this technology. The company has raised $5.2 million in investment, with more expected to be announced soon.

An anonymous reader quotes a report from ScienceAlert: Peering into the jungle of microbes that live within us, researchers have stumbled across what seem to be an entire new class of virus-like objects. "It's insane," says University of North Carolina cell biologist Mark Peifer, who was not involved in the study, told Elizabeth Pennisi at Science Magazine. "The more we look, the more crazy things we see." These mysterious bits of genetic material have no detectable sequences or even structural similarities known to any other biological agents.

So Stanford University biologist Ivan Zheludev and colleagues argue their strange discovery may not be viruses at all, but instead an entirely new group of entities that may help bridge the ancient gap between the simplest genetic molecules and more complex viruses. "Obelisks comprise a class of diverse RNAs that have colonized, and gone unnoticed in, human, and global microbiomes," the researchers write in a preprint paper. Named after the highly-symmetrical, rod-like structures formed by its twisted lengths of RNA, the Obelisks' genetic sequences are only around 1,000 characters (nucleotides) in size. In fact, this brevity is likely one of the reasons we've failed to notice them previously.

In a study that has yet to be peer reviewed, Zheludev and team searched 5.4 million datasets of published genetic sequences and identified almost 30,000 different Obelisks. They appeared in about 10 percent of the human microbiomes the team examined. In one set of data, Obelisks turned up in 50 percent of the patients' oral samples. What's more, different types of Obelisks appear to be present in different areas of our bodies. "[This] supports the notion that Obelisks might include colonists of said human microbiomes," the researchers explain. They managed to isolate one type of host cell from our microbiome, the bacterium Streptococcus sanguinis -- a common human mouth microbe. The Obelisk in these microbes had a loop 1,137 nucleotides long. "While we don't know the 'hosts' of other Obelisks," write Zheludev and colleagues. "it is reasonable to assume that at least a fraction may be present in bacteria." The question of the Obelisks' source aside, all seem to include codes for a new class of protein the researchers have named Oblins. Zheludev and team couldn't identify any impact of the Obelisks on their bacterial hosts, or a means by which they could spread between cells. "These elements might not even be 'viral' in nature and might more closely resemble 'RNA plasmids,'" they conclude.

This research appears in the preprint server bioRxiv.

According to Neuralink founder Elon Musk, the first human received an implant from the brain-chip startup on Sunday and is recovering well. "Initial results show promising neuron spike detection," Musk added. Reuters reports: The U.S. Food and Drug Administration had given the company clearance last year to conduct its first trial to test its implant on humans. The startup's PRIME Study is a trial for its wireless brain-computer interface to evaluate the safety of the implant and surgical robot. The study will assess the functionality of the interface which enables people with quadriplegia, or paralysis of all four limbs, to control devices with their thoughts, according to the company's website.

An anonymous reader quotes a report from ProPublica: Reeling from one of the most catastrophic recalls in decades, Philips Respironics said it will stop selling sleep apnea machines and other respiratory devices in the United States under a settlement with the federal government that will all but end the company's reign as one of the top makers of breathing machines in the country. The agreement, announced by Philips early Monday, comes more than two years after the company pulled millions of its popular breathing devices off the shelves after admitting that an industrial foam fitted in the machines to reduce noise could break apart and release potentially toxic particles and fumes into the masks worn by patients.

It could be years before Philips can resume sales of the devices, made in two factories outside Pittsburgh. The company said all the conditions of the multiyear consent decree -- negotiated in the wake of the recall with the Department of Justice on behalf of the Food and Drug Administration -- must be met first. The move by a company that aggressively promoted its machines in ad campaigns and health conferences -- in one case with the help of an Elvis impersonator -- follows relentless criticism about the safety of the machines. A ProPublica and Pittsburgh Post-Gazette investigation found the company held back thousands of complaints about the crumbling foam for more than a decade before warning customers about the dangers. Those using the machines included some of the most fragile people in the country, including infants, the elderly, veterans and patients with chronic conditions.

"It's about time," said Richard Callender, a former mayor in Pennsylvania who spent years using one of the recalled machines. "How many people have to suffer and get sick and die?" Philips said the agreement includes other requirements the company must meet before it can start selling the machines again, including the marquee DreamStation 2, a continuous positive airway pressure, or CPAP, device heralded by Philips when it was unveiled in 2021 for the treatment of sleep apnea. The settlement, which is still being finalized, has to be approved by a court and has not yet been released by the government. It remains unclear how the halt in sales will impact patients and doctors. The company's U.S. market share for sleep apnea devices in 2020 was about 37% -- behind only one competitor, medical device maker ResMed, according to an analysis by iData Research. Philips has dominated the market in ventilator sales, the data shows.

In an announcement earlier today, Prime Minister Rishi Sunak said single-use vapes will be banned in Britain, with certain flavors restricted and regulations put in place around their packaging and displays. The New York Times reports: Mr. Sunak said that the ban, which is part of legislation that still has to be approved by Parliament, was intended to halt "one of the most worrying trends at the moment," before it becomes "endemic." "The long-term impacts of vaping are unknown and the nicotine within them can be highly addictive, so while vaping can be a useful tool to help smokers quit, marketing vapes to children is not acceptable," he said in a statement. Andrea Leadsom, Britain's health minister, said the measures were intended to make sure that vapes were aimed at adults who were quitting smoking, rather than children.

"Nicotine is highly addictive -- and so it is completely unacceptable that children are getting their hands on these products, many of which are undeniably designed to appeal to young people," she said in a statement. [...] While it is not illegal for people under 18 to smoke or vape in Britain, it is illegal for those products to be sold to them. By banning disposable vapes, and restricting the flavors and packaging of refillable vapes, the government hopes to make it far less likely that young people will experiment with e-cigarettes.