A 19-month-old girl named Teddi recently became the first child in the U.K. outside a clinical trial to receive a new gene therapy for metachromatic leukodystrophy (MLD), a fatal genetic disorder, the National Health Service (NHS) announced. Roughly six months out from treatment, "Teddi is a happy and healthy toddler showing no signs of the devastating disease she was born with," the NHS statement reads. Live Science reports: The genetic disorder MLD disrupts cells' ability to break down sulfatides, a fatty material used to insulate the wiring that runs through the white matter of the brain and much of the nervous system beyond the brain. Sulfatide buildup destroys brain and nerve cells, resulting in cognitive problems, a loss of motor control and sensation, seizures, paralysis and blindness, according to the Genetic and Rare Diseases Information Center. Eventually, the disorder leads to death. [...]

The new gene therapy, called Libmeldy (generic name atidarsagene autotemcel), was only recently cleared for use by the NHS and works by inserting into the body working copies of the genes that are faulty in MLD, thus restoring the ability to break down sulfatides. Libmeldy is made using stem cells that are derived from a patient's blood or bone marrow and can give rise to different types of blood cells, according to the European Medicines Agency (EMA). These stem cells carry the new, functional genes into the body, where they give rise to white blood cells that travel through the bloodstream. In clinical trials, Libmeldy offered clear benefits to infantile and juvenile patients who hadn't yet developed MLD symptoms; these patients were able to break down sulfatides at normal rates and showed typical patterns of motor development, for example. The benefit of the therapy seemed to last several years, but at this point, "it is not yet clear whether it will persist life-long, and extended follow-up is needed," the EMA noted.

An anonymous reader quotes a report from Ars Technica: New data suggests that psychedelics may activate serotonin signaling in a very different way than serotonin itself can, reaching the receptors in parts of the cell that serotonin can't get to. Serotonin signaling is complicated. There are seven classes of receptors in humans; some activate signaling pathways, while others inhibit them. One group of receptors allows ions into a cell in response to serotonin, triggering nerve impulses. The rest interact with proteins inside the cell, triggering longer-term responses to serotonin. Psychedelics such as LSD and mescaline bind to members of this latter group and activate it.

This action produces some rather dramatic changes in how people perceive their surroundings. But there's also some evidence that psychedelics promote changes to nerve cells that allow these cells to alter their connectivity. This occurs by causing the structures that receive input from other nerve cells, called dendrites, to grow and branch, potentially allowing additional or altered inputs. One hypothesis is that this altered connectivity allows cells to escape whatever network configuration has been associated with a medical disorder. The researchers confirmed these results using DMT, a psychedelic found in ayahuasca, and psilocin, the active form of the drug psilocybin, which is typically obtained from mushrooms. Twenty-four hours after mice received one of these drugs, nerve cells in their brains had an increased density of extensions from their dendrites. This growth was accompanied by an increased frequency of activity in individual nerve cells. Running the same tests in mice that lacked the gene for the specific serotonin receptor that these drugs target blocked both of these effects, confirming that serotonin signaling is central to the changes.

The researchers then started testing close chemical relatives of the drugs and saw a clear pattern: Making the drug less likely to interact with water boosted their effects on neurons. This suggested that the ability to cross membranes, which are very water-repellant, might be needed to promote changes in dendrites. To confirm this, the researchers poked holes in the membranes, which boosted the activity of water-friendly drug variants that wouldn't readily cross the membrane. This is all a bit confusing because the serotonin receptors sit inside the membrane and interact with the cell's exterior. They have to -- that's where the serotonin is. So why would anything that interacted with those receptors need to cross a membrane to the cell's interior? The receptors on the cell's surface are definitely key to the cell's response to serotonin. But the receptors don't just magically appear on the cell's surface -- they're made elsewhere in the cell and take a while to be processed and transported to the surface. The researchers found a population of serotonin receptors sitting inside a structure called the Golgi. It's not clear whether this population is simply on its way to the cell surface or whether it's retained there by some specific biological activity. Normally, these receptors wouldn't come into contact with serotonin, so they wouldn't signal from this location. But the researchers modified a protein to make it pump serotonin inside of cells and showed that it had the same effect the psychedelics had, suggesting the receptors could be activated and that this activation was key to altering neural connectivity. The study has been published in the journal Science.

The oceans soak up enormous quantities of carbon dioxide, and MIT researchers say they've developed a way of releasing and capturing it that uses far less energy than direct air capture -- with some other environmental benefits to boot. New Atlas reports: According to IEA figures from 2022, even the more efficient air capture technologies require about 6.6 gigajoules of energy, or 1.83 megawatt-hours per ton of carbon dioxide captured. Most of that energy isn't used to directly separate the CO2 from the air, it's in heat energy to keep the absorbers at operating temperatures, or electrical energy used to compress large amounts of air to the point where the capture operation can be done efficiently. But either way, the costs are out of control, with 2030 price estimates per ton ranging between US$300-$1,000. According to Statista, there's not a nation on Earth currently willing to tax carbon emitters even half of the lower estimate; first-placed Uruguay taxes it at US$137/ton. Direct air capture is not going to work as a business unless its costs come way down.

It turns out there's another option: seawater. As atmospheric carbon concentrations rise, carbon dioxide begins to dissolve into seawater. The ocean currently soaks up some 30-40% of all humanity's annual carbon emissions, and maintains a constant free exchange with the air. Suck the carbon out of the seawater, and it'll suck more out of the air to re-balance the concentrations. Best of all, the concentration of carbon dioxide in seawater is more than 100 times greater than in air. Previous research teams have managed to release CO2 from seawater and capture it, but their methods have required expensive membranes and a constant supply of chemicals to keep the reactions going. MIT's team, on the other hand, has announced the successful testing of a system that uses neither, and requires vastly less energy than air capture methods.

In the new system, seawater is passed through two chambers. The first uses reactive electrodes to release protons into the seawater, which acidifies the water, turning dissolved inorganic bicarbonates into carbon dioxide gas, which bubbles out and is collected using a vacuum. Then the water's pushed through to a second set of cells with a reversed voltage, calling those protons back in and turning the acidic water back to alkaline before releasing it back into the sea. Periodically, when the active electrode is depleted of protons, the polarity of the voltage is reversed, and the same reaction continues with water flowing in the opposite direction. In a new study published in the peer-reviewed journal Energy & Environmental Science, the team says its technique requires an energy input of 122 kJ/mol, equating by our math to 0.77 mWh per ton. And the team is confident it can do even better: "Though our base energy consumption of 122 kJ/mol-CO2 is a record-low," reads the study, "it may still be substantially decreased towards the thermodynamic limit of 32 kJ/mol-CO2."

For those of us who struggle to leave our beds in the winter, taunts of "lazy" could well be misplaced. From a report: New research suggests that while humans do not hibernate, we may need more sleep during the colder months. Analysis of people undergoing sleep studies found that people get more REM (rapid eye movement) sleep in the winter. While total sleep time appeared to be about an hour longer in the winter than the summer, this result was not considered statistically significant.

However, REM sleep -- known to be directly linked to the circadian clock, which is affected by changing light -- was 30 minutes longer in the winter than in summer. The research suggests that even in an urban population experiencing disrupted sleep, humans experience longer REM sleep in winter than summer and less deep sleep in autumn. Researchers say if the study's findings can be replicated in people with healthy sleep, this would provide the first evidence for a need to adjust sleep habits to season -- perhaps by going to sleep earlier in the darker and colder months.

New submitter kalieaire writes: Steve Trimble of Aviation week reports that a Hobby Club's missing ballon might have been inadvertently targeted as a malicious UFO and subsequently shot down. When Scientific Balloon Solutions (SBS) company founder, Ron Meadows, reached out to Gov't resources at the FBI and DoD, they were brushed off. "I'm guessing probably they were pico balloons," said Tom Medlin, a retired FedEx engineer and co-host of the Amateur Radio Roundtable show. Merlin has three pico balloons in flight in the Northern and Southern hemispheres. According to Trimble, the description of all three UFOs shot down during 2/10-12 match the description of pico balloon models which can be purchased for $12-180 each, depending on the type. "Launching high-altitude, circumnavigational pico balloons has emerged only within the past decade," writes Trimble. He continues: Meadows and his son Lee discovered it was possible to calculate the amount of helium gas necessary to make a common latex balloon neutrally buoyant at altitudes above 43,000 ft. The balloons carry an 11-gram tracker on a tether, along with HF and VHF/UHF antennas to update their positions to ham radio receivers around the world. At any given moment, several dozen such balloons are aloft, with some circling the globe several times before they malfunction or fail for other reasons. The launch teams seldom recover their balloons.

The balloons can come in several forms. Some enthusiasts still use common, Mylar party balloons, with a set of published calculations to determine the amount of gas to inject. But the round-shaped Mylar balloons often are unable to ascend higher than 20,000-30,000 ft., so some pico balloonists have upgraded to different materials. [...] In fact, the pico balloons weigh less than 6 lb. and therefore are exempt from most FAA airspace restrictions, Meadows and Medlin said. Three countries -- North Korea, Yemen and the UK -- restrict transmissions from balloons in their airspace, so the community has integrated geofencing software into the tracking devices. The balloons still overfly the countries, but do not transmit their positions over their airspace. On Feb. 15, NSC spokesman John Kirby told reporters all three objects "could just be balloons tied to some commercial or benign purpose," but he did not mention the possibility of pico balloons.

Genetically modified seedlings from biotechnology company Living Carbon have been planted in a low-lying tract of southern Georgia's pine belt. According to a paper that has yet to be peer reviewed, these trees are engineered to grow 50 percent faster than non-modified ones over five months in the greenhouse. The New York Times reports: The poplars may be the first genetically modified trees planted in the United States outside of a research trial or a commercial fruit orchard. Just as the introduction of the Flavr Savr tomato in 1994 introduced a new industry of genetically modified food crops, the tree planters on Monday hope to transform forestry. Living Carbon, a San Francisco-based biotechnology company that produced the poplars, intends for its trees to be a large-scale solution to climate change. "We've had people tell us it's impossible," Maddie Hall, the company's co-founder and chief executive, said of her dream to deploy genetic engineering on behalf of the climate. But she and her colleagues have also found believers -- enough to invest $36 million in the four-year-old company.

The company's researchers created the greenhouse-tested trees using a bacterium that splices foreign DNA into another organism's genome. But for the trees they planted in Georgia, they turned to an older and cruder technique known as the gene gun method, which essentially blasts foreign genes into the trees' chromosomes. In a field accustomed to glacial progress and heavy regulation, Living Carbon has moved fast and freely. The gene gun-modified poplars avoided a set of federal regulations of genetically modified organisms that can stall biotech projects for years. (Those regulations have since been revised.) By contrast, a team of scientists who genetically engineered a blight-resistant chestnut tree using the same bacterium method employed earlier by Living Carbon have been awaiting a decision since 2020. [...]

In contrast to fast-growing pines, hardwoods that grow in bottomlands like these produce wood so slowly that a landowner might get only one harvest in a lifetime, said [Vince Stanley, a seventh-generation farmer who manages more than 25,000 forested acres in Georgia's pine belt]. He hopes Living Carbon's "elite seedlings" will allow him to grow bottomland trees and make money faster. "We're taking a timber rotation of 50 to 60 years and we're cutting that in half," he said. "It's totally a win-win." [...] The U.S. Forest Service, which plants large numbers of trees every year, has said little about whether it would use engineered trees. To be considered for planting in national forests, which make up nearly a fifth of U.S. forestland, Living Carbon's trees would need to align with existing management plans that typically prioritize forest health and diversity over reducing the amount of atmospheric carbon, said Dana Nelson, a geneticist with the service. "I find it hard to imagine that it would be a good fit on a national forest," Dr. Nelson said. Living Carbon is focusing for now on private land, where it will face fewer hurdles. Later this spring it will plant poplars on abandoned coal mines in Pennsylvania. By next year Ms. Hall and Mr. Mellor hope to be putting millions of trees in the ground. The report notes that the modified trees are all female, "so they won't produce pollen."

"They're also being planted alongside native trees like sweet gum, tulip trees and bald cypress, to avoid genetically identical stands of trees known as monocultures; non-engineered poplars are being planted as experimental controls."

An anonymous reader quotes a report from Phys.Org: A new paper in Annals of Botany indicates that watching nature documentaries makes people more interested in plants, potentially provoking an involvement in botany and ecology. [T]he researchers investigated whether nature documentaries can promote plant awareness, which may ultimately increase audience engagement with plant conservation programs. They focused on "Green Planet," a 2022 BBC documentary narrated by Sir David Attenborough. The show, watched by nearly 5 million people in the United Kingdom, featured a diversity of plant species, highlighting vegetation from tropical rainforests, aquatic environments, seasonal lands, deserts, and urban spaces. The program also addressed environmental concerns directly, examining the dangers of invasive monocultures and deforestation.

The researchers measured whether "Green Planet" drove interest in the plants by exploring people's online behavior around the time of the broadcast. First, they noted the species that appeared on the show and the time each one appeared on-screen. Then they extracted Google Trends and Wikipedia page hits for those same species before and after the episodes of the documentary aired. The researchers here found a substantial effect of "Green Planet" on viewers' awareness and interest in the portrayed plant species. Some 28.1% of search terms representing plants mentioned in the BBC documentary had peak popularity in the UK, measured using Google Trends, the week after the broadcast of the relevant episode. Wikipedia data showed this as well. Almost a third (31.3%) of the Wikipedia pages related to plants mentioned in "Green Planet" showed increased visits the week after the broadcast. The investigators also note that people were more likely to do online searches for plants that enjoyed more screen time on "Green Planet." "I think that increasing public awareness of plants is essential and fascinating," said the paper's lead author, Joanna Kacprzyk. "In this study, we show that nature documentaries can increase plant awareness among the audience. Our results also suggest that the viewers found certain plant species particularly captivating. These plants could be used for promoting plant conservation efforts and counteracting the alarming loss of plant biodiversity."

Observations of supermassive black holes at the centers of galaxies point to a likely source of dark energy -- the 'missing' 70% of the universe. Phys.Org reports: The measurements from ancient and dormant galaxies show black holes growing more than expected, aligning with a phenomenon predicted in Einstein's theory of gravity. The result potentially means nothing new has to be added to our picture of the universe to account for dark energy: black holes combined with Einstein's gravity are the source. The conclusion was reached by a team of 17 researchers in nine countries, led by the University of Hawai'i and including Imperial College London and STFC RAL Space physicists. The work is published in two papers in the journals The Astrophysical Journal and The Astrophysical Journal Letters.

The conclusion was made by studying nine billion years of black hole evolution. [...] The researchers looked at a particular type of galaxy called giant elliptical galaxies, which evolved early in the universe and then became dormant. Dormant galaxies have finished forming stars, leaving little material for the black hole at their center to accrete, meaning any further growth cannot be explained by these normal astrophysical processes. Comparing observations of distant galaxies (when they were young) with local elliptical galaxies (which are old and dead) showed growth much larger than predicted by accretion or mergers: the black holes of today are 7-20 times larger than they were nine billion years ago.

Further measurements with related populations of galaxies at different points in the universe's evolution show good agreement between the size of the universe and the mass of the black holes. These show that the measured amount of dark energy in the universe can be accounted for by black hole vacuum energy. This is the first observational evidence that black holes actually contain vacuum energy and that they are 'coupled' to the expansion of the universe, increasing in mass as the universe expands -- a phenomenon called 'cosmological coupling.' If further observations confirm it, cosmological coupling will redefine our understanding of what a black hole is.

The idea of using dirt on the Moon to manufacture solar cells, which could power a permanent human settlement, may seem outlandish, but two companies say they've made big progress on that front: they each say they've already made solar cells using fake Moon dirt. From a report: Jeff Bezos' company Blue Origin says it's been making solar cells this way since 2021 but just made that information public in a blog post on Friday. Separately, Lunar Resources, which aims to develop technologies for the "large-scale industrialization of Space," told The Verge in a call today that it's been doing the same for the last couple of years. Each company still has to make an enormous leap: from crafting solar cells out of fake dirt in Earth-bound labs to accomplishing the same thing on the harsh surface of the Moon. But this is a dream decades in the making. And if their technologies succeed, they could help make it possible to build outposts on the Moon. The idea of tapping the Moon's resources to support human settlements, called in-situ resource utilization (ISRU) in technical speak, has only recently moved out of the realm of science fiction. Now, with its Artemis program, NASA is looking to establish "the first long-term presence on the Moon."

Glaxo says the heartburn drug doesn't cause tumors. But the company was warned by its own scientists and independent researchers about the potential danger. From a report: The small British company was sometimes called Glaxo University, because it conducted important pharmaceutical research that rarely resulted in profitable drugs. Then the scientists at Glaxo Laboratories created a molecule they called ranitidine, and in 1978 the company was granted a US patent. The molecule was new, but not novel. The scientists had, as scientists sometimes do, looked for a way to mimic the success of an established drug -- in this case, one that healed ulcers and could be used to treat heartburn. They developed ranitidine quickly, and the US Food and Drug Administration reviewed it quickly. Glaxo gave it the brand name Zantac. Glaxo marketed it as better and safer than the drug that inspired it, Tagamet, and before long, Zantac overtook Tagamet to become the world's bestselling prescription medication. For years, Glaxo counted on Zantac for nearly half of its sales and almost as much of its profit. The company won an award from Queen Elizabeth; the chief executive officer was knighted. Zantac created reputations and fortunes. It financed the modern version of Glaxo, which, after mergers and takeovers and spinoffs, ended up as GSK, a company now worth some $73 billion. Among its most popular drugs are the antidepressants Paxil and Wellbutrin and the shingles vaccine Shingrix.

But not Zantac. In 2019 the drug was found to be tainted with high levels of a probable carcinogen. Not by chance or mistake in a few batches. The poison is created by ranitidine itself. Zantac's makers and health regulators around the world recalled the drug, and in the spring of 2020 the FDA forced it off the market altogether. No company could manufacture it; nobody should ingest it. The carcinogen, called NDMA, was once added to rocket fuel and is now used only to induce cancer in lab rats. The FDA says consuming minuscule amounts isn't harmful. But tests were revealing excessive amounts of NDMA in ranitidine -- and a capacity to create even more over time. No version seemed safe. From ranitidine's beginning to its end, Glaxo had been warned by its own scientists and independent researchers about the potential danger. An account of those four decades emerges in hundreds of documents, thousands of pages, many of which have never been made public. Bloomberg Businessweek reviewed court filings, many still under seal, as well as studies, FDA transcripts and new drug applications obtained via Freedom of Information Act requests. They show that the FDA considered the cancer risks when approving ranitidine. But Glaxo didn't share a critical study. Over the years, the company also backed flawed research designed to minimize concerns and chose not to routinely transport and store the medication in ways that could have eased the problem. Glaxo sold a drug that might harm people, tried to discount evidence of that and never gave anyone the slightest warning. More than 70,000 people who took Zantac or generic versions of it are suing the company in US state courts for selling a potentially contaminated and dangerous drug.

An anonymous reader quotes a report from the Wall Street Journal: A drug aimed at treating eyes immobilized sperm and prevented pregnancy in mice, encouraging researchers that it might work as a contraceptive for men. Injected into male mice, the drug was 100% effective in preventing pregnancy for 2 1/2 hours and about 91% effective for up to 3 1/2 hours, according to a study published Tuesday in the journal Nature Communications. The male mice were fertile after a day, the study found. The new approach is appealing for how quickly the contraceptive acts. The researchers said they would test the drug in other animals and aim for human trials in the coming years.

The drug presented in Tuesday's study acts by deactivating an enzyme in mice and men that make sperm swim. "It's like your on-switch on your TV," said Jochen Buck, a pharmacologist at Weill Cornell Medicine, an author of the study. When the researchers added the drug to human and mice sperm in a dish, the cells stopped moving temporarily. Lower doses of the drug resulted in progressively more mobile sperm cells, Dr. Buck said. The drug took about 15 minutes to take effect. Male mice injected with the drug didn't alter their mating behavior. Allowed to mate in the 2.5 hours after injection, none of 52 pairs of mice produced offspring. A third of mice partners in a control group of 50 had pregnancies. Mice given the drug were later able to father healthy pups, the study said.

Bruce66423 shares a report from Nature: The World Health Organization (WHO) has quietly shelved the second phase of its much-anticipated scientific investigation into the origins of the COVID-19 pandemic, citing ongoing challenges over attempts to conduct crucial studies in China, Nature has learned. Researchers say they are disappointed that the investigation isn't going ahead, because understanding how the coronavirus SARS-CoV-2 first infected people is important for preventing future outbreaks. But without access to China, there is little that the WHO can do to advance the studies, says Angela Rasmussen, a virologist at the University of Saskatchewan in Saskatoon, Canada. "Their hands are really tied." [...]

"There is no phase two," Maria Van Kerkhove, an epidemiologist at the WHO in Geneva, Switzerland, told Nature. The WHO planned for work to be done in phases, she said, but "that plan has changed." "The politics across the world of this really hampered progress on understanding the origins," she said. Researchers are undertaking some work to pin down a timeline of the virus's initial spread. This includes efforts to trap bats in regions bordering China in search of viruses closely related to SARS-CoV-2; experimental studies to help narrow down which animals are susceptible to the virus and could be hosts; and testing of archived wastewater and blood samples collected around the world in late 2019 and early 2020. But researchers say that too much time has passed to gather some of the data needed to pinpoint where the virus originated. "The ending of the investigation is not a surprise," adds Bruce66423. "But why 'quietly'?"

A new report (PDF) from the Data Science 4 Everyone coalition reveals that data literacy skills among fourth and eighth-grade students have declined significantly over the last decade even as these skills have become increasingly essential in our modern, data-driven society. Phys.Org reports: Based on data from the latest National Assessment of Educational Progress results, the report uncovered several trends that raise concerns about whether the nation's educational system is sufficiently preparing young people for a world reshaped by the rise of big data and artificial intelligence. Key findings include:

- The pandemic decline is part of a much longer-term trend. Between 2019 and 2022, scores in the data analysis, statistics, and probability section of the NAEP math exam fell by 10 points for eighth-graders and by four points for fourth-graders. Declining scores are part of a longer-term trend, with scores down 17 points for eighth-graders and down 10 points for fourth-graders over the last decade. That means today's eighth-graders have the data literacy of sixth-graders from a decade ago, and today's fourth-graders have the data literacy of third-graders from a decade ago.

- There are large racial gaps in scores. These gaps exist across all grade levels but are at times most dramatic in the middle and high school levels. For instance, fourth-grade Black students scored 28 points lower -- the equivalent of nearly three grade levels -- than their white peers in data analysis, statistics, and probability.

- Data-related instruction is in decline. Every state except Alabama reported a decline or stagnant trend in data-related instruction, with some states -- like Maryland and Iowa -- seeing double-digit drops. The national share of fourth-grade math teachers reporting "moderate" or "heavy" emphasis on data analysis dropped five percentage points between 2019 and 2022.

Russia's space agency will hold off returning three astronauts from the International Space Station as it works with NASA to investigate a coolant leak issue that impacted an uncrewed freighter spacecraft last weekend. The Register reports: The Progress MS-21 -- also known as the Progress 82 spacecraft -- arrived at the floating space lab in October 2022 carrying water and other supplies. After months of being docked to the station's Poisk module, the vehicle suddenly began spewing liquid coolant. On February 11, engineers at the Russian Mission Control Center detected a drop in pressure inside its coolant loop, but the station and the crew onboard are safe.

The Progress 82 spacecraft is currently being filled with trash and is scheduled to undock on February 17 and be disposed of over the Pacific Ocean. It began leaking coolant just as the Russian uncrewed Progress 83 cargo spacecraft successfully docked with the station's Zvezda service module. NASA and Roscosmos are now investigating the coolant glitch on Progress 82 as it's the second Soyuz incident of late after the Soyuz MS-22 began leaking in December. It's not clear what might have caused that malfunction, although one possibility that has been floated is that a micrometeoroid pierced an exterior radiator.

Yury Borisov, Roscosmos's director general, said cosmonauts Sergey Prokopyev and Dmitry Petelin, as well as NASA astronaut Frank Rubio, will have to remain onboard until March at the earliest while officials examine the coolant loop's depressurization, according to Reuters. Their space ferry had been due to launch on February 20 but that has been pushed back to March 10 at the earliest. "Officials are monitoring all International Space Station systems and are not tracking any other issues," NASA concluded.

An anonymous reader quotes a report from Ars Technica: On Friday, in a blog post not even promoted by the company's Twitter account or a news release, Blue Origin quietly said its "Blue Alchemist" program has been working on [using the dusty lunar surface to manufacture solar panels] for the last two years. The company, founded by Jeff Bezos, has made both solar cells and electricity transmission wires from simulated lunar soil -- a material that is chemically and mineralogically equivalent to lunar regolith. The engineering work is based on a process known as "molten regolith electrolysis," and Blue Origin has advanced the state of the art for solar cell manufacturing. In this process, a direct electric current is applied to the simulated regolith at a high temperature, above 1,600-degrees Celsius. Through this electrolysis process, iron, silicon, and aluminum can be extracted from the lunar regolith. Blue Origin says it has produced silicon to more than 99.999 percent purity through molten regolith electrolysis.

The key advance made by Blue Alchemist is that its engineers and scientists have taken the byproducts of this reaction -- and these materials alone -- to fabricate solar cells as well as the protective glass cover that would allow them to survive a decade or longer on the lunar surface. Blue Origin will attempt to market the technology to NASA for use by its Artemis program to return humans to the Moon in a "sustainable" way. NASA and its international partners seek to differentiate Artemis from the Apollo program by more extended stays on the Moon and building infrastructure such as power systems.

"Although our vision is technically ambitious, our technology is real now," the company said in its blog post. "Blue Origin's goal of producing solar power using only lunar resources is aligned with NASA's highest priority Moon-to-Mars infrastructure development objective." This is a notable research breakthrough, as the same electrolysis process could also be used to produce metals for building habitats and other structures, as well as oxygen. These are all important for "living off the land" if humans are to avoid the expense of needing to bring everything from Earth to live and work in space. While it is a long way from lab experiments to manufacturing on the Moon, these experiments are a critical first step.

"In the foothills of a Martian mountain, NASA's Curiosity rover found stunning new evidence of an ancient lake in the form of rocks etched with the ripples of waves," reports CNN.

But they add that the evidence "appeared in an unlikely place." The rover is traversing an area of Mars called the "sulfate-bearing unit" that researchers previously thought would only show evidence of mere trickles of water, as scientists believed the rocks there formed as the surface of the red planet was drying out. Instead, the rover found some of the clearest evidence yet of ancient waters.

"This is the best evidence of water and waves that we've seen in the entire mission," said Ashwin Vasavada, Curiosity's project scientist at NASA's Jet Propulsion Laboratory in Pasadena, California, in a statement. "We climbed through thousands of feet of lake deposits and never saw evidence like this — and now we found it in a place we expected to be dry...."

"Billions of years ago, waves on the surface of a shallow lake stirred up sediment at the lake bottom, over time creating rippled textures left in rock," according to a NASA news release.
From NASA's announcement: Having climbed nearly a half-mile above the mountain's base, Curiosity has found these rippled rock textures preserved in what's nicknamed the 'Marker Band' — a thin layer of dark rock that stands out from the rest of Mount Sharp....

Far ahead of the Marker Band, scientists can see another clue to the history of Mars' ancient water in a valley named Gediz Vallis. Wind carved the valley, but a channel running through it that starts higher up on Mount Sharp is thought to have been eroded by a small river.

NBC News reports: Eating fewer calories appears to slow the pace of aging and increase longevity in healthy adults, according to a study published Thursday in the journal Nature Aging.

The study, which was funded by the National Institute on Aging, part of the National Institutes of Health, is the first-ever randomized controlled trial that looked at the long-term impact of calorie restriction. It adds to an already large body of evidence that a calorie-restricted diet can provide substantial health benefits, including delayed aging, said the study's senior author, Dan Belsky, who is assistant professor of epidemiology at Columbia University's Mailman School of Public Health in New York City. "The main take-home of our study is that it is possible to slow the pace of biological aging and that it may be possible to achieve that slowing through modification of lifestyle and behavior," Belsky said.

In a phase 2 clinical trial, which ran for two years, 220 adults were randomized to cut their caloric intake by as much as 25% — 500 calories for people who generally consume 2,000 calories a day — or to make no changes to their diet. The participants had a body mass index, or BMI, ranging from 22 to 27.... Dr. Evan Hadley, director of the geriatrics and clinical gerontology division at the National Institute of Aging, said that most people in the calorie-restriction group only ended up cutting their daily caloric intake by about 12%. "But that 12% was enough to have significant changes," he said....

The researchers found that people who cut their calories slowed the pace of their aging by 2% to 3%, compared to people who were on a normal diet. That translates, Belsky said, to a 10% to 15% reduction in the likelihood of dying early. "We all have the power to change the trajectories of aging," he said.
Thanks to long-time Slashdot reader schwit1 for submitting the story.

A new pill could help alleviate constipation by delivering vibrations that "help kickstart the body's nature processes for getting rid of waste," reports Gizmodo. From the report: Vibrant still comes in the form of a pill, but before swallowing (around bedtime each night), it first needs to be activated by inserting it into a smartphone-connected pod. The pill makes its way through the body the same way food and other orally consumed medications do, but it isn't dissolved or broken down by stomach acids. Vibrant capsules are made from the same medical-grade material as pill cameras and are engineered to be durable enough to survive even accidental bites. Instead, it delivers relief by making small vibrations in three second intervals (three seconds on, three seconds off) to help stimulate nerve cells that trigger peristalsis: the wave like muscle contractions that push food and waste through the body.

After being swallowed, the pill vibrates for about two hours, goes dormant for around six hours, and then vibrates once again for another two hours. It remains completely intact until it exits the body (hopefully along with the blockage causing the constipation), when it's then flushed away. It doesn't sound like the motorized mechanism inside the pills is rechargeable -- not that you'd want to reuse one after its first fantastic voyage.

The pill's efficacy was tested in a study where 200 people dealing with chronic constipation took it every night for eight weeks, with 40% of the group reporting at least one additional bowel movement every week. Only 23% of an additional group of 149 people who took a placebo during the study reported having at least one more bowel movement per week. Unlike most laxatives, Vibrant doesn't cause side effects like diarrhea; however, a small minority of test subjects were actually able to feel the pill vibrating inside them. But it wasn't uncomfortable enough to stop them from taking it on a daily basis.

An anonymous reader quotes a report from MIT Technology Review: Imagine that you were provided no-cost fertility treatment and also offered a free DNA test to gauge which of those little IVF embryos floating in a dish stood the best chance of getting into a top college someday. Would you have the test performed? If you said yes, you're among about 40% percent of Americans who told pollsters they'd be more likely than not to test and pick IVF embryos for intellectual aptitude, despite hand-wringing by ethicists and gene scientists who think it's a bad idea. The opinion survey, published in the journal Science, was carried out by economists and other researchers who say surprisingly strong support for the embryo tests means the US might need to hurry up and set policies for the technology.

The new poll compared people's willingness to advance their children's prospects in three ways: using SAT prep courses, embryo tests, and gene editing on embryos. It found some support even for the most radical option, genetic modification of children, which is prohibited in the US and many other countries. About 28% of those polled said they'd probably do that if it was safe. The authors of the new poll are wrestling with the consequences of information that they helped discover via a series of ever larger studies to locate genetic causes of human social and cognitive traits, including sexual orientation and intelligence. That includes a report published last year on how the DNA differences among more than 3 million people related to how far they'd gone in school, a life result that is correlated with a person's intelligence.

The result of such research is a so-called "polygenic score," or a genetic test that can predict from genes whether -- among other things -- someone is going to be more or less likely to attend college. Of course, environmental factors matter plenty, and DNA is not destiny. Yet the gene tests are surprisingly predictive. In their poll, the researchers told people to assume that around 3% of kids will go to a top-100 college. By picking the one of 10 IVF embryos with the highest gene score, parents would increase that chance to 5% for their kid. It's tempting to dismiss the advantage gained as negligible, but "assuming they are right," Carmi says, it's actually "a very large relative increase" in the chance of going to such a school for the offspring in question -- about 67%. "The current poll found only 6% of people are morally opposed to IVF today, only about 17% have strong moral qualms about testing embryos, and 38% would probably do to boost education prospects if given the opportunity," adds the report.